ATE201873T1 - Aryl- und heteroaryl- purin- und pyridopyrimidin- derivate - Google Patents

Aryl- und heteroaryl- purin- und pyridopyrimidin- derivate

Info

Publication number
ATE201873T1
ATE201873T1 AT96934673T AT96934673T ATE201873T1 AT E201873 T1 ATE201873 T1 AT E201873T1 AT 96934673 T AT96934673 T AT 96934673T AT 96934673 T AT96934673 T AT 96934673T AT E201873 T1 ATE201873 T1 AT E201873T1
Authority
AT
Austria
Prior art keywords
aryl
pyridopyrimidine derivatives
purine
heteroaryl
heteroaryl purine
Prior art date
Application number
AT96934673T
Other languages
English (en)
Inventor
Franco Buzzetti
Maria Gabriella Brasca
Antonio Longo
Dario Ballinari
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9523242.7A external-priority patent/GB9523242D0/en
Priority claimed from GBGB9524131.1A external-priority patent/GB9524131D0/en
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Application granted granted Critical
Publication of ATE201873T1 publication Critical patent/ATE201873T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/36—Sulfur atom
    • C07D473/38—Sulfur atom attached in position 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT96934673T 1995-11-14 1996-10-14 Aryl- und heteroaryl- purin- und pyridopyrimidin- derivate ATE201873T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9523242.7A GB9523242D0 (en) 1995-11-14 1995-11-14 Aryl and heteroaryl purine compounds
GBGB9524131.1A GB9524131D0 (en) 1995-11-24 1995-11-24 Pyrido-pyrimidine compounds as tyrosine kinase inhibitors
PCT/EP1996/004460 WO1997018212A1 (en) 1995-11-14 1996-10-14 Aryl and heteroaryl purine compounds

Publications (1)

Publication Number Publication Date
ATE201873T1 true ATE201873T1 (de) 2001-06-15

Family

ID=26308112

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96934673T ATE201873T1 (de) 1995-11-14 1996-10-14 Aryl- und heteroaryl- purin- und pyridopyrimidin- derivate

Country Status (17)

Country Link
US (1) US5965563A (de)
EP (1) EP0802914B1 (de)
JP (1) JPH10512896A (de)
CN (1) CN1168138A (de)
AR (1) AR004320A1 (de)
AT (1) ATE201873T1 (de)
AU (1) AU7292096A (de)
BR (1) BR9607089A (de)
CA (1) CA2209598C (de)
DE (1) DE69613211T2 (de)
EA (1) EA000072B1 (de)
ES (1) ES2159760T3 (de)
HU (1) HUP9801177A3 (de)
IL (1) IL121090A0 (de)
NO (1) NO973198L (de)
PL (1) PL321296A1 (de)
WO (1) WO1997018212A1 (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL112249A (en) 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
TW321649B (de) * 1994-11-12 1997-12-01 Zeneca Ltd
GB9424233D0 (en) * 1994-11-30 1995-01-18 Zeneca Ltd Quinazoline derivatives
GB9508565D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quiazoline derivative
GB9508537D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
DE69613367T2 (de) * 1995-04-27 2002-04-18 Astrazeneca Ab Chinazolin derivate
GB9508535D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivative
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
SK285141B6 (sk) 1996-02-13 2006-07-07 Astrazeneca Uk Limited Použitie chinazolínového derivátu, chinazolínový derivát, spôsob jeho prípravy a farmaceutická kompozícia, ktorá ho obsahuje
GB9603097D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline compounds
EP0885198B1 (de) 1996-03-05 2001-12-19 AstraZeneca AB 4-anilinochinazolin derivate
EP0892789B2 (de) 1996-04-12 2009-11-18 Warner-Lambert Company LLC Umkehrbare inhibitoren von tyrosin kinasen
HRP970371A2 (en) * 1996-07-13 1998-08-31 Kathryn Jane Smith Heterocyclic compounds
US5866702A (en) * 1996-08-02 1999-02-02 Cv Therapeutics, Incorporation Purine inhibitors of cyclin dependent kinase 2
WO1999002162A1 (en) * 1997-07-12 1999-01-21 Cancer Research Campaign Technology Limited Cyclin dependent kinase inhibiting purine derivatives
RS49779B (sr) 1998-01-12 2008-06-05 Glaxo Group Limited, Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze
ID26698A (id) 1998-06-19 2001-02-01 Pfizer Prod Inc SENYAWA-SENYAWA PIROLO [2,3-d] PIRIMIDINA
PA8474101A1 (es) 1998-06-19 2000-09-29 Pfizer Prod Inc Compuestos de pirrolo [2,3-d] pirimidina
US6933299B1 (en) 1999-07-09 2005-08-23 Smithkline Beecham Corporation Anilinoquinazolines as protein tyrosine kinase inhibitors
ATE377597T1 (de) 1999-07-09 2007-11-15 Glaxo Group Ltd Anilinochinazoline als protein-tyrosin- kinasehemmer
ES2306306T3 (es) 1999-11-05 2008-11-01 Astrazeneca Ab Nuevos derivados de quinazolina.
SK287188B6 (sk) 1999-12-10 2010-02-08 Pfizer Products Inc. Pyrolo [2,3-d]pyrimidínová zlúčenina, jej použitie a farmaceutická kompozícia alebo kombinácia s jej obsahom
SI1294724T1 (sl) 2000-06-26 2006-08-31 Pfizer Prod Inc Pirolo(2,3-d)primidinske spojine kot imunosupresivna sredstva
US7301023B2 (en) 2001-05-31 2007-11-27 Pfizer Inc. Chiral salt resolution
AU2002346729A1 (en) * 2001-12-20 2003-07-09 Bristol-Myers Squibb Company Barbituric acid derivatives as inhibitors of tnf-$g(a) converting enzyme (tace) and/or matrix metalloproteinases
EP1352910A1 (de) * 2002-04-10 2003-10-15 Grünenthal GmbH Neue Analoga von Nitrobenzylthioinosine
CN1717236A (zh) 2002-11-26 2006-01-04 辉瑞产品公司 治疗移植排斥的方法
US20050124637A1 (en) * 2003-08-15 2005-06-09 Irm Llc Compounds and compositions as inhibitors of receptor tyrosine kinase activity
CA2553433A1 (en) 2004-01-23 2005-08-11 Amgen Inc. Quinoline quinazoline pyridine and pyrimidine compounds and their use in the treatment of inflammation angiogenesis and cancer
CN1933839A (zh) * 2004-01-23 2007-03-21 安进公司 化合物和使用方法
ES2294400T3 (es) * 2004-06-29 2008-04-01 Grunenthal Gmbh Nuevos analogos de notrobenciltioinosina.
US7652009B2 (en) * 2004-11-30 2010-01-26 Amgem Inc. Substituted heterocycles and methods of use
JO2787B1 (en) * 2005-04-27 2014-03-15 امجين إنك, Alternative amide derivatives and methods of use
WO2007076034A2 (en) * 2005-12-21 2007-07-05 Abbott Laboratories Anti-viral compounds
WO2007081517A2 (en) 2005-12-21 2007-07-19 Abbott Laboratories Anti-viral compounds
TWI399380B (zh) * 2006-12-20 2013-06-21 Abbott Lab 抗病毒化合物
JP5343082B2 (ja) * 2007-10-29 2013-11-13 アムジエン・インコーポレーテツド ベンゾモルホリン誘導体および使用方法
DK2384326T3 (da) 2008-08-20 2014-05-05 Zoetis Llc Pyrrolo[2,3-d]pyrimidinforbindelser
DE102011111400A1 (de) * 2011-08-23 2013-02-28 Merck Patent Gmbh Bicyclische heteroaromatische Verbindungen
CN104470931B (zh) 2012-05-21 2016-10-26 拜耳医药股份有限公司 取代的苯并噻吩并嘧啶
TW201412740A (zh) 2012-09-20 2014-04-01 Bayer Pharma AG 經取代之吡咯并嘧啶胺基苯并噻唑酮
ES2686909B1 (es) 2017-03-22 2019-08-16 Consejo Superior Investigacion Compuestos inhibidores de cdc-7 y su uso para el tratamiento de patologias neurologicas
FR3066761B1 (fr) 2017-05-23 2020-10-30 Centre Nat Rech Scient Nouveaux composes inhibiteurs des canaux ioniques

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB828522A (en) * 1956-11-02 1960-02-17 Geigy Ag J R Purine derivatives and a process for the preparation thereof
US3112192A (en) * 1960-09-19 1963-11-26 Shell Oil Co Preservation of cut flowers
AU575438B2 (en) * 1984-10-26 1988-07-28 Warner-Lambert Company N6 - substituted deoxyribose analogues of adenosines
US4751292A (en) * 1985-07-02 1988-06-14 The Plant Cell Research Institute, Inc. Adamantyl purines
DE3529497A1 (de) * 1985-08-17 1987-02-26 Boehringer Mannheim Gmbh N(pfeil hoch)6(pfeil hoch)-disubstituierte purinderivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
AU626983B2 (en) * 1989-01-31 1992-08-13 Whitby Research, Inc. N6-substituted 9-methyladenines
US5034393A (en) * 1989-07-27 1991-07-23 Dowelanco Fungicidal use of pyridopyrimidine, pteridine, pyrimidopyrimidine, pyrimidopyridazine, and pyrimido-1,2,4-triazine derivatives
DK0619805T3 (da) * 1991-11-25 2000-06-05 Pfizer 5-(Hetero-eller carbocyclylamino)-indolderivater, deres fremstilling og anvendelse som 5-HT1-agonister
US5670501A (en) * 1994-09-01 1997-09-23 Discovery Therapeutics, Inc. N-substituted 9-alkyladenines

Also Published As

Publication number Publication date
EP0802914B1 (de) 2001-06-06
HUP9801177A2 (hu) 1998-09-28
CA2209598C (en) 2005-06-07
ES2159760T3 (es) 2001-10-16
DE69613211T2 (de) 2001-11-15
US5965563A (en) 1999-10-12
PL321296A1 (en) 1997-12-08
EA199700107A1 (ru) 1997-12-30
NO973198D0 (no) 1997-07-09
AU7292096A (en) 1997-06-05
HUP9801177A3 (en) 1998-11-30
BR9607089A (pt) 1997-11-11
CA2209598A1 (en) 1997-05-22
AR004320A1 (es) 1998-11-04
EP0802914A1 (de) 1997-10-29
DE69613211D1 (de) 2001-07-12
NO973198L (no) 1997-07-09
EA000072B1 (ru) 1998-06-25
CN1168138A (zh) 1997-12-17
JPH10512896A (ja) 1998-12-08
IL121090A0 (en) 1997-11-20
WO1997018212A1 (en) 1997-05-22
MX9705010A (es) 1997-10-31

Similar Documents

Publication Publication Date Title
DE69613211T2 (de) Aryl- und heteroaryl- purin- und pyridopyrimidin- derivate
ATE198329T1 (de) Chinazolin-derivate
ATE205483T1 (de) Chinazolinderivate
IS2268B (is) Gúanín afleiður
NO953406D0 (no) Pyrrolo-pyridinderivater
ATE228135T1 (de) Rapamycinderivate
DE69610698T2 (de) Chinazolin-derivate
ATE199150T1 (de) Diphenylmethylenpiperidin-derivate
FI940167A0 (fi) Puriinijohdannaisia
DE69601527T2 (de) Pyrrolylbenzimidazol-Derivate
ATA100695A (de) Prothrombin-derivate
DE69524611D1 (de) Pyrimidon-derivate
NO952508D0 (no) Purinderivater
ATE240307T1 (de) Diarylalkenylamin-derivate
DE69627830D1 (de) Pyrazol-derivate
DE59607054D1 (de) 4-Amino-benzoylguanidin-Derivate
DE59610106D1 (de) Fluorbenzylether-Derivate
ATE177102T1 (de) Chromanderivate
DE69624122D1 (de) Aza-anthracyclinone-derivate
DE59607055D1 (de) 4-Mercapto-benzoylguanidin-Derivate
DE69620514T2 (de) 5-aminoflavon-derivate
ATA45796A (de) Lysin-prolin-derivate
BR9609892A (pt) Derivados de imidazopiridina
NO940123D0 (no) Purinderivater

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties