CN1168138A - 芳基和杂芳基嘌呤化合物 - Google Patents

芳基和杂芳基嘌呤化合物 Download PDF

Info

Publication number: CN1168138A
Authority: CN; China
Prior art keywords: pyrimidine; pyrido; methoxyl group; tetralyl; indenyl
Prior art date: 1995-11-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

CN96191448A

Other languages

English (en)

Chinese (zh)

Inventor

F·布泽蒂

M·G·博拉斯卡

A·龙高

D·巴里纳利

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pfizer Italia SRL

Pharmacia and Upjohn Co

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-14

Filing date

1996-10-14

Publication date

1997-12-17

1995-11-14 Priority claimed from GBGB9523242.7A external-priority patent/GB9523242D0/en

1995-11-24 Priority claimed from GBGB9524131.1A external-priority patent/GB9524131D0/en

1996-10-14 Application filed by Upjohn Co filed Critical Upjohn Co

1997-12-17 Publication of CN1168138A publication Critical patent/CN1168138A/zh

Status Pending legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
- C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/36—Sulfur atom
- C07D473/38—Sulfur atom attached in position 6

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Hematology (AREA)
Oncology (AREA)
Transplantation (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

CN96191448A 1995-11-14 1996-10-14 芳基和杂芳基嘌呤化合物 Pending CN1168138A (zh)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GBGB9523242.7A GB9523242D0 (en)	1995-11-14	1995-11-14	Aryl and heteroaryl purine compounds
GB9523242.7		1995-11-14
GBGB9524131.1A GB9524131D0 (en)	1995-11-24	1995-11-24	Pyrido-pyrimidine compounds as tyrosine kinase inhibitors
GB9524131.1		1995-11-24

Publications (1)

Publication Number	Publication Date
CN1168138A true CN1168138A (zh)	1997-12-17

Family

ID=26308112

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CN96191448A Pending CN1168138A (zh)	1995-11-14	1996-10-14	芳基和杂芳基嘌呤化合物

Country Status (17)

Country	Link
US (1)	US5965563A (es)
EP (1)	EP0802914B1 (es)
JP (1)	JPH10512896A (es)
CN (1)	CN1168138A (es)
AR (1)	AR004320A1 (es)
AT (1)	ATE201873T1 (es)
AU (1)	AU7292096A (es)
BR (1)	BR9607089A (es)
CA (1)	CA2209598C (es)
DE (1)	DE69613211T2 (es)
EA (1)	EA000072B1 (es)
ES (1)	ES2159760T3 (es)
HU (1)	HUP9801177A3 (es)
IL (1)	IL121090A0 (es)
NO (1)	NO973198L (es)
PL (1)	PL321296A1 (es)
WO (1)	WO1997018212A1 (es)

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* Cited by examiner, † Cited by third party
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IL112249A (en)	1994-01-25	2001-11-25	Warner Lambert Co	Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
TW321649B (es) *	1994-11-12	1997-12-01	Zeneca Ltd
GB9424233D0 (en) *	1994-11-30	1995-01-18	Zeneca Ltd	Quinazoline derivatives
GB9508537D0 (en) *	1995-04-27	1995-06-14	Zeneca Ltd	Quinazoline derivatives
DE69613367T2 (de) *	1995-04-27	2002-04-18	Astrazeneca Ab, Soedertaelje	Chinazolin derivate
GB9508535D0 (en) *	1995-04-27	1995-06-14	Zeneca Ltd	Quinazoline derivative
GB9508565D0 (en) *	1995-04-27	1995-06-14	Zeneca Ltd	Quiazoline derivative
GB9624482D0 (en) *	1995-12-18	1997-01-15	Zeneca Phaema S A	Chemical compounds
WO1997030035A1 (en)	1996-02-13	1997-08-21	Zeneca Limited	Quinazoline derivatives as vegf inhibitors
GB9603097D0 (en) *	1996-02-14	1996-04-10	Zeneca Ltd	Quinazoline compounds
WO1997032856A1 (en)	1996-03-05	1997-09-12	Zeneca Limited	4-anilinoquinazoline derivatives
ATE213730T1 (de)	1996-04-12	2002-03-15	Warner Lambert Co	Umkehrbare inhibitoren von tyrosin kinasen
HRP970371A2 (en) *	1996-07-13	1998-08-31	Kathryn Jane Smith	Heterocyclic compounds
US5866702A (en) *	1996-08-02	1999-02-02	Cv Therapeutics, Incorporation	Purine inhibitors of cyclin dependent kinase 2
WO1999002162A1 (en) *	1997-07-12	1999-01-21	Cancer Research Campaign Technology Limited	Cyclin dependent kinase inhibiting purine derivatives
RS49779B (sr)	1998-01-12	2008-06-05	Glaxo Group Limited,	Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze
PA8474101A1 (es)	1998-06-19	2000-09-29	Pfizer Prod Inc	Compuestos de pirrolo [2,3-d] pirimidina
TW505646B (en)	1998-06-19	2002-10-11	Pfizer Prod Inc	Pyrrolo [2,3-d] pyrimidine compounds
WO2001004111A1 (en)	1999-07-09	2001-01-18	Glaxo Group Limited	Anilinoquinazolines as protein tyrosine kinase inhibitors
US6933299B1 (en)	1999-07-09	2005-08-23	Smithkline Beecham Corporation	Anilinoquinazolines as protein tyrosine kinase inhibitors
UA72946C2 (uk)	1999-11-05	2005-05-16	Астразенека Аб	Похідні хіназоліну як інгібітори васкулярного ендотеліального фактора росту (vegf)
PL218519B1 (pl)	1999-12-10	2014-12-31	Pfizer Prod Inc	Związki pirolo [2,3-d] pirymidynowe, środek farmaceutyczny zawierający te związki oraz ich zastosowanie
SK17342002A3 (sk)	2000-06-26	2004-06-08	Pfizer Products Inc.	Derivát pyrolo[2,3-d]pyrimidínu ako činidlo potlačujúce imunitu
US7301023B2 (en)	2001-05-31	2007-11-27	Pfizer Inc.	Chiral salt resolution
AU2002346729A1 (en) *	2001-12-20	2003-07-09	Bristol-Myers Squibb Company	Barbituric acid derivatives as inhibitors of tnf-$g(a) converting enzyme (tace) and/or matrix metalloproteinases
EP1352910A1 (en) *	2002-04-10	2003-10-15	Grünenthal GmbH	New analogs of nitrobenzylthioinosine
EP1572213A1 (en)	2002-11-26	2005-09-14	Pfizer Products Inc.	Method of treatment of transplant rejection
MXPA06001758A (es) *	2003-08-15	2006-08-11	Irm Llc	Anilino purinas sustituidas en la posicion 6 utiles como inhibidores de rtk.
US7626030B2 (en)	2004-01-23	2009-12-01	Amgen Inc.	Compounds and methods of use
KR20070026390A (ko) *	2004-01-23	2007-03-08	암젠 인코포레이션	화합물 및 사용방법
ES2294400T3 (es) *	2004-06-29	2008-04-01	Grunenthal Gmbh	Nuevos analogos de notrobenciltioinosina.
EP1827434B1 (en) *	2004-11-30	2014-01-15	Amgen Inc.	Quinolines and quinazoline analogs and their use as medicaments for treating cancer
JO2787B1 (en) *	2005-04-27	2014-03-15	امجين إنك,	Alternative amide derivatives and methods of use
WO2007081517A2 (en)	2005-12-21	2007-07-19	Abbott Laboratories	Anti-viral compounds
JP2009521479A (ja) *	2005-12-21	2009-06-04	アボット・ラボラトリーズ	抗ウイルス化合物
TWI399380B (zh) *	2006-12-20	2013-06-21	Abbott Lab	抗病毒化合物
ES2417009T3 (es) *	2007-10-29	2013-08-05	Amgen, Inc	Derivados de benzomorfolina y métodos de uso
WO2010020905A1 (en)	2008-08-20	2010-02-25	Pfizer Inc.	Pyrrolo[2,3-d]pyrimidine compounds
DE102011111400A1 (de) *	2011-08-23	2013-02-28	Merck Patent Gmbh	Bicyclische heteroaromatische Verbindungen
ES2592404T3 (es)	2012-05-21	2016-11-30	Bayer Pharma Aktiengesellschaft	Benzotienopirimidinas sustituidas
TW201412740A (zh) *	2012-09-20	2014-04-01	Bayer Pharma AG	經取代之吡咯并嘧啶胺基苯并噻唑酮
ES2686909B1 (es)	2017-03-22	2019-08-16	Consejo Superior Investigacion	Compuestos inhibidores de cdc-7 y su uso para el tratamiento de patologias neurologicas
FR3066761B1 (fr) *	2017-05-23	2020-10-30	Centre Nat Rech Scient	Nouveaux composes inhibiteurs des canaux ioniques

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB828522A (en) *	1956-11-02	1960-02-17	Geigy Ag J R	Purine derivatives and a process for the preparation thereof
US3112192A (en) *	1960-09-19	1963-11-26	Shell Oil Co	Preservation of cut flowers
AU575438B2 (en) *	1984-10-26	1988-07-28	Warner-Lambert Company	N6 - substituted deoxyribose analogues of adenosines
US4751292A (en) *	1985-07-02	1988-06-14	The Plant Cell Research Institute, Inc.	Adamantyl purines
DE3529497A1 (de) *	1985-08-17	1987-02-26	Boehringer Mannheim Gmbh	N(pfeil hoch)6(pfeil hoch)-disubstituierte purinderivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
EP0457773A4 (en) *	1989-01-31	1993-03-10	Whitby Research Incorporated	N?6 -substituted 9-methyladenines: a new class of adenosine receptor antagonists
US5034393A (en) *	1989-07-27	1991-07-23	Dowelanco	Fungicidal use of pyridopyrimidine, pteridine, pyrimidopyrimidine, pyrimidopyridazine, and pyrimido-1,2,4-triazine derivatives
UA41297C2 (uk) *	1991-11-25	2001-09-17	Пфайзер, Інк.	Похідні індолу, фармацевтична композиція і спосіб лікування
US5670501A (en) *	1994-09-01	1997-09-23	Discovery Therapeutics, Inc.	N-substituted 9-alkyladenines

1996
- 1996-10-14 AT AT96934673T patent/ATE201873T1/de not_active IP Right Cessation
- 1996-10-14 PL PL96321296A patent/PL321296A1/xx unknown
- 1996-10-14 EP EP96934673A patent/EP0802914B1/en not_active Expired - Lifetime
- 1996-10-14 DE DE69613211T patent/DE69613211T2/de not_active Expired - Fee Related
- 1996-10-14 WO PCT/EP1996/004460 patent/WO1997018212A1/en not_active Application Discontinuation
- 1996-10-14 IL IL12109096A patent/IL121090A0/xx unknown
- 1996-10-14 HU HU9801177A patent/HUP9801177A3/hu unknown
- 1996-10-14 CN CN96191448A patent/CN1168138A/zh active Pending
- 1996-10-14 BR BR9607089A patent/BR9607089A/pt not_active Application Discontinuation
- 1996-10-14 ES ES96934673T patent/ES2159760T3/es not_active Expired - Lifetime
- 1996-10-14 AU AU72920/96A patent/AU7292096A/en not_active Abandoned
- 1996-10-14 US US08/860,717 patent/US5965563A/en not_active Expired - Fee Related
- 1996-10-14 EA EA199700107A patent/EA000072B1/ru not_active IP Right Cessation
- 1996-10-14 CA CA002209598A patent/CA2209598C/en not_active Expired - Fee Related
- 1996-10-14 JP JP9518527A patent/JPH10512896A/ja not_active Ceased
- 1996-11-13 AR ARP960105153A patent/AR004320A1/es unknown
1997
- 1997-07-09 NO NO973198A patent/NO973198L/no unknown

Also Published As

Publication number	Publication date
US5965563A (en)	1999-10-12
ES2159760T3 (es)	2001-10-16
NO973198D0 (no)	1997-07-09
IL121090A0 (en)	1997-11-20
NO973198L (no)	1997-07-09
ATE201873T1 (de)	2001-06-15
AR004320A1 (es)	1998-11-04
JPH10512896A (ja)	1998-12-08
DE69613211T2 (de)	2001-11-15
CA2209598A1 (en)	1997-05-22
CA2209598C (en)	2005-06-07
DE69613211D1 (de)	2001-07-12
BR9607089A (pt)	1997-11-11
EP0802914B1 (en)	2001-06-06
EP0802914A1 (en)	1997-10-29
HUP9801177A2 (hu)	1998-09-28
MX9705010A (es)	1997-10-31
AU7292096A (en)	1997-06-05
HUP9801177A3 (en)	1998-11-30
PL321296A1 (en)	1997-12-08
EA000072B1 (ru)	1998-06-25
EA199700107A1 (ru)	1997-12-30
WO1997018212A1 (en)	1997-05-22

Legal Events

Date	Code	Title
1997-12-17	C06	Publication
1997-12-17	PB01	Publication
1999-08-18	C01	Deemed withdrawal of patent application (patent law 1993)
1999-08-18	WD01	Invention patent application deemed withdrawn after publication

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