EA201290324A1 - Киназные ингибиторы - Google Patents

Киназные ингибиторы

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Publication number
EA201290324A1
EA201290324A1 EA201290324A EA201290324A EA201290324A1 EA 201290324 A1 EA201290324 A1 EA 201290324A1 EA 201290324 A EA201290324 A EA 201290324A EA 201290324 A EA201290324 A EA 201290324A EA 201290324 A1 EA201290324 A1 EA 201290324A1
Authority
EA
Eurasian Patent Office
Prior art keywords
protein kinase
provides
diseases
pyropyrimidine
pyrazolopyrimidine
Prior art date
Application number
EA201290324A
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English (en)
Other versions
EA024729B1 (ru
Inventor
Джаекиоо Ли
Хо-Джун Сонг
Джонг Сунг Кох
Хее Киу Ли
Янгсам Ким
Хонг Ву Ким
Сунва Чэнг
Сун-Хее Лим
Джэнг-Сик Чой
Джанг-Хо Ким
Се-Вон Ким
Original Assignee
Джиноско
Оскотек Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Джиноско, Оскотек Инк. filed Critical Джиноско
Publication of EA201290324A1 publication Critical patent/EA201290324A1/ru
Publication of EA024729B1 publication Critical patent/EA024729B1/ru

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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Abstract

В изобретении заявлена новая группа протеинкиназных ингибиторов, производных пирропиримидина и пиразолопиримидина, и их фармацевтически приемлемые соли и пролекарства, которые применяют для лечения пролиферативных заболеваний и расстройств клеток, таких как рак, аутоиммунные заболевания, инфекции, сердечно-сосудистые заболевания и нейродегенеративные заболевания и расстройства. В данном изобретении представлены способы синтеза и введения соединений протеинкиназных ингибиторов. В изобретении также представлены фармацевтические композиции, содержащие по меньшей мере одно соединение протеинкиназного ингибитора вместе с фармацевтически приемлемым носителем, разбавителем или наполнителем. В изобретении также представлены промежуточные соединения, полученные во время синтеза производных пирропиримидина и пиразолопиримидина.
EA201290324A 2009-11-13 2010-11-12 Киназные ингибиторы EA024729B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26110009P 2009-11-13 2009-11-13
PCT/US2010/056583 WO2011060295A1 (en) 2009-11-13 2010-11-12 Kinase inhibitors

Publications (2)

Publication Number Publication Date
EA201290324A1 true EA201290324A1 (ru) 2012-12-28
EA024729B1 EA024729B1 (ru) 2016-10-31

Family

ID=43992073

Family Applications (1)

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EA201290324A EA024729B1 (ru) 2009-11-13 2010-11-12 Киназные ингибиторы

Country Status (17)

Country Link
US (1) US8629132B2 (ru)
EP (1) EP2498607B1 (ru)
JP (1) JP5740409B2 (ru)
KR (1) KR101663637B1 (ru)
CN (1) CN102811619B (ru)
BR (1) BR112012011287B1 (ru)
CA (1) CA2780892C (ru)
CL (1) CL2012001221A1 (ru)
EA (1) EA024729B1 (ru)
HK (1) HK1179477A1 (ru)
IL (1) IL219726A (ru)
MX (1) MX2012005332A (ru)
MY (1) MY160820A (ru)
NZ (1) NZ599041A (ru)
SG (1) SG10201407453TA (ru)
WO (1) WO2011060295A1 (ru)
ZA (1) ZA201204246B (ru)

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