EA201270730A1 - ИНГИБИТОРЫ КИНАЗЫ Cdc7 И ИХ ПРИМЕНЕНИЕ - Google Patents

ИНГИБИТОРЫ КИНАЗЫ Cdc7 И ИХ ПРИМЕНЕНИЕ

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EA201270730A1
EA201270730A1 EA201270730A EA201270730A EA201270730A1 EA 201270730 A1 EA201270730 A1 EA 201270730A1 EA 201270730 A EA201270730 A EA 201270730A EA 201270730 A EA201270730 A EA 201270730A EA 201270730 A1 EA201270730 A1 EA 201270730A1
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Eurasian Patent Office
Prior art keywords
compounds
methods
cdc7
dihydrogranaticin
inhibit
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EA201270730A
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English (en)
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EA025443B1 (ru
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Марк Фраттини
Аким Джабалла
Томас Дж. Келли
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Слоан-Кеттеринг Институт Фор Кэнсер
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Publication of EA201270730A1 publication Critical patent/EA201270730A1/ru
Publication of EA025443B1 publication Critical patent/EA025443B1/ru

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Abstract

Изобретение относится к соединениям, способам, фармацевтическим композициям и наборам для лечения пролиферативных нарушений, таких как злокачественная опухоль. В одном аспекте способы предусматривают соединения, которые ингибируют активность протеинкиназ, таких как киназа клеточного цикла (Cdc). В другом аспекте способы предусматривают соединения, которые ингибируют активность Cdc7 и/или Dbf4. В другом аспекте способы предусматривают соединения, которые проявляют антипролиферативные свойства, применимые в лечении заболеваний, таких как злокачественная опухоль. Соединения, применимые для какого-либо из способов, включают соединения формулы (А) или (В) или их фармацевтически приемлемые соли. Типичные соединения формулы (А) или (В) включают гранатицин А, гранатицин В, дигидрогранатицин А, дигидрогранатицин В, медермицин и актинорходин.
EA201270730A 2010-03-08 2011-03-08 ПРИМЕНЕНИЕ В КАЧЕСТВЕ ИНГИБИТОРА КИНАЗЫ Cdc7 ГРАНАТИЦИНА B EA025443B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31174110P 2010-03-08 2010-03-08
PCT/US2011/027619 WO2011112635A1 (en) 2010-03-08 2011-03-08 Cdc7 kinase inhibitors and uses thereof

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EA201270730A1 true EA201270730A1 (ru) 2013-02-28
EA025443B1 EA025443B1 (ru) 2016-12-30

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EA201270730A EA025443B1 (ru) 2010-03-08 2011-03-08 ПРИМЕНЕНИЕ В КАЧЕСТВЕ ИНГИБИТОРА КИНАЗЫ Cdc7 ГРАНАТИЦИНА B

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US (7) US9180105B2 (ru)
EP (3) EP2544674B1 (ru)
JP (1) JP5827962B2 (ru)
CN (1) CN102844023B (ru)
AU (1) AU2011224457B2 (ru)
CA (1) CA2789484C (ru)
DK (1) DK2544674T3 (ru)
EA (1) EA025443B1 (ru)
ES (1) ES2661367T3 (ru)
HK (1) HK1257444A1 (ru)
TR (1) TR201800962T4 (ru)
WO (1) WO2011112635A1 (ru)

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