WO2014125408A3 - Substituted 1h-pyrrolopyridinone derivatives as kinase inhibitors - Google Patents

Substituted 1h-pyrrolopyridinone derivatives as kinase inhibitors Download PDF

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Publication number
WO2014125408A3
WO2014125408A3 PCT/IB2014/058881 IB2014058881W WO2014125408A3 WO 2014125408 A3 WO2014125408 A3 WO 2014125408A3 IB 2014058881 W IB2014058881 W IB 2014058881W WO 2014125408 A3 WO2014125408 A3 WO 2014125408A3
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WO
WIPO (PCT)
Prior art keywords
present
kinase inhibitors
substituted
disorder
diseases
Prior art date
Application number
PCT/IB2014/058881
Other languages
French (fr)
Other versions
WO2014125408A2 (en
Inventor
Anima BORUAH
Srikanth CHITTY VENKATA
Subramanya Hosahalli
Sunil Kumar Panigrahi
Original Assignee
Aurigene Discovery Technologies Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aurigene Discovery Technologies Limited filed Critical Aurigene Discovery Technologies Limited
Publication of WO2014125408A2 publication Critical patent/WO2014125408A2/en
Publication of WO2014125408A3 publication Critical patent/WO2014125408A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

The present invention provides novel substituted 1H-Pyrrolopyridinone derivatives of formula (1) as protein kinase inhibitors, in which R1, R2, R3, R4, R5, R6 and 'p' have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention in diseases or disorder, in particular their use in diseases or disorder where there is an advantage in inhibiting kinase enzyme, more particularly BTK enzyme. The present invention also provides methods for synthesizing and administering the kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor.
PCT/IB2014/058881 2013-02-12 2014-02-10 Substituted 1h-pyrrolopyridinone derivatives as kinase inhibitors WO2014125408A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN598CH2013 2013-02-12
IN598/CHE/2013 2013-02-12

Publications (2)

Publication Number Publication Date
WO2014125408A2 WO2014125408A2 (en) 2014-08-21
WO2014125408A3 true WO2014125408A3 (en) 2014-12-18

Family

ID=51354636

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2014/058881 WO2014125408A2 (en) 2013-02-12 2014-02-10 Substituted 1h-pyrrolopyridinone derivatives as kinase inhibitors

Country Status (1)

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WO (1) WO2014125408A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2016012808A (en) * 2014-04-02 2017-01-05 Intermune Inc Anti-fibrotic pyridinones.
MA40943A (en) * 2014-11-10 2017-09-19 Constellation Pharmaceuticals Inc SUBSTITUTED PYRROLOPYRIDINES USED AS BROMODOMA INHIBITORS
EP3218376B1 (en) 2014-11-10 2019-12-25 Genentech, Inc. Bromodomain inhibitors and uses thereof
MA40940A (en) * 2014-11-10 2017-09-19 Constellation Pharmaceuticals Inc SUBSTITUTED PYRROLOPYRIDINES USED AS BROMODOMA INHIBITORS
WO2016123391A1 (en) 2015-01-29 2016-08-04 Genentech, Inc. Therapeutic compounds and uses thereof
SG11201808003RA (en) * 2016-04-15 2018-10-30 Abbvie Inc Bromodomain inhibitors
CN110167939B (en) * 2017-01-11 2021-12-31 江苏豪森药业集团有限公司 Pyrrolo [2,3-c ] pyridine derivatives, preparation method and medical application thereof
MA47409A (en) * 2017-02-06 2019-12-11 Idorsia Pharmaceuticals Ltd NEW PROCESS FOR THE SYNTHESIS OF 1-ARYL-1-TRIFLUOROMETHYLCYCLOPROPANES
WO2020007322A1 (en) * 2018-07-04 2020-01-09 清华大学 Compound targeted to degrade bet protein and application thereof
WO2020132004A1 (en) * 2018-12-20 2020-06-25 Saint Louis University Bet inhibitors for modulating dux4 expression in fshd
CA3133131A1 (en) * 2019-03-17 2020-09-24 Shanghai Ringene Biopharma Co., Ltd. Pyrrole amidopyridone compound, preparation method therefor and use thereof
GB201905721D0 (en) * 2019-04-24 2019-06-05 Univ Dundee Compounds
CN112625036A (en) * 2019-10-08 2021-04-09 上海海和药物研究开发股份有限公司 Compound with BRD4 inhibitory activity, preparation method and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007068728A2 (en) * 2005-12-16 2007-06-21 Pfizer Italia Srl N-substituted pyrrolopyridinones active as kinase inhibitors
EP2003129A1 (en) * 2007-06-11 2008-12-17 Nerviano Medical Sciences S.r.l. 1H-Pyrido[3,4-B]indol-1-one and 2,3,4,9-Tetrahydro-1H-Beta-Carbolin-1-one Derivatives
US20100056556A1 (en) * 2007-02-27 2010-03-04 Nerviano Medical Sciences S.R.L. Isoquinolinopyrrolopyridinones active as kinase inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007068728A2 (en) * 2005-12-16 2007-06-21 Pfizer Italia Srl N-substituted pyrrolopyridinones active as kinase inhibitors
US20100056556A1 (en) * 2007-02-27 2010-03-04 Nerviano Medical Sciences S.R.L. Isoquinolinopyrrolopyridinones active as kinase inhibitors
EP2003129A1 (en) * 2007-06-11 2008-12-17 Nerviano Medical Sciences S.r.l. 1H-Pyrido[3,4-B]indol-1-one and 2,3,4,9-Tetrahydro-1H-Beta-Carbolin-1-one Derivatives

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Publication number Publication date
WO2014125408A2 (en) 2014-08-21

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