EA201071337A1 - СОЛИ 2-ФТОР-N-МЕТИЛ-4-[7-(ХИНОЛИН-6-ИЛ-МЕТИЛ)ИМИДАЗО[1,2-b][1,2,4]ТРИАЗИН-2-ИЛ]БЕНЗАМИДА И СПОСОБЫ ИХ ПОЛУЧЕНИЯ - Google Patents

СОЛИ 2-ФТОР-N-МЕТИЛ-4-[7-(ХИНОЛИН-6-ИЛ-МЕТИЛ)ИМИДАЗО[1,2-b][1,2,4]ТРИАЗИН-2-ИЛ]БЕНЗАМИДА И СПОСОБЫ ИХ ПОЛУЧЕНИЯ

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EA201071337A1
EA201071337A1 EA201071337A EA201071337A EA201071337A1 EA 201071337 A1 EA201071337 A1 EA 201071337A1 EA 201071337 A EA201071337 A EA 201071337A EA 201071337 A EA201071337 A EA 201071337A EA 201071337 A1 EA201071337 A1 EA 201071337A1
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Prior art keywords
quinolin
imidazo
methyl
salts
triazin
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EA201071337A
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English (en)
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EA021364B1 (ru
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Линкай Вен
Лэй Цяо
Цзячэн Чжоу
Пинли Лю
Юнчунь Пань
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Инсайт Корпорейшн
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Application filed by Инсайт Корпорейшн filed Critical Инсайт Корпорейшн
Publication of EA201071337A1 publication Critical patent/EA201071337A1/ru
Publication of EA021364B1 publication Critical patent/EA021364B1/ru

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Данное изобретение направлено на дигидрохлоридную и дибензолсульфоновую соли ингибитора c-Met киназы 2-фтор-N-метил-4-[7-(хинолин-6-илметил)имидазо[1,2-b][1,2,4]триазин-2-ил]бензамида и его фармацевтические композиции, которые могут эффективно использоваться при лечении рака и других заболеваний, относящихся к дисрегуляции киназных сигнальных путей. Данное изобретение дополнительно относится к способам и промежуточным соединениям для получения 2-фтор-N-метил-4-[7-(хинолин-6-илметил)имидазо[1,2-b][1,2,4]триазин-2-ил]бензамида и его солей.
EA201071337A 2008-05-21 2009-05-20 СОЛИ 2-ФТОР-N-МЕТИЛ-4-[7-(ХИНОЛИН-6-ИЛ-МЕТИЛ)ИМИДАЗО[1,2-b][1,2,4]ТРИАЗИН-2-ИЛ]БЕНЗАМИДА И СПОСОБЫ ИХ ПОЛУЧЕНИЯ EA021364B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5499508P 2008-05-21 2008-05-21
PCT/US2009/044622 WO2009143211A2 (en) 2008-05-21 2009-05-20 Salts of 2-fluoro-n-methyl-4-[7-(quinolin-6-yl-methyl)- imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same

Publications (2)

Publication Number Publication Date
EA201071337A1 true EA201071337A1 (ru) 2011-06-30
EA021364B1 EA021364B1 (ru) 2015-06-30

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EA201071337A EA021364B1 (ru) 2008-05-21 2009-05-20 СОЛИ 2-ФТОР-N-МЕТИЛ-4-[7-(ХИНОЛИН-6-ИЛ-МЕТИЛ)ИМИДАЗО[1,2-b][1,2,4]ТРИАЗИН-2-ИЛ]БЕНЗАМИДА И СПОСОБЫ ИХ ПОЛУЧЕНИЯ

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US (7) US8420645B2 (ru)
EP (2) EP3287449A3 (ru)
JP (2) JP6022158B2 (ru)
KR (1) KR101706784B1 (ru)
CN (4) CN102083814B (ru)
AR (3) AR071873A1 (ru)
BR (1) BRPI0912882A2 (ru)
CA (1) CA2724742C (ru)
CL (1) CL2009001250A1 (ru)
CO (1) CO6300934A2 (ru)
CY (1) CY1119813T1 (ru)
DK (1) DK2300455T3 (ru)
EA (1) EA021364B1 (ru)
EC (1) ECSP10010685A (ru)
ES (1) ES2643363T3 (ru)
HK (1) HK1251568A1 (ru)
HR (1) HRP20171528T1 (ru)
HU (1) HUE034716T2 (ru)
IL (3) IL209229A (ru)
LT (1) LT2300455T (ru)
MA (1) MA32405B1 (ru)
MX (3) MX2010012718A (ru)
MY (2) MY187131A (ru)
NZ (2) NZ589622A (ru)
PL (1) PL2300455T3 (ru)
PT (1) PT2300455T (ru)
SI (1) SI2300455T1 (ru)
TW (1) TWI472529B (ru)
WO (1) WO2009143211A2 (ru)
ZA (1) ZA201008212B (ru)

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