EA201001017A1 - 3h-[1,2,3]триазоло[4,5-d]пиримидиновые соединения, их применение в качестве ингибиторов киназы mtor и киназы pi3 и их синтезы - Google Patents
3h-[1,2,3]триазоло[4,5-d]пиримидиновые соединения, их применение в качестве ингибиторов киназы mtor и киназы pi3 и их синтезыInfo
- Publication number
- EA201001017A1 EA201001017A1 EA201001017A EA201001017A EA201001017A1 EA 201001017 A1 EA201001017 A1 EA 201001017A1 EA 201001017 A EA201001017 A EA 201001017A EA 201001017 A EA201001017 A EA 201001017A EA 201001017 A1 EA201001017 A1 EA 201001017A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- kinase
- triazolo
- synthesis
- application
- pyrimidine compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Изобретение относится к 3Н-[1,2,3]триазоло[4,5-d]пиримидиновым соединениям формулы 1 или их фармацевтически приемлемым солям, где переменные являются такими, как здесь определено, композициям, содержащим эти соединения, и способам получения и применения этих соединений.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2108408P | 2008-01-15 | 2008-01-15 | |
US3468008P | 2008-03-07 | 2008-03-07 | |
PCT/US2009/030939 WO2009091788A1 (en) | 2008-01-15 | 2009-01-14 | 3h-[1,2,3]triazolo[4,5-d]pyrimidine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201001017A1 true EA201001017A1 (ru) | 2011-02-28 |
Family
ID=40377318
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201001017A EA201001017A1 (ru) | 2008-01-15 | 2009-01-14 | 3h-[1,2,3]триазоло[4,5-d]пиримидиновые соединения, их применение в качестве ингибиторов киназы mtor и киназы pi3 и их синтезы |
Country Status (21)
Country | Link |
---|---|
US (1) | US20090181963A1 (ru) |
EP (1) | EP2252296A1 (ru) |
JP (1) | JP2011510010A (ru) |
KR (1) | KR20100113567A (ru) |
CN (1) | CN102014914A (ru) |
AP (1) | AP2010005346A0 (ru) |
AU (1) | AU2009205501A1 (ru) |
BR (1) | BRPI0906519A2 (ru) |
CA (1) | CA2712267A1 (ru) |
CO (1) | CO6321259A2 (ru) |
CR (1) | CR11568A (ru) |
DO (1) | DOP2010000217A (ru) |
EA (1) | EA201001017A1 (ru) |
EC (1) | ECSP10010346A (ru) |
IL (1) | IL206820A0 (ru) |
MA (1) | MA32341B1 (ru) |
MX (1) | MX2010007746A (ru) |
NI (1) | NI201000119A (ru) |
SV (1) | SV2010003621A (ru) |
WO (1) | WO2009091788A1 (ru) |
ZA (2) | ZA201004603B (ru) |
Families Citing this family (31)
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EP2231661A1 (en) | 2007-12-19 | 2010-09-29 | Amgen, Inc. | Inhibitors of pi3 kinase |
WO2009120094A2 (en) * | 2008-03-27 | 2009-10-01 | Auckland Uniservices Limited | Substituted pyrimidines and triazines and their use in cancer therapy |
TWI378933B (en) | 2008-10-14 | 2012-12-11 | Daiichi Sankyo Co Ltd | Morpholinopurine derivatives |
NZ595372A (en) | 2009-03-27 | 2013-11-29 | Vetdc Inc | Pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides and their use in cancer therapy |
EP2445346A4 (en) * | 2009-06-24 | 2012-12-05 | Genentech Inc | OXOHETEROCYCLIC FUSIONED PYRIMIDINE COMPOUNDS AND COMPOSITIONS AND METHOD FOR THEIR USE |
EP2451802A1 (en) * | 2009-07-07 | 2012-05-16 | Pathway Therapeutics, Inc. | Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy |
BR112012019459A2 (pt) | 2010-02-03 | 2017-10-17 | Signal Pharm Llc | identificação de mutação de lkb1 como um biomarcador preditivo para sensibilidade para inibidores de tor quinase. |
ES2714384T3 (es) | 2010-10-06 | 2019-05-28 | Glaxosmithkline Llc | Derivados de bencimidazol como inhibidores de PI3 quinasa |
WO2012135160A1 (en) | 2011-03-28 | 2012-10-04 | Pathway Therapeutics Inc. | (alpha- substituted aralkylamino and heteroarylalkylamino) pyrimidinyl and 1,3,5 -triazinyl benzimidazoles, pharmaceutical compositions containing them, and these compounds for use in treating proliferative diseases |
US20140303172A1 (en) * | 2011-11-01 | 2014-10-09 | Exelixis, Inc. | Phosphatidylinositol 3-Kinase Inhibitors for the Treatment of Lymphoproliferative Malignancies |
JP6077642B2 (ja) * | 2012-04-10 | 2017-02-08 | シャンハイ インリ ファーマシューティカル カンパニー リミティド | 縮合ピリミジン化合物、その調製法、中間体、組成物、及び使用 |
KR20160027219A (ko) | 2012-05-23 | 2016-03-09 | 에프. 호프만-라 로슈 아게 | 내배엽 및 간세포를 수득하고 사용하는 조성물 및 방법 |
AU2013203714B2 (en) | 2012-10-18 | 2015-12-03 | Signal Pharmaceuticals, Llc | Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity |
MX2015014455A (es) | 2013-04-17 | 2016-07-21 | Signal Pharm Llc | Terapia de combinacion que comprende un inhibidor de tor cinasa y n-(3-(5-fluoro-2-(4-(2-metoxietoxi)fenilamino)pirimidin-4-ilamino )fenil)acrilamida para tratar cancer. |
CA2908957C (en) | 2013-04-17 | 2021-05-18 | Signal Pharmaceuticals, Llc | Combination therapy comprising a dihydropyrazino-pyrazine compound and an androgen receptor antagonist for treating prostate cancer |
AU2014253978B2 (en) | 2013-04-17 | 2019-06-06 | Signal Pharmaceuticals, Llc | Combination therapy comprising a TOR kinase inhibitor and a 5-Substituted Quinazolinone Compound for treating cancer |
NZ629230A (en) | 2013-04-17 | 2017-05-26 | Signal Pharm Llc | Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one |
CA2908830C (en) | 2013-04-17 | 2021-12-07 | Signal Pharmaceuticals, Llc | Treatment of cancer with dihydropyrazino-pyrazines |
EP2986321A1 (en) | 2013-04-17 | 2016-02-24 | Signal Pharmaceuticals, LLC | Combination therapy comprising a tor kinase inhibitor and a cytidine analog for treating cancer |
NZ629332A (en) | 2013-04-17 | 2017-05-26 | Signal Pharm Llc | Treatment of cancer with dihydropyrazino-pyrazines |
JP6401250B2 (ja) | 2013-05-29 | 2018-10-10 | シグナル ファーマシューティカルズ,エルエルシー | 7−(6−(2−ヒドロキシプロパン−2−イル)ピリジン−3−イル)−1−((trans)−4−メトキシシクロヘキシル)−3,4−ジヒドロピラジノ[2,3−b]ピラジン−2(1H)−オン、その固体形態の医薬組成物、及びその使用方法 |
JP6441910B2 (ja) | 2013-09-30 | 2018-12-19 | シャンハイ インリ ファーマシューティカル カンパニー リミティド | 縮合ピリミジン化合物、中間体、その調製方法、組成物及び使用 |
WO2015160880A1 (en) | 2014-04-16 | 2015-10-22 | Signal Pharmaceuticals, Llc | SOLID FORMS COMPRISING 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL) PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO(2,3-b)PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF |
NZ714742A (en) | 2014-04-16 | 2017-04-28 | Signal Pharm Llc | Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use |
CN106459048A (zh) | 2014-05-14 | 2017-02-22 | 辉瑞公司 | 吡唑并吡啶类和吡唑并嘧啶类 |
WO2017087818A1 (en) * | 2015-11-19 | 2017-05-26 | The Regents Of The University Of Michigan | Dual src/p38 kinase inhibitor compounds and their use as therapeutic agents |
MX2019013862A (es) | 2017-05-23 | 2020-01-20 | Mei Pharma Inc | Terapia de combinacion. |
BR112019027402A2 (pt) | 2017-06-22 | 2020-07-07 | Celgene Corporation | tratamento de carcinoma hepatocelular caracterizado por infecção pelo vírus da hepatite b |
US20220106316A2 (en) * | 2018-09-27 | 2022-04-07 | Suzhou Raymon Pharmaceuticals Company, Ltd. | Pyrazolopyrimidine compound and preparation method therefor and use thereof in preparation of anti-cancer drug |
CN113549080B (zh) * | 2021-08-27 | 2023-05-16 | 中国医学科学院放射医学研究所 | 一类1,2,3-三氮唑并嘧啶类化合物、其制备方法和用途 |
KR20240015978A (ko) | 2022-07-28 | 2024-02-06 | 박수산 | 다층 수력 발전시스템 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100345830C (zh) * | 2000-04-27 | 2007-10-31 | 安斯泰来制药有限公司 | 稠合杂芳基衍生物 |
-
2009
- 2009-01-14 CN CN2009801084548A patent/CN102014914A/zh active Pending
- 2009-01-14 CA CA2712267A patent/CA2712267A1/en not_active Abandoned
- 2009-01-14 KR KR1020107018006A patent/KR20100113567A/ko not_active Application Discontinuation
- 2009-01-14 EA EA201001017A patent/EA201001017A1/ru unknown
- 2009-01-14 MX MX2010007746A patent/MX2010007746A/es not_active Application Discontinuation
- 2009-01-14 JP JP2010543208A patent/JP2011510010A/ja not_active Withdrawn
- 2009-01-14 EP EP09701825A patent/EP2252296A1/en not_active Withdrawn
- 2009-01-14 WO PCT/US2009/030939 patent/WO2009091788A1/en active Application Filing
- 2009-01-14 BR BRPI0906519-9A patent/BRPI0906519A2/pt not_active IP Right Cessation
- 2009-01-14 AP AP2010005346A patent/AP2010005346A0/en unknown
- 2009-01-14 AU AU2009205501A patent/AU2009205501A1/en not_active Abandoned
- 2009-01-15 US US12/354,027 patent/US20090181963A1/en not_active Abandoned
-
2010
- 2010-06-30 ZA ZA2010/04603A patent/ZA201004603B/en unknown
- 2010-07-05 IL IL206820A patent/IL206820A0/en unknown
- 2010-07-14 DO DO2010000217A patent/DOP2010000217A/es unknown
- 2010-07-14 CR CR11568A patent/CR11568A/es not_active Application Discontinuation
- 2010-07-14 NI NI201000119A patent/NI201000119A/es unknown
- 2010-07-15 SV SV2010003621A patent/SV2010003621A/es not_active Application Discontinuation
- 2010-07-15 MA MA33020A patent/MA32341B1/fr unknown
- 2010-07-15 EC EC2010010346A patent/ECSP10010346A/es unknown
- 2010-08-12 CO CO10099284A patent/CO6321259A2/es not_active Application Discontinuation
- 2010-08-13 ZA ZA2010/05793A patent/ZA201005793B/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2009091788A1 (en) | 2009-07-23 |
JP2011510010A (ja) | 2011-03-31 |
MA32341B1 (fr) | 2011-06-01 |
BRPI0906519A2 (pt) | 2015-07-14 |
IL206820A0 (en) | 2010-12-30 |
ECSP10010346A (es) | 2010-08-31 |
CO6321259A2 (es) | 2011-09-20 |
AP2010005346A0 (en) | 2010-08-31 |
ZA201004603B (en) | 2011-03-30 |
CN102014914A (zh) | 2011-04-13 |
DOP2010000217A (es) | 2010-07-31 |
CR11568A (es) | 2010-08-11 |
CA2712267A1 (en) | 2009-07-23 |
AU2009205501A1 (en) | 2009-07-23 |
MX2010007746A (es) | 2010-08-18 |
US20090181963A1 (en) | 2009-07-16 |
KR20100113567A (ko) | 2010-10-21 |
SV2010003621A (es) | 2011-07-05 |
NI201000119A (es) | 2011-05-04 |
EP2252296A1 (en) | 2010-11-24 |
ZA201005793B (en) | 2011-04-28 |
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