EA200200411A1 - 2,4-диаминопиримидиновые соединения, полезные в качестве иммуносупрессоров - Google Patents

2,4-диаминопиримидиновые соединения, полезные в качестве иммуносупрессоров

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Publication number
EA200200411A1
EA200200411A1 EA200200411A EA200200411A EA200200411A1 EA 200200411 A1 EA200200411 A1 EA 200200411A1 EA 200200411 A EA200200411 A EA 200200411A EA 200200411 A EA200200411 A EA 200200411A EA 200200411 A1 EA200200411 A1 EA 200200411A1
Authority
EA
Eurasian Patent Office
Prior art keywords
immunosupressors
compounds useful
diaminopyrimidine compounds
compounds
alkylaminocarbonylamino
Prior art date
Application number
EA200200411A
Other languages
English (en)
Inventor
Тодд Эндрю Блуменкопф
Эйлин Эллиотт Мюллер
Эрик Ян Роскэмп
Original Assignee
Пфайзер Продактс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Продактс Инк. filed Critical Пфайзер Продактс Инк.
Publication of EA200200411A1 publication Critical patent/EA200200411A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

Новые соединения формулы (I) и их фармацевтически приемлемые соли, сольваты или гидраты; где в каждом случае А независимо выбран из СН или N; Х выбран из группы, состоящей из -CH-, -О-, -NH-, (С-С)алкиламино-, (C-С)алкиламинокарбониламино-, (С-С)алкилкарбониламино-, (С-С)алкилсульфониламино-, фенилсульфониламино-, карбонила, -NH-C(O)-, -N(С-С)алкил-С(O)-, -S(O)-, где y равен 0, 1 или 2 и n в -(СН)- равен 1, 2 или 3; и R, Rи Rтакие, как описаны здесь; фармацевтические композиции, которые включают в себя эти соединения, и способы лечения аутоиммунного заболевания, воспаления, аллергии, отторжения трансплантата и других случаев, при которых введение иммуносупрессивного агента имеет терапевтическую пользу.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200200411A 1999-11-30 2000-11-09 2,4-диаминопиримидиновые соединения, полезные в качестве иммуносупрессоров EA200200411A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16822499P 1999-11-30 1999-11-30
PCT/IB2000/001628 WO2001040215A1 (en) 1999-11-30 2000-11-09 2,4-diaminopyrimidine compounds usful as immunosuppressants

Publications (1)

Publication Number Publication Date
EA200200411A1 true EA200200411A1 (ru) 2002-10-31

Family

ID=22610621

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200200411A EA200200411A1 (ru) 1999-11-30 2000-11-09 2,4-диаминопиримидиновые соединения, полезные в качестве иммуносупрессоров

Country Status (33)

Country Link
EP (1) EP1242403B1 (ru)
JP (1) JP3955468B2 (ru)
KR (1) KR20020059826A (ru)
CN (1) CN1402720A (ru)
AP (1) AP2002002530A0 (ru)
AT (1) ATE315036T1 (ru)
AU (1) AU1047601A (ru)
BG (1) BG106695A (ru)
BR (1) BR0015995A (ru)
CA (1) CA2392971C (ru)
CO (1) CO5261519A1 (ru)
CZ (1) CZ20021703A3 (ru)
DE (1) DE60025385T2 (ru)
EA (1) EA200200411A1 (ru)
EE (1) EE200200275A (ru)
ES (1) ES2253266T3 (ru)
GT (1) GT200000200A (ru)
HN (1) HN2000000264A (ru)
HU (1) HUP0203300A3 (ru)
IL (1) IL149103A0 (ru)
IS (1) IS6339A (ru)
MA (1) MA26846A1 (ru)
MX (1) MXPA02005350A (ru)
NO (1) NO20022557D0 (ru)
OA (1) OA12097A (ru)
PA (1) PA8506801A1 (ru)
PE (1) PE20010900A1 (ru)
PL (1) PL355946A1 (ru)
SV (1) SV2002000231A (ru)
TN (1) TNSN00232A1 (ru)
TR (1) TR200201431T2 (ru)
UY (1) UY26455A1 (ru)
WO (1) WO2001040215A1 (ru)

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CA2400447C (en) * 2000-02-17 2008-04-22 Amgen Inc. Kinase inhibitors
EA200300205A1 (ru) * 2000-08-31 2003-06-26 Пфайзер Продактс Инк. Производные пиразола и их применение в качестве ингибиторов протеинкиназы
CA2422354C (en) 2000-09-15 2009-12-08 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
US6660731B2 (en) 2000-09-15 2003-12-09 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
NZ526469A (en) 2000-12-21 2005-10-28 Vertex Pharma Pyrazole compounds useful as protein kinase inhibitors
WO2003030909A1 (en) * 2001-09-25 2003-04-17 Bayer Pharmaceuticals Corporation 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer
CN1319968C (zh) 2002-08-02 2007-06-06 沃泰克斯药物股份有限公司 用作gsk－3的抑制剂的吡唑组合物
US20040204458A1 (en) 2002-08-16 2004-10-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Use of Lck inhibitors for treatment of immunologic diseases
DE10237423A1 (de) * 2002-08-16 2004-02-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen
WO2005068437A1 (en) * 2004-01-16 2005-07-28 Novartis Ag 2, 4 - diaminopyrimidines and their use for inducing cardiomyogenesis
MX2007004526A (es) * 2004-10-12 2007-09-21 Decode Genetics Inc Arilsulfonamidas biciclicas peri-sustituidas para la enfermedad arterial oclusiva.
US20060161001A1 (en) * 2004-12-20 2006-07-20 Amgen Inc. Substituted heterocyclic compounds and methods of use
PE20060777A1 (es) 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
TW200804389A (en) 2006-02-14 2008-01-16 Vertex Pharma Dihydrodiazepines useful as inhibitors of protein kinases
AU2007227602A1 (en) * 2006-03-16 2007-09-27 Novartis Ag Heterocyclic organic compounds for the treatment of in particular melanoma
MX2009011923A (es) 2007-05-10 2009-11-18 Amr Technology Inc Tetrahidrobenzo-1,4-diazepinas aril- y heteroaril-sustituidas y uso de las mismas para bloquear reabsorcion de norepinefrina, dopamina y serotonina.
MX2010004232A (es) * 2007-10-16 2010-09-30 Daiichi Sankyo Co Ltd Compuesto de indolina de pirimidilo.
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TWI513694B (zh) * 2010-05-11 2015-12-21 Amgen Inc 抑制間變性淋巴瘤激酶的嘧啶化合物
KR101708761B1 (ko) * 2012-04-13 2017-02-21 주식회사 머쉬메드 퓨린 유도체 또는 그의 염을 포함하는 아토피성 피부염의 예방 또는 치료용 조성물
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US11390609B2 (en) 2017-06-30 2022-07-19 Beijing Tide Pharmaceutical Co., Ltd. Rho-associated protein kinase inhibitor, pharmaceutical composition comprising same, and preparation method and use thereof
CN110573501B (zh) * 2017-06-30 2023-09-29 北京泰德制药股份有限公司 Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途
US10323023B2 (en) 2017-06-30 2019-06-18 Beijing Tide Pharmaceutical Co., Ltd. Rho-associated protein kinase inhibitor, pharmaceutical composition comprising the same, as well as preparation method and use thereof

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Also Published As

Publication number Publication date
BG106695A (bg) 2002-12-29
ES2253266T3 (es) 2006-06-01
KR20020059826A (ko) 2002-07-13
HUP0203300A2 (hu) 2003-02-28
MA26846A1 (fr) 2004-12-20
HN2000000264A (es) 2001-05-21
UY26455A1 (es) 2001-07-31
CA2392971A1 (en) 2001-06-07
OA12097A (en) 2006-05-04
WO2001040215A1 (en) 2001-06-07
DE60025385D1 (de) 2006-03-30
BR0015995A (pt) 2002-08-06
CN1402720A (zh) 2003-03-12
GT200000200A (es) 2002-05-23
CA2392971C (en) 2008-10-07
MXPA02005350A (es) 2002-12-11
AP2002002530A0 (en) 2002-06-30
ATE315036T1 (de) 2006-02-15
SV2002000231A (es) 2002-07-16
DE60025385T2 (de) 2006-08-24
TR200201431T2 (tr) 2002-09-23
TNSN00232A1 (fr) 2005-11-10
PE20010900A1 (es) 2001-09-08
EE200200275A (et) 2003-10-15
IL149103A0 (en) 2002-11-10
HUP0203300A3 (en) 2003-10-28
NO20022557L (no) 2002-05-29
PA8506801A1 (es) 2002-04-25
IS6339A (is) 2002-04-12
EP1242403A1 (en) 2002-09-25
JP3955468B2 (ja) 2007-08-08
AU1047601A (en) 2001-06-12
NO20022557D0 (no) 2002-05-29
CO5261519A1 (es) 2003-03-31
PL355946A1 (en) 2004-05-31
JP2003515602A (ja) 2003-05-07
CZ20021703A3 (cs) 2003-06-18
EP1242403B1 (en) 2006-01-04

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