HUP0203300A3 - 2,4-diaminopyrimidine compounds useful as immunosuppressants, pharmaceutical compositions containing them and their use - Google Patents

2,4-diaminopyrimidine compounds useful as immunosuppressants, pharmaceutical compositions containing them and their use

Info

Publication number: HUP0203300A3
Authority: HU; Hungary
Prior art keywords: immunosuppressants; pharmaceutical compositions; compositions containing; compounds useful; diaminopyrimidine compounds
Prior art date: 1999-11-30

Application number

HU0203300A

Other languages

English (en)

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-11-30

Filing date

2000-11-09

Publication date

2003-10-28

2000-11-09 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2003-02-28 Publication of HUP0203300A2 publication Critical patent/HUP0203300A2/hu

2003-10-28 Publication of HUP0203300A3 publication Critical patent/HUP0203300A3/hu

Links

229960003444 immunosuppressant agent Drugs 0.000 title 1
239000003018 immunosuppressive agent Substances 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
YAAWASYJIRZXSZ-UHFFFAOYSA-N pyrimidine-2,4-diamine Chemical class NC1=CC=NC(N)=N1 YAAWASYJIRZXSZ-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

HU0203300A 1999-11-30 2000-11-09 2,4-diaminopyrimidine compounds useful as immunosuppressants, pharmaceutical compositions containing them and their use HUP0203300A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US16822499P	1999-11-30	1999-11-30
PCT/IB2000/001628 WO2001040215A1 (en)	1999-11-30	2000-11-09	2,4-diaminopyrimidine compounds usful as immunosuppressants

Publications (2)

Publication Number	Publication Date
HUP0203300A2 HUP0203300A2 (hu)	2003-02-28
HUP0203300A3 true HUP0203300A3 (en)	2003-10-28

Family

ID=22610621

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU0203300A HUP0203300A3 (en)	1999-11-30	2000-11-09	2,4-diaminopyrimidine compounds useful as immunosuppressants, pharmaceutical compositions containing them and their use

Country Status (33)

Country	Link
EP (1)	EP1242403B1 (hu)
JP (1)	JP3955468B2 (hu)
KR (1)	KR20020059826A (hu)
CN (1)	CN1402720A (hu)
AP (1)	AP2002002530A0 (hu)
AT (1)	ATE315036T1 (hu)
AU (1)	AU1047601A (hu)
BG (1)	BG106695A (hu)
BR (1)	BR0015995A (hu)
CA (1)	CA2392971C (hu)
CO (1)	CO5261519A1 (hu)
CZ (1)	CZ20021703A3 (hu)
DE (1)	DE60025385T2 (hu)
EA (1)	EA200200411A1 (hu)
EE (1)	EE200200275A (hu)
ES (1)	ES2253266T3 (hu)
GT (1)	GT200000200A (hu)
HN (1)	HN2000000264A (hu)
HU (1)	HUP0203300A3 (hu)
IL (1)	IL149103A0 (hu)
IS (1)	IS6339A (hu)
MA (1)	MA26846A1 (hu)
MX (1)	MXPA02005350A (hu)
NO (1)	NO20022557D0 (hu)
OA (1)	OA12097A (hu)
PA (1)	PA8506801A1 (hu)
PE (1)	PE20010900A1 (hu)
PL (1)	PL355946A1 (hu)
SV (1)	SV2002000231A (hu)
TN (1)	TNSN00232A1 (hu)
TR (1)	TR200201431T2 (hu)
UY (1)	UY26455A1 (hu)
WO (1)	WO2001040215A1 (hu)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2001060816A1 (en) *	2000-02-17	2001-08-23	Amgen Inc.	Kinase inhibitors
CN1518543A (zh) *	2000-08-31	2004-08-04	�Ʒ�	吡唑衍生物和它们作为蛋白激酶抑制剂的用途
AU2001292670A1 (en)	2000-09-15	2002-03-26	Vertex Pharmaceuticals Incorporated	Pyrazole compounds useful as protein kinase inhibitors
US6660731B2 (en)	2000-09-15	2003-12-09	Vertex Pharmaceuticals Incorporated	Pyrazole compounds useful as protein kinase inhibitors
BR0116411A (pt)	2000-12-21	2003-11-11	Vertex Pharma	Compostos de pirazol úteis como inibidores de proteìna cinase
WO2003030909A1 (en) *	2001-09-25	2003-04-17	Bayer Pharmaceuticals Corporation	2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer
BR0313176A (pt)	2002-08-02	2005-06-14	Vertex Pharma	Composições de pirazol úteis como inibidores de gsk-3
US20040204458A1 (en)	2002-08-16	2004-10-14	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Use of Lck inhibitors for treatment of immunologic diseases
DE10237423A1 (de) *	2002-08-16	2004-02-19	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen
WO2005068437A1 (en) *	2004-01-16	2005-07-28	Novartis Ag	2, 4 - diaminopyrimidines and their use for inducing cardiomyogenesis
CA2583710A1 (en) *	2004-10-12	2006-04-27	Decode Genetics, Inc.	Aryl sulfonamide peri-substituted bicyclics for occlusive artery disease
US20060161001A1 (en) *	2004-12-20	2006-07-20	Amgen Inc.	Substituted heterocyclic compounds and methods of use
PE20060777A1 (es)	2004-12-24	2006-10-06	Boehringer Ingelheim Int	Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
DE602007008837D1 (de)	2006-02-14	2010-10-14	Vertex Pharma	Als protein-kinase-inhibitoren nutzbare dyhydrodiazepine
US20090069360A1 (en) *	2006-03-16	2009-03-12	David Bryant Batt	Organic Compounds
JP2010526825A (ja)	2007-05-10	2010-08-05	エーエムアールテクノロジーインコーポレイテッド	アリール置換およびヘテロアリール置換テトラヒドロベンゾ−１，４−ジアゼピンならびにノルエピネフリン、ドーパミンおよびセロトニンの再取り込みを遮断するためのその使用
EP2210886B1 (en)	2007-10-16	2015-09-23	Daiichi Sankyo Company, Limited	Pyrimidyl indoline compound
JP2013505927A (ja)	2009-09-25	2013-02-21	バーテックスファーマシューティカルズインコーポレイテッド	プロテインキナーゼ阻害剤として有用なピリミジン誘導体の調製方法
AU2010298190A1 (en)	2009-09-25	2012-05-03	Vertex Pharmaceuticals Incorporated	Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors
TWI513694B (zh) *	2010-05-11	2015-12-21	Amgen Inc	抑制間變性淋巴瘤激酶的嘧啶化合物
KR101708761B1 (ko) *	2012-04-13	2017-02-21	주식회사 머쉬메드	퓨린 유도체 또는 그의 염을 포함하는 아토피성 피부염의 예방 또는 치료용 조성물
CN104903312B (zh) *	2013-10-07	2019-01-29	卡德门企业有限公司	Rho激酶抑制剂
JP7039802B2 (ja)	2017-06-30	2022-03-23	ベイジンタイドファーマシューティカルカンパニーリミテッド	Ｒｈｏ－関連プロテインキナーゼ阻害剤、ｒｈｏ－関連プロテインキナーゼ阻害剤を含む医薬組成物、当該医薬組成物の調製方法及び使用
WO2019000682A1 (zh)	2017-06-30	2019-01-03	北京泰德制药股份有限公司	Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途
CN117343049A (zh)	2017-06-30	2024-01-05	北京泰德制药股份有限公司	Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9523675D0 (en) *	1995-11-20	1996-01-24	Celltech Therapeutics Ltd	Chemical compounds
EP0837063A1 (en) *	1996-10-17	1998-04-22	Pfizer Inc.	4-Aminoquinazoline derivatives
GB9905075D0 (en) *	1999-03-06	1999-04-28	Zeneca Ltd	Chemical compounds

2000
- 2000-11-09 CZ CZ20021703A patent/CZ20021703A3/cs unknown
- 2000-11-09 PL PL00355946A patent/PL355946A1/xx not_active Application Discontinuation
- 2000-11-09 DE DE60025385T patent/DE60025385T2/de not_active Expired - Lifetime
- 2000-11-09 KR KR1020027006941A patent/KR20020059826A/ko not_active Application Discontinuation
- 2000-11-09 AP APAP/P/2002/002530A patent/AP2002002530A0/en unknown
- 2000-11-09 CN CN00816506A patent/CN1402720A/zh active Pending
- 2000-11-09 HU HU0203300A patent/HUP0203300A3/hu unknown
- 2000-11-09 WO PCT/IB2000/001628 patent/WO2001040215A1/en active IP Right Grant
- 2000-11-09 AT AT00971650T patent/ATE315036T1/de not_active IP Right Cessation
- 2000-11-09 TR TR2002/01431T patent/TR200201431T2/xx unknown
- 2000-11-09 EA EA200200411A patent/EA200200411A1/ru unknown
- 2000-11-09 ES ES00971650T patent/ES2253266T3/es not_active Expired - Lifetime
- 2000-11-09 IL IL14910300A patent/IL149103A0/xx unknown
- 2000-11-09 EP EP00971650A patent/EP1242403B1/en not_active Expired - Lifetime
- 2000-11-09 BR BR0015995-6A patent/BR0015995A/pt not_active Application Discontinuation
- 2000-11-09 CA CA002392971A patent/CA2392971C/en not_active Expired - Fee Related
- 2000-11-09 OA OA1200200156A patent/OA12097A/en unknown
- 2000-11-09 EE EEP200200275A patent/EE200200275A/xx unknown
- 2000-11-09 JP JP2001541899A patent/JP3955468B2/ja not_active Expired - Fee Related
- 2000-11-09 MX MXPA02005350A patent/MXPA02005350A/es active IP Right Grant
- 2000-11-09 AU AU10476/01A patent/AU1047601A/en not_active Abandoned
- 2000-11-22 PA PA20008506801A patent/PA8506801A1/es unknown
- 2000-11-23 HN HN2000000264A patent/HN2000000264A/es unknown
- 2000-11-28 PE PE2000001268A patent/PE20010900A1/es not_active Application Discontinuation
- 2000-11-28 UY UY26455A patent/UY26455A1/es not_active Application Discontinuation
- 2000-11-29 SV SV2000000231A patent/SV2002000231A/es unknown
- 2000-11-29 TN TNTNSN00232A patent/TNSN00232A1/fr unknown
- 2000-11-29 GT GT200000200A patent/GT200000200A/es unknown
- 2000-11-30 CO CO00091745A patent/CO5261519A1/es unknown
2002
- 2002-04-12 IS IS6339A patent/IS6339A/is unknown
- 2002-05-13 BG BG106695A patent/BG106695A/bg unknown
- 2002-05-28 MA MA26655A patent/MA26846A1/fr unknown
- 2002-05-29 NO NO20022557A patent/NO20022557D0/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
EA200200411A1 (ru)	2002-10-31
PL355946A1 (en)	2004-05-31
ES2253266T3 (es)	2006-06-01
IS6339A (is)	2002-04-12
IL149103A0 (en)	2002-11-10
HN2000000264A (es)	2001-05-21
CZ20021703A3 (cs)	2003-06-18
NO20022557L (no)	2002-05-29
EP1242403A1 (en)	2002-09-25
KR20020059826A (ko)	2002-07-13
MXPA02005350A (es)	2002-12-11
MA26846A1 (fr)	2004-12-20
CO5261519A1 (es)	2003-03-31
JP2003515602A (ja)	2003-05-07
CA2392971A1 (en)	2001-06-07
UY26455A1 (es)	2001-07-31
AU1047601A (en)	2001-06-12
TNSN00232A1 (fr)	2005-11-10
OA12097A (en)	2006-05-04
JP3955468B2 (ja)	2007-08-08
AP2002002530A0 (en)	2002-06-30
BR0015995A (pt)	2002-08-06
WO2001040215A1 (en)	2001-06-07
CA2392971C (en)	2008-10-07
HUP0203300A2 (hu)	2003-02-28
NO20022557D0 (no)	2002-05-29
EE200200275A (et)	2003-10-15
PE20010900A1 (es)	2001-09-08
SV2002000231A (es)	2002-07-16
DE60025385T2 (de)	2006-08-24
PA8506801A1 (es)	2002-04-25
TR200201431T2 (tr)	2002-09-23
EP1242403B1 (en)	2006-01-04
BG106695A (bg)	2002-12-29
ATE315036T1 (de)	2006-02-15
DE60025385D1 (de)	2006-03-30
GT200000200A (es)	2002-05-23
CN1402720A (zh)	2003-03-12

Publication	Publication Date	Title
HUP0203300A3 (en)	2003-10-28	2,4-diaminopyrimidine compounds useful as immunosuppressants, pharmaceutical compositions containing them and their use
HUP0200714A3 (en)	2003-01-28	Pharmaceutical compounds, pharmaceutical compositions containing them and their use
HUP0200308A2 (en)	2002-06-29	Quinolinecarboxamides as antiviral agents, pharmaceutical compositions containing them and their use
HUP0400708A3 (en)	2007-10-29	Substituted 1,3,5-triazine and pyrimidine derivatives, their use and pharmaceutical compositions containing them
HUP0401567A3 (en)	2005-06-28	Novel 4,5-dyhydro-1h-pyrazole derivatives having cb1-antagonistic activity, their use and pharmaceutical compositions containing them
HUP0203939A3 (en)	2004-12-28	Pharmaceutical compounds and compositions containing them and their use
HUP0301722A3 (en)	2004-03-29	Pyrimidine derivatives, pharmaceutical compositions containing them and their use
HUP0204413A3 (en)	2003-07-28	Quinazoline compounds, their preparation, their use and pharmaceutical compositions containing them
HUP0200355A3 (en)	2004-07-28	4-aminopyrrolopyrimidines as kinase inhibitors, pharmaceutical compositions containing them and their use
HUP0204081A3 (en)	2003-07-28	4-pyrimidinyl-n-acyl-l-phenylalanines, pharmaceutical compositions containing them and their use
HUP0302969A3 (en)	2005-05-30	Npyy5 antagonists, pharmaceutical compositions containing them and their use
HUP0203542A3 (en)	2003-07-28	3(5)-amino-pyrazole derivatives, process for their preparation, their use and pharmaceutical compositions containing the same
ZA200110022B (en)	2003-05-28	Thiazoloderivatives and pharmaceutical compositions containing them.
HUP0203378A3 (en)	2004-07-28	Pharmaceutical compounds and pharmaceutical compositions containing them
HUP0102372A3 (en)	2003-01-28	Dihydropyrimidines, preparation thereof and pharmaceutical compositions containing the same
HUP0102453A3 (en)	2002-10-28	Adenosine derivatives, their use and pharmaceutical compositions containing the compounds
HUP0303825A3 (en)	2005-06-28	1h-benzimidazole and 3h-imidazo-[4,5b]pyridine-derivatives, their use and pharmaceutical compositions containing them
HUP0300207A3 (en)	2005-07-28	1,2,3,4-tetrahydroisquinoline derivatives, pharmaceutical compositions containing them and their preparation processes
HUP0400837A3 (en)	2007-11-28	2-phenyl-thiazole derivatives, their use and pharmaceutical compositions containing them
HUP0204474A3 (en)	2004-07-28	1h-imidazopyridine derivatives, pharmaceutical compositions containing them and their use
HUP0103884A3 (en)	2002-11-28	Arylsulfonanilide urea-derivatives, pharmaceutical compositions containing them and their use
HUP0301573A3 (en)	2004-03-29	Substituted arylpyrazines, pharmaceutical compositions containing them and their use
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