MX2009011923A - Tetrahidrobenzo-1,4-diazepinas aril- y heteroaril-sustituidas y uso de las mismas para bloquear reabsorcion de norepinefrina, dopamina y serotonina. - Google Patents

Tetrahidrobenzo-1,4-diazepinas aril- y heteroaril-sustituidas y uso de las mismas para bloquear reabsorcion de norepinefrina, dopamina y serotonina.

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Publication number
MX2009011923A
MX2009011923A MX2009011923A MX2009011923A MX2009011923A MX 2009011923 A MX2009011923 A MX 2009011923A MX 2009011923 A MX2009011923 A MX 2009011923A MX 2009011923 A MX2009011923 A MX 2009011923A MX 2009011923 A MX2009011923 A MX 2009011923A
Authority
MX
Mexico
Prior art keywords
heteroaryl
aryl
diazepines
norepinephrine
serotonin
Prior art date
Application number
MX2009011923A
Other languages
English (en)
Inventor
Richard E Olson
Bruce F Molino
Shuang Liu
Peter R Guzzo
Wenge Cui
Original Assignee
Amr Technology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amr Technology Inc filed Critical Amr Technology Inc
Publication of MX2009011923A publication Critical patent/MX2009011923A/es

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    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
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    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

Se describen en la presente invención compuestos derivados de tetrahidrobenzo-1,4-diazepina aril- y heteroaril-sustituidos representados por las fórmulas I(A-D) que tienen la siguiente estructura: (ver fórmula I) en donde los sustituyentes X y R1-R8 son como se define en la presente.
MX2009011923A 2007-05-10 2008-05-08 Tetrahidrobenzo-1,4-diazepinas aril- y heteroaril-sustituidas y uso de las mismas para bloquear reabsorcion de norepinefrina, dopamina y serotonina. MX2009011923A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91718907P 2007-05-10 2007-05-10
PCT/US2008/063039 WO2008141081A1 (en) 2007-05-10 2008-05-08 Aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin

Publications (1)

Publication Number Publication Date
MX2009011923A true MX2009011923A (es) 2009-11-18

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MX2009011923A MX2009011923A (es) 2007-05-10 2008-05-08 Tetrahidrobenzo-1,4-diazepinas aril- y heteroaril-sustituidas y uso de las mismas para bloquear reabsorcion de norepinefrina, dopamina y serotonina.

Country Status (14)

Country Link
US (1) US9096546B2 (es)
EP (1) EP2146722A4 (es)
JP (1) JP2010526825A (es)
KR (1) KR20100017766A (es)
CN (1) CN101686983A (es)
AU (1) AU2008251557B2 (es)
BR (1) BRPI0811204A8 (es)
CA (1) CA2685860A1 (es)
CO (1) CO6251238A2 (es)
EA (1) EA017249B8 (es)
IL (1) IL201922A0 (es)
MX (1) MX2009011923A (es)
NZ (1) NZ580801A (es)
WO (1) WO2008141081A1 (es)

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WO2008141081A1 (en) 2008-11-20
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AU2008251557A1 (en) 2008-11-20
KR20100017766A (ko) 2010-02-16
JP2010526825A (ja) 2010-08-05
US20100137287A1 (en) 2010-06-03
BRPI0811204A8 (pt) 2015-09-22
IL201922A0 (en) 2010-06-16
BRPI0811204A2 (pt) 2014-10-29
CN101686983A (zh) 2010-03-31
CA2685860A1 (en) 2008-11-20
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