ES2178037T3 - Derivados de ciclosporina, su preparacion y las composiciones farmaceuticas que los contienen. - Google Patents
Derivados de ciclosporina, su preparacion y las composiciones farmaceuticas que los contienen.Info
- Publication number
- ES2178037T3 ES2178037T3 ES97952998T ES97952998T ES2178037T3 ES 2178037 T3 ES2178037 T3 ES 2178037T3 ES 97952998 T ES97952998 T ES 97952998T ES 97952998 T ES97952998 T ES 97952998T ES 2178037 T3 ES2178037 T3 ES 2178037T3
- Authority
- ES
- Spain
- Prior art keywords
- contain
- preparation
- pharmaceutical compositions
- cyclosporine derivatives
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
DERIVADOS DE CICLOSPORINA CARACTERIZADOS PORQUE RESPONDEN A LA FORMULA GENERAL (I) EN LA QUE ALK ES ALQUILENO 2 A 6 C EN CADENA RECTA O RAMIFICADA O CICLOALQUILENO QUE CONTIENEN ENTRE 3 Y 6 C Y R ES O BIEN: COOH O ALQUILOXICARBONILO, O BIEN NR SUB,1 R 2 PARA LE CUAL R 1 Y R 2 IDENTICOS O DIFE RENTES SON H, O ALQUILO, ALCENILO (2 A 4 C), CICLOALQUILO (3 A 6 C), FENILO OPCIONALMENTE SUSTITUIDO (POR HALOGENO, ALQUILOXI, ALQUILOXICARBONILO, AMINO, ALQUILAMINO O DIALQUILAMINO), O SON RADICALES BENCILO O HETEROCICLO SATURADO O INSATURADO QUE CONTIENEN ENTRE 5 Y 6 ESLABONES Y ENTRE 1 Y 3 HETEROATOMOS, O PARA EL CUAL R 1 Y R 2 FORMAN CON EL ATOMO DE NITROGENO AL QUE ESTAN UNIDOS UN HETEROCICLO QUE CONTIENE ENTRE 4 Y 6 ESLABONES QUE PUEDEN CONTENER OTRO HETEROATOMO ELEGIDO ENTRE N, O O S Y OPCIONALMENTE SUSTITUIDO POR ALQUILO, FENILO O BENCILO, O BIEN UN RADICAL DE FORMULA GENERAL (I'') PARA EL CUAL R 1 Y R 2 SE DEFINEN COMO ANTERIORMENTE, R 3 Y H O AL QUILO Y N ES UN NUMERO ENTERO DE ENTRE 2 Y 4, SIENDO LAS PARTES O RADICALES ALQUILO DEFINIDOS ANTERIORMENTE RECTOS O RAMIFICADOS Y CONTENIENDO ENTRE 1 Y 4 C, ASI COMO SUS SALES FARMACEUTICAMENTE ACEPTABLES CUANDO EXISTEN. ESTOS NUEVOS PRODUCTOS SON DE UTILIDAD, SOBRE TODO, PARA EL TRATAMIENTO Y/O LA PROFILAXIS DE LAS INFECCIONES CON RETROVIRUS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9615956A FR2757522B1 (fr) | 1996-12-24 | 1996-12-24 | Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2178037T3 true ES2178037T3 (es) | 2002-12-16 |
Family
ID=9499089
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97952998T Expired - Lifetime ES2178037T3 (es) | 1996-12-24 | 1997-12-23 | Derivados de ciclosporina, su preparacion y las composiciones farmaceuticas que los contienen. |
Country Status (14)
Country | Link |
---|---|
US (1) | US5965527A (es) |
EP (1) | EP0948527B1 (es) |
JP (1) | JP4172822B2 (es) |
AT (1) | ATE218580T1 (es) |
AU (1) | AU5669298A (es) |
DE (1) | DE69713148D1 (es) |
DK (1) | DK0948527T3 (es) |
ES (1) | ES2178037T3 (es) |
FR (1) | FR2757522B1 (es) |
MA (1) | MA26459A1 (es) |
PT (1) | PT948527E (es) |
TN (1) | TNSN97211A1 (es) |
WO (1) | WO1998028329A1 (es) |
ZA (1) | ZA9711606B (es) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT1086124E (pt) * | 1998-06-12 | 2004-04-30 | Chem Ag C | Ciclosporinas novas |
PT1091975E (pt) | 1998-07-01 | 2006-05-31 | Debiopharm Sa | Nova ciclosporina com um perfil de actividade melhorado |
US6254860B1 (en) | 1999-04-13 | 2001-07-03 | Allergan Sales, Inc. | Ocular treatment using cyclosporin-A derivatives |
AR036852A1 (es) * | 2001-10-19 | 2004-10-06 | Isotechnika Inc | Preconcentrado de una microemulsion de analogos de ciclosporina, su metodo de preparacion y metodos para producir inmunosupresion |
ES2326040T3 (es) | 2001-10-19 | 2009-09-29 | Isotechnika Inc. | Sintesis de analogos de ciclosporina. |
US6987090B2 (en) * | 2002-05-09 | 2006-01-17 | Lg Household & Health Care Ltd. | Use of 3-position cyclosporin derivatives for hair growth |
KR20040039622A (ko) * | 2002-11-04 | 2004-05-12 | 주식회사 엘지생활건강 | 모발 성장 효과를 갖는 사이클로스포린 3 위치 유도체를유효성분으로 하는 모발 성장 촉진제 |
GB0320638D0 (en) | 2003-09-03 | 2003-10-01 | Novartis Ag | Organic compounds |
US7196161B2 (en) | 2004-10-01 | 2007-03-27 | Scynexis Inc. | 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection |
PL1793844T3 (pl) * | 2004-10-01 | 2011-05-31 | Debiopharm Sa | Zastosowanie [d-meala]3-[etval]4-cyklosporyny do leczenia zakażenia wirusem zapalenia wątroby typu c |
KR101309409B1 (ko) * | 2004-10-01 | 2013-09-23 | 싸이넥시스, 인크. | C형 간염 바이러스 감염의 치료 및 예방을 위한 3-에테르및 3-티오에테르 치환된 시클로스포린 유도체 |
NZ555142A (en) * | 2004-12-23 | 2010-03-26 | Novartis Ag | Compounds for flaviviridae treatment |
US7897565B2 (en) * | 2004-12-23 | 2011-03-01 | Novartis Ag | Compositions for HCV treatment |
KR20080059270A (ko) * | 2005-09-30 | 2008-06-26 | 싸이넥시스, 인크. | C형 간염 감염의 치료 및 예방을 위한 방법 및 제약조성물 |
CA2623864C (en) * | 2005-09-30 | 2014-12-16 | Scynexis, Inc. | Arylalkyl and heteroarylalkyl derivatives of cyclosporine a for the treatment and prevention of viral infection |
US7696166B2 (en) | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders |
US7696165B2 (en) | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders |
WO2007136759A2 (en) | 2006-05-19 | 2007-11-29 | Scynexis, Inc. | Method for the treatment and prevention of ocular disorders |
EP2027761A1 (fr) * | 2006-06-02 | 2009-02-25 | Claude Annie Perrichon | Gestion des electrons actifs |
BRPI0719189A2 (pt) * | 2006-10-12 | 2018-08-14 | Univ Kyushu Nat Univ Corp | uso de ciclosporinas modificadas |
WO2008069917A2 (en) | 2006-11-20 | 2008-06-12 | Scynexis, Inc. | Novel cyclic peptides |
US20080255038A1 (en) * | 2007-04-11 | 2008-10-16 | Samuel Earl Hopkins | Pharmaceutical compositions |
AU2008304313B2 (en) | 2007-09-26 | 2013-01-10 | Oregon Health & Science University | Cyclic undecapeptides and derivatives as multiple sclerosis therapies |
WO2010002428A2 (en) | 2008-06-06 | 2010-01-07 | Scynexis, Inc. | Novel macrocyclic peptides |
WO2009148615A1 (en) * | 2008-06-06 | 2009-12-10 | Scynexis, Inc. | Cyclosporin analogs and their use in the treatment of hcv infections |
BRPI0915552A2 (pt) * | 2008-07-10 | 2017-06-20 | Allergan Inc | derivados de ciclosporina, seu uso e sua composição farmacêutica |
DE102008060549A1 (de) | 2008-12-04 | 2010-06-10 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung |
US8536114B2 (en) * | 2008-12-31 | 2013-09-17 | Scynexis, Inc. | Macrocycles |
US8524671B2 (en) * | 2009-05-27 | 2013-09-03 | Allergan, Inc | Cyclosporin derivatives for treating inflammatory diseases and conditions |
GB0912584D0 (en) * | 2009-07-20 | 2009-08-26 | Ucl Business Plc | Cyclosporin conjugates |
CN103153329A (zh) * | 2010-07-16 | 2013-06-12 | 美国科技环球有限公司 | 新颖的环孢霉素a衍生物在病毒感染的治疗和预防中的应用 |
US9573978B2 (en) | 2010-08-12 | 2017-02-21 | S&T Global, Inc. | Cyclosporin derivatives for the treatment and prevention of a viral infection |
JP5805773B2 (ja) * | 2010-10-12 | 2015-11-10 | アラーガン、インコーポレイテッドAllergan,Incorporated | シクロスポリンアナログ |
WO2012051194A1 (en) | 2010-10-12 | 2012-04-19 | Allergan, Inc. | Cyclosporin analogs |
US9890198B2 (en) | 2010-12-03 | 2018-02-13 | S&T Global Inc. | Cyclosporin derivatives and uses thereof |
MY165152A (en) | 2010-12-15 | 2018-02-28 | Contravir Pharmaceuticals Inc | Cyclosporine analogue molecules modified at amino acid 1 and 3 |
EP2705856A1 (en) | 2012-09-07 | 2014-03-12 | Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. | Compounds for the treatment of neurodegenerative disorders |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0194972B1 (en) * | 1985-03-11 | 1992-07-29 | Sandoz Ag | Novel cyclosporins |
US4814323A (en) * | 1986-03-25 | 1989-03-21 | Andrieu J M | Process for the treatment and the prevention of AIDS and other disorders induced by the LAV/HTLV III virus |
SK278808B6 (sk) * | 1990-11-02 | 1998-03-04 | Novartis Ag | Cyklosporíny, ich použitie pri príprave liečiva na |
ATE209216T1 (de) * | 1995-07-17 | 2001-12-15 | Chem Ag C | Cyclosporin-derivate mit anti-hiv-wirkung |
-
1996
- 1996-12-24 FR FR9615956A patent/FR2757522B1/fr not_active Expired - Fee Related
-
1997
- 1997-12-19 MA MA24908A patent/MA26459A1/fr unknown
- 1997-12-23 DK DK97952998T patent/DK0948527T3/da active
- 1997-12-23 JP JP52848998A patent/JP4172822B2/ja not_active Expired - Fee Related
- 1997-12-23 WO PCT/FR1997/002405 patent/WO1998028329A1/fr active IP Right Grant
- 1997-12-23 AU AU56692/98A patent/AU5669298A/en not_active Abandoned
- 1997-12-23 PT PT97952998T patent/PT948527E/pt unknown
- 1997-12-23 ZA ZA9711606A patent/ZA9711606B/xx unknown
- 1997-12-23 TN TNTNSN97211A patent/TNSN97211A1/fr unknown
- 1997-12-23 ES ES97952998T patent/ES2178037T3/es not_active Expired - Lifetime
- 1997-12-23 US US08/996,699 patent/US5965527A/en not_active Expired - Fee Related
- 1997-12-23 DE DE69713148T patent/DE69713148D1/de not_active Expired - Lifetime
- 1997-12-23 EP EP97952998A patent/EP0948527B1/fr not_active Expired - Lifetime
- 1997-12-23 AT AT97952998T patent/ATE218580T1/de active
Also Published As
Publication number | Publication date |
---|---|
AU5669298A (en) | 1998-07-17 |
EP0948527B1 (fr) | 2002-06-05 |
ATE218580T1 (de) | 2002-06-15 |
JP4172822B2 (ja) | 2008-10-29 |
ZA9711606B (en) | 1998-06-25 |
US5965527A (en) | 1999-10-12 |
EP0948527A1 (fr) | 1999-10-13 |
JP2001507346A (ja) | 2001-06-05 |
TNSN97211A1 (fr) | 2005-03-15 |
MA26459A1 (fr) | 2004-12-20 |
DK0948527T3 (da) | 2002-09-16 |
FR2757522A1 (fr) | 1998-06-26 |
FR2757522B1 (fr) | 1999-01-29 |
WO1998028329A1 (fr) | 1998-07-02 |
DE69713148D1 (de) | 2002-07-11 |
PT948527E (pt) | 2002-11-29 |
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