MX9405111A - Nuevos derivados de (1-fenil-1-heterociclil)metanol y(1-fenil-1-heterociclil-metilamina). - Google Patents

Nuevos derivados de (1-fenil-1-heterociclil)metanol y(1-fenil-1-heterociclil-metilamina).

Info

Publication number
MX9405111A
MX9405111A MX9405111A MX9405111A MX9405111A MX 9405111 A MX9405111 A MX 9405111A MX 9405111 A MX9405111 A MX 9405111A MX 9405111 A MX9405111 A MX 9405111A MX 9405111 A MX9405111 A MX 9405111A
Authority
MX
Mexico
Prior art keywords
lower alkyl
phenyl
heterociclil
compounds
acyl
Prior art date
Application number
MX9405111A
Other languages
English (en)
Inventor
Bernard Robin Boar
Alan John Cross
Duncan Alastair Gray
Alfred Richard Green
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9302334A external-priority patent/SE9302334D0/xx
Application filed by Astra Ab filed Critical Astra Ab
Publication of MX9405111A publication Critical patent/MX9405111A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

La presente invención se relaciona con compuestos heterocíclicos novedososque tienen la fórmula general (1) en la que: X es O, S o Se; R1 es H,alquilo inferior, alcoxi inferior-alquilo inferior, arilalquilo inferior oCF3; R2 es H, alquilo inferior, alcoxi inferior-alquilo inferior,arilalquilo inferior o CF3; W es O, S, NH o N-alquilo inferior; R3 es H,alquilo inferior o acilo inferior; Ar es fenilo, furilo, tienilo, naftilo,piridilo o pirrolilo opcionalmente sustituido por R6; R6 son uno o másgrupos seleccionados de alquilo inferior, acilo inferior, halógeno, alcoxiinferior, CF3, OH, NO2 o NR4R5, en el que R4 y R5 son independientementeH, alquilo inferior o acilo inferior; los isómeros geométricos y ópticos yracematos de los mismos, cuando existan tales isómeros, así como las salesde adición de ácido farmacéuticamente aceptables de los mismos y lossolvatos de los mismos que tengan actividad terapéutica, con procesosintermediarios para su preparación, con formulaciones farmacéuticas quecontienen tales compuestos y con el uso médico de tales compuestos.
MX9405111A 1993-07-06 1994-07-05 Nuevos derivados de (1-fenil-1-heterociclil)metanol y(1-fenil-1-heterociclil-metilamina). MX9405111A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9302334A SE9302334D0 (sv) 1993-07-06 1993-07-06 New compounds
US08/379,469 US5712299A (en) 1993-07-03 1994-07-05 (1-phenyl-1-heterocyclyl)methanol and (1-phenyl-1-heterocyclyl methylamine derivatives
US45663795A 1995-06-02 1995-06-02

Publications (1)

Publication Number Publication Date
MX9405111A true MX9405111A (es) 1995-01-31

Family

ID=27355726

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9405111A MX9405111A (es) 1993-07-06 1994-07-05 Nuevos derivados de (1-fenil-1-heterociclil)metanol y(1-fenil-1-heterociclil-metilamina).

Country Status (19)

Country Link
US (1) US5712299A (es)
EP (1) EP0707574A1 (es)
JP (1) JPH08512314A (es)
CN (1) CN1047169C (es)
AU (1) AU691821B2 (es)
BR (1) BR9406925A (es)
CA (1) CA2164960A1 (es)
CZ (1) CZ4296A3 (es)
FI (1) FI960078A0 (es)
HU (1) HUT74671A (es)
IL (1) IL110158A (es)
MX (1) MX9405111A (es)
NO (1) NO305953B1 (es)
NZ (1) NZ268691A (es)
PL (1) PL179015B1 (es)
SG (1) SG48081A1 (es)
SK (1) SK160095A3 (es)
WO (1) WO1995001968A1 (es)
ZA (1) ZA944647B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2313995A (en) * 1994-05-02 1995-11-29 Zeneca Limited Herbicidal hydroxybenzyl-substituted heteroaryl compounds and derivatives thereof
ATE293102T1 (de) * 1998-04-23 2005-04-15 Takeda Pharmaceutical Naphthalene derivate ,ihre herstellung und verwendung
SE9904177D0 (sv) * 1999-11-18 1999-11-18 Astra Ab Novel compounds
BR0115687A (pt) 2000-11-27 2003-09-09 Pfizer Prod Inc Agonistas seletivos do receptor ep4 no tratamento de osteoporose
GB0711776D0 (en) * 2007-06-18 2007-07-25 Syngenta Participations Ag Substituted aromatic heterocyclic compounds as fungicides
CN102958924B (zh) * 2010-05-05 2017-06-27 伊利诺伊大学评议会 治疗脑病症的化合物和方法
US9150527B2 (en) 2011-08-30 2015-10-06 Innocrin Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
CN103214396B (zh) * 2013-04-10 2015-01-21 湖北工业大学 3-氰基苯甲酸的生产方法
CN103193658A (zh) * 2013-04-18 2013-07-10 苏州永健生物医药有限公司 一种（r）-2-对硝基苯乙胺基-1-苯乙醇及其盐的合成方法

Also Published As

Publication number Publication date
SK160095A3 (en) 1997-06-04
US5712299A (en) 1998-01-27
JPH08512314A (ja) 1996-12-24
HU9503743D0 (en) 1996-02-28
CZ4296A3 (en) 1996-06-12
NO960030L (no) 1996-01-04
BR9406925A (pt) 1996-07-30
NO960030D0 (no) 1996-01-04
FI960078A (fi) 1996-01-08
FI960078A0 (fi) 1996-01-08
AU7197994A (en) 1995-02-06
PL312428A1 (en) 1996-04-29
AU691821B2 (en) 1998-05-28
CN1047169C (zh) 1999-12-08
WO1995001968A1 (en) 1995-01-19
NO305953B1 (no) 1999-08-23
HUT74671A (en) 1997-01-28
ZA944647B (en) 1995-01-06
CN1126991A (zh) 1996-07-17
IL110158A0 (en) 1994-10-07
IL110158A (en) 1999-07-14
NZ268691A (en) 1997-09-22
SG48081A1 (en) 1998-04-17
CA2164960A1 (en) 1995-01-19
EP0707574A1 (en) 1996-04-24
PL179015B1 (pl) 2000-07-31

Similar Documents

Publication Publication Date Title
EA200500018A1 (ru) Бензконденсированные гетероариламидные производные тиенопиридинов, применяемые в качестве терапевтических агентов, фармацевтические композиции, включающие их, и способы их применения
MX9305379A (es) Nuevos derivados de aminoacidos, procedimiento para su preparacion y preparado farmaceutico que los contiene.
ES2081187T3 (es) Nuevas naftil-alquil-aminas, su procedimiento de preparacion y composiciones farmaceuticas que las contienen.
AR024060A1 (es) Nuevos compuestos farmaceuticamente activos
AR046297A1 (es) Inhibidores de la dpp - iv metodos para prepararlos y composiciones farmaceuticas que los contienen como agente activo
SE9302080D0 (sv) New compounds
UY27336A1 (es) Derivados de 4-piperacinilindol con afinidad receptora de 5-ht6
ES2123039T3 (es) Nuevas 3-(hidroxi-bencilidenil)-indolin-2-onas, su procedimiento de preparacion y composiciones farmaceuticas que las contienen.
AR045040A1 (es) Derivados de compuestos espiroazabiciclicos, composiciones farmaceuticas que los contienen y su uso en la preparacion de medicamentos
DE69000364T2 (de) Von benzocyclischen oder benzoheterocyclischen saeuren abgeleitete sulfonamide, ihre herstellung und ihre anwendung in der heilkunde.
BR9812239A (pt) Composto, formulação farmacêutica, uso do composto, processos para o tratamento de distúrbios, para o tratamento de distúrbios mediados por 5-hidroxitriptamina, e, para a preparação do composto
UY24429A1 (es) Acetidinas
MX9405111A (es) Nuevos derivados de (1-fenil-1-heterociclil)metanol y(1-fenil-1-heterociclil-metilamina).
AR012436A1 (es) Compuestos de 4-aminopirido[2,3-d]pirimidina 5,7-disustituidos, composicion farmaceutica que los comprende, el uso de los mismos para lamanufactura de medicamentos, un procedimiento para su preparacion.
AR007108A1 (es) Agentes antitumorales y antivirales alquilantes, procedimiento para su preparacion, utilizacion de los mismos para la fabricacion de un medicamento y composicion farmaceutica que contiene a dichos agentes.
ATE267826T1 (de) Pharmazeutisch wirksame sulfonyl hydrazid- derivate
ES2111352T3 (es) Uso de diester fosfato para el tratamiento de enfermedades retinianas.
AR019256A1 (es) Utilizacion de derivados tetraciclo[6-6-2-0(2.27).0(9.14)] hexadeca-2(7), 3, 5, 9(14), 10,12-hexaeno, para la preparacion de preparados farmaceuticos conaccion inhibitoria de la fosfolipasa, los referidos derivados y preparado farmaceutico que contiene por lo menos a uno de dichos derivados
AR033430A1 (es) Derivados de alcoxicarbonilamino tetrazolil fenilo o acido alcoxicarbonilamino benzoico, su uso, un proceso para su preparacion y composiciones farmaceuticas que los comprenden
MX9405110A (es) Nuevos derivados de (1-heteroazolil-1-heterociclil)alcano y su uso comoagentes neuroprotectores.
HUP0103166A2 (hu) Karbamát- és karbamidtartalmú készítmények, és neurotróf alkalmazásuk
AR033429A1 (es) Derivados del acido alcoxicarbonilamino-heteroarilcarboxilico, su uso, un procedimiento para prepararlos y composiciones farmaceuticas que los comprenden
AR007052A1 (es) Un derivado de carbohidrato, su uso y una composicion farmaceutica que lo comprende
ATE13423T1 (de) Guanidinderivate und diese enthaltende pharmazeutische zusammensetzungen.
AR027454A1 (es) Derivados de beta-alanina, utiles como antagonistas de receptores, las composiciones farmaceuticas que las contienen y el uso de los mismos para lapreparacion de medicamentos

Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees