MX2010004232A - Compuesto de indolina de pirimidilo. - Google Patents

Compuesto de indolina de pirimidilo.

Info

Publication number
MX2010004232A
MX2010004232A MX2010004232A MX2010004232A MX2010004232A MX 2010004232 A MX2010004232 A MX 2010004232A MX 2010004232 A MX2010004232 A MX 2010004232A MX 2010004232 A MX2010004232 A MX 2010004232A MX 2010004232 A MX2010004232 A MX 2010004232A
Authority
MX
Mexico
Prior art keywords
compound
indoline compound
pyrimidyl
pyrimidyl indoline
disclosed
Prior art date
Application number
MX2010004232A
Other languages
English (en)
Inventor
Toshio Kaneko
Takeshi Shida
Takayuki Baba
Koji Matsumoto
Kazumasa Aoki
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of MX2010004232A publication Critical patent/MX2010004232A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

Se describe un compuesto de indolina de pirimidilo que tiene una estructura diferente a la de un compuesto utilizado como un ingrediente activo para un agente hiperglucémico oral convencional, y que tiene una excelente actividad hipergiucémica. Se describe en forma específica un compuesto representado por la fórmula general (I) o una sal farmacéuticamente aceptable del mismo.
MX2010004232A 2007-10-16 2008-10-15 Compuesto de indolina de pirimidilo. MX2010004232A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007268937 2007-10-16
PCT/JP2008/068607 WO2009051119A1 (ja) 2007-10-16 2008-10-15 ピリミジルインドリン化合物

Publications (1)

Publication Number Publication Date
MX2010004232A true MX2010004232A (es) 2010-09-30

Family

ID=40567381

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010004232A MX2010004232A (es) 2007-10-16 2008-10-15 Compuesto de indolina de pirimidilo.

Country Status (16)

Country Link
US (1) US8232287B2 (es)
EP (1) EP2210886B1 (es)
JP (1) JP5317354B2 (es)
KR (1) KR101536021B1 (es)
CN (1) CN101896481B (es)
AU (1) AU2008312948C1 (es)
BR (1) BRPI0818338A2 (es)
CA (1) CA2710182C (es)
IL (1) IL205057A0 (es)
MX (1) MX2010004232A (es)
MY (1) MY151295A (es)
NZ (1) NZ585284A (es)
RU (1) RU2464269C2 (es)
TW (1) TWI421074B (es)
WO (1) WO2009051119A1 (es)
ZA (1) ZA201002552B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2399914A4 (en) * 2009-02-18 2012-08-29 Takeda Pharmaceutical FUSED HETEROCYCLIC RING CONNECTION
EP2427448A1 (en) * 2009-05-08 2012-03-14 Pfizer Inc. Gpr 119 modulators
CA2759843A1 (en) * 2009-05-08 2010-11-10 Pfizer Inc. Gpr 119 modulators
AR077214A1 (es) * 2009-06-24 2011-08-10 Neurocrine Biosciences Inc Heterociclos nitrogenados y composiciones farmaceuticas que los contienen
JP5467151B2 (ja) 2009-06-24 2014-04-09 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規化合物、医薬組成物及びそれに関する方法
WO2011017296A1 (en) * 2009-08-04 2011-02-10 Schering Corporation 4, 5, 6-trisubstituted pyrimidine derivatives as factor ixa inhibitors
EP2474540A4 (en) * 2009-08-31 2013-03-13 Nippon Chemiphar Co GPR119 AGONIST
WO2011061679A1 (en) * 2009-11-23 2011-05-26 Pfizer Inc. Imidazo-pyrazoles as gpr119 inhibitors
JP5833570B2 (ja) * 2010-01-20 2015-12-16 サノフイ アルキル−複素環カルバメート誘導体、この調製およびこの治療的適用
FR2955580A1 (fr) * 2010-01-28 2011-07-29 Sanofi Aventis Derives de carbamate d'alkyl-heterocycles, leur preparation et leur application en therapeutique
TW201204733A (en) 2010-06-25 2012-02-01 Kowa Co Novel condensed pyridine or condensed pyrimidine derivative, and medicinal agent comprising same
WO2012025811A1 (en) 2010-08-23 2012-03-01 Lupin Limited Indolylpyrimidines as modulators of gpr119
DK2625177T3 (en) 2010-10-08 2015-10-12 Cadila Healthcare Ltd New GPR 119 agonists
CA2818050A1 (en) * 2010-11-26 2012-05-31 Lupin Limited Bicyclic gpr119 modulators
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US9233958B2 (en) 2012-01-18 2016-01-12 Daiichi Sankyo Company, Limited Substituted phenylazole derivatives
US20160060235A1 (en) * 2013-03-29 2016-03-03 National University Corporation Kumamoto University Therapeutic Agent for Type 2 Diabetes
CA3125900A1 (en) * 2019-01-08 2020-07-16 Kyorin Pharmaceutical Co., Ltd. 15-pgdh inhibitor

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW406075B (en) * 1994-12-13 2000-09-21 Upjohn Co Alkyl substituted piperidinyl and piperazinyl anti-AIDS compounds
CZ20021703A3 (cs) 1999-11-30 2003-06-18 Pfizer Products Inc. 2,4-Diaminopyrimidinové sloučeniny užitečné jako imunosupresiva
US7101869B2 (en) 1999-11-30 2006-09-05 Pfizer Inc. 2,4-diaminopyrimidine compounds useful as immunosuppressants
SI1529043T1 (sl) 2002-06-19 2006-12-31 Biovitrum Ab Postopek za pripravo 2-metil piperazinskih derivatov
US7078419B2 (en) * 2003-03-10 2006-07-18 Boehringer Ingelheim Pharmaceuticals, Inc. Cytokine inhibitors
AR045047A1 (es) 2003-07-11 2005-10-12 Arena Pharm Inc Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
UA86943C2 (ru) * 2003-07-11 2009-06-10 Арена Фармасьютикалз, Инк. Тризамещенные производные арилов и гетероарилов как модуляторы метаболизма и профилактика и лечение связанных с ними нарушений
FR2866884B1 (fr) 2004-02-26 2007-08-31 Sanofi Synthelabo Derives d'aryl-et d'heteroaryl-piperidinecarboxylates, leur preparation et leur application en therapeutique
DE602005011279D1 (de) * 2004-06-04 2009-01-08 Arena Pharm Inc Substituierte aryl- und heteroarylderivate als modulatoren des stoffwechsels und für die prophylaxe und behandlung von damit in zusammenhang stehenden erkrankungen
MY148521A (en) 2005-01-10 2013-04-30 Arena Pharm Inc Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto
AU2006264649A1 (en) 2005-06-30 2007-01-11 Prosidion Limited GPCR agonists
WO2008008887A2 (en) * 2006-07-13 2008-01-17 Smithkline Beecham Corporation Gpr119 agonists for treating metabolic disorders

Also Published As

Publication number Publication date
EP2210886A4 (en) 2011-08-17
RU2010119487A (ru) 2011-11-27
JP5317354B2 (ja) 2013-10-16
EP2210886B1 (en) 2015-09-23
IL205057A0 (en) 2010-11-30
KR20100071068A (ko) 2010-06-28
CN101896481A (zh) 2010-11-24
BRPI0818338A2 (pt) 2015-04-22
AU2008312948A1 (en) 2009-04-23
WO2009051119A1 (ja) 2009-04-23
US20100292259A1 (en) 2010-11-18
EP2210886A1 (en) 2010-07-28
JPWO2009051119A1 (ja) 2011-03-03
CN101896481B (zh) 2014-04-30
TWI421074B (zh) 2014-01-01
RU2464269C2 (ru) 2012-10-20
ZA201002552B (en) 2011-10-26
CA2710182C (en) 2012-08-14
US8232287B2 (en) 2012-07-31
CA2710182A1 (en) 2009-04-23
NZ585284A (en) 2011-03-31
KR101536021B1 (ko) 2015-07-10
AU2008312948C1 (en) 2012-08-09
AU2008312948B2 (en) 2012-03-01
MY151295A (en) 2014-04-30
TW200922588A (en) 2009-06-01

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