DK403080A - Fremgangsmaade til fremstilling af 4-thioalkylpyridin- eller -pyrimidin-forbindelser eller syreadditionssalte deraf - Google Patents

Fremgangsmaade til fremstilling af 4-thioalkylpyridin- eller -pyrimidin-forbindelser eller syreadditionssalte deraf

Info

Publication number
DK403080A
DK403080A DK403080A DK403080A DK403080A DK 403080 A DK403080 A DK 403080A DK 403080 A DK403080 A DK 403080A DK 403080 A DK403080 A DK 403080A DK 403080 A DK403080 A DK 403080A
Authority
DK
Denmark
Prior art keywords
preparing
procedure
acid addition
addition salts
pyrimidine compounds
Prior art date
Application number
DK403080A
Other languages
English (en)
Other versions
DK152427B (da
DK152427C (da
Inventor
J G Lombardino
C A Harbert
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of DK403080A publication Critical patent/DK403080A/da
Publication of DK152427B publication Critical patent/DK152427B/da
Application granted granted Critical
Publication of DK152427C publication Critical patent/DK152427C/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32Sulfur atoms
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01DHARVESTING; MOWING
    • A01D34/00Mowers; Mowing apparatus of harvesters
    • A01D34/001Accessories not otherwise provided for
    • A01D34/003Means for cleaning the machine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C33/00Moulds or cores; Details thereof or accessories therefor
    • B29C33/56Coatings, e.g. enameled or galvanised; Releasing, lubricating or separating agents
    • B29C33/60Releasing, lubricating or separating agents
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C70/00Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts
    • B29C70/68Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts by incorporating or moulding on preformed parts, e.g. inserts or layers, e.g. foam blocks
    • B29C70/84Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts by incorporating or moulding on preformed parts, e.g. inserts or layers, e.g. foam blocks by moulding material on preformed parts to be joined
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55Acids; Esters
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/63One oxygen atom
    • C07D213/65One oxygen atom attached in position 3 or 5
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16CSHAFTS; FLEXIBLE SHAFTS; ELEMENTS OR CRANKSHAFT MECHANISMS; ROTARY BODIES OTHER THAN GEARING ELEMENTS; BEARINGS
    • F16C11/00Pivots; Pivotal connections
    • F16C11/04Pivotal connections
    • F16C11/06Ball-joints; Other joints having more than one degree of angular freedom, i.e. universal joints
    • F16C11/0604Construction of the male part
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16CSHAFTS; FLEXIBLE SHAFTS; ELEMENTS OR CRANKSHAFT MECHANISMS; ROTARY BODIES OTHER THAN GEARING ELEMENTS; BEARINGS
    • F16C11/00Pivots; Pivotal connections
    • F16C11/04Pivotal connections
    • F16C11/06Ball-joints; Other joints having more than one degree of angular freedom, i.e. universal joints
    • F16C11/068Special features relating to lubrication

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Composite Materials (AREA)
  • Environmental Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
DK403080A 1979-10-15 1980-09-24 Analogifremgangsmaade til fremstilling af 4-thiomethylpyridinforbindelser eller farmaceutisk acceptable syreadditionssalte deraf DK152427C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/085,011 US4246263A (en) 1979-10-15 1979-10-15 Antiinflammatory and immunoregulatory pyrimidines, their method of use and pharmaceutical compositions
US8501179 1979-10-15

Publications (3)

Publication Number Publication Date
DK403080A true DK403080A (da) 1981-04-16
DK152427B DK152427B (da) 1988-02-29
DK152427C DK152427C (da) 1988-07-25

Family

ID=22188737

Family Applications (1)

Application Number Title Priority Date Filing Date
DK403080A DK152427C (da) 1979-10-15 1980-09-24 Analogifremgangsmaade til fremstilling af 4-thiomethylpyridinforbindelser eller farmaceutisk acceptable syreadditionssalte deraf

Country Status (39)

Country Link
US (1) US4246263A (da)
JP (1) JPS5663962A (da)
KR (2) KR840001614B1 (da)
AR (3) AR226864A1 (da)
AT (2) AT377513B (da)
AU (1) AU517763B2 (da)
BE (1) BE885709A (da)
CA (1) CA1156231A (da)
CH (1) CH646425A5 (da)
CS (2) CS226020B2 (da)
DD (2) DD154816B3 (da)
DE (1) DE3038593A1 (da)
DK (1) DK152427C (da)
EG (1) EG14676A (da)
ES (2) ES495932A0 (da)
FI (1) FI75560C (da)
FR (1) FR2467199A1 (da)
GB (2) GB2092133B (da)
GR (1) GR70311B (da)
HK (2) HK1185A (da)
HU (2) HU191824B (da)
IE (1) IE50665B1 (da)
IL (1) IL61261A (da)
IN (2) IN154554B (da)
IT (1) IT1195269B (da)
KE (2) KE3461A (da)
LU (1) LU82844A1 (da)
MY (2) MY8500323A (da)
NL (1) NL8005652A (da)
NO (1) NO156566C (da)
NZ (1) NZ195246A (da)
PH (1) PH18277A (da)
PL (2) PL125402B1 (da)
PT (1) PT71917B (da)
SE (1) SE437023B (da)
SG (2) SG56384G (da)
SU (2) SU1083907A3 (da)
YU (2) YU41740B (da)
ZA (1) ZA806306B (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4371696A (en) * 1980-07-14 1983-02-01 Pfizer Inc. Certain pyridine methylthio acetaldehyde derivatives and non-cyclic and cyclic acetals thereof
GB8405896D0 (en) * 1984-03-07 1984-04-11 Sandoz Ltd Organic compounds
JPH01502980A (ja) * 1986-06-17 1989-10-12 レイチ,スティーブン デー ガンマインターフェロンと抗炎症剤または抗発熱剤との組合せ並びに疾患処置方法
WO2003024955A2 (en) * 2001-09-18 2003-03-27 Sunesis Pharmaceuticals, Inc. Small molecule inhibitors of caspases
EP1896401B1 (en) * 2005-02-25 2013-04-10 Temple University - Of The Commonwealth System of Higher Education Unsaturated sulfides, sulfones, sulfoxides and sulfonamides synthesis
JP5287033B2 (ja) * 2007-08-23 2013-09-11 住友化学株式会社 含フッ素有機硫黄化合物およびその有害節足動物防除剤
CN108530606B (zh) * 2018-04-19 2020-11-20 山东师范大学 一种pH敏感性医用聚氨酯脲材料及其制备方法
US11981625B2 (en) 2018-10-08 2024-05-14 Ecolab Usa Inc. Sulfide-based compounds and uses thereof
CN110483740B (zh) * 2019-08-12 2021-08-27 山东师范大学 一种聚合物、pH敏感性纳米囊泡及制备方法与应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3409626A (en) * 1963-09-17 1968-11-05 Neisler Lab Inc Indolylethyl pyridinium quaternary ammonium compounds
NL144484B (nl) * 1967-07-26 1975-01-15 Merck & Co Inc Werkwijze ter bereiding van een geneesmiddel met anti-anflammatoire werking, alsmede werkwijze ter bereiding van de anti-inflammatoir werkzame aralkylmercaptoaminozuren.
US3558640A (en) * 1967-12-20 1971-01-26 Merck & Co Inc Certain pyridyl and thiazolyl methylthiopropionic acids and derivatives
US3636074A (en) * 1968-08-05 1972-01-18 Hooker Chemical Corp Novel mercaptophenol derivatives
US3591584A (en) 1968-08-27 1971-07-06 Pfizer Benzothiazine dioxides
US3818009A (en) * 1969-12-29 1974-06-18 Lilly Co Eli Alpha, alpha-disubstituted-5-pyrimidinemethanes
US3676463A (en) 1970-10-15 1972-07-11 Pfizer Oxobenzofuran carboxamides
US3707475A (en) 1970-11-16 1972-12-26 Pfizer Antiinflammatory imidazoles
JPS52125170A (en) * 1976-04-12 1977-10-20 Yoshitomi Pharmaceut Ind Ltd Pyridine derivatives

Also Published As

Publication number Publication date
KR840001615B1 (ko) 1984-10-11
YU266882A (en) 1983-09-30
NO803073L (no) 1981-04-21
PL231782A1 (da) 1982-03-01
KE3466A (en) 1984-11-09
GB2092133A (en) 1982-08-11
GR70311B (da) 1982-09-08
PL125314B1 (en) 1983-04-30
SG56384G (en) 1985-03-08
ES505544A0 (es) 1982-08-16
DE3038593A1 (de) 1981-04-23
ATA268783A (de) 1985-07-15
YU262680A (en) 1983-09-30
FI75560B (fi) 1988-03-31
ES8201972A1 (es) 1982-01-16
IT1195269B (it) 1988-10-12
AR227089A1 (es) 1982-09-15
IL61261A0 (en) 1980-12-31
SE437023B (sv) 1985-02-04
FI75560C (fi) 1988-07-11
CH646425A5 (fr) 1984-11-30
SU1083907A3 (ru) 1984-03-30
AT379801B (de) 1986-03-10
KE3461A (en) 1984-10-12
PH18277A (en) 1985-05-17
HU183233B (en) 1984-04-28
JPS6129342B2 (da) 1986-07-05
FR2467199B1 (da) 1984-12-28
MY8500323A (en) 1985-12-31
GB2061928B (en) 1983-06-02
YU42059B (en) 1988-04-30
PT71917A (en) 1980-12-01
NZ195246A (en) 1983-07-15
SU1144617A3 (ru) 1985-03-07
AT377513B (de) 1985-03-25
FR2467199A1 (fr) 1981-04-17
DD154816A5 (de) 1982-04-21
DD202543A5 (de) 1983-09-21
EG14676A (en) 1985-03-31
NO156566B (no) 1987-07-06
IL61261A (en) 1984-08-31
AU6324080A (en) 1981-04-30
HU191824B (en) 1987-04-28
CS226020B2 (en) 1984-03-19
KR830004263A (ko) 1983-07-09
IN163553B (da) 1988-10-08
GB2061928A (en) 1981-05-20
KR840001614B1 (ko) 1984-10-11
AU517763B2 (en) 1981-08-27
FI803239L (fi) 1981-04-16
US4246263A (en) 1981-01-20
YU41740B (en) 1987-12-31
IE802125L (en) 1981-04-15
PL227307A1 (da) 1981-11-13
CA1156231A (en) 1983-11-01
ZA806306B (en) 1981-10-28
DK152427B (da) 1988-02-29
DD154816B3 (de) 1987-05-13
DK152427C (da) 1988-07-25
AR227576A1 (es) 1982-11-15
SG69184G (en) 1985-03-15
IE50665B1 (en) 1986-06-11
GB2092133B (en) 1983-03-16
ATA508980A (de) 1984-08-15
SE8007193L (sv) 1981-04-16
ES495932A0 (es) 1982-01-16
DE3038593C2 (da) 1988-11-10
CS226034B2 (en) 1984-03-19
JPS5663962A (en) 1981-05-30
PT71917B (en) 1983-01-10
LU82844A1 (fr) 1981-06-04
HK66887A (en) 1987-09-25
BE885709A (fr) 1981-04-14
MY8500325A (en) 1985-12-31
PL125402B1 (en) 1983-05-31
NL8005652A (nl) 1981-04-21
AR226864A1 (es) 1982-08-31
IN154554B (da) 1984-11-10
NO156566C (no) 1987-10-14
ES8206478A1 (es) 1982-08-16
HK1185A (en) 1985-01-11
IT8025324A0 (it) 1980-10-14

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