DK3741883T3 - Antistofbiblioteker - Google Patents
Antistofbiblioteker Download PDFInfo
- Publication number
- DK3741883T3 DK3741883T3 DK20152442.8T DK20152442T DK3741883T3 DK 3741883 T3 DK3741883 T3 DK 3741883T3 DK 20152442 T DK20152442 T DK 20152442T DK 3741883 T3 DK3741883 T3 DK 3741883T3
- Authority
- DK
- Denmark
- Prior art keywords
- antibodies libraries
- libraries
- antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
- C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1089—Design, preparation, screening or analysis of libraries using computer algorithms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
- G16B35/20—Screening of libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
- G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
- G16C20/60—In silico combinatorial chemistry
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Library & Information Science (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Evolutionary Biology (AREA)
- Theoretical Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Medical Informatics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36519410P | 2010-07-16 | 2010-07-16 | |
| EP17192812.0A EP3336225B1 (en) | 2010-07-16 | 2011-07-14 | Antibody libraries |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3741883T3 true DK3741883T3 (da) | 2023-02-20 |
Family
ID=45470085
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17192812.0T DK3336225T3 (da) | 2010-07-16 | 2011-07-14 | Antistofbiblioteker |
| DK11807533.2T DK2593594T3 (da) | 2010-07-16 | 2011-07-14 | Antistofbiblioteker |
| DK20152442.8T DK3741883T3 (da) | 2010-07-16 | 2011-07-14 | Antistofbiblioteker |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17192812.0T DK3336225T3 (da) | 2010-07-16 | 2011-07-14 | Antistofbiblioteker |
| DK11807533.2T DK2593594T3 (da) | 2010-07-16 | 2011-07-14 | Antistofbiblioteker |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US9354228B2 (da) |
| EP (4) | EP4219805A1 (da) |
| JP (6) | JP6266343B2 (da) |
| KR (5) | KR101963709B1 (da) |
| CN (2) | CN103282560B (da) |
| AU (4) | AU2011279073B2 (da) |
| BR (1) | BR112013001175A2 (da) |
| CA (3) | CA3086837C (da) |
| DK (3) | DK3336225T3 (da) |
| HK (1) | HK1256463A1 (da) |
| MX (1) | MX360336B (da) |
| WO (1) | WO2012009568A2 (da) |
Families Citing this family (134)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8617554B2 (en) | 2009-05-13 | 2013-12-31 | Genzyme Corporation | Anti-human CD52 immunoglobulins |
| DK3336225T3 (da) | 2010-07-16 | 2020-03-30 | Adimab Llc | Antistofbiblioteker |
| PT2668208E (pt) | 2012-04-17 | 2015-10-12 | Arsanis Biosciences Gmbh | Anticorpo de staphylococcus aureus de reação cruzada |
| WO2014111516A1 (en) | 2013-01-17 | 2014-07-24 | Arsanis Biosciences Gmbh | Mdr e. coli specific antibody |
| AR095199A1 (es) * | 2013-03-15 | 2015-09-30 | Genzyme Corp | Anticuerpos anti-cd52 |
| EP2983710B1 (en) | 2013-04-09 | 2019-07-31 | Annexon, Inc. | Methods of treatment for neuromyelitis optica |
| WO2014187746A2 (en) | 2013-05-21 | 2014-11-27 | Arsanis Biosciences Gmbh | Generation of highly potent antibodies neutralizing the lukgh (lukab) toxin of staphylococcus aureus |
| WO2015006507A1 (en) | 2013-07-09 | 2015-01-15 | Annexon, Inc. | Methods of treatment for alzheimer's disease and huntington's disease |
| JP7133902B2 (ja) * | 2013-10-01 | 2022-09-09 | カイマブ・リミテッド | 動物モデル及び治療用分子 |
| AU2014336111A1 (en) | 2013-10-17 | 2016-04-14 | Arsanis Biosciences Gmbh | Cross-reactive Staphylococcus aureus antibody sequences |
| SG11201604503XA (en) | 2013-12-03 | 2016-07-28 | Agency Science Tech & Res | Cytotoxic antibody |
| EP3825326A1 (en) | 2014-04-01 | 2021-05-26 | Adimab, LLC | Multispecific antibody analogs comprising a common light chain, and methods of their preparation and use |
| TWI695011B (zh) | 2014-06-18 | 2020-06-01 | 美商梅爾莎納醫療公司 | 抗ｈｅｒ２表位之單株抗體及其使用之方法 |
| CA3090240A1 (en) | 2014-08-08 | 2016-02-11 | Alector Llc | Anti-trem2 antibodies and methods of use thereof |
| JP6859259B2 (ja) | 2014-11-19 | 2021-04-14 | ジェネンテック， インコーポレイテッド | ＢＡＣＥｌに対する抗体及び神経疾患免疫療法のためのその使用 |
| EP3221361B1 (en) | 2014-11-19 | 2021-04-21 | Genentech, Inc. | Anti-transferrin receptor / anti-bace1 multispecific antibodies and methods of use |
| KR101694832B1 (ko) * | 2014-12-31 | 2017-01-12 | 앱클론(주) | 항체 라이브러리 및 그의 제작방법 |
| CN107371365B (zh) | 2015-02-17 | 2022-01-11 | X4制药(奥地利)有限责任公司 | 靶向克雷伯氏肺炎菌半乳聚糖类o-抗原的抗体 |
| EP3280441B1 (en) | 2015-04-07 | 2021-09-29 | Alector LLC | Anti-sortilin antibodies and methods of use thereof |
| AU2016245887B2 (en) | 2015-04-10 | 2021-09-23 | Adimab, Llc. | Methods for purifying heterodimeric multispecific antibodies from parental homodimeric antibody species |
| JP2018513168A (ja) | 2015-04-17 | 2018-05-24 | アルサニス・バイオサイエンスズ・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 抗スタフィロコッカス・アウレウス抗体組み合わせ製剤 |
| US11174313B2 (en) | 2015-06-12 | 2021-11-16 | Alector Llc | Anti-CD33 antibodies and methods of use thereof |
| CA2988982A1 (en) | 2015-06-12 | 2016-12-15 | Alector Llc | Anti-cd33 antibodies and methods of use thereof |
| CN104894652A (zh) * | 2015-06-25 | 2015-09-09 | 黄薇 | 一种cTnI人源化单链抗体库的构建及应用 |
| CN115960235A (zh) | 2015-08-28 | 2023-04-14 | 艾利妥 | 抗siglec-7抗体及其使用方法 |
| CN108368176B (zh) | 2015-10-01 | 2022-06-07 | 波滕扎治疗公司 | 抗tigit抗原结合蛋白及其使用方法 |
| EP3359186B1 (en) * | 2015-10-05 | 2021-06-02 | The Feinstein Institute for Medical Research | Inhibition of autism spectrum disorder using decoy antigens to maternal brain-reactive antibodies |
| CN117069841A (zh) | 2015-10-06 | 2023-11-17 | 艾利妥 | 抗trem2抗体及其使用方法 |
| WO2017064258A1 (en) | 2015-10-16 | 2017-04-20 | Arsanis Biosciences Gmbh | Bactericidal monoclonal antibody targeting klebsiella pneumoniae |
| SG11201803567XA (en) | 2015-10-29 | 2018-05-30 | Alector Llc | Anti-siglec-9 antibodies and methods of use thereof |
| KR102216032B1 (ko) * | 2016-01-19 | 2021-02-16 | 주무토르 바이오로직스 인코포레이티드 | 합성 항체 라이브러리의 생성 방법, 상기 라이브러리 및 그 적용(들) |
| AU2017209083A1 (en) | 2016-01-22 | 2018-07-12 | Adimab, Llc | Anti-coagulation factor XI antibodies |
| EP3423493A2 (en) | 2016-03-04 | 2019-01-09 | Alector LLC | Anti-trem1 antibodies and methods of use thereof |
| EP3426680A4 (en) | 2016-03-10 | 2020-03-11 | Acceleron Pharma Inc. | TYPE 2 ACTIVIN RECEPTOR BINDING PROTEINS AND USES THEREOF |
| CN109310885B (zh) | 2016-03-15 | 2022-05-31 | 梅尔莎纳医疗公司 | NaPi2b靶向抗体-药物缀合物及其使用方法 |
| JP7101621B2 (ja) | 2016-05-20 | 2022-07-15 | ハープーン セラピューティクス，インク． | 単一ドメイン血清アルブミン結合タンパク質 |
| US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
| GEP20227382B (en) | 2016-06-14 | 2022-05-25 | Merck Sharp & Dohme | Anti-coagulation factor xi antibodies |
| JP2019531708A (ja) | 2016-08-12 | 2019-11-07 | エックスフォー・ファーマシューティカルズ（オーストリア）ゲーエムべーハー | クレブシエラ・ニューモニエｏ３特異的抗体 |
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| WO2018118887A1 (en) | 2016-12-22 | 2018-06-28 | Wake Forest University Health Sciences | Sirp-gamma targeted agents for use in the treatment of cancer |
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| CN108239150A (zh) | 2016-12-24 | 2018-07-03 | 信达生物制药(苏州)有限公司 | 抗pcsk9抗体及其用途 |
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| CN111566125A (zh) * | 2017-09-11 | 2020-08-21 | 特韦斯特生物科学公司 | Gpcr结合蛋白及其合成 |
| EP3694545A4 (en) | 2017-10-11 | 2021-12-01 | Board Of Regents, The University Of Texas System | HUMAN PD-L1 ANTIBODIES AND METHOD OF USING THEM |
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| CA3106535A1 (en) | 2018-07-27 | 2020-01-30 | Alector Llc | Anti-siglec-5 antibodies and methods of use thereof |
| WO2020033926A2 (en) | 2018-08-09 | 2020-02-13 | Compass Therapeutics Llc | Antibodies that bind cd277 and uses thereof |
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| EP3833443A1 (en) | 2018-08-09 | 2021-06-16 | Compass Therapeutics LLC | Antigen binding agents that bind cd277 and uses thereof |
| KR20210057053A (ko) | 2018-08-23 | 2021-05-20 | 씨젠 인크. | 항-tigit 항체 |
| US10815311B2 (en) | 2018-09-25 | 2020-10-27 | Harpoon Therapeutics, Inc. | DLL3 binding proteins and methods of use |
| WO2020069133A1 (en) | 2018-09-27 | 2020-04-02 | Tizona Therapeutics | Anti-hla-g antibodies, compositions comprising anti-hla-g antibodies and methods of using anti-hla-g antibodies |
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