DE659440T1 - Calcium-modifiziertes und- oxydiertes Zelluloses haemostatisches Material. - Google Patents
Calcium-modifiziertes und- oxydiertes Zelluloses haemostatisches Material.Info
- Publication number
- DE659440T1 DE659440T1 DE0659440T DE94309709T DE659440T1 DE 659440 T1 DE659440 T1 DE 659440T1 DE 0659440 T DE0659440 T DE 0659440T DE 94309709 T DE94309709 T DE 94309709T DE 659440 T1 DE659440 T1 DE 659440T1
- Authority
- DE
- Germany
- Prior art keywords
- calcium
- hemostatic agent
- surgical hemostatic
- salt
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims abstract 9
- 239000011575 calcium Substances 0.000 title claims abstract 9
- 229910052791 calcium Inorganic materials 0.000 title claims abstract 9
- 239000000463 material Substances 0.000 title claims abstract 8
- 230000002439 hemostatic effect Effects 0.000 title 1
- 239000002874 hemostatic agent Substances 0.000 claims abstract 12
- 239000002253 acid Substances 0.000 claims abstract 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract 4
- 239000011734 sodium Substances 0.000 claims abstract 4
- 229910052708 sodium Inorganic materials 0.000 claims abstract 4
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000011591 potassium Substances 0.000 claims abstract 2
- 229910052700 potassium Inorganic materials 0.000 claims abstract 2
- 229940030225 antihemorrhagics Drugs 0.000 claims 10
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 4
- 108090000190 Thrombin Proteins 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 229960004072 thrombin Drugs 0.000 claims 3
- 159000000007 calcium salts Chemical class 0.000 claims 2
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims 2
- 238000005406 washing Methods 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 1
- 229920002201 Oxidized cellulose Polymers 0.000 abstract 4
- 229940107304 oxidized cellulose Drugs 0.000 abstract 4
- 230000023597 hemostasis Effects 0.000 abstract 2
- 230000002452 interceptive effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/64—Use of materials characterised by their function or physical properties specially adapted to be resorbable inside the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
- C08L1/02—Cellulose; Modified cellulose
- C08L1/04—Oxycellulose; Hydrocellulose, e.g. microcrystalline cellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S602/00—Surgery: splint, brace, or bandage
- Y10S602/90—Method of making bandage structure
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Polymers & Plastics (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
- Cosmetics (AREA)
- Jellies, Jams, And Syrups (AREA)
- Medicinal Preparation (AREA)
Claims (11)
1. Bioresorbierbares chirurgisches Hämostatikum, umfassend einen neutralisierten, oxidierten Cellulosestoff
mit einem Gehalt an etwa 0,5 bis etwa 4,0% Calcium.
2. Chirurgisches Hämostatikum nach Anspruch 1, wobei
der Stoff etwa 2,0 bis etwa 3,5% Calcium enthält.
3. Chirurgisches Hämostatikum nach Anspruch 1, ferner
enthaltend etwa 2 bis etwa 6% Natrium oder Kalium.
4. Chirurgisches Hämostatikum nach Anspruch 3, ferner
enthaltend eine hämostatisch wirksame Menge an Thrombin.
5. Verfahren zur Herstellung eines bioresorbierbaren
chirurgischen Hämostatikums, umfassend folgende Stufen:
(a) Kontaktieren eines oxidierten Cellulosematerials, das eine vorbestimmte Konzentration an Carbonsäure mit einer
vorbestimmten Menge einer chloridfreien Lösung eines Calciumsalzes einer schwachen Säure mit einer vorbestimmten
Molarität, die zur Neutralisation von etwa 5,5 bis etwa 45% der Carbonsäure und zur Bereitstellung eines Calciumgehalts
im Gewebe von etwa 0,5 bis etwa 4,0% ausgewählt wird, enthält; und
(b) Waschen des Materials zur Entfernung von überschüssigem Salz.
6. Verfahren zur Herstellung eines bioresorbierbaren
chirurgischen Hämostatikums, umfassend folgende Stufen:
(a) Kontaktieren eines oxidierten Cellulosematerials,
das eine vorbestimmte Konzentration an Carbonsäure mit einer vorbestimmten Menge einer chloridfreien Lösung eines
Calciumsalzes einer schwachen Säure und ein Natrium- oder Kaliumsalz einer schwachen" Säure zur Neutralisation von etwa
50 bis etwa 80% der Carbonsäure enthält, wobei die
Salzkonzentrationen so gewählt sind, daß das Calcium etwa 5,5 bis etwa 45% der Säure und das Natrium- oder Kaliumsalz den
Rest neutralisiert, und zur Bereitstellung eines Calciumanteils im Gewebe von etwa 0,5 bis etwa 4,0%; und
(b) Waschen des Materials zur Entfernung von überschüssigem Salz.
7. Verfahren nach Anspruch 6, umfassend die zusätzliche Stufe des Imprägnierens des getrockneten
Materials mit einer hämostatisch wirksamen Menge an Thrombin.
8. Chirurgisches Hämostatikum nach Anspruch 3, wobei
das Gewebe etwa 2,0 bis 3,5% Calcium enthält.
9. Chirurgisches Hämostatikum nach Anspruch 9, wobei das Gewebe einen pH-Wert von 5,0 bis 8,0 aufweist.
10. Chirurgisches Hämostatikum nach Anspruch 9, wobei das Gewebe einen pH-Wert von 6,5 bis 7,0 aufweist.
11. Chirurgisches Hämostatikum nach Anspruch 10, ferner enthaltend eine hämostatisch wirksame Menge an Thrombin.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17332593A | 1993-12-23 | 1993-12-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE659440T1 true DE659440T1 (de) | 1996-10-10 |
Family
ID=22631515
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE0659440T Pending DE659440T1 (de) | 1993-12-23 | 1994-12-22 | Calcium-modifiziertes und- oxydiertes Zelluloses haemostatisches Material. |
DE69430897T Expired - Lifetime DE69430897T2 (de) | 1993-12-23 | 1994-12-22 | Calcium-modifiziertes und- oxydiertes Zelluloses haemostatisches Material |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69430897T Expired - Lifetime DE69430897T2 (de) | 1993-12-23 | 1994-12-22 | Calcium-modifiziertes und- oxydiertes Zelluloses haemostatisches Material |
Country Status (23)
Country | Link |
---|---|
US (1) | US5484913A (de) |
EP (1) | EP0659440B1 (de) |
JP (1) | JP3602178B2 (de) |
KR (1) | KR950016789A (de) |
CN (1) | CN1070704C (de) |
AT (1) | ATE219949T1 (de) |
AU (1) | AU677118B2 (de) |
BR (1) | BR9405232A (de) |
CA (1) | CA2138850C (de) |
CZ (1) | CZ288792B6 (de) |
DE (2) | DE659440T1 (de) |
DK (1) | DK0659440T3 (de) |
ES (1) | ES2080034T3 (de) |
FI (1) | FI946038A (de) |
GR (1) | GR950300073T1 (de) |
HU (1) | HUT71587A (de) |
MY (1) | MY131908A (de) |
NO (1) | NO944986L (de) |
PL (1) | PL178356B1 (de) |
PT (1) | PT659440E (de) |
RU (1) | RU2136319C1 (de) |
SG (1) | SG75781A1 (de) |
ZA (1) | ZA9410283B (de) |
Families Citing this family (137)
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US5800373A (en) * | 1995-03-23 | 1998-09-01 | Focal, Inc. | Initiator priming for improved adherence of gels to substrates |
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US5900245A (en) * | 1996-03-22 | 1999-05-04 | Focal, Inc. | Compliant tissue sealants |
US5696101A (en) * | 1996-04-16 | 1997-12-09 | Eastman Chemical Company | Oxidized cellulose and vitamin E blend for topical hemostatic applications |
TW411277B (en) * | 1996-05-13 | 2000-11-11 | Hisamitsu Pharmaceutical Co | Percutaneous tape preparation containing fentanyl |
ZA978537B (en) | 1996-09-23 | 1998-05-12 | Focal Inc | Polymerizable biodegradable polymers including carbonate or dioxanone linkages. |
ZA987019B (en) * | 1997-08-06 | 1999-06-04 | Focal Inc | Hemostatic tissue sealants |
IE990615A1 (en) | 1998-07-21 | 2000-05-03 | Alpenstock Holdings Ltd | Slow Release Formulations |
US6627749B1 (en) * | 1999-11-12 | 2003-09-30 | University Of Iowa Research Foundation | Powdered oxidized cellulose |
US6187347B1 (en) | 2000-02-09 | 2001-02-13 | Ecosafe, Llc. | Composition for arresting the flow of blood and method |
WO2003034925A2 (en) | 2001-10-23 | 2003-05-01 | Tyco Healthcare Group Lp | Surgical fasteners |
JP4474165B2 (ja) * | 2002-02-20 | 2010-06-02 | 株式会社ネクスト21 | 噴射用薬剤の調製方法 |
JP2005075815A (ja) * | 2003-09-03 | 2005-03-24 | Masao Tanihara | 止血性組織修復材 |
EP1689787A2 (de) | 2003-11-28 | 2006-08-16 | Eastman Chemical Company | Cellulose-mischpolymere und oxidationsverfahren |
DK1766003T3 (da) * | 2004-06-22 | 2008-12-08 | Zymogenetics Inc | Thrombinpræparater |
US7938307B2 (en) | 2004-10-18 | 2011-05-10 | Tyco Healthcare Group Lp | Support structures and methods of using the same |
US7845536B2 (en) | 2004-10-18 | 2010-12-07 | Tyco Healthcare Group Lp | Annular adhesive structure |
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US9364229B2 (en) | 2005-03-15 | 2016-06-14 | Covidien Lp | Circular anastomosis structures |
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-
1994
- 1994-12-20 CZ CZ19943245A patent/CZ288792B6/cs not_active IP Right Cessation
- 1994-12-20 RU RU94044342A patent/RU2136319C1/ru active
- 1994-12-22 ZA ZA9410283A patent/ZA9410283B/xx unknown
- 1994-12-22 AT AT94309709T patent/ATE219949T1/de not_active IP Right Cessation
- 1994-12-22 PT PT94309709T patent/PT659440E/pt unknown
- 1994-12-22 JP JP33546894A patent/JP3602178B2/ja not_active Expired - Lifetime
- 1994-12-22 NO NO944986A patent/NO944986L/no unknown
- 1994-12-22 DE DE0659440T patent/DE659440T1/de active Pending
- 1994-12-22 FI FI946038A patent/FI946038A/fi unknown
- 1994-12-22 EP EP94309709A patent/EP0659440B1/de not_active Expired - Lifetime
- 1994-12-22 PL PL94306475A patent/PL178356B1/pl not_active IP Right Cessation
- 1994-12-22 ES ES94309709T patent/ES2080034T3/es not_active Expired - Lifetime
- 1994-12-22 MY MYPI94003495A patent/MY131908A/en unknown
- 1994-12-22 DK DK94309709T patent/DK0659440T3/da active
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- 1994-12-22 AU AU81718/94A patent/AU677118B2/en not_active Expired
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- 1994-12-22 DE DE69430897T patent/DE69430897T2/de not_active Expired - Lifetime
- 1994-12-23 HU HU9403781A patent/HUT71587A/hu unknown
- 1994-12-23 BR BR9405232A patent/BR9405232A/pt not_active Application Discontinuation
- 1994-12-23 KR KR1019940036157A patent/KR950016789A/ko active IP Right Grant
- 1994-12-23 CN CN94120734A patent/CN1070704C/zh not_active Expired - Lifetime
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1995
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1996
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