DE2643670C2 - 5-Benzyl-4-pyrimidon-Derivate, ihre Salze mit Säuren, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel - Google Patents

5-Benzyl-4-pyrimidon-Derivate, ihre Salze mit Säuren, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Info

Publication number
DE2643670C2
DE2643670C2 DE2643670A DE2643670A DE2643670C2 DE 2643670 C2 DE2643670 C2 DE 2643670C2 DE 2643670 A DE2643670 A DE 2643670A DE 2643670 A DE2643670 A DE 2643670A DE 2643670 C2 DE2643670 C2 DE 2643670C2
Authority
DE
Germany
Prior art keywords
pyrimidone
methyl
ethanol
histamine
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2643670A
Other languages
German (de)
English (en)
Other versions
DE2643670A1 (de
Inventor
Thomas Henry Brown
Graham John Welwyn Garden City Hertfordshire Durant
John Colin Codicote Hertfordshire Emmett
Charon Robin Welwyn Garden City Hertfordshire Ganellin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Publication of DE2643670A1 publication Critical patent/DE2643670A1/de
Application granted granted Critical
Publication of DE2643670C2 publication Critical patent/DE2643670C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE2643670A 1975-10-02 1976-09-28 5-Benzyl-4-pyrimidon-Derivate, ihre Salze mit Säuren, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel Expired DE2643670C2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4034175 1975-10-02

Publications (2)

Publication Number Publication Date
DE2643670A1 DE2643670A1 (de) 1977-04-14
DE2643670C2 true DE2643670C2 (de) 1982-07-01

Family

ID=10414412

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2643670A Expired DE2643670C2 (de) 1975-10-02 1976-09-28 5-Benzyl-4-pyrimidon-Derivate, ihre Salze mit Säuren, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Country Status (36)

Country Link
JP (2) JPS5246087A (ko)
AR (1) AR221682A1 (ko)
AT (1) AT358045B (ko)
AU (1) AU504897B2 (ko)
BE (1) BE846452A (ko)
BG (1) BG25224A3 (ko)
CA (1) CA1067076A (ko)
CH (1) CH625801A5 (ko)
CS (1) CS203003B2 (ko)
DD (1) DD126563A5 (ko)
DE (1) DE2643670C2 (ko)
DK (1) DK442476A (ko)
ES (1) ES452060A1 (ko)
FI (1) FI61701C (ko)
FR (1) FR2326192A1 (ko)
GR (1) GR61307B (ko)
HU (1) HU175537B (ko)
IE (1) IE44845B1 (ko)
IL (1) IL50503A (ko)
IN (1) IN146736B (ko)
IT (2) IT1070839B (ko)
LU (1) LU75922A1 (ko)
MW (1) MW3476A1 (ko)
MX (1) MX4614E (ko)
NL (1) NL7609917A (ko)
NO (1) NO145792C (ko)
NZ (1) NZ181959A (ko)
OA (1) OA05445A (ko)
PH (1) PH13921A (ko)
PL (1) PL105828B1 (ko)
PT (1) PT65590B (ko)
RO (1) RO73511A (ko)
SE (1) SE431872B (ko)
YU (1) YU237276A (ko)
ZA (1) ZA765498B (ko)
ZM (1) ZM12176A1 (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2658267A1 (de) * 1975-12-29 1977-07-07 Smith Kline French Lab Pyrimid-4-on- und -thion-derivate, ihre salze mit saeuren, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ186511A (en) 1977-03-19 1980-11-14 Smith Kline French Lab 3-substituted alkylamino-6-substituted alkyl-1,2,4-triazin-5-ones and pharmaceutical compositions 3-substituted thio-1,2,4-triazin-5-ones
GR62452B (en) 1977-04-20 1979-04-12 Ici Ltd Preparation process of guanidine derivatives
US4165378A (en) 1977-04-20 1979-08-21 Ici Americas Inc. Guanidine derivatives of imidazoles and thiazoles
JPS54104816A (en) * 1978-01-27 1979-08-17 Memorex Corp Magnetic recorder tape reel
IN151188B (ko) * 1978-02-13 1983-03-05 Smith Kline French Lab
PH16240A (en) * 1978-04-11 1983-08-11 Smith Kline French Lab Process for making histamine antagonist
IL57416A (en) * 1978-05-30 1983-03-31 Smith Kline French Lab Nitro compounds,processes for preparing them and compositions containing them
ZA793443B (en) * 1978-07-26 1980-12-31 Glaxo Group Ltd Heterocyclic derivatives
US4374836A (en) 1978-10-16 1983-02-22 Imperial Chemical Industries Ltd. Antisecretory heterocyclic derivatives, process for their manufacture and pharmaceutical compositions containing them
US4496567A (en) * 1978-11-13 1985-01-29 Smith Kline & French Laboratories Limited Phenyl alkylaminopyrimidones
US4521418A (en) * 1979-02-21 1985-06-04 Smith Kline & French Laboratories Limited Guanidinothiazolyl derivatives
JPS55145683A (en) * 1979-04-26 1980-11-13 Smith Kline French Lab Pyrimidone derivative
CA1155842A (en) * 1980-03-29 1983-10-25 Thomas H. Brown Compounds
ZW21281A1 (en) * 1980-10-01 1981-11-18 Smith Kline French Lab Amine derivatives
IE53068B1 (en) * 1981-06-15 1988-05-25 Merck & Co Inc Diamino isothiazole-1-oxides and -1,1-dioxides as gastic secretion inhibitors
PT75074B (en) * 1981-06-27 1986-02-26 Smith Kline French Lab Process for preparing certain pyrimidone derivatives and compositions containing them
NZ202797A (en) * 1981-12-28 1985-08-30 Lilly Co Eli Pyrimidine derivatives and pharmaceutical compositions
JPS5993074A (ja) * 1982-10-01 1984-05-29 スミス・クライン・アンド・フレンチ・ラボラトリ−ス・リミテツド ピリミドン誘導体
DE8309239U1 (de) * 1983-03-29 1983-09-29 Basf Ag, 6700 Ludwigshafen Bandspule, insbesondere fuer magnetbaender

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1397436A (en) * 1972-09-05 1975-06-11 Smith Kline French Lab Heterocyclic n-cyanoguinidines
GB1419994A (en) * 1973-05-03 1976-01-07 Smith Kline French Lab Heterocyclicalkylaminotheterocyclic compounds methods for their preparation and compositions comprising them

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2658267A1 (de) * 1975-12-29 1977-07-07 Smith Kline French Lab Pyrimid-4-on- und -thion-derivate, ihre salze mit saeuren, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
FI61701C (fi) 1982-09-10
FR2326192B1 (ko) 1979-01-12
CS203003B2 (en) 1981-02-27
JPS609755B2 (ja) 1985-03-12
PL105828B1 (pl) 1979-11-30
CH625801A5 (en) 1981-10-15
LU75922A1 (ko) 1977-05-06
NO145792B (no) 1982-02-22
AU504897B2 (en) 1979-11-01
NZ181959A (en) 1978-07-28
MX4614E (es) 1982-07-07
PT65590A (en) 1976-10-01
GR61307B (en) 1978-10-19
IE44845B1 (en) 1982-04-21
PT65590B (en) 1978-03-28
ZM12176A1 (en) 1977-07-21
IT1070839B (it) 1985-04-02
AR221682A1 (es) 1981-03-13
IL50503A0 (en) 1976-11-30
AT358045B (de) 1980-08-11
JPS5246087A (en) 1977-04-12
DD126563A5 (ko) 1977-07-27
CA1067076A (en) 1979-11-27
OA05445A (fr) 1981-03-31
SE431872B (sv) 1984-03-05
RO73511A (ro) 1981-04-30
FI762803A (ko) 1977-04-03
YU237276A (en) 1983-01-21
IL50503A (en) 1980-12-31
JPS5695186A (en) 1981-08-01
ATA711976A (de) 1980-01-15
ES452060A1 (es) 1977-10-01
AU1829576A (en) 1978-04-06
ZA765498B (en) 1977-08-31
PH13921A (en) 1980-11-04
IE44845L (en) 1977-04-02
FR2326192A1 (fr) 1977-04-29
BG25224A3 (en) 1978-08-10
DE2643670A1 (de) 1977-04-14
BE846452A (fr) 1977-03-22
JPS5635674B2 (ko) 1981-08-19
SE7610409L (sv) 1977-04-03
NL7609917A (nl) 1977-04-05
NO145792C (no) 1982-06-02
NO763371L (ko) 1977-04-05
IN146736B (ko) 1979-08-25
FI61701B (fi) 1982-05-31
MW3476A1 (en) 1977-11-09
HU175537B (hu) 1980-08-28
IT7830708A0 (it) 1978-12-11
DK442476A (da) 1977-04-03

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Legal Events

Date Code Title Description
OD Request for examination
OI Miscellaneous see part 1
OI Miscellaneous see part 1
OI Miscellaneous see part 1
D2 Grant after examination
8328 Change in the person/name/address of the agent

Free format text: TAUCHNER, P., DIPL.-CHEM. DR.RER.NAT. HEUNEMANN, D., DIPL.-PHYS. DR.RER.NAT. RAUH, P., DIPL.-CHEM. DR.RER.NAT. HERMANN, G., DIPL.-PHYS. DR.RER.NAT. SCHMIDT, J., DIPL.-ING. JAENICHEN, H., DIPL.-BIOL. DR.RER.NAT., PAT.-ANWAELTE TREMMEL, H., RECHTSANW., 8000 MUENCHEN

8339 Ceased/non-payment of the annual fee