FR2326192A1 - Nouvelles pyrimidones, leur procede de preparation et leur application therapeutique - Google Patents

Nouvelles pyrimidones, leur procede de preparation et leur application therapeutique

Info

Publication number: FR2326192A1
Authority: FR; France
Prior art keywords: pyrimidones; new; preparation process; formula; therapeutic application
Prior art date: 1975-10-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

FR7628824A

Other languages

English (en)

French (fr)

Other versions

FR2326192B1 (ko

Inventor

Thomas Henry Brown

Graham John Durant

John Colin Emmett

Charon Robin Ganellin

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Smith Kline and French Laboratories Ltd

Original Assignee

Smith Kline and French Laboratories Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-10-02

Filing date

1976-09-24

Publication date

1977-04-29

1976-09-24 Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd

1977-04-29 Publication of FR2326192A1 publication Critical patent/FR2326192A1/fr

1979-01-12 Application granted granted Critical

1979-01-12 Publication of FR2326192B1 publication Critical patent/FR2326192B1/fr

Status Granted legal-status Critical Current

Links

238000002360 preparation method Methods 0.000 title 1
150000008318 pyrimidones Chemical class 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Substances 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
239000000938 histamine H1 antagonist Substances 0.000 abstract 1
239000003485 histamine H2 receptor antagonist Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
CYQAYERJWZKYML-UHFFFAOYSA-N phosphorus pentasulfide Chemical compound S1P(S2)(=S)SP3(=S)SP1(=S)SP2(=S)S3 CYQAYERJWZKYML-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

FR7628824A 1975-10-02 1976-09-24 Nouvelles pyrimidones, leur procede de preparation et leur application therapeutique Granted FR2326192A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB4034175		1975-10-02

Publications (2)

Publication Number	Publication Date
FR2326192A1 true FR2326192A1 (fr)	1977-04-29
FR2326192B1 FR2326192B1 (ko)	1979-01-12

Family

ID=10414412

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FR7628824A Granted FR2326192A1 (fr)	1975-10-02	1976-09-24	Nouvelles pyrimidones, leur procede de preparation et leur application therapeutique

Country Status (36)

Country	Link
JP (2)	JPS5246087A (ko)
AR (1)	AR221682A1 (ko)
AT (1)	AT358045B (ko)
AU (1)	AU504897B2 (ko)
BE (1)	BE846452A (ko)
BG (1)	BG25224A3 (ko)
CA (1)	CA1067076A (ko)
CH (1)	CH625801A5 (ko)
CS (1)	CS203003B2 (ko)
DD (1)	DD126563A5 (ko)
DE (1)	DE2643670C2 (ko)
DK (1)	DK442476A (ko)
ES (1)	ES452060A1 (ko)
FI (1)	FI61701C (ko)
FR (1)	FR2326192A1 (ko)
GR (1)	GR61307B (ko)
HU (1)	HU175537B (ko)
IE (1)	IE44845B1 (ko)
IL (1)	IL50503A (ko)
IN (1)	IN146736B (ko)
IT (2)	IT1070839B (ko)
LU (1)	LU75922A1 (ko)
MW (1)	MW3476A1 (ko)
MX (1)	MX4614E (ko)
NL (1)	NL7609917A (ko)
NO (1)	NO145792C (ko)
NZ (1)	NZ181959A (ko)
OA (1)	OA05445A (ko)
PH (1)	PH13921A (ko)
PL (1)	PL105828B1 (ko)
PT (1)	PT65590B (ko)
RO (1)	RO73511A (ko)
SE (1)	SE431872B (ko)
YU (1)	YU237276A (ko)
ZA (1)	ZA765498B (ko)
ZM (1)	ZM12176A1 (ko)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0003677A2 (en) *	1978-02-13	1979-08-22	Smith Kline & French Laboratories Limited	Pyrimidones, processes for their preparation and pharmaceutical compositions containing them
WO1980000966A1 (en) *	1978-11-13	1980-05-15	Smith Kline French Lab	New histamine h2-antagonists
EP0039989B1 (en) *	1980-03-29	1984-08-29	Smith Kline & French Laboratories Limited	Pyrimidone derivatives, processes for their preparation and pharmaceutical compositions containing them

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MW5076A1 (en) *	1975-12-29	1978-02-08	Smith Kline French Lab	Pharmacologicalle active compounds
NZ186511A (en)	1977-03-19	1980-11-14	Smith Kline French Lab	3-substituted alkylamino-6-substituted alkyl-1,2,4-triazin-5-ones and pharmaceutical compositions 3-substituted thio-1,2,4-triazin-5-ones
GR62452B (en)	1977-04-20	1979-04-12	Ici Ltd	Preparation process of guanidine derivatives
US4165378A (en)	1977-04-20	1979-08-21	Ici Americas Inc.	Guanidine derivatives of imidazoles and thiazoles
JPS54104816A (en) *	1978-01-27	1979-08-17	Memorex Corp	Magnetic recorder tape reel
PH16240A (en) *	1978-04-11	1983-08-11	Smith Kline French Lab	Process for making histamine antagonist
IL57416A (en) *	1978-05-30	1983-03-31	Smith Kline French Lab	Nitro compounds,processes for preparing them and compositions containing them
ZA793443B (en) *	1978-07-26	1980-12-31	Glaxo Group Ltd	Heterocyclic derivatives
US4374836A (en)	1978-10-16	1983-02-22	Imperial Chemical Industries Ltd.	Antisecretory heterocyclic derivatives, process for their manufacture and pharmaceutical compositions containing them
US4521418A (en) *	1979-02-21	1985-06-04	Smith Kline & French Laboratories Limited	Guanidinothiazolyl derivatives
JPS55145683A (en) *	1979-04-26	1980-11-13	Smith Kline French Lab	Pyrimidone derivative
ZW21281A1 (en) *	1980-10-01	1981-11-18	Smith Kline French Lab	Amine derivatives
IE53068B1 (en) *	1981-06-15	1988-05-25	Merck & Co Inc	Diamino isothiazole-1-oxides and -1,1-dioxides as gastic secretion inhibitors
PT75074B (en) *	1981-06-27	1986-02-26	Smith Kline French Lab	Process for preparing certain pyrimidone derivatives and compositions containing them
NZ202797A (en) *	1981-12-28	1985-08-30	Lilly Co Eli	Pyrimidine derivatives and pharmaceutical compositions
JPS5993074A (ja) *	1982-10-01	1984-05-29	スミス・クライン・アンド・フレンチ・ラボラトリ−ス・リミテツド	ピリミドン誘導体
DE8309239U1 (de) *	1983-03-29	1983-09-29	Basf Ag, 6700 Ludwigshafen	Bandspule, insbesondere fuer magnetbaender

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1397436A (en) *	1972-09-05	1975-06-11	Smith Kline French Lab	Heterocyclic n-cyanoguinidines
GB1419994A (en) *	1973-05-03	1976-01-07	Smith Kline French Lab	Heterocyclicalkylaminotheterocyclic compounds methods for their preparation and compositions comprising them

1976
- 1976-09-06 IN IN1633/CAL/76A patent/IN146736B/en unknown
- 1976-09-07 NL NL7609917A patent/NL7609917A/xx unknown
- 1976-09-07 NZ NZ181959A patent/NZ181959A/xx unknown
- 1976-09-10 MW MW34/76A patent/MW3476A1/xx unknown
- 1976-09-14 ZA ZA765498A patent/ZA765498B/xx unknown
- 1976-09-14 PT PT65590A patent/PT65590B/pt unknown
- 1976-09-14 IT IT27192/76A patent/IT1070839B/it active
- 1976-09-16 IL IL50503A patent/IL50503A/xx unknown
- 1976-09-20 SE SE7610409A patent/SE431872B/xx not_active IP Right Cessation
- 1976-09-22 BE BE170830A patent/BE846452A/xx not_active IP Right Cessation
- 1976-09-24 PH PH18943A patent/PH13921A/en unknown
- 1976-09-24 AT AT711976A patent/AT358045B/de not_active IP Right Cessation
- 1976-09-24 FR FR7628824A patent/FR2326192A1/fr active Granted
- 1976-09-27 CS CS766222A patent/CS203003B2/cs unknown
- 1976-09-28 GR GR51794A patent/GR61307B/el unknown
- 1976-09-28 YU YU02372/76A patent/YU237276A/xx unknown
- 1976-09-28 DE DE2643670A patent/DE2643670C2/de not_active Expired
- 1976-09-28 CA CA262,162A patent/CA1067076A/en not_active Expired
- 1976-09-29 OA OA55946A patent/OA05445A/xx unknown
- 1976-09-29 IE IE2154/76A patent/IE44845B1/en unknown
- 1976-09-30 AU AU18295/76A patent/AU504897B2/en not_active Expired
- 1976-09-30 AR AR264926A patent/AR221682A1/es active
- 1976-09-30 DD DD195067A patent/DD126563A5/xx unknown
- 1976-10-01 ZM ZM121/76A patent/ZM12176A1/xx unknown
- 1976-10-01 BG BG7600034338A patent/BG25224A3/xx unknown
- 1976-10-01 NO NO763371A patent/NO145792C/no unknown
- 1976-10-01 HU HU76SI1543A patent/HU175537B/hu unknown
- 1976-10-01 LU LU75922A patent/LU75922A1/xx unknown
- 1976-10-01 PL PL1976192809A patent/PL105828B1/pl unknown
- 1976-10-01 JP JP51118904A patent/JPS5246087A/ja active Granted
- 1976-10-01 ES ES452060A patent/ES452060A1/es not_active Expired
- 1976-10-01 DK DK442476A patent/DK442476A/da not_active Application Discontinuation
- 1976-10-01 FI FI762803A patent/FI61701C/fi not_active IP Right Cessation
- 1976-10-01 CH CH1248276A patent/CH625801A5/de not_active IP Right Cessation
- 1976-10-01 MX MX764951U patent/MX4614E/es unknown
- 1976-10-02 RO RO7687887A patent/RO73511A/ro unknown
1978
- 1978-12-11 IT IT7830708A patent/IT7830708A0/it unknown
1980
- 1980-12-09 JP JP55174447A patent/JPS609755B2/ja not_active Expired

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0003677A2 (en) *	1978-02-13	1979-08-22	Smith Kline & French Laboratories Limited	Pyrimidones, processes for their preparation and pharmaceutical compositions containing them
EP0003677A3 (en) *	1978-02-13	1979-09-05	Smith Kline & French Laboratories Limited	Pyrimidones, processes for their preparation and pharmaceutical compositions containing them
WO1980000966A1 (en) *	1978-11-13	1980-05-15	Smith Kline French Lab	New histamine h2-antagonists
EP0013071A1 (en) *	1978-11-13	1980-07-09	Smith Kline & French Laboratories Limited	Pyrimidinone derivatives, processes for preparing them and pharmaceutical compositions containing them
EP0039989B1 (en) *	1980-03-29	1984-08-29	Smith Kline & French Laboratories Limited	Pyrimidone derivatives, processes for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number	Publication date
FI61701C (fi)	1982-09-10
FR2326192B1 (ko)	1979-01-12
CS203003B2 (en)	1981-02-27
JPS609755B2 (ja)	1985-03-12
PL105828B1 (pl)	1979-11-30
CH625801A5 (en)	1981-10-15
LU75922A1 (ko)	1977-05-06
NO145792B (no)	1982-02-22
AU504897B2 (en)	1979-11-01
NZ181959A (en)	1978-07-28
MX4614E (es)	1982-07-07
PT65590A (en)	1976-10-01
GR61307B (en)	1978-10-19
IE44845B1 (en)	1982-04-21
PT65590B (en)	1978-03-28
ZM12176A1 (en)	1977-07-21
IT1070839B (it)	1985-04-02
AR221682A1 (es)	1981-03-13
IL50503A0 (en)	1976-11-30
AT358045B (de)	1980-08-11
JPS5246087A (en)	1977-04-12
DD126563A5 (ko)	1977-07-27
CA1067076A (en)	1979-11-27
OA05445A (fr)	1981-03-31
SE431872B (sv)	1984-03-05
RO73511A (ro)	1981-04-30
FI762803A (ko)	1977-04-03
DE2643670C2 (de)	1982-07-01
YU237276A (en)	1983-01-21
IL50503A (en)	1980-12-31
JPS5695186A (en)	1981-08-01
ATA711976A (de)	1980-01-15
ES452060A1 (es)	1977-10-01
AU1829576A (en)	1978-04-06
ZA765498B (en)	1977-08-31
PH13921A (en)	1980-11-04
IE44845L (en)	1977-04-02
BG25224A3 (en)	1978-08-10
DE2643670A1 (de)	1977-04-14
BE846452A (fr)	1977-03-22
JPS5635674B2 (ko)	1981-08-19
SE7610409L (sv)	1977-04-03
NL7609917A (nl)	1977-04-05
NO145792C (no)	1982-06-02
NO763371L (ko)	1977-04-05
IN146736B (ko)	1979-08-25
FI61701B (fi)	1982-05-31
MW3476A1 (en)	1977-11-09
HU175537B (hu)	1980-08-28
IT7830708A0 (it)	1978-12-11
DK442476A (da)	1977-04-03

Legal Events

Date	Code	Title	Description
1994-07-29	ST	Notification of lapse

Publication	Publication Date	Title
FR2326192A1 (fr)	1977-04-29	Nouvelles pyrimidones, leur procede de preparation et leur application therapeutique
FR2430938A1 (fr)	1980-02-08	Nouvelles oxybenzylidenes bornanones, leur procede de preparation, et compositions cosmetiques les contenant
FR2336935A1 (fr)	1977-07-29	Nouvelles pyrimidones, leur procede de preparation et leur application
ES2040208T3 (es)	1993-10-16	Pirazolinas insecticidas.
FR2406629A1 (fr)	1979-05-18	5-trifluoromethylpyridines substituees en position 2 et leur procede de preparation
FR2366297A1 (fr)	1978-04-28	Nouvelles cephalosporines, leur procede de preparation et leur application en therapeutique
OA05386A (fr)	1981-02-28	Nouvelles N-(3-trifluorométhyl-4-halogéno-phényl)-N'-benzolyl-urées, leur procédé de préparation et leur application comme insecticides.
BE848911A (fr)	1977-05-31	Nouveaux sulfures de bis-carbamoyle n-substitues asymetriques, leur procede de preparation et leur application comme insecticides et acaricides
BE845529A (fr)	1977-02-28	Nouvelles 3-alkoxy-benzo-1,2,4-triazines, leur procede de preparation et leur application comme fongicides et bactericides
BE858024A (fr)	1978-02-23	Nouvelles benzylurees substituees, leur procede de preparation et leur application comme insecticides
FR2421900A1 (fr)	1979-11-02	Piperazino-3-indoles, leur procede de preparation et leurs applications therapeutiques
FI793459A (fi)	1980-05-08	Estrar av 1,1,2-trifenylalkenderivat
FR2567520B1 (fr)	1987-01-02	Nouvelles phenyl-naphthyridines, leur procede de preparation, medicaments les contenant, notamment anti-ulceres
FR2314192A1 (fr)	1977-01-07	Procede de preparation d'oxaphospholannes-1,2
FR2361881A2 (fr)	1978-03-17	Nouveaux sulfoxydes, leur procede de preparation et leur application
FR2304603A1 (fr)	1976-10-15	Nouvelles 2,3-dihalogeno-alcanoyl-urees, leur procede de preparation et leur application comme fongicides
LU78874A1 (fr)	1979-09-06	Procede de preparation de nouvelles sulfonylhydrazones de 1,4-dioxo-et 4-oxoquinoxaline-2-carboxaldehyde
BE845327A (fr)	1977-02-21	Procede de preparation de 4,4'-dihydroxy-3-3'-5-5'-tretralcoyldiphenylalcanes
FR2368489A1 (fr)	1978-05-19	Derives de la clavuline, leur procede de preparation et leur application en therapeutique
FR2416228A1 (fr)	1979-08-31	Sulfures de 4-pyrimidyle, leur procede de preparation et leur application en therapeutique
FR2297917A1 (fr)	1976-08-13	Procede de desulfuration d'aciers en fusion
FR2326422A1 (fr)	1977-04-29	Procede de production de nouvelles triazine-2,4-diones et leur application comme insecticides
FR2318166A1 (fr)	1977-02-11	Procede de preparation continue de 2,5-dioxo-1-oxa-2-phospholanes
BE838832A (fr)	1976-08-23	Analogues d'acides prostanoiques, leur procede de preparation et leurs applications
FR2398070A1 (fr)	1979-02-16	Nouvelles 1-piperazinyl-triazolo-thieno-1,4-diazepines substituees et leur application comme medicaments