DD154542A5 - Verfahren zur herstellung von 6 beta-hydroxyalkylpenicillansaeuren - Google Patents

Verfahren zur herstellung von 6 beta-hydroxyalkylpenicillansaeuren Download PDF

Info

Publication number: DD154542A5
Authority: DD; German Democratic Republic
Prior art keywords: benzyl; carbon atoms; acid; added; ethyl acetate
Prior art date: 1979-10-22

Application number

DD80224691A

Other languages

German (de)

English (en)

Inventor

Michael S Kellogg

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-10-22

Filing date

1980-10-22

Publication date

1982-03-31

1980-10-22 Application filed by Pfizer filed Critical Pfizer

1982-03-31 Publication of DD154542A5 publication Critical patent/DD154542A5/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/04—Preparation
- C07D499/08—Modification of a carboxyl radical directly attached in position 2, e.g. esterification
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
- C07D499/74—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with carbocyclic rings directly attached to the carboxamido radical

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Pharmacology & Pharmacy (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Catalysts (AREA)

DD80224691A 1979-10-22 1980-10-22 Verfahren zur herstellung von 6 beta-hydroxyalkylpenicillansaeuren DD154542A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/086,864 US4287181A (en)	1979-10-22	1979-10-22	Derivatives of 6β-hydroxyalkylpenicillanic acids as β-lactamase inhibitors

Publications (1)

Publication Number	Publication Date
DD154542A5 true DD154542A5 (de)	1982-03-31

Family

ID=22201393

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD80224691A DD154542A5 (de)	1979-10-22	1980-10-22	Verfahren zur herstellung von 6 beta-hydroxyalkylpenicillansaeuren

Country Status (38)

Country	Link
US (1)	US4287181A (fr)
JP (2)	JPS5665892A (fr)
KR (1)	KR840000797B1 (fr)
AR (1)	AR227164A1 (fr)
AT (2)	AT369372B (fr)
AU (1)	AU519578B2 (fr)
BE (1)	BE885812A (fr)
BG (2)	BG35189A3 (fr)
CA (2)	CA1144159A (fr)
CH (2)	CH646175A5 (fr)
CS (2)	CS219291B2 (fr)
DD (1)	DD154542A5 (fr)
DE (1)	DE3039504C2 (fr)
DK (1)	DK389480A (fr)
ES (1)	ES8204437A1 (fr)
FI (1)	FI71156C (fr)
FR (1)	FR2467852A1 (fr)
GB (3)	GB2061930B (fr)
GR (1)	GR70714B (fr)
GT (1)	GT198065892A (fr)
HU (1)	HU183236B (fr)
IE (3)	IE51027B1 (fr)
IL (1)	IL61307A (fr)
IN (1)	IN154918B (fr)
IT (1)	IT1149259B (fr)
LU (1)	LU82880A1 (fr)
MX (1)	MX6094E (fr)
NL (1)	NL183358C (fr)
NO (1)	NO159019C (fr)
NZ (1)	NZ195307A (fr)
PH (5)	PH16219A (fr)
PL (2)	PL129534B1 (fr)
PT (1)	PT71946B (fr)
RO (2)	RO86176B (fr)
SE (1)	SE451455B (fr)
SU (2)	SU1122227A3 (fr)
YU (2)	YU41743B (fr)
ZA (1)	ZA806452B (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE49770B1 (en) *	1979-05-21	1985-12-11	Leo Pharm Prod Ltd	6beta-halopenicillanic acid derivatives
GB2076812A (en) *	1980-05-22	1981-12-09	Ciba Geigy Ag	Penam-dioxide compounds, processes for their manufacture, and their use
US4444687A (en) *	1981-06-08	1984-04-24	Bristol-Myers Company	2β-Chloromethyl-2α-methylpenam-3α-carboxylic acid sulfone methylene diol mixed esters
ZA826687B (en) *	1981-09-14	1983-07-27	Pfizer	Beta-lactamase inhibiting 2-beta-substituted-2-alpha-methyl 5(r)penam-3-alpha-carboxylic acid 1,1-dioxides and intermediates therefor
US4351840A (en)	1981-09-18	1982-09-28	Pfizer Inc.	Antibacterial esters of resorcinol with ampicillin and penicillanic acid 1,1-dioxide derivatives
JPS58109490A (ja) *	1981-12-21	1983-06-29	Sankyo Co Ltd	ペニシリン誘導体
RO84910B (ro) *	1982-01-11	1984-09-30	Pfizer Inc.	Procedeu pentru prepararea unor derivati 1, 1-dioxizi ai acidului 6-aminoalchilpenicilanic
US4452796A (en) *	1982-06-14	1984-06-05	Pfizer Inc.	6-Aminoalkylpenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
US4377590A (en) *	1982-05-10	1983-03-22	Pfizer Inc.	Derivatives of ampicillin and amoxicillin with beta-lactamase inhibitors
US4588527A (en) *	1983-06-06	1986-05-13	Pfizer Inc.	Process for preparing penicillanic acid 1,1-dioxide derivatives
US4536393A (en) *	1983-06-06	1985-08-20	Pfizer Inc.	6-(Aminomethyl)penicillanic acid 1,1-dioxide esters and intermediates therefor
US4502990A (en) *	1983-06-06	1985-03-05	Pfizer Inc.	Process for 6-(aminomethyl)penicillanic acid 1,1-dioxide and derivatives thereof
US4499017A (en) *	1983-06-06	1985-02-12	Pfizer Inc.	Beta-lactamase inhibiting 6-(alkoxyamino-methyl) penicillanic acid 1,1-dioxide and derivatives
US4502988A (en) *	1983-08-08	1985-03-05	Eli Lilly And Company	Oxidation process
US4826833A (en) *	1984-01-30	1989-05-02	Pfizer Inc.	6-(Substituted)methylene-penicillanic and 6-(substituted)hydroxymethylpenicillanic acids and derivatives thereof
PT79893B (en) *	1984-01-30	1987-02-03	Pfizer	Process for preparing 6-(substituted)methylenepenicillanic and 6-(substituted)hydroxymethylpenicilanic and derivatives thereof
US5015473A (en) *	1984-01-30	1991-05-14	Pfizer Inc.	6-(substituted)methylenepenicillanic and 6-(substituted)hydroxymethylpenicillanic acids and derivatives thereof
DE3584015D1 (de) *	1984-01-30	1991-10-17	Pfizer	6-(substituierte) methylen-penicillansaeure und 6-(substituierte) hydroxymethyl-penicillansaeure und deren derivate.
US4503040A (en) *	1984-02-27	1985-03-05	Pfizer Inc.	6-(Aminoacyloxymethyl)penicillanic acid 1,1-dioxides as beta-lactamase inhibitors
US4847247A (en) *	1984-07-30	1989-07-11	Merck & Co., Inc.	Penicillin derivatives as anti-inflammatory and antidegenerative agents
US4590073A (en) *	1984-10-22	1986-05-20	Pfizer Inc.	6-substituted penicillanic acid 1,1-dioxide compounds
US4591459A (en) *	1984-12-03	1986-05-27	Pfizer Inc.	Intermediates for 6-(aminoacyloxymethyl) penicillanic acid 1,1-dioxides
US4675186A (en) *	1985-04-18	1987-06-23	Pfizer Inc.	6-(1-acyl-1-hydroxymethyl)penicillanic acid derivatives
US4762921A (en) *	1985-04-18	1988-08-09	Pfizer Inc.	6-(1-acyl-1-hydroxymethyl)penicillanic acid derivatives
US4613462A (en) *	1985-07-02	1986-09-23	Pfizer, Inc.	6-substituted penicillanic acid 1,1-dioxide compounds
MY102312A (en) *	1987-01-27	1992-05-28	Pfizer	6-beta (substituted)-c-hydroxymethyl-penicillanic acids and derivatives thereof
US4782050A (en) *	1987-01-27	1988-11-01	Pfizer Inc.	6-beta(substituted)-(S)-hydroxymethylpenicillanic acids and derivatives thereof
US6395726B1 (en)	1999-01-26	2002-05-28	American Cyanamid Company	3,6-disubstituted penam sulfone derivatives
PA8579701A1 (es) *	2002-08-23	2005-05-24	Pfizer Prod Inc	Profarmaco inhibidor de beta-lactamasa
WO2004108733A1 (fr) *	2003-06-05	2004-12-16	Pfizer Products Inc.	Promedicament inhibiteur de la beta-lactamase
KR101491868B1 (ko) *	2007-03-09	2015-02-09	오츠카 가가쿠 가부시키가이샤	６-히드록시에틸페남 화합물의 제조 방법
CN109422765B (zh) *	2017-09-05	2020-08-28	香港理工大学深圳研究院	C类β-内酰胺酶抑制剂及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5749555B2 (fr) *	1973-04-04	1982-10-22
US4207323A (en) *	1975-11-21	1980-06-10	Merck & Co., Inc.	6-Substituted methyl penicillins, derivatives and analogues thereof
US4053468A (en) *	1976-02-25	1977-10-11	Smithkline Corporation	Process for preparing 7-oxo cephalosporins and 6-oxo penicillins
US4093625A (en) *	1976-08-09	1978-06-06	Massachusetts Institute Of Technology	6-Sulfur analogs of penicillins and cephalosporins
US4123539A (en) *	1977-12-29	1978-10-31	Merck & Co., Inc.	6-Ethylpenicillanic acid
US4272439A (en) *	1978-06-02	1981-06-09	Schering Corporation	6-(Substituted-hydroxymethylene penams)
JPS5598186A (en) *	1979-01-10	1980-07-25	Beecham Group Ltd	Manufacture of penicillin derivative
GB2076812A (en) *	1980-05-22	1981-12-09	Ciba Geigy Ag	Penam-dioxide compounds, processes for their manufacture, and their use

1979
- 1979-10-22 US US06/086,864 patent/US4287181A/en not_active Expired - Lifetime
1980
- 1980-09-12 DK DK389480A patent/DK389480A/da not_active Application Discontinuation
- 1980-10-08 IN IN736/DEL/80A patent/IN154918B/en unknown
- 1980-10-11 GR GR63135A patent/GR70714B/el unknown
- 1980-10-16 GB GB33342A patent/GB2061930B/en not_active Expired
- 1980-10-17 GT GT198065892A patent/GT198065892A/es unknown
- 1980-10-20 CA CA000362762A patent/CA1144159A/fr not_active Expired
- 1980-10-20 CS CS807098A patent/CS219291B2/cs unknown
- 1980-10-20 DE DE3039504A patent/DE3039504C2/de not_active Expired
- 1980-10-20 AR AR282932A patent/AR227164A1/es active
- 1980-10-20 PH PH24748A patent/PH16219A/en unknown
- 1980-10-20 SE SE8007354A patent/SE451455B/sv not_active IP Right Cessation
- 1980-10-20 JP JP14677480A patent/JPS5665892A/ja active Granted
- 1980-10-20 YU YU2676/80A patent/YU41743B/xx unknown
- 1980-10-20 AT AT0518580A patent/AT369372B/de not_active IP Right Cessation
- 1980-10-20 IL IL61307A patent/IL61307A/xx unknown
- 1980-10-20 NZ NZ195307A patent/NZ195307A/en unknown
- 1980-10-21 IE IE293/85A patent/IE51027B1/en unknown
- 1980-10-21 BE BE0/202544A patent/BE885812A/fr not_active IP Right Cessation
- 1980-10-21 MX MX809112U patent/MX6094E/es unknown
- 1980-10-21 SU SU802999190A patent/SU1122227A3/ru active
- 1980-10-21 PT PT71946A patent/PT71946B/pt unknown
- 1980-10-21 BG BG049416A patent/BG35189A3/xx unknown
- 1980-10-21 IE IE2229/85A patent/IE51028B1/en unknown
- 1980-10-21 PL PL1980227420A patent/PL129534B1/pl unknown
- 1980-10-21 HU HU802552A patent/HU183236B/hu not_active IP Right Cessation
- 1980-10-21 FR FR8022477A patent/FR2467852A1/fr active Granted
- 1980-10-21 FI FI803311A patent/FI71156C/fi not_active IP Right Cessation
- 1980-10-21 NO NO803136A patent/NO159019C/no unknown
- 1980-10-21 ZA ZA00806452A patent/ZA806452B/xx unknown
- 1980-10-21 IE IE2174/80A patent/IE51026B1/en unknown
- 1980-10-21 BG BG061372A patent/BG38639A3/xx unknown
- 1980-10-21 IT IT25488/80A patent/IT1149259B/it active
- 1980-10-21 AU AU63548/80A patent/AU519578B2/en not_active Ceased
- 1980-10-21 KR KR1019800004041A patent/KR840000797B1/ko active
- 1980-10-21 PL PL1980235907A patent/PL129638B1/pl unknown
- 1980-10-22 DD DD80224691A patent/DD154542A5/de unknown
- 1980-10-22 RO RO108549A patent/RO86176B/ro unknown
- 1980-10-22 LU LU82880A patent/LU82880A1/fr unknown
- 1980-10-22 ES ES496166A patent/ES8204437A1/es not_active Expired
- 1980-10-22 RO RO102404A patent/RO81225B/ro unknown
- 1980-10-22 NL NLAANVRAGE8005810,A patent/NL183358C/xx not_active IP Right Cessation
- 1980-10-22 CH CH788180A patent/CH646175A5/fr not_active IP Right Cessation
1981
- 1981-06-05 CS CS814222A patent/CS219292B2/cs unknown
- 1981-08-26 SU SU813325756A patent/SU1026654A3/ru active
- 1981-11-06 PH PH26448A patent/PH17315A/en unknown
- 1981-11-06 PH PH26449A patent/PH17317A/en unknown
- 1981-11-06 PH PH26451A patent/PH18316A/en unknown
- 1981-11-06 PH PH26450A patent/PH17458A/en unknown
1982
- 1982-01-13 AT AT0010882A patent/AT374479B/de not_active IP Right Cessation
- 1982-12-17 CA CA000418062A patent/CA1163924A/fr not_active Expired
1983
- 1983-03-21 YU YU671/83A patent/YU42075B/xx unknown
- 1983-06-21 GB GB08316829A patent/GB2128986B/en not_active Expired
- 1983-06-21 GB GB08316830A patent/GB2129421B/en not_active Expired
1984
- 1984-03-06 CH CH1089/84A patent/CH647242A5/fr not_active IP Right Cessation
1986
- 1986-02-06 JP JP61024914A patent/JPS61178988A/ja active Pending

Also Published As

Publication number	Publication date
FR2467852B1 (fr)	1983-10-07
KR830004309A (ko)	1983-07-09
CH646175A5 (fr)	1984-11-15
JPS6135197B2 (fr)	1986-08-12
AR227164A1 (es)	1982-09-30
PL129638B1 (en)	1984-05-31
HU183236B (en)	1984-04-28
ZA806452B (en)	1981-10-28
PT71946B (en)	1981-08-31
US4287181A (en)	1981-09-01
PH17317A (en)	1984-07-20
NZ195307A (en)	1984-08-24
PL129534B1 (en)	1984-05-31
IE51027B1 (en)	1986-09-17
DE3039504C2 (de)	1984-10-11
DK389480A (da)	1981-04-23
CS219292B2 (en)	1983-03-25
GT198065892A (es)	1982-04-10
RO81225A (fr)	1983-02-15
PL227420A1 (fr)	1982-08-30
FR2467852A1 (fr)	1981-04-30
YU42075B (en)	1988-04-30
PH18316A (en)	1985-05-29
PL235907A1 (fr)	1982-09-13
SU1122227A3 (ru)	1984-10-30
CS219291B2 (en)	1983-03-25
FI803311L (fi)	1981-04-23
GB2061930A (en)	1981-05-20
RO86176B (ro)	1985-03-31
RO86176A (fr)	1985-03-15
PH17315A (en)	1984-07-20
IT1149259B (it)	1986-12-03
FI71156C (fi)	1986-11-24
GB8316830D0 (en)	1983-07-27
PH17458A (en)	1984-08-29
IE852229L (en)	1981-04-22
DE3039504A1 (de)	1981-04-30
AU6354880A (en)	1981-04-30
NL8005810A (nl)	1981-04-24
RO81225B (ro)	1983-02-28
CH647242A5 (fr)	1985-01-15
YU41743B (en)	1987-12-31
IN154918B (fr)	1984-12-22
NO159019B (no)	1988-08-15
IE51026B1 (en)	1986-09-17
IT8025488A0 (it)	1980-10-21
NO803136L (no)	1981-04-23
GR70714B (fr)	1983-01-18
NO159019C (no)	1988-11-23
NL183358B (nl)	1988-05-02
ES496166A0 (es)	1982-05-01
YU67183A (en)	1984-02-29
MX6094E (es)	1984-11-12
JPS61178988A (ja)	1986-08-11
JPS5665892A (en)	1981-06-03
BG38639A3 (en)	1986-01-15
PH16219A (en)	1983-08-09
ES8204437A1 (es)	1982-05-01
PT71946A (en)	1980-11-01
BE885812A (fr)	1981-04-21
IE850293L (en)	1981-04-22
SE8007354L (sv)	1981-04-23
YU267680A (en)	1983-09-30
KR840000797B1 (ko)	1984-06-12
GB8316829D0 (en)	1983-07-27
GB2129421A (en)	1984-05-16
GB2128986A (en)	1984-05-10
NL183358C (nl)	1988-10-03
AU519578B2 (en)	1981-12-10
GB2129421B (en)	1984-11-14
AT369372B (de)	1982-12-27
GB2128986B (en)	1985-06-19
LU82880A1 (fr)	1981-06-04
IE51028B1 (en)	1986-09-17
BG35189A3 (en)	1984-02-15
SE451455B (sv)	1987-10-12
IL61307A (en)	1984-03-30
ATA518580A (de)	1982-05-15
CA1144159A (fr)	1983-04-05
IL61307A0 (en)	1980-12-31
FI71156B (fi)	1986-08-14
ATA10882A (de)	1983-09-15
SU1026654A3 (ru)	1983-06-30
AT374479B (de)	1984-04-25
CA1163924A (fr)	1984-03-20
GB2061930B (en)	1984-06-13
IE802174L (en)	1981-04-22

Publication	Publication Date	Title
DD154542A5 (de)	1982-03-31	Verfahren zur herstellung von 6 beta-hydroxyalkylpenicillansaeuren
DE2824535C3 (de)	1981-01-22	Penicillansäure-l,l-dioxide, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
EP0042026A1 (fr)	1981-12-23	Dérivés d'azétidin-2-one 3,4-disubstitués et procédé de préparation
DE2258221C2 (de)	1981-10-08	Verfahren zur Herstellung von Penicillinen und Cepholosporinen mit einem weiteren Substituenten in 6- bzw. 7-Stellung
EP0050805B1 (fr)	1985-07-24	Bêta-lactames, intermédiaires et procédé de préparation, ainsi que les compositions pharmaceutiques les contenant
EP0041047A2 (fr)	1981-12-02	Composés dioxydes, procédé pour leur préparation et leur application
DE3344317C2 (fr)	1992-02-27
DE3008316C2 (de)	1982-12-16	6-&beta;-Jodpenicillansäure-Derivate, Verfahren zu ihrer Herstellung und solche Derivate enthaltende Arzneimittel
DE2912483A1 (de)	1979-10-11	Beta -lactamverbindungen, verfahren zu deren herstellung und arzneimittel
DE2857696C2 (de)	1984-08-30	Cephalosporine
DE2130730A1 (de)	1971-12-23	Bicyclische ss-Lactame und Verfahren zu ihrer Herstellung
DD149367A5 (de)	1981-07-08	Verfahren zur herstellung von penicillansaeure-1,1-dioxid und dessen estern
DE2128605A1 (de)	1971-12-23	Neue Cephalosporansäurederivaten und Verfahren zu ihrer Herstellung
DE2534926A1 (de)	1976-02-19	Sauerstoffanaloge von cephalosporinen
DE2107650A1 (fr)	1971-09-02
DD234015A5 (de)	1986-03-19	Verfahren zur herstellung von 6-(subst.)-methylen-penicillan-und 6-(subst.)-hydroxymethyl-penicillansaeure und deren derivaten
DE2633005A1 (de)	1977-02-10	Cephem- und penamverbindungen und verfahren zu ihrer herstellung
DE2612926A1 (de)	1977-10-06	Neue acyl-derivate der 6-(alpha- amino-phenylacetamido)-penicillansaeure
DE2345236A1 (de)	1974-08-22	Quaternaere ammoniumverbindungen, verfahren zu deren herstellung und sie enthaltende arzneimittel
CH620444A5 (en)	1980-11-28	Process for the preparation of bicyclic unsaturated thiaaza compounds
DE3231596A1 (de)	1983-03-10	Penem-3-carbonsaeurederivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen
DD209462A5 (de)	1984-05-09	Verfahren zur herstellung von 6-aminoalkylpenicillansaeure-1,1-dioxiden und derivaten als beta-lactamase-inhibitoren
DE3224055A1 (de)	1983-01-20	Verfahren zur herstellung von optisch aktiven trans-6-substituierten-5(r)-2-penem-3-karbonsaeurederivaten, sowie neuen optisch aktiven trans-6(s)-substituierten-5(r)-2-penem-3-karbonsaeurederivaten
DE2702552A1 (de)	1977-07-28	7alpha-methoxy-cephalosporine und verfahren zur herstellung derselben
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