CY1124787T1 - Αντισωματα anti-gitr και μεθοδοι χρησης αυτων - Google Patents

Αντισωματα anti-gitr και μεθοδοι χρησης αυτων

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Publication number
CY1124787T1
CY1124787T1 CY20211100215T CY211100215T CY1124787T1 CY 1124787 T1 CY1124787 T1 CY 1124787T1 CY 20211100215 T CY20211100215 T CY 20211100215T CY 211100215 T CY211100215 T CY 211100215T CY 1124787 T1 CY1124787 T1 CY 1124787T1
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CY
Cyprus
Prior art keywords
gitr
antibodies
activity
human
present disclosure
Prior art date
Application number
CY20211100215T
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English (en)
Inventor
Dennis J. Underwood
David SCHAER
Takemasa Tsuji
Gerd Ritter
Ana M. Gonzalez
Nicolas S Wilson
Roberta ZAPPASODI
Taha MERGHOUB
Jedd David WOLCHOK
Volker Siebert
Olivier Leger
Marc VAN DIJK
Original Assignee
Agenus Inc.
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Publication date
Application filed by Agenus Inc. filed Critical Agenus Inc.
Publication of CY1124787T1 publication Critical patent/CY1124787T1/el

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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07—ORGANIC CHEMISTRY
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    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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Abstract

Η παρούσα κοινοποίηση παρέχει αντισώματα που δεσμεύονται ειδικά με ανθρώπινο υποδοχέα που σχετίζεται με τον TNFR (GITR) που προκαλείται από ανθρώπινα γλυκοκορτικοειδή και συνθέσεις που περιλαμβάνουν τέτοια αντισώματα. Σε μια συγκεκριμένη πτυχή, τα αντισώματα δεσμεύονται ειδικά στην ανθρώπινη GITR και ρυθμίζουν τη δραστηριότητα της GITR, π.χ., ενισχύουν, ενεργοποιούν ή επάγουν τη δραστηριότητα της GITR, χρησιμοποιώντας τέτοια αντισώματα. Η παρούσα κοινοποίηση παρέχει επίσης μεθόδους για τη θεραπεία διαταραχών, όπως καρκίνου και μολυσματικών ασθενειών, χορηγώντας ένα αντίσωμα που δεσμεύεται ειδικά στην ανθρώπινη GITR και ρυθμίζει τη δραστηριότητα της GITR π.χ. ενισχύει, ενεργοποιεί ή επάγει τη δραστηριότητα της GITR.
CY20211100215T 2014-05-28 2021-03-12 Αντισωματα anti-gitr και μεθοδοι χρησης αυτων CY1124787T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462004071P 2014-05-28 2014-05-28
US201562161250P 2015-05-13 2015-05-13
PCT/US2015/032895 WO2015184099A1 (en) 2014-05-28 2015-05-28 Anti-gitr antibodies and methods of use thereof

Publications (1)

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CY1124787T1 true CY1124787T1 (el) 2022-11-25

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US (9) US10155818B2 (el)
EP (2) EP3148579B1 (el)
JP (3) JP6847666B2 (el)
KR (2) KR20220116578A (el)
CN (2) CN108064242B (el)
AU (3) AU2015266958A1 (el)
CA (1) CA2949998A1 (el)
CY (1) CY1124787T1 (el)
DK (1) DK3148579T3 (el)
EA (1) EA201692458A1 (el)
ES (1) ES2860751T3 (el)
HR (1) HRP20210364T1 (el)
HU (1) HUE053857T2 (el)
IL (3) IL249092B (el)
LT (1) LT3148579T (el)
MA (2) MA47849A (el)
MX (2) MX2016015614A (el)
NZ (1) NZ726513A (el)
PH (1) PH12016502345A1 (el)
PL (1) PL3148579T3 (el)
PT (1) PT3148579T (el)
RS (1) RS61678B1 (el)
SG (2) SG10201912986PA (el)
SI (1) SI3148579T1 (el)
TW (2) TW202132337A (el)
WO (1) WO2015184099A1 (el)

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MX2020013062A (es) 2021-03-02
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