US459007A
(en)
|
|
1891-09-08 |
|
Porte |
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
CU22545A1
(es)
|
1994-11-18 |
1999-03-31 |
Centro Inmunologia Molecular |
Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
US4169888A
(en)
|
1977-10-17 |
1979-10-02 |
The Upjohn Company |
Composition of matter and process
|
US4307016A
(en)
|
1978-03-24 |
1981-12-22 |
Takeda Chemical Industries, Ltd. |
Demethyl maytansinoids
|
US4256746A
(en)
|
1978-11-14 |
1981-03-17 |
Takeda Chemical Industries |
Dechloromaytansinoids, their pharmaceutical compositions and method of use
|
JPS55102583A
(en)
|
1979-01-31 |
1980-08-05 |
Takeda Chem Ind Ltd |
20-acyloxy-20-demethylmaytansinoid compound
|
JPS55162791A
(en)
|
1979-06-05 |
1980-12-18 |
Takeda Chem Ind Ltd |
Antibiotic c-15003pnd and its preparation
|
JPS6023084B2
(ja)
|
1979-07-11 |
1985-06-05 |
味の素株式会社 |
代用血液
|
JPS5645483A
(en)
|
1979-09-19 |
1981-04-25 |
Takeda Chem Ind Ltd |
C-15003phm and its preparation
|
EP0028683A1
(en)
|
1979-09-21 |
1981-05-20 |
Takeda Chemical Industries, Ltd. |
Antibiotic C-15003 PHO and production thereof
|
JPS5645485A
(en)
|
1979-09-21 |
1981-04-25 |
Takeda Chem Ind Ltd |
Production of c-15003pnd
|
US4364935A
(en)
|
1979-12-04 |
1982-12-21 |
Ortho Pharmaceutical Corporation |
Monoclonal antibody to a human prothymocyte antigen and methods of preparing same
|
WO1982001188A1
(en)
|
1980-10-08 |
1982-04-15 |
Takeda Chemical Industries Ltd |
4,5-deoxymaytansinoide compounds and process for preparing same
|
US4450254A
(en)
|
1980-11-03 |
1984-05-22 |
Standard Oil Company |
Impact improvement of high nitrile resins
|
US4315929A
(en)
|
1981-01-27 |
1982-02-16 |
The United States Of America As Represented By The Secretary Of Agriculture |
Method of controlling the European corn borer with trewiasine
|
US4313946A
(en)
|
1981-01-27 |
1982-02-02 |
The United States Of America As Represented By The Secretary Of Agriculture |
Chemotherapeutically active maytansinoids from Trewia nudiflora
|
JPS57192389A
(en)
|
1981-05-20 |
1982-11-26 |
Takeda Chem Ind Ltd |
Novel maytansinoid
|
US4640835A
(en)
|
1981-10-30 |
1987-02-03 |
Nippon Chemiphar Company, Ltd. |
Plasminogen activator derivatives
|
US4496689A
(en)
|
1983-12-27 |
1985-01-29 |
Miles Laboratories, Inc. |
Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
|
US4943533A
(en)
|
1984-03-01 |
1990-07-24 |
The Regents Of The University Of California |
Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor
|
US4970198A
(en)
|
1985-10-17 |
1990-11-13 |
American Cyanamid Company |
Antitumor antibiotics (LL-E33288 complex)
|
DE3675588D1
(de)
|
1985-06-19 |
1990-12-20 |
Ajinomoto Kk |
Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
|
EP0272253A4
(en)
|
1986-03-07 |
1990-02-05 |
Massachusetts Inst Technology |
METHOD FOR IMPROVING GLYCOPROTE INSTABILITY.
|
JPH0684377B1
(ru)
|
1986-04-17 |
1994-10-26 |
Kyowa Hakko Kogyo Kk |
|
US4791192A
(en)
|
1986-06-26 |
1988-12-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified protein with polyethyleneglycol
|
US4880935A
(en)
|
1986-07-11 |
1989-11-14 |
Icrf (Patents) Limited |
Heterobifunctional linking agents derived from N-succinimido-dithio-alpha methyl-methylene-benzoates
|
IL85035A0
(en)
|
1987-01-08 |
1988-06-30 |
Int Genetic Eng |
Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
|
US5770701A
(en)
|
1987-10-30 |
1998-06-23 |
American Cyanamid Company |
Process for preparing targeted forms of methyltrithio antitumor agents
|
US5606040A
(en)
|
1987-10-30 |
1997-02-25 |
American Cyanamid Company |
Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group
|
US5053394A
(en)
|
1988-09-21 |
1991-10-01 |
American Cyanamid Company |
Targeted forms of methyltrithio antitumor agents
|
WO1989006692A1
(en)
|
1988-01-12 |
1989-07-27 |
Genentech, Inc. |
Method of treating tumor cells by inhibiting growth factor receptor function
|
FI102355B1
(fi)
|
1988-02-11 |
1998-11-30 |
Bristol Myers Squibb Co |
Menetelmä yhdistävän välikappaleen omaavien antrasykliini-immunokonjugaattien valmistamiseksi
|
US5084468A
(en)
|
1988-08-11 |
1992-01-28 |
Kyowa Hakko Kogyo Co., Ltd. |
Dc-88a derivatives
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
JP2598116B2
(ja)
|
1988-12-28 |
1997-04-09 |
協和醗酵工業株式会社 |
新規物質dc113
|
JP2510335B2
(ja)
|
1989-07-03 |
1996-06-26 |
協和醗酵工業株式会社 |
Dc―88a誘導体
|
US5187186A
(en)
|
1989-07-03 |
1993-02-16 |
Kyowa Hakko Kogyo Co., Ltd. |
Pyrroloindole derivatives
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
CA2026147C
(en)
|
1989-10-25 |
2006-02-07 |
Ravi J. Chari |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
US5859205A
(en)
|
1989-12-21 |
1999-01-12 |
Celltech Limited |
Humanised antibodies
|
EP0530225A4
(en)
|
1990-05-07 |
1993-09-22 |
Scripps Clinic And Research Foundation |
Intermediates in the formation of the calicheamicin and esperamicin oligosaccharides
|
US5968509A
(en)
|
1990-10-05 |
1999-10-19 |
Btp International Limited |
Antibodies with binding affinity for the CD3 antigen
|
CZ282603B6
(cs)
|
1991-03-06 |
1997-08-13 |
Merck Patent Gesellschaft Mit Beschränkter Haftun G |
Humanizované a chimerické monoklonální protilátky
|
ATE255131T1
(de)
|
1991-06-14 |
2003-12-15 |
Genentech Inc |
Humanisierter heregulin antikörper
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
US5264586A
(en)
|
1991-07-17 |
1993-11-23 |
The Scripps Research Institute |
Analogs of calicheamicin gamma1I, method of making and using the same
|
US5622929A
(en)
|
1992-01-23 |
1997-04-22 |
Bristol-Myers Squibb Company |
Thioether conjugates
|
GB9206422D0
(en)
|
1992-03-24 |
1992-05-06 |
Bolt Sarah L |
Antibody preparation
|
CA2076465C
(en)
|
1992-03-25 |
2002-11-26 |
Ravi V. J. Chari |
Cell binding agent conjugates of analogues and derivatives of cc-1065
|
ZA932522B
(en)
|
1992-04-10 |
1993-12-20 |
Res Dev Foundation |
Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens
|
US6329507B1
(en)
|
1992-08-21 |
2001-12-11 |
The Dow Chemical Company |
Dimer and multimer forms of single chain polypeptides
|
US5736137A
(en)
|
1992-11-13 |
1998-04-07 |
Idec Pharmaceuticals Corporation |
Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
|
US5635483A
(en)
|
1992-12-03 |
1997-06-03 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Tumor inhibiting tetrapeptide bearing modified phenethyl amides
|
DK0672142T3
(da)
|
1992-12-04 |
2001-06-18 |
Medical Res Council |
Multivalente og multispecifikke bindingsproteiner samt fremstilling og anvendelse af disse
|
JP3312357B2
(ja)
|
1992-12-11 |
2002-08-05 |
ザ ダウ ケミカル カンパニー |
多価の一本鎖抗体
|
US5780588A
(en)
|
1993-01-26 |
1998-07-14 |
Arizona Board Of Regents |
Elucidation and synthesis of selected pentapeptides
|
US6214345B1
(en)
|
1993-05-14 |
2001-04-10 |
Bristol-Myers Squibb Co. |
Lysosomal enzyme-cleavable antitumor drug conjugates
|
CA2173150C
(en)
|
1993-10-01 |
2004-11-30 |
Kyoichi Sakakibara |
Novel peptide derivatives
|
GB9401182D0
(en)
|
1994-01-21 |
1994-03-16 |
Inst Of Cancer The Research |
Antibodies to EGF receptor and their antitumour effect
|
EP0705833B1
(en)
|
1994-04-22 |
2004-07-21 |
Kyowa Hakko Kogyo Co., Ltd. |
Dc-89 derivative
|
JPH07309761A
(ja)
|
1994-05-20 |
1995-11-28 |
Kyowa Hakko Kogyo Co Ltd |
デュオカルマイシン誘導体の安定化法
|
US5773001A
(en)
|
1994-06-03 |
1998-06-30 |
American Cyanamid Company |
Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
|
US5945311A
(en)
|
1994-06-03 |
1999-08-31 |
GSF--Forschungszentrumfur Umweltund Gesundheit |
Method for producing heterologous bi-specific antibodies
|
US5550246A
(en)
|
1994-09-07 |
1996-08-27 |
The Scripps Research Institute |
Calicheamicin mimics
|
US5541087A
(en)
|
1994-09-14 |
1996-07-30 |
Fuji Immunopharmaceuticals Corporation |
Expression and export technology of proteins as immunofusins
|
US5663149A
(en)
|
1994-12-13 |
1997-09-02 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
AU6267896A
(en)
|
1995-06-07 |
1996-12-30 |
Imclone Systems Incorporated |
Antibody and antibody fragments for inhibiting the growth oftumors
|
US5712374A
(en)
|
1995-06-07 |
1998-01-27 |
American Cyanamid Company |
Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
|
US5714586A
(en)
|
1995-06-07 |
1998-02-03 |
American Cyanamid Company |
Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
|
US7696338B2
(en)
|
1995-10-30 |
2010-04-13 |
The United States Of America As Represented By The Department Of Health And Human Services |
Immunotoxin fusion proteins and means for expression thereof
|
DK0871490T3
(da)
|
1995-12-22 |
2003-07-07 |
Bristol Myers Squibb Co |
Forgrenede hydrazonlinkere
|
WO1997024373A1
(en)
|
1995-12-29 |
1997-07-10 |
Medvet Science Pty. Limited |
Monoclonal antibody antagonists to haemopoietic growth factors
|
AUPN999096A0
(en)
|
1996-05-22 |
1996-06-13 |
Northstar Biologicals Pty Ltd |
Peptides, antibodies, vaccines & uses thereof
|
WO1998048032A2
(en)
|
1997-04-21 |
1998-10-29 |
Donlar Corporation |
POLY-(α-L-ASPARTIC ACID), POLY-(α-L-GLUTAMIC ACID) AND COPOLYMERS OF L-ASP AND L-GLU, METHOD FOR THEIR PRODUCTION AND THEIR USE
|
DE69830901T2
(de)
|
1997-05-02 |
2006-05-24 |
Genentech Inc., San Francisco |
ein verfahren zur herstellung multispezifischer antikörper die heteromultimere und gemeinsame komponenten besitzen
|
US6235883B1
(en)
|
1997-05-05 |
2001-05-22 |
Abgenix, Inc. |
Human monoclonal antibodies to epidermal growth factor receptor
|
WO1999037791A1
(en)
|
1998-01-23 |
1999-07-29 |
Vlaams Interuniversitair Instituut Voor Biotechnologie |
Multipurpose antibody derivatives
|
ATE458007T1
(de)
|
1998-04-20 |
2010-03-15 |
Glycart Biotechnology Ag |
Glykosylierungs-engineering von antikörpern zur verbesserung der antikörperabhängigen zellvermittelten zytotoxizität
|
JP4169478B2
(ja)
|
1998-04-21 |
2008-10-22 |
マイクロメット アーゲー |
Cd19×cd3特異的ポリペプチドおよびその使用
|
US6455677B1
(en)
|
1998-04-30 |
2002-09-24 |
Boehringer Ingelheim International Gmbh |
FAPα-specific antibody with improved producibility
|
US7074405B1
(en)
|
1998-06-22 |
2006-07-11 |
Immunomedics, Inc. |
Use of bi-specific antibodies for pre-targeting diagnosis and therapy
|
GB9815909D0
(en)
|
1998-07-21 |
1998-09-16 |
Btg Int Ltd |
Antibody preparation
|
US6723538B2
(en)
|
1999-03-11 |
2004-04-20 |
Micromet Ag |
Bispecific antibody and chemokine receptor constructs
|
EP3031917A1
(en)
|
1999-04-09 |
2016-06-15 |
Kyowa Hakko Kirin Co., Ltd. |
Method for controlling the activity of immunologically functional molecule
|
US6939545B2
(en)
|
1999-04-28 |
2005-09-06 |
Genetics Institute, Llc |
Composition and method for treating inflammatory disorders
|
KR100996759B1
(ko)
|
1999-08-24 |
2010-11-25 |
메다렉스, 인코포레이티드 |
인간 씨티엘에이-4 항체 및 그의 용도
|
US7303749B1
(en)
|
1999-10-01 |
2007-12-04 |
Immunogen Inc. |
Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
|
WO2001024763A2
(en)
|
1999-10-01 |
2001-04-12 |
Immunogen, Inc. |
Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
|
CA2388245C
(en)
|
1999-10-19 |
2012-01-10 |
Tatsuya Ogawa |
The use of serum-free adapted rat cells for producing heterologous polypeptides
|
US6716410B1
(en)
|
1999-10-26 |
2004-04-06 |
The Regents Of The University Of California |
Reagents and methods for diagnosing, imaging and treating atherosclerotic disease
|
EP1266009B1
(en)
|
2000-02-25 |
2008-12-31 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
ANTI-EGFRvIII SCFVS WITH IMPROVED CYTOTOXICITY AND YIELD, IMMUNOTOXINS BASED THEREON, AND METHODS OF USE THEREOF
|
US7449443B2
(en)
|
2000-03-23 |
2008-11-11 |
California Institute Of Technology |
Method for stabilization of proteins using non-natural amino acids
|
US20010035606A1
(en)
|
2000-03-28 |
2001-11-01 |
Schoen Alan H. |
Set of blocks for packing a cube
|
WO2001083525A2
(en)
|
2000-05-03 |
2001-11-08 |
Amgen Inc. |
Modified peptides, comprising an fc domain, as therapeutic agents
|
EP1278851B1
(en)
|
2000-05-19 |
2006-01-18 |
Scancell Limited |
Humanised antibodies to the epidermal growth factor receptor
|
CA2409991A1
(en)
|
2000-05-24 |
2001-11-29 |
Imclone Systems Incorporated |
Bispecific immunoglobulin-like antigen binding proteins and method of production
|
US6586207B2
(en)
|
2000-05-26 |
2003-07-01 |
California Institute Of Technology |
Overexpression of aminoacyl-tRNA synthetases for efficient production of engineered proteins containing amino acid analogues
|
CA2417185A1
(en)
|
2000-07-25 |
2002-01-31 |
Shui-On Leung |
Multivalent target binding protein
|
US6333410B1
(en)
|
2000-08-18 |
2001-12-25 |
Immunogen, Inc. |
Process for the preparation and purification of thiol-containing maytansinoids
|
DE10043437A1
(de)
|
2000-09-04 |
2002-03-28 |
Horst Lindhofer |
Verwendung von trifunktionellen bispezifischen und trispezifischen Antikörpern zur Behandlung von malignem Aszites
|
WO2002031140A1
(fr)
|
2000-10-06 |
2002-04-18 |
Kyowa Hakko Kogyo Co., Ltd. |
Cellules produisant des compositions d'anticorps
|
AU2001294175A1
(en)
|
2000-10-06 |
2002-04-22 |
Kyowa Hakko Kogyo Co. Ltd. |
Method of purifying antibody
|
US20030133939A1
(en)
|
2001-01-17 |
2003-07-17 |
Genecraft, Inc. |
Binding domain-immunoglobulin fusion proteins
|
AU2002251913A1
(en)
|
2001-02-02 |
2002-08-19 |
Millennium Pharmaceuticals, Inc. |
Hybrid antibodies and uses thereof
|
EP1243276A1
(en)
|
2001-03-23 |
2002-09-25 |
Franciscus Marinus Hendrikus De Groot |
Elongated and multiple spacers containing activatible prodrugs
|
WO2002079255A1
(en)
|
2001-04-02 |
2002-10-10 |
Idec Pharmaceuticals Corporation |
RECOMBINANT ANTIBODIES COEXPRESSED WITH GnTIII
|
US6884869B2
(en)
|
2001-04-30 |
2005-04-26 |
Seattle Genetics, Inc. |
Pentapeptide compounds and uses related thereto
|
US6441163B1
(en)
|
2001-05-31 |
2002-08-27 |
Immunogen, Inc. |
Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
|
CN101671335A
(zh)
|
2001-05-31 |
2010-03-17 |
梅达莱克斯公司 |
细胞毒素、其有用的前体药物、连接基团和稳定剂
|
IL159225A0
(en)
|
2001-06-13 |
2004-06-01 |
Genmab As |
Human monoclonal antibodies to epidermal growth factor receptor (egfr)
|
JP2003111595A
(ja)
*
|
2001-06-25 |
2003-04-15 |
Kyogo Ito |
腫瘍抗原
|
CA2452058A1
(en)
|
2001-06-26 |
2003-01-09 |
Imclone Systems Incorporated |
Bispecific antibodies that bind to vegf receptors
|
US6513428B1
(en)
|
2001-07-23 |
2003-02-04 |
Heidelberger Druckmaschinen Ag |
Device and method for attaching a printing web to a webbing sail and device and method for webbing-up a printing machine
|
EP1443961B1
(en)
|
2001-10-25 |
2009-05-06 |
Genentech, Inc. |
Glycoprotein compositions
|
CN100522999C
(zh)
*
|
2002-02-14 |
2009-08-05 |
免疫医疗公司 |
抗cd20抗体及其融合蛋白和使用方法
|
AU2003248370A1
(en)
|
2002-02-27 |
2003-09-09 |
California Institute Of Technology |
Computational method for designing enzymes for incorporation of amino acid analogs into proteins
|
US8188231B2
(en)
|
2002-09-27 |
2012-05-29 |
Xencor, Inc. |
Optimized FC variants
|
US20080219974A1
(en)
|
2002-03-01 |
2008-09-11 |
Bernett Matthew J |
Optimized antibodies that target hm1.24
|
US7332580B2
(en)
|
2002-04-05 |
2008-02-19 |
The Regents Of The University Of California |
Bispecific single chain Fv antibody molecules and methods of use thereof
|
NZ571508A
(en)
|
2002-05-24 |
2010-05-28 |
Schering Corp |
Neutralizing human anti-IGFR antibody
|
CA2494105C
(en)
|
2002-07-31 |
2013-04-02 |
Seattle Genetics, Inc. |
Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
|
US8946387B2
(en)
|
2002-08-14 |
2015-02-03 |
Macrogenics, Inc. |
FcγRIIB specific antibodies and methods of use thereof
|
US20060235208A1
(en)
|
2002-09-27 |
2006-10-19 |
Xencor, Inc. |
Fc variants with optimized properties
|
US7820166B2
(en)
|
2002-10-11 |
2010-10-26 |
Micromet Ag |
Potent T cell modulating molecules
|
EP1560599A1
(en)
|
2002-11-14 |
2005-08-10 |
Syntarga B.V. |
Prodrugs built as multiple self-elimination-release spacers
|
BRPI0316282B8
(pt)
|
2002-11-15 |
2021-05-25 |
Genmab As |
anticorpo humano isolado monoclonal, composição, imunoconjugado, molécula biespecífica ou multiespecífica, método e conjunto de diagnóstico para detectar a presença de antígeno cd25 ou uma célula que expressa cd25, e, vetor de expressão
|
US8084582B2
(en)
|
2003-03-03 |
2011-12-27 |
Xencor, Inc. |
Optimized anti-CD20 monoclonal antibodies having Fc variants
|
US7610156B2
(en)
|
2003-03-31 |
2009-10-27 |
Xencor, Inc. |
Methods for rational pegylation of proteins
|
WO2004103272A2
(en)
|
2003-05-20 |
2004-12-02 |
Immunogen, Inc. |
Improved cytotoxic agents comprising new maytansinoids
|
US7276497B2
(en)
|
2003-05-20 |
2007-10-02 |
Immunogen Inc. |
Cytotoxic agents comprising new maytansinoids
|
CA2522586C
(en)
|
2003-05-31 |
2017-02-21 |
Micromet Ag |
Pharmaceutical compositions comprising bispecific anti-cd3, anti-cd19 antibody constructs for the treatment of b-cell related disorders
|
BRPI0410338A
(pt)
|
2003-05-31 |
2006-05-30 |
Micromet Ag |
composição farmacêutica compreendendo um constructo de anticorpo biespecìfico para epcam, processo para sua produção, uso de um constructo biespecìfico, kit contendo o mesmo e método para a prevenção, tratamento ou alìvio de uma doença tumoral
|
US7888134B2
(en)
|
2003-06-05 |
2011-02-15 |
Oakland University |
Immunosensors: scFv-linker design for surface immobilization
|
AU2004255216B2
(en)
|
2003-07-01 |
2010-08-19 |
Immunomedics, Inc. |
Multivalent carriers of bi-specific antibodies
|
US20060134105A1
(en)
|
2004-10-21 |
2006-06-22 |
Xencor, Inc. |
IgG immunoglobulin variants with optimized effector function
|
US20150071948A1
(en)
|
2003-09-26 |
2015-03-12 |
Gregory Alan Lazar |
Novel immunoglobulin variants
|
SG176455A1
(en)
|
2003-10-09 |
2011-12-29 |
Ambrx Inc |
Polymer derivatives
|
US20050176028A1
(en)
|
2003-10-16 |
2005-08-11 |
Robert Hofmeister |
Deimmunized binding molecules to CD3
|
KR101520209B1
(ko)
|
2003-11-06 |
2015-05-13 |
시애틀 지네틱스, 인크. |
리간드에 접합될 수 있는 모노메틸발린 화합물
|
EP1701979A2
(en)
|
2003-12-03 |
2006-09-20 |
Xencor, Inc. |
Optimized antibodies that target the epidermal growth factor receptor
|
AU2004297616B2
(en)
|
2003-12-04 |
2008-12-18 |
Xencor, Inc. |
Methods of generating variant proteins with increased host string content and compositions thereof
|
ATE554107T1
(de)
|
2003-12-19 |
2012-05-15 |
Genentech Inc |
Als therapeutika geeignete monovalente antikörperfragmente
|
US7235641B2
(en)
|
2003-12-22 |
2007-06-26 |
Micromet Ag |
Bispecific antibodies
|
NZ586034A
(en)
|
2004-02-02 |
2011-10-28 |
Ambrx Inc |
Modified human growth hormone polypeptides and their uses
|
JP2008504013A
(ja)
|
2004-02-06 |
2008-02-14 |
モルフォシス・アクチェンゲゼルシャフト |
抗cd38ヒト抗体及びその用途
|
KR20070012408A
(ko)
*
|
2004-04-16 |
2007-01-25 |
제넨테크, 인크. |
B 세포 고갈을 증대시키는 방법
|
US7850962B2
(en)
|
2004-04-20 |
2010-12-14 |
Genmab A/S |
Human monoclonal antibodies against CD20
|
US7691962B2
(en)
|
2004-05-19 |
2010-04-06 |
Medarex, Inc. |
Chemical linkers and conjugates thereof
|
NZ550934A
(en)
|
2004-05-19 |
2010-05-28 |
Medarex Inc |
Chemical linkers and conjugates thereof
|
SG188175A1
(en)
|
2004-06-03 |
2013-03-28 |
Novimmune Sa |
Anti-cd3 antibodies and methods of use thereof
|
US20060018897A1
(en)
|
2004-06-28 |
2006-01-26 |
Transtarget Inc. |
Bispecific antibodies
|
EP1786918A4
(en)
|
2004-07-17 |
2009-02-11 |
Imclone Systems Inc |
NEW BISPECIFIC ANTIBODY TETRAVALENT
|
JP2008515780A
(ja)
|
2004-09-02 |
2008-05-15 |
ジェネンテック・インコーポレーテッド |
抗FcγRIIBレセプター抗体およびその使用
|
US7521541B2
(en)
|
2004-09-23 |
2009-04-21 |
Genetech Inc. |
Cysteine engineered antibodies and conjugates
|
MX2007003320A
(es)
|
2004-09-24 |
2007-05-18 |
Amgen Inc |
Moleculas fc modificadas.
|
US8367805B2
(en)
|
2004-11-12 |
2013-02-05 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
US8546543B2
(en)
|
2004-11-12 |
2013-10-01 |
Xencor, Inc. |
Fc variants that extend antibody half-life
|
US8066989B2
(en)
|
2004-11-30 |
2011-11-29 |
Trion Pharma Gmbh |
Method of treating tumor growth and metastasis by using trifunctional antibodies to reduce the risk for GvHD in allogeneic antitumor cell therapy
|
RS50752B
(sr)
|
2005-01-05 |
2010-08-31 |
F-Star Biotechnologische Forschungs-Und Entwicklungsges M.B.H. |
Domeni sintetskih imunoglobulina sa svojstvima vezivanja, konstruisani u regionima molekula, koji se razlikuju od regiona, koji određuju komplementarnost
|
WO2006075668A1
(ja)
|
2005-01-12 |
2006-07-20 |
Kirin Beer Kabushiki Kaisha |
安定化されたヒトIgG2およびIgG3抗体
|
EP1870459B1
(en)
|
2005-03-31 |
2016-06-29 |
Chugai Seiyaku Kabushiki Kaisha |
Methods for producing polypeptides by regulating polypeptide association
|
US7714016B2
(en)
|
2005-04-08 |
2010-05-11 |
Medarex, Inc. |
Cytotoxic compounds and conjugates with cleavable substrates
|
US9284375B2
(en)
|
2005-04-15 |
2016-03-15 |
Macrogenics, Inc. |
Covalent diabodies and uses thereof
|
AU2006247565A1
(en)
|
2005-05-12 |
2006-11-23 |
The Government Of The United States, As Represented By The Secretary Of Health And Human Services |
Anti-mesothelin antibodies useful for immunological assays
|
CN105153306B
(zh)
|
2005-06-07 |
2020-12-11 |
艾斯巴技术-诺华有限责任公司 |
抑制TNFα的稳定和可溶的抗体
|
JP2009500344A
(ja)
|
2005-07-01 |
2009-01-08 |
メディミューン,エルエルシー |
マルチドメインタンパク質治療薬を製造するための統合的手法
|
WO2007045998A2
(en)
|
2005-07-01 |
2007-04-26 |
Dako Denmark A/S |
New nucleic acid base pairs
|
PL1912675T3
(pl)
|
2005-07-25 |
2014-10-31 |
Emergent Product Dev Seattle |
Zmniejszanie liczby komórek B za pomocą cząsteczek wiążących swoistych dla antygenów CD37 i CD20
|
CN101267836A
(zh)
|
2005-07-25 |
2008-09-17 |
特鲁比昂药品公司 |
单剂量cd20特异性结合分子的用途
|
US8158590B2
(en)
|
2005-08-05 |
2012-04-17 |
Syntarga B.V. |
Triazole-containing releasable linkers, conjugates thereof, and methods of preparation
|
US7612181B2
(en)
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
CN101309703A
(zh)
|
2005-09-12 |
2008-11-19 |
诺维莫尼公司 |
抗cd3抗体组合物
|
DK1931709T3
(en)
|
2005-10-03 |
2017-03-13 |
Xencor Inc |
FC VARIETIES WITH OPTIMIZED FC RECEPTOR BINDING PROPERTIES
|
JP5686953B2
(ja)
|
2005-10-11 |
2015-03-18 |
アムゲン リサーチ (ミュンヘン) ゲーエムベーハー |
交差種特異的(cross−species−specific)抗体を含む組成物および該組成物の使用
|
NZ566915A
(en)
|
2005-10-12 |
2011-09-30 |
Morphosys Ag |
Generation and profiling of human derived therapeutic antibodies specific for human CD38
|
CA2625619A1
(en)
|
2005-10-14 |
2007-04-26 |
Medimmune, Inc. |
Cell display of antibody libraries
|
WO2007047829A2
(en)
|
2005-10-19 |
2007-04-26 |
Laboratoires Serono S.A. |
Novel heterodimeric proteins and uses thereof
|
EP1777294A1
(en)
|
2005-10-20 |
2007-04-25 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins
|
TW200732350A
(en)
|
2005-10-21 |
2007-09-01 |
Amgen Inc |
Methods for generating monovalent IgG
|
WO2007059404A2
(en)
|
2005-11-10 |
2007-05-24 |
Medarex, Inc. |
Duocarmycin derivatives as novel cytotoxic compounds and conjugates
|
WO2007062037A2
(en)
|
2005-11-21 |
2007-05-31 |
Laboratoires Serono Sa |
Compositions and methods of producing hybrid antigen binding molecules and uses thereof
|
RU2008129827A
(ru)
|
2005-12-21 |
2010-01-27 |
МЕДИММЬЮН, ЭлЭлСи (US) |
МОЛЕКУЛЫ EphA2-BiTE И ИХ ПРИМЕНЕНИЕ
|
CN102796743B
(zh)
|
2006-01-13 |
2015-11-18 |
美国政府健康及人类服务部国立卫生研究院 |
用于在哺乳动物细胞中表达的密码子优化的IL-15和IL-15Rα基因
|
RU2489423C2
(ru)
|
2006-02-02 |
2013-08-10 |
Синтарга Б.В. |
Водорастворимые аналоги сс-1065 и их конъюгаты
|
EP1820513A1
(en)
|
2006-02-15 |
2007-08-22 |
Trion Pharma Gmbh |
Destruction of tumor cells expressing low to medium levels of tumor associated target antigens by trifunctional bispecific antibodies
|
EP1829895A1
(en)
|
2006-03-03 |
2007-09-05 |
f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. |
Bispecific molecule binding TLR9 and CD32 and comprising a T cell epitope for treatment of allergies
|
KR101516823B1
(ko)
|
2006-03-17 |
2015-05-07 |
바이오겐 아이덱 엠에이 인코포레이티드 |
안정화된 폴리펩티드 조성물
|
WO2007110205A2
(en)
|
2006-03-24 |
2007-10-04 |
Merck Patent Gmbh |
Engineered heterodimeric protein domains
|
DK2009101T3
(en)
|
2006-03-31 |
2018-01-15 |
Chugai Pharmaceutical Co Ltd |
Antibody modification method for purification of a bispecific antibody
|
EP3056568B1
(en)
|
2006-03-31 |
2021-09-15 |
Chugai Seiyaku Kabushiki Kaisha |
Methods for controlling blood pharmacokinetics of antibodies
|
EP2007423A2
(en)
|
2006-04-05 |
2008-12-31 |
Pfizer Products Incorporated |
Ctla4 antibody combination therapy
|
US20090182127A1
(en)
|
2006-06-22 |
2009-07-16 |
Novo Nordisk A/S |
Production of Bispecific Antibodies
|
AT503889B1
(de)
|
2006-07-05 |
2011-12-15 |
Star Biotechnologische Forschungs Und Entwicklungsges M B H F |
Multivalente immunglobuline
|
AT503902B1
(de)
|
2006-07-05 |
2008-06-15 |
F Star Biotech Forsch & Entw |
Verfahren zur manipulation von immunglobulinen
|
AT503861B1
(de)
|
2006-07-05 |
2008-06-15 |
F Star Biotech Forsch & Entw |
Verfahren zur manipulation von t-zell-rezeptoren
|
WO2008042754A2
(en)
|
2006-10-02 |
2008-04-10 |
Sea Lane Biotechnologies, Llc |
Design and construction of diverse synthetic peptide and polypeptide libraries
|
US7795411B2
(en)
|
2006-10-05 |
2010-09-14 |
Fred Hutchinson Cancer Research Center |
Vectors for expressing in vivo biotinylated recombinant proteins
|
ES2526292T3
(es)
|
2006-10-16 |
2015-01-09 |
The Salk Institute For Biological Studies |
Antagonistas de la somatostatina selectivos para receptor (SSTR2)
|
EP1914242A1
(en)
|
2006-10-19 |
2008-04-23 |
Sanofi-Aventis |
Novel anti-CD38 antibodies for the treatment of cancer
|
US7862825B2
(en)
|
2007-02-21 |
2011-01-04 |
Mladen Vranic |
Method of controlling tight blood glucose by somatostatin receptor antagonists
|
EP2132312B1
(en)
|
2007-03-27 |
2016-01-27 |
Sea Lane Biotechnologies,llc. |
Constructs and libraries comprising antibody surrogate light chain sequences
|
EP1975178A1
(en)
|
2007-03-30 |
2008-10-01 |
f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. |
Transcytotic modular antibody
|
WO2008119566A2
(en)
|
2007-04-03 |
2008-10-09 |
Micromet Ag |
Cross-species-specific bispecific binders
|
AU2008234020B2
(en)
|
2007-04-03 |
2013-02-07 |
Amgen Research (Munich) Gmbh |
Cross-species-specific CD3-epsilon binding domain
|
WO2008124858A2
(en)
|
2007-04-11 |
2008-10-23 |
F-Star Biotechnologische Forschungs- Und Entwicklungsges. M.B.H. |
Targeted receptor
|
NZ581395A
(en)
|
2007-05-14 |
2012-08-31 |
Biogen Idec Inc |
Single-chain fc (scfc) regions, binding polypeptides comprising same, and methods related thereto
|
DK2176298T3
(en)
|
2007-05-30 |
2018-02-12 |
Xencor Inc |
Methods and compositions for inhibiting CD32B-expressing cells
|
EP2666787B1
(en)
|
2007-05-31 |
2022-02-09 |
Genmab A/S |
STABLE IgG4 ANTIBODIES
|
RU2010100638A
(ru)
|
2007-06-12 |
2011-07-20 |
УАЙТ ЭлЭлСи (US) |
Композиции и способы лечения, направленные против cd20
|
EP3241842B1
(en)
|
2007-06-26 |
2024-01-31 |
F-star Therapeutics Limited |
Display of binding agents
|
EP2187971A2
(en)
|
2007-08-01 |
2010-05-26 |
The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services |
A fold-back diabody diphtheria toxin immunotoxin and methods of use
|
US8680293B2
(en)
|
2007-08-01 |
2014-03-25 |
Syntarga B.V. |
Substituted CC-1065 analogs and their conjugates
|
CA2697922A1
(en)
|
2007-08-28 |
2009-03-12 |
Biogen Idec Ma Inc. |
Compositions that bind multiple epitopes of igf-1r
|
EP2033657A1
(de)
|
2007-09-04 |
2009-03-11 |
Trion Pharma Gmbh |
Intraoperative trifunktionale Antikörper-Applikation zur Prophylaxe intraperitonealer Tumorzelldissemination
|
AU2008298904B2
(en)
|
2007-09-14 |
2014-10-16 |
Amgen Inc. |
Homogeneous antibody populations
|
CN106519025B
(zh)
|
2007-09-26 |
2021-04-23 |
中外制药株式会社 |
利用cdr的氨基酸取代来改变抗体等电点的方法
|
EP3415529B1
(en)
|
2007-09-26 |
2020-11-04 |
Chugai Seiyaku Kabushiki Kaisha |
Modified antibody constant region
|
EP2535351A3
(en)
|
2007-09-26 |
2013-04-03 |
UCB Pharma S.A. |
Dual specificity antibody fusions
|
WO2009086320A1
(en)
|
2007-12-26 |
2009-07-09 |
Xencor, Inc |
Fc variants with altered binding to fcrn
|
EP2235064B1
(en)
|
2008-01-07 |
2015-11-25 |
Amgen Inc. |
Method for making antibody fc-heterodimeric molecules using electrostatic steering effects
|
WO2009106096A1
(en)
|
2008-02-27 |
2009-09-03 |
Fresenius Biotech Gmbh |
Treatment of resistant tumors with trifunctional antibodies
|
CN102099377A
(zh)
|
2008-04-11 |
2011-06-15 |
新兴产品开发西雅图有限公司 |
Cd37免疫治疗剂及其与双功能化学治疗剂的联合
|
US8314213B2
(en)
|
2008-04-18 |
2012-11-20 |
Xencor, Inc. |
Human equivalent monoclonal antibodies engineered from nonhuman variable regions
|
ES2458541T3
(es)
|
2008-05-02 |
2014-05-06 |
Seattle Genetics, Inc. |
Métodos y composiciones para elaborar anticuerpos y derivados de anticuerpos con fucosilación del núcleo reducida
|
CA2726087A1
(en)
|
2008-06-03 |
2009-12-10 |
Tariq Ghayur |
Dual variable domain immunoglobulins and uses thereof
|
CN101628940B
(zh)
*
|
2008-07-15 |
2011-11-23 |
中国科学院生物物理研究所 |
一种单克隆抗体及其应用
|
US20110250203A1
(en)
|
2008-08-29 |
2011-10-13 |
Symphogen A/S |
Anti-cd5 antibodies
|
WO2010028796A1
(en)
|
2008-09-10 |
2010-03-18 |
F. Hoffmann-La Roche Ag |
Trispecific hexavalent antibodies
|
US20170247470A9
(en)
|
2008-09-17 |
2017-08-31 |
Xencor, Inc. |
Rapid clearance of antigen complexes using novel antibodies
|
ES2927192T3
(es)
|
2008-09-17 |
2022-11-03 |
Xencor Inc |
Nuevas composiciones y métodos para tratar trastornos mediados por IgE
|
CN102643345A
(zh)
|
2008-09-26 |
2012-08-22 |
罗氏格黎卡特股份公司 |
双特异性抗-egfr/抗-igf-1r抗体
|
WO2010037838A2
(en)
|
2008-10-01 |
2010-04-08 |
Micromet Ag |
Cross-species-specific single domain bispecific single chain antibody
|
HRP20160857T4
(hr)
|
2008-10-01 |
2022-12-09 |
Amgen Research (Munich) Gmbh |
Bispecifična jednolančana protutijela, specifična za visokomolekulske ciljne antigene
|
MX338038B
(es)
|
2008-10-01 |
2016-03-30 |
Amgen Res Munich Gmbh |
Anticuerpo de una sola cadena bis-especifico de pscaxcd3, cd19xcd3, c-metxcd3, endosialinaxcd3, epcamxcd3, igf-1rxcd3 o fapalfaxcd3 de especies cruzadas.
|
KR101820535B1
(ko)
|
2008-10-01 |
2018-01-19 |
암젠 리서치 (뮌헨) 게엠베하 |
종간특이적 psmaxcd3 이중특이적 단일쇄 항체
|
SG172754A1
(en)
|
2008-10-10 |
2011-08-29 |
Trubion Pharmaceuticals Inc |
Tcr complex immunotherapeutics
|
WO2010062171A2
(en)
|
2008-11-03 |
2010-06-03 |
Syntarga B.V. |
Novel cc-1065 analogs and their conjugates
|
JP2012515556A
(ja)
|
2009-01-23 |
2012-07-12 |
バイオジェン・アイデック・エムエイ・インコーポレイテッド |
低下したエフェクタ機能を有する安定化Fcポリペプチドおよび使用方法
|
EP2403874A1
(en)
|
2009-03-06 |
2012-01-11 |
Genentech, Inc. |
Antibody formulation
|
EP2233500A1
(en)
|
2009-03-20 |
2010-09-29 |
LFB Biotechnologies |
Optimized Fc variants
|
PE20120591A1
(es)
|
2009-04-02 |
2012-05-23 |
Roche Glycart Ag |
Anticuerpos multiespecificos que comprenden anticuerpos de longitud completa y fragmentos fab de cadena sencilla
|
MX2011010166A
(es)
|
2009-04-07 |
2011-10-11 |
Roche Glycart Ag |
Anticuerpos biespecificos anti-erbb-3/anti-c-met.
|
CA2757669A1
(en)
|
2009-04-07 |
2010-10-14 |
Roche Glycart Ag |
Bispecific anti-erbb-1/anti-c-met antibodies
|
AU2010234031B2
(en)
|
2009-04-07 |
2015-10-01 |
Roche Glycart Ag |
Trivalent, bispecific antibodies
|
EP2241576A1
(en)
|
2009-04-17 |
2010-10-20 |
Trion Pharma Gmbh |
Use of trifunctional bispecific antibodies for the treatment of tumors associated with CD133+/EpCAM+ cancer stem cells
|
TW201100543A
(en)
|
2009-05-27 |
2011-01-01 |
Hoffmann La Roche |
Tri-or tetraspecific antibodies
|
MX2012000129A
(es)
|
2009-06-26 |
2012-02-01 |
Sea Lane Biotechnologies Llc |
Expresion de las cadenas ligeras sustitutas.
|
MX2011014008A
(es)
|
2009-06-26 |
2012-06-01 |
Regeneron Pharma |
Anticuerpos biespecificos facilmente aislados con formato de inmunoglobulina original.
|
AU2010270844A1
(en)
|
2009-07-08 |
2011-12-22 |
Amgen Inc. |
Design of stable and aggregation free antibody Fc molecules through CH3 domain interface engineering
|
WO2011028952A1
(en)
|
2009-09-02 |
2011-03-10 |
Xencor, Inc. |
Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
|
DE102009045006A1
(de)
|
2009-09-25 |
2011-04-14 |
Technische Universität Dresden |
Anti-CD33 Antikörper und ihre Anwendung zum Immunotargeting bei der Behandlung von CD33-assoziierten Erkrankungen
|
HUE025759T2
(en)
|
2009-10-27 |
2016-04-28 |
Amgen Res (Munich) Gmbh |
Dosage system for administering CD19xCD3 bispecific antibody
|
WO2011063348A1
(en)
|
2009-11-23 |
2011-05-26 |
Amgen Inc. |
Monomeric antibody fc
|
US20130017199A1
(en)
|
2009-11-24 |
2013-01-17 |
AMPLIMMUNE ,Inc. a corporation |
Simultaneous inhibition of pd-l1/pd-l2
|
KR101791430B1
(ko)
|
2009-11-30 |
2017-10-30 |
얀센 바이오테크 인코포레이티드 |
이펙터 기능이 제거된 항체 Fc 돌연변이체
|
PL2522724T3
(pl)
|
2009-12-25 |
2020-07-13 |
Chugai Seiyaku Kabushiki Kaisha |
Sposób modyfikowania polipetydów do oczyszczania multimerów polipeptydowych
|
US20130129723A1
(en)
|
2009-12-29 |
2013-05-23 |
Emergent Product Development Seattle, Llc |
Heterodimer Binding Proteins and Uses Thereof
|
LT2519543T
(lt)
|
2009-12-29 |
2016-10-10 |
Emergent Product Development Seattle, Llc |
Heterodimerus rišantys baltymai ir jų panaudojimas
|
US20110189178A1
(en)
|
2010-02-04 |
2011-08-04 |
Xencor, Inc. |
Immunoprotection of Therapeutic Moieties Using Enhanced Fc Regions
|
ES2547142T5
(es)
|
2010-02-08 |
2021-12-09 |
Regeneron Pharma |
Cadena ligera común de ratón
|
WO2011120134A1
(en)
|
2010-03-29 |
2011-10-06 |
Zymeworks, Inc. |
Antibodies with enhanced or suppressed effector function
|
TWI653333B
(zh)
|
2010-04-01 |
2019-03-11 |
安進研究(慕尼黑)有限責任公司 |
跨物種專一性之PSMAxCD3雙專一性單鏈抗體
|
CN110066339A
(zh)
|
2010-04-20 |
2019-07-30 |
根马布股份公司 |
含异二聚体抗体fc的蛋白及其制备方法
|
MX346731B
(es)
|
2010-04-23 |
2017-03-30 |
Genentech Inc * |
Producción de proteínas heteromultiméricas.
|
WO2011143545A1
(en)
|
2010-05-14 |
2011-11-17 |
Rinat Neuroscience Corporation |
Heterodimeric proteins and methods for producing and purifying them
|
EP2580243B1
(en)
|
2010-06-09 |
2019-10-16 |
Genmab A/S |
Antibodies against human cd38
|
US9163087B2
(en)
|
2010-06-18 |
2015-10-20 |
The Brigham And Women's Hospital, Inc. |
Bi-specific antibodies against TIM-3 and PD-1 for immunotherapy in chronic immune conditions
|
AU2011283694B2
(en)
|
2010-07-29 |
2017-04-13 |
Xencor, Inc. |
Antibodies with modified isoelectric points
|
MX339622B
(es)
|
2010-08-02 |
2016-06-02 |
Macrogenics Inc |
Diacuerpos covalentes y sus usos.
|
RU2013110875A
(ru)
*
|
2010-08-24 |
2014-09-27 |
Ф.Хоффманн-Ля Рош Аг |
БИСПЕЦИФИЧЕСКИЕ АНТИТЕЛА, СОДЕРЖАЩИЕ СТАБИЛИЗИРОВАННЫЙ ДИСУЛЬФИДОМ ФРАГМЕНТ Fv
|
WO2012032080A1
(en)
|
2010-09-07 |
2012-03-15 |
F-Star Biotechnologische Forschungs- Und Entwicklungsges.M.B.H |
Stabilised human fc
|
ES2758994T3
(es)
|
2010-11-05 |
2020-05-07 |
Zymeworks Inc |
Diseño anticuerpo heterodimérico estable con mutaciones en el dominio Fc
|
ES2842937T3
(es)
|
2010-11-10 |
2021-07-15 |
Amgen Res Munich Gmbh |
Prevención de efectos adversos provocados por dominios de unión específicos de CD3
|
WO2012065055A2
(en)
|
2010-11-12 |
2012-05-18 |
The Rockefeller University |
Fusion proteins for hiv therapy
|
PT2647707T
(pt)
|
2010-11-30 |
2018-11-15 |
Chugai Pharmaceutical Co Ltd |
Agente terapêutico indutor de toxicidade
|
AU2012215573B2
(en)
|
2011-02-10 |
2015-11-26 |
Roche Glycart Ag |
Mutant interleukin-2 polypeptides
|
EP2681245B1
(en)
|
2011-03-03 |
2018-05-09 |
Zymeworks Inc. |
Multivalent heteromultimer scaffold design and constructs
|
MX2013010172A
(es)
|
2011-03-11 |
2013-10-25 |
Amgen Inc |
Metodo de analisis mutacional correlacionado para mejorar anticuerpos terapeuticos.
|
CA2830254C
(en)
|
2011-03-16 |
2019-09-10 |
Amgen Inc. |
Fc variants
|
AU2012235758B2
(en)
|
2011-03-25 |
2015-05-07 |
Ichnos Sciences SA |
Hetero-dimeric immunoglobulins
|
TWI803876B
(zh)
|
2011-03-28 |
2023-06-01 |
法商賽諾菲公司 |
具有交叉結合區定向之雙重可變區類抗體結合蛋白
|
KR101614195B1
(ko)
|
2011-03-29 |
2016-04-20 |
로슈 글리카트 아게 |
항체 Fc 변이체
|
US10191034B2
(en)
|
2011-04-28 |
2019-01-29 |
Amgen Research (Munich) Gmbh |
Dosage regimen for administrating a CD19×CD3 bispecific antibody to patients at risk for potential adverse effects
|
EA201892619A1
(ru)
|
2011-04-29 |
2019-04-30 |
Роше Гликарт Аг |
Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2
|
RS58765B1
(sr)
|
2011-05-21 |
2019-06-28 |
Macrogenics Inc |
Cd3-vezujući molekuli sposobni za vezivanje za humani i nehumani cd3
|
EP2714732A4
(en)
|
2011-05-25 |
2014-12-10 |
Merck Sharp & Dohme |
PROCESS FOR PREPARING FC-CONTAINING POLYPEPTIDES WITH IMPROVED PROPERTIES
|
EP2729488A4
(en)
|
2011-07-06 |
2015-01-14 |
Medimmune Llc |
PROCESS FOR PREPARING MULTIMANT POLYPEPTIDES
|
EP2736928B1
(en)
|
2011-07-28 |
2019-01-09 |
i2 Pharmaceuticals, Inc. |
Sur-binding proteins against erbb3
|
WO2013018892A1
(ja)
|
2011-08-04 |
2013-02-07 |
東レ株式会社 |
癌の治療及び/又は予防用医薬組成物
|
WO2013022855A1
(en)
|
2011-08-05 |
2013-02-14 |
Xencor, Inc. |
Antibodies with modified isoelectric points and immunofiltering
|
DK2744931T3
(en)
|
2011-08-18 |
2018-08-06 |
Affinity Biosciences Pty Ltd |
SOLUBLE POLYPEPTIDES
|
EP3892640A1
(en)
|
2011-08-23 |
2021-10-13 |
Roche Glycart AG |
Bispecific t cell activating antigen binding molecules
|
CN103857700A
(zh)
|
2011-08-26 |
2014-06-11 |
梅里麦克制药股份有限公司 |
串联fc双特异性抗体
|
US20150050269A1
(en)
|
2011-09-30 |
2015-02-19 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities
|
CA3182462A1
(en)
|
2011-10-10 |
2013-04-18 |
Xencor, Inc. |
A method for purifying antibodies
|
US10851178B2
(en)
*
|
2011-10-10 |
2020-12-01 |
Xencor, Inc. |
Heterodimeric human IgG1 polypeptides with isoelectric point modifications
|
RU2018112861A
(ru)
|
2011-10-20 |
2019-03-04 |
ИЭсБиЭйТЕК - Э НОВАРТИС КОМПАНИ ЭлЭлСи |
Стабильные антитела, связывающиеся с несколькими антигенами
|
EA201700111A1
(ru)
|
2011-10-28 |
2018-02-28 |
Тева Фармасьютикал Австралия Пти Лтд |
Полипептидные конструкции и их применение
|
KR102398736B1
(ko)
|
2011-10-31 |
2022-05-16 |
추가이 세이야쿠 가부시키가이샤 |
중쇄와 경쇄의 회합이 제어된 항원 결합 분자
|
CN104080811B
(zh)
|
2011-11-04 |
2019-09-27 |
酵活有限公司 |
在Fc结构域中具有突变的稳定异源二聚的抗体设计
|
CN103906533A
(zh)
*
|
2011-11-07 |
2014-07-02 |
米迪缪尼有限公司 |
多特异性和多价结合蛋白及其用途
|
US20140212425A1
(en)
*
|
2011-12-05 |
2014-07-31 |
Immunomedics, Inc. |
Therapeutic use of anti-cd22 antibodies for inducing trogocytosis
|
EP2794658B1
(en)
|
2011-12-19 |
2017-03-15 |
Synimmune GmbH |
Bispecific antibody molecule
|
CA2859744A1
(en)
|
2011-12-22 |
2013-06-27 |
Sea Lane Biotechnologies, Llc |
Surrogate binding proteins
|
RU2736349C2
(ru)
|
2012-02-24 |
2020-11-16 |
Чугаи Сейяку Кабусики Кайся |
АНТИГЕНСВЯЗЫВАЮЩАЯ МОЛЕКУЛА ДЛЯ УСКОРЕНИЯ ИСЧЕЗНОВЕНИЯ АНТИГЕНА ЧЕРЕЗ FcγRIIB
|
JP6272299B2
(ja)
|
2012-04-20 |
2018-01-31 |
メルス ナムローゼ フェンノートシャップ |
Ig様分子を生産する方法、Ig様分子の混合物、組み換え宿主細胞、医薬組成物、宿主細胞を作成する方法、および培養物
|
CA3004695C
(en)
|
2012-04-30 |
2020-08-04 |
Biocon Limited |
Targeted/immunomodulatory fusion proteins and methods for making same
|
WO2013173820A2
(en)
*
|
2012-05-18 |
2013-11-21 |
Scott & White Healthcare |
Bispecific scfv immunofusion (bif)
|
JPWO2013180201A1
(ja)
|
2012-05-30 |
2016-01-21 |
中外製薬株式会社 |
会合化した抗原を消失させる抗原結合分子
|
US9499634B2
(en)
|
2012-06-25 |
2016-11-22 |
Zymeworks Inc. |
Process and methods for efficient manufacturing of highly pure asymmetric antibodies in mammalian cells
|
JP2015528003A
(ja)
|
2012-07-13 |
2015-09-24 |
ザイムワークス,インコーポレイテッド |
抗cd3構築物を含む二重特異性の非対称ヘテロ二量体
|
CN104640561A
(zh)
|
2012-07-23 |
2015-05-20 |
酵活有限公司 |
包含轻链和重链的选择性配对的免疫球蛋白构建体
|
US9682143B2
(en)
*
|
2012-08-14 |
2017-06-20 |
Ibc Pharmaceuticals, Inc. |
Combination therapy for inducing immune response to disease
|
JOP20200236A1
(ar)
*
|
2012-09-21 |
2017-06-16 |
Regeneron Pharma |
الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها
|
CA2886433C
(en)
|
2012-10-04 |
2022-01-04 |
Dana-Farber Cancer Institute, Inc. |
Human monoclonal anti-pd-l1 antibodies and methods of use
|
CA2879768A1
(en)
|
2012-10-08 |
2014-04-17 |
Roche Glycart Ag |
Fc-free antibodies comprising two fab-fragments and methods of use
|
US20140161790A1
(en)
|
2012-11-19 |
2014-06-12 |
Xencor, Inc. |
Engineered immunoglobulins with extended in vivo half-life
|
CN112079929A
(zh)
|
2012-11-21 |
2020-12-15 |
武汉友芝友生物制药有限公司 |
双特异性抗体
|
US9951145B2
(en)
*
|
2012-11-27 |
2018-04-24 |
Ajou University Industry—Academic Cooperation Foundation |
CH3 domain variant pair inducing formation of heterodimer of heavy chain constant region of antibody at high efficiency, method for preparing same, and use thereof
|
EP2934577A1
(en)
|
2012-12-19 |
2015-10-28 |
Adimab, LLC |
Multivalent antibody analogs, and methods of their preparation and use
|
US9605084B2
(en)
*
|
2013-03-15 |
2017-03-28 |
Xencor, Inc. |
Heterodimeric proteins
|
US9701759B2
(en)
*
|
2013-01-14 |
2017-07-11 |
Xencor, Inc. |
Heterodimeric proteins
|
US10131710B2
(en)
|
2013-01-14 |
2018-11-20 |
Xencor, Inc. |
Optimized antibody variable regions
|
US10968276B2
(en)
|
2013-03-12 |
2021-04-06 |
Xencor, Inc. |
Optimized anti-CD3 variable regions
|
WO2014110601A1
(en)
|
2013-01-14 |
2014-07-17 |
Xencor, Inc. |
Novel heterodimeric proteins
|
US10487155B2
(en)
|
2013-01-14 |
2019-11-26 |
Xencor, Inc. |
Heterodimeric proteins
|
AU2014207549B2
(en)
|
2013-01-15 |
2018-12-06 |
Xencor, Inc. |
Rapid clearance of antigen complexes using novel antibodies
|
EP3889182A1
(en)
|
2013-03-13 |
2021-10-06 |
Imaginab, Inc. |
Antigen binding constructs to cd8
|
US10858417B2
(en)
|
2013-03-15 |
2020-12-08 |
Xencor, Inc. |
Heterodimeric proteins
|
EP2970486B1
(en)
|
2013-03-15 |
2018-05-16 |
Xencor, Inc. |
Modulation of t cells with bispecific antibodies and fc fusions
|
US10519242B2
(en)
|
2013-03-15 |
2019-12-31 |
Xencor, Inc. |
Targeting regulatory T cells with heterodimeric proteins
|
MX357011B
(es)
|
2013-03-15 |
2018-06-22 |
Amgen Inc |
Anticuerpos biespecificos heterodimericos.
|
EP3587448B1
(en)
|
2013-03-15 |
2021-05-19 |
Xencor, Inc. |
Heterodimeric proteins
|
US10106624B2
(en)
|
2013-03-15 |
2018-10-23 |
Xencor, Inc. |
Heterodimeric proteins
|
WO2014209804A1
(en)
|
2013-06-24 |
2014-12-31 |
Biomed Valley Discoveries, Inc. |
Bispecific antibodies
|
GB201311487D0
(en)
|
2013-06-27 |
2013-08-14 |
Alligator Bioscience Ab |
Bispecific molecules
|
SI3030575T1
(sl)
|
2013-08-08 |
2018-11-30 |
Cytune Pharma |
Modulokini na osnovi IL-15 in IL-15R-alfa sushi domene
|
AR097306A1
(es)
|
2013-08-20 |
2016-03-02 |
Merck Sharp & Dohme |
Modulación de la inmunidad tumoral
|
EP2839842A1
(en)
|
2013-08-23 |
2015-02-25 |
MacroGenics, Inc. |
Bi-specific monovalent diabodies that are capable of binding CD123 and CD3 and uses thereof
|
AU2014343636A1
(en)
|
2013-11-04 |
2016-06-02 |
Glenmark Pharmaceuticals S.A. |
Production of T cell retargeting hetero-dimeric immunoglobulins
|
JP2017501157A
(ja)
|
2013-12-17 |
2017-01-12 |
ジェネンテック, インコーポレイテッド |
Pd−1軸結合アンタゴニスト及び抗cd20抗体を使用してがんを治療する方法
|
EP3527587A1
(en)
|
2013-12-17 |
2019-08-21 |
F. Hoffmann-La Roche AG |
Combination therapy comprising ox40 binding agonists and pd-l1 binding antagonists
|
SI3083689T1
(sl)
|
2013-12-17 |
2020-10-30 |
Genentech, Inc. |
Anti-CD3 protitelesa in načini uporabe
|
EP3089994B1
(en)
|
2013-12-30 |
2022-05-04 |
Epimab Biotherapeutics, Inc. |
Fabs-in-tandem immunoglobulin and uses thereof
|
JP6484634B2
(ja)
|
2014-01-08 |
2019-03-13 |
シャンハイ ヘンルイ ファーマスーティカル カンパニー リミテッドShanghai Hengrui Pharmaceutical Co., Ltd. |
Il−15ヘテロ二量体タンパク質及びその用途
|
US9603927B2
(en)
|
2014-02-28 |
2017-03-28 |
Janssen Biotech, Inc. |
Combination therapies with anti-CD38 antibodies
|
TWI754319B
(zh)
|
2014-03-19 |
2022-02-01 |
美商再生元醫藥公司 |
用於腫瘤治療之方法及抗體組成物
|
PL3122781T3
(pl)
|
2014-03-28 |
2020-06-15 |
Xencor, Inc. |
Dwuswoiste przeciwciała, które wiążą się z CD38 i CD3
|
RU2577226C2
(ru)
|
2014-04-10 |
2016-03-10 |
Общество с ограниченной ответственностью, "Международный биотехнологический центр "Генериум" ("МБЦ "Генериум") |
Способ получения биспецифических антител против cd3*cd19 формата флексибоди в клетках млекопитающих
|
WO2015168379A2
(en)
|
2014-04-30 |
2015-11-05 |
President And Fellows Of Harvard College |
Combination vaccine devices and methods of killing cancer cells
|
KR102355609B1
(ko)
|
2014-05-29 |
2022-01-27 |
마크로제닉스, 인크. |
다중 암 항원에 특이적으로 결합하는 삼중-특이적 결합 분자 및 그것의 사용 방법
|
US20160060360A1
(en)
|
2014-07-24 |
2016-03-03 |
Xencor, Inc. |
Rapid clearance of antigen complexes using novel antibodies
|
JO3663B1
(ar)
|
2014-08-19 |
2020-08-27 |
Merck Sharp & Dohme |
الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين
|
LT3183268T
(lt)
|
2014-08-19 |
2020-06-10 |
Novartis Ag |
Anti-cd123 chimerinis antigeno receptorius (car), skirtas naudoti vėžio gydymui
|
CR20170086A
(es)
|
2014-09-09 |
2017-05-22 |
Janssen Biotech Inc |
Terapias de combinación con anticuerpos anti-cd38
|
MA40764A
(fr)
|
2014-09-26 |
2017-08-01 |
Chugai Pharmaceutical Co Ltd |
Agent thérapeutique induisant une cytotoxicité
|
MA40894A
(fr)
|
2014-11-04 |
2017-09-12 |
Glenmark Pharmaceuticals Sa |
Immunoglobulines hétéro-dimères reciblant des lymphocytes t cd3/cd38 et leurs procédés de production
|
BR112017010324A2
(pt)
|
2014-11-20 |
2018-05-15 |
F. Hoffmann-La Roche Ag |
método para tratar ou retardar a progressão de um câncer em um indivíduo, moléculas, métodos para aumentar a função imune em um indivíduo e para selecionar um paciente para tratamento, kits, composição farmacêutica e usos de uma combinação de uma molécula
|
US10259887B2
(en)
|
2014-11-26 |
2019-04-16 |
Xencor, Inc. |
Heterodimeric antibodies that bind CD3 and tumor antigens
|
JP6696982B2
(ja)
|
2014-11-26 |
2020-05-20 |
ゼンコー・インコーポレイテッドXencor、 Inc. |
Cd3および腫瘍抗原に結合するヘテロ二量体抗体
|
WO2016086186A2
(en)
|
2014-11-26 |
2016-06-02 |
Xencor, Inc. |
Heterodimeric antibodies including binding to cd8
|
TN2017000222A1
(en)
|
2014-11-26 |
2018-10-19 |
Xencor Inc |
Heterodimeric antibodies that bind cd3 and cd38
|
WO2016105450A2
(en)
|
2014-12-22 |
2016-06-30 |
Xencor, Inc. |
Trispecific antibodies
|
RS59693B1
(sr)
|
2015-01-08 |
2020-01-31 |
BioNTech SE |
Agonistička sredstva za vezivanje tnf receptora
|
EP3245227A4
(en)
|
2015-01-14 |
2018-07-25 |
Compass Therapeutics LLC |
Multispecific immunomodulatory antigen-binding constructs
|
MA41414A
(fr)
|
2015-01-28 |
2017-12-05 |
Centre Nat Rech Scient |
Protéines de liaison agonistes d' icos
|
US10227411B2
(en)
|
2015-03-05 |
2019-03-12 |
Xencor, Inc. |
Modulation of T cells with bispecific antibodies and FC fusions
|
CN115536750A
(zh)
*
|
2015-05-08 |
2022-12-30 |
森科股份有限公司 |
结合cd3和肿瘤抗原的异二聚体抗体
|
US20160376373A1
(en)
|
2015-06-24 |
2016-12-29 |
Janssen Biotech, Inc. |
Immune Modulation and Treatment of Solid Tumors with Antibodies that Specifically Bind CD38
|
CN116333138A
(zh)
|
2015-07-30 |
2023-06-27 |
宏观基因有限公司 |
Pd-1结合分子和其使用方法
|
TWI796283B
(zh)
|
2015-07-31 |
2023-03-21 |
德商安美基研究(慕尼黑)公司 |
Msln及cd3抗體構築體
|
JOP20160154B1
(ar)
|
2015-07-31 |
2021-08-17 |
Regeneron Pharma |
أجسام ضادة مضاد لل psma، وجزيئات رابطة لمستضد ثنائي النوعية الذي يربط psma و cd3، واستخداماتها
|
KR20180055824A
(ko)
|
2015-08-21 |
2018-05-25 |
카르스젠 테라퓨틱스 리미티드 |
항 메소텔린 완전 인간 항체 및 메소텔린을 타겟팅하는 면역효과 세포
|
AR106365A1
(es)
|
2015-10-02 |
2018-01-10 |
Hoffmann La Roche |
Moléculas biespecíficas de unión a antígeno activadoras de células t
|
WO2017072366A1
(en)
|
2015-10-30 |
2017-05-04 |
Nbe-Therapeutics Ag |
Anti-mesothelin antibodies
|
US20180305465A1
(en)
|
2015-11-25 |
2018-10-25 |
Amgen Inc. |
Heterodimeric antibodies that bind cd3 and cd38
|
WO2017100372A1
(en)
|
2015-12-07 |
2017-06-15 |
Xencor, Inc. |
Heterodimeric antibodies that bind cd3 and psma
|
HUE063377T2
(hu)
|
2015-12-22 |
2024-01-28 |
Regeneron Pharma |
Anti-PD-1 antitestek és bispecifikus anti-CD20/anti-CD3 antitestek kombinációja a rák kezelésére
|
BR112018015415A2
(pt)
|
2016-02-03 |
2018-12-18 |
Amgen Res Munich Gmbh |
célula t biespecífica de psma e cd3 de engate de construtos de anticorpos
|
US20170349657A1
(en)
|
2016-06-01 |
2017-12-07 |
Xencor, Inc. |
Bispecific antibodies that bind cd20 and cd3
|
EP3464365A1
(en)
|
2016-06-01 |
2019-04-10 |
Xencor, Inc. |
Bispecific antibodies that bind cd123 and cd3
|
EP3252078A1
(en)
|
2016-06-02 |
2017-12-06 |
F. Hoffmann-La Roche AG |
Type ii anti-cd20 antibody and anti-cd20/cd3 bispecific antibody for treatment of cancer
|
MA45192A
(fr)
|
2016-06-07 |
2019-04-10 |
Macrogenics Inc |
Traitement d'association
|
MX2018015592A
(es)
|
2016-06-14 |
2019-04-24 |
Xencor Inc |
Anticuerpos inhibidores de puntos de control biespecificos.
|
IL263834B2
(en)
|
2016-06-20 |
2024-01-01 |
Kymab Ltd |
Antibodies against PD-L1
|
CN109715663B
(zh)
|
2016-06-28 |
2022-11-25 |
Xencor股份有限公司 |
结合生长抑素受体2的异源二聚抗体
|
US20190309092A1
(en)
|
2016-07-21 |
2019-10-10 |
Development Center For Biotechnology |
Modified antigen-binding fab fragments and antigen-binding molecules comprising the same
|
US20190194690A1
(en)
|
2016-08-29 |
2019-06-27 |
Psioxus Therapeutics Limited |
Adenovirus armed with bispecific t cell engager (bite)
|
US10793632B2
(en)
|
2016-08-30 |
2020-10-06 |
Xencor, Inc. |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
CN107840891A
(zh)
|
2016-09-19 |
2018-03-27 |
上海吉倍生物技术有限公司 |
高亲和力的抗msln抗体及其应用
|
KR102649972B1
(ko)
|
2016-10-14 |
2024-03-22 |
젠코어 인코포레이티드 |
IL15/IL15Rα 이종이량체 Fc-융합 단백질
|
KR102617264B1
(ko)
|
2016-10-19 |
2023-12-29 |
인벤라 인코포레이티드 |
항체 구조물
|
US11111305B2
(en)
|
2017-01-09 |
2021-09-07 |
Torch Therapeutics |
Method of using a bispecific antibody to conditionally inhibit a receptor signaling complex
|
WO2018209304A1
(en)
|
2017-05-12 |
2018-11-15 |
Harpoon Therapeutics, Inc. |
Msln targeting trispecific proteins and methods of use
|
KR20200041834A
(ko)
*
|
2017-06-01 |
2020-04-22 |
젠코어 인코포레이티드 |
Cd123 및 cd3에 결합하는 이중특이성 항체
|
WO2018223004A1
(en)
*
|
2017-06-01 |
2018-12-06 |
Xencor, Inc. |
Bispecific antibodies that bind cd20 and cd3
|
US20210061911A1
(en)
|
2017-09-07 |
2021-03-04 |
Macrogenics, Inc. |
Dosing Regiments of Bi-Specific CD123 x CD3 Diabodies in the Treatment of Hematologic Malignancies
|
KR20200061402A
(ko)
|
2017-10-10 |
2020-06-02 |
사노피 |
항-cd38 항체 및 항-cd3 및 항-cd28 항체와의 조합
|
AU2018366199A1
(en)
|
2017-11-08 |
2020-05-28 |
Xencor, Inc. |
Bispecific and monospecific antibodies using novel anti-PD-1 sequences
|
US10981992B2
(en)
|
2017-11-08 |
2021-04-20 |
Xencor, Inc. |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
RU2020120411A
(ru)
|
2017-11-21 |
2021-12-23 |
Новартис Аг |
Триспецифические связывающие молекулы, направленные против опухолеассоциированных антигенов, и пути их применения
|
AU2019231205A1
(en)
|
2018-03-06 |
2020-09-24 |
The Trustees Of The University Of Pennsylvania |
Prostate-specific membrane antigen cars and methods of use thereof
|
US10869888B2
(en)
|
2018-04-17 |
2020-12-22 |
Innovative Cellular Therapeutics CO., LTD. |
Modified cell expansion and uses thereof
|
CR20200563A
(es)
|
2018-05-24 |
2021-05-11 |
Janssen Biotech Inc |
Agentes aglutinantes de psma y usos de estos
|
CN112789294A
(zh)
|
2018-07-24 |
2021-05-11 |
印希比股份有限公司 |
含有受限cd3结合结构域和受体结合区的多特异性多肽构建体及其使用方法
|
JP2021534096A
(ja)
|
2018-08-08 |
2021-12-09 |
ドラゴンフライ セラピューティクス, インコーポレイテッド |
Nkg2d、cd16および腫瘍関連抗原に結合するタンパク質
|
US20230071196A1
(en)
|
2019-05-21 |
2023-03-09 |
Novartis Ag |
Variant cd58 domains and uses thereof
|
US20210102002A1
(en)
|
2019-08-06 |
2021-04-08 |
Xencor, Inc. |
HETERODIMERIC IgG-LIKE BISPECIFIC ANTIBODIES
|