CY1124090T1 - Συνθεσεις αντισωματων για τη θεραπεια ογκων - Google Patents
Συνθεσεις αντισωματων για τη θεραπεια ογκωνInfo
- Publication number
- CY1124090T1 CY1124090T1 CY20211100383T CY211100383T CY1124090T1 CY 1124090 T1 CY1124090 T1 CY 1124090T1 CY 20211100383 T CY20211100383 T CY 20211100383T CY 211100383 T CY211100383 T CY 211100383T CY 1124090 T1 CY1124090 T1 CY 1124090T1
- Authority
- CY
- Cyprus
- Prior art keywords
- amphiphilic
- antibodies
- antigen
- certain embodiments
- binding
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
Η παρούσα εφεύρεση παρέχει αμφιειδικά αντισώματα που δεσμεύονται σε αντιγόνα CD3 και όγκων, καθώς και μεθόδους χρήσης αυτών. Σύμφωνα με ορισμένες υλοποιήσεις, τα αμφιειδικά αντισώματα της εφεύρεσης εμφανίζουν μειωμένες λειτουργίες τελεστή και έχουν μοναδικό προφίλ δέσμευσης αναφορικά με τους υποδοχείς Fcy. Τα αμφιειδικά αντισώματα είναι τροποποιημένα ώστε να επάγουν αποτελεσματικά τη μεσολαβούμενη από τα Τ κύτταρα θανάτωση κυττάρων όγκου. Σύμφωνα με ορισμένες υλοποιήσεις, η παρούσα εφεύρεση παρέχει αμφιειδικά αντιγονοδεσμευτικά μόρια που περιλαμβάνουν έναν πρώτο αντιγονοδεσμευτικό τομέα ο οποίος δεσμεύει ειδικά το ανθρώπινο CD3, ένα δεύτερο αντιγονοδεσμευτικό μόριο το οποίο δεσμεύει ειδικά το ανθρώπινο CD20 και έναν τομέα Fc ο οποίος δεσμεύει τους υποδοχείς Fcy με συγκεκριμένο μοτίβο δέσμευσης. Σε ορισμένες υλοποιήσεις, τα αμφιειδικά αντιγονοδεσμευτικά μόρια της παρούσας εφεύρεσης είναι ικανά να αναστέλλουν την ανάπτυξη Β-κυτταρικών όγκων ή όγκων μελανώματος που εκφράζουν το CD20. Τα αμφιειδικά αντισώματα της εφεύρεσης είναι χρήσιμα για τη θεραπεία διαφόρων καρκίνων, καθώς και άλλων νόσων και διαταραχών που σχετίζονται με το CD20.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461955663P | 2014-03-19 | 2014-03-19 | |
US201461981641P | 2014-04-18 | 2014-04-18 | |
US201462007385P | 2014-06-03 | 2014-06-03 | |
US201462033460P | 2014-08-05 | 2014-08-05 | |
EP15714116.9A EP3119808B1 (en) | 2014-03-19 | 2015-03-18 | Antibody compositions for tumor treatment |
PCT/US2015/021322 WO2015143079A1 (en) | 2014-03-19 | 2015-03-18 | Antibody compositions for tumor treatment |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1124090T1 true CY1124090T1 (el) | 2022-05-27 |
Family
ID=52808172
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20191101220T CY1122315T1 (el) | 2014-03-19 | 2019-11-21 | Συνθεσεις αντισωματων για τη θεραπεια ογκων |
CY20211100383T CY1124090T1 (el) | 2014-03-19 | 2021-05-06 | Συνθεσεις αντισωματων για τη θεραπεια ογκων |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20191101220T CY1122315T1 (el) | 2014-03-19 | 2019-11-21 | Συνθεσεις αντισωματων για τη θεραπεια ογκων |
Country Status (25)
Country | Link |
---|---|
US (3) | US10550193B2 (el) |
EP (3) | EP3594238B1 (el) |
JP (2) | JP6559697B2 (el) |
KR (1) | KR102435081B1 (el) |
CN (2) | CN113045669A (el) |
AU (1) | AU2015231295C1 (el) |
CA (1) | CA2943084C (el) |
CY (2) | CY1122315T1 (el) |
DK (2) | DK3594238T3 (el) |
EA (1) | EA035164B1 (el) |
ES (2) | ES2868330T3 (el) |
HR (1) | HRP20192170T1 (el) |
HU (2) | HUE054397T2 (el) |
IL (2) | IL247845B (el) |
LT (2) | LT3594238T (el) |
MA (1) | MA55629A (el) |
ME (1) | ME03544B (el) |
MX (2) | MX2016012094A (el) |
PL (2) | PL3594238T3 (el) |
PT (2) | PT3594238T (el) |
RS (2) | RS61856B1 (el) |
SI (2) | SI3594238T1 (el) |
TW (2) | TWI754319B (el) |
WO (1) | WO2015143079A1 (el) |
ZA (1) | ZA201606597B (el) |
Families Citing this family (147)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10851178B2 (en) | 2011-10-10 | 2020-12-01 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
JOP20200236A1 (ar) | 2012-09-21 | 2017-06-16 | Regeneron Pharma | الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها |
US10131710B2 (en) | 2013-01-14 | 2018-11-20 | Xencor, Inc. | Optimized antibody variable regions |
US10487155B2 (en) | 2013-01-14 | 2019-11-26 | Xencor, Inc. | Heterodimeric proteins |
US9701759B2 (en) | 2013-01-14 | 2017-07-11 | Xencor, Inc. | Heterodimeric proteins |
US9605084B2 (en) | 2013-03-15 | 2017-03-28 | Xencor, Inc. | Heterodimeric proteins |
CN110981964B (zh) | 2013-01-14 | 2023-09-15 | Xencor股份有限公司 | 新型异二聚体蛋白 |
US11053316B2 (en) | 2013-01-14 | 2021-07-06 | Xencor, Inc. | Optimized antibody variable regions |
US10968276B2 (en) | 2013-03-12 | 2021-04-06 | Xencor, Inc. | Optimized anti-CD3 variable regions |
TWI635098B (zh) * | 2013-02-01 | 2018-09-11 | 再生元醫藥公司 | 含嵌合恆定區之抗體 |
US10519242B2 (en) | 2013-03-15 | 2019-12-31 | Xencor, Inc. | Targeting regulatory T cells with heterodimeric proteins |
AR095196A1 (es) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
AU2014232416B2 (en) | 2013-03-15 | 2017-09-28 | Xencor, Inc. | Modulation of T Cells with Bispecific Antibodies and FC Fusions |
US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
US10106624B2 (en) | 2013-03-15 | 2018-10-23 | Xencor, Inc. | Heterodimeric proteins |
PL3192812T3 (pl) | 2013-12-17 | 2020-10-19 | Genentech, Inc. | Przeciwciała anty-CD3 i sposoby ich zastosowania |
TWI680138B (zh) | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | 抗pd-l1之人類抗體 |
TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對pd-1的人類抗體 |
TWI754319B (zh) * | 2014-03-19 | 2022-02-01 | 美商再生元醫藥公司 | 用於腫瘤治療之方法及抗體組成物 |
KR102497443B1 (ko) | 2014-03-28 | 2023-02-08 | 젠코어 인코포레이티드 | Cd38 및 cd3에 결합하는 이중특이적 항체 |
MA40579A (fr) | 2014-09-12 | 2016-03-17 | Genentech Inc | Anticorps anti-cll-1 et immunoconjugués |
EP3699198A1 (en) | 2014-11-17 | 2020-08-26 | Regeneron Pharmaceuticals, Inc. | Methods for tumor treatment using cd3xcd20 bispecific antibody |
PL3689140T3 (pl) | 2014-11-24 | 2022-09-05 | Regeneron Pharmaceuticals, Inc. | Zwierzęta inne niż ludzie eksprymujące humanizowany kompleks CD3 |
CA2967426A1 (en) | 2014-11-26 | 2016-06-02 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and tumor antigens |
US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
PE20171103A1 (es) | 2014-11-26 | 2017-08-07 | Xencor Inc | Anticuerpos heterodimericos que se unen a cd3 y cd38 |
US10428155B2 (en) | 2014-12-22 | 2019-10-01 | Xencor, Inc. | Trispecific antibodies |
AU2016205967B2 (en) | 2015-01-08 | 2021-11-11 | Genmab A/S | Bispecific antibodies against CD3 and CD20 |
US10227411B2 (en) | 2015-03-05 | 2019-03-12 | Xencor, Inc. | Modulation of T cells with bispecific antibodies and FC fusions |
JP6773679B2 (ja) | 2015-03-30 | 2020-10-21 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | Fcガンマ受容体に対する結合が低下した重鎖定常領域 |
EA039429B1 (ru) * | 2015-05-13 | 2022-01-26 | Ридженерон Фармасьютикалз, Инк. | Способы лечения опухолей с применением биспецифического антитела cd3xcd20 |
US10501545B2 (en) | 2015-06-16 | 2019-12-10 | Genentech, Inc. | Anti-CLL-1 antibodies and methods of use |
JP2018526972A (ja) | 2015-06-16 | 2018-09-20 | ジェネンテック, インコーポレイテッド | 抗cd3抗体及び使用方法 |
IL256079B2 (en) | 2015-06-16 | 2024-01-01 | Genentech Inc | Human antibodies with improved affinity to FCRH5 - and methods of use |
WO2017010423A1 (ja) * | 2015-07-10 | 2017-01-19 | 中外製薬株式会社 | 内因性cd3遺伝子をヒトcd3遺伝子に置換した非ヒト動物 |
JOP20160154B1 (ar) * | 2015-07-31 | 2021-08-17 | Regeneron Pharma | أجسام ضادة مضاد لل psma، وجزيئات رابطة لمستضد ثنائي النوعية الذي يربط psma و cd3، واستخداماتها |
TW202340452A (zh) | 2015-08-04 | 2023-10-16 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
CN108699136B (zh) | 2015-12-07 | 2022-03-18 | Xencor股份有限公司 | 结合cd3和psma的异二聚抗体 |
BR112018012929A2 (pt) * | 2015-12-22 | 2018-12-11 | Regeneron Pharma | anticorpos anti-cd20/anti-cd3 biespecíficos para tratar leucemia linfoblástica aguda |
PT3394103T (pt) * | 2015-12-22 | 2023-09-04 | Regeneron Pharma | Combinação de anticorpos anti-pd-1 e anticorpos biespecíj'icos anti-cd20/anti-cd3 para tratar cancro |
CN116478293A (zh) | 2016-01-12 | 2023-07-25 | 克雷森多生物制剂有限公司 | 治疗分子 |
BR112018071283A2 (pt) | 2016-04-20 | 2019-02-12 | Regeneron Pharma | célula, conjunto de vetores para expressar uma proteína de ligação a antígeno biespecífica em uma célula, conjunto de vetores, método, e, método para produção de uma proteína de ligação a antígeno. |
KR20180134894A (ko) | 2016-04-20 | 2018-12-19 | 리제너론 파마슈티칼스 인코포레이티드 | 발현 강화 유전자좌의 사용에 기초하여 항체를 만들기 위한 조성물 및 방법 |
GB201607968D0 (en) | 2016-05-06 | 2016-06-22 | Crescendo Biolog Ltd | Chimeric antigen receptor |
TWI755395B (zh) | 2016-05-13 | 2022-02-21 | 美商再生元醫藥公司 | 抗-pd-1抗體與輻射治療癌症之組合 |
US20170349657A1 (en) * | 2016-06-01 | 2017-12-07 | Xencor, Inc. | Bispecific antibodies that bind cd20 and cd3 |
RU2022104399A (ru) | 2016-06-14 | 2022-05-05 | Ксенкор, Инк. | Биспецифические антитела-ингибиторы контрольных точек |
KR20190053835A (ko) * | 2016-06-21 | 2019-05-20 | 테네오바이오, 인코포레이티드 | Cd3 결합 항체 |
AU2017290086A1 (en) | 2016-06-28 | 2019-01-24 | Xencor, Inc. | Heterodimeric antibodies that bind somatostatin receptor 2 |
JP7125347B2 (ja) | 2016-08-22 | 2022-08-24 | 中外製薬株式会社 | ヒトgpc3ポリペプチドを発現する遺伝子改変非ヒト動物 |
WO2018039499A1 (en) | 2016-08-24 | 2018-03-01 | Regeneron Pharmaceuticals, Inc. | Host cell protein modification |
US10793632B2 (en) | 2016-08-30 | 2020-10-06 | Xencor, Inc. | Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors |
WO2018052503A1 (en) * | 2016-09-14 | 2018-03-22 | Teneobio, Inc. | Cd3 binding antibodies |
PL3515487T3 (pl) * | 2016-09-23 | 2024-01-15 | Regeneron Pharmaceuticals, Inc. | Dwuswoiste przeciwciała anty-muc16-cd3 oraz koniugaty przeciwciało anty-muc16 - lek |
CN110214148A (zh) | 2016-10-14 | 2019-09-06 | Xencor股份有限公司 | 含有IL-15/IL-15Rα Fc融合蛋白和PD-1抗体片段的双特异性异源二聚体融合蛋白 |
JP2020503260A (ja) * | 2016-11-15 | 2020-01-30 | ジェネンテック, インコーポレイテッド | 抗cd20/抗cd3二重特異性抗体による処置のための投与 |
JP7254699B2 (ja) | 2016-12-21 | 2023-04-10 | テネオバイオ, インコーポレイテッド | 抗bcma重鎖のみ抗体 |
EP3565841A1 (en) | 2017-01-06 | 2019-11-13 | Crescendo Biologics Limited | Single domain antibodies to programmed cell death (pd-1) |
CA3054289A1 (en) | 2017-02-21 | 2018-08-30 | Regeneron Pharmaceuticals, Inc. | Anti-pd-1 antibodies for treatment of lung cancer |
US11603407B2 (en) | 2017-04-06 | 2023-03-14 | Regeneron Pharmaceuticals, Inc. | Stable antibody formulation |
JOP20190222A1 (ar) * | 2017-04-11 | 2019-09-24 | Zymeworks Inc | الأجسام المضادة ثنائية النوعية المضادة لـ pd-l1 والمضادة لـ tim-3 |
CN117567624A (zh) | 2017-06-20 | 2024-02-20 | 特纳奥尼股份有限公司 | 仅有重链的抗bcma抗体 |
KR20200018498A (ko) | 2017-06-20 | 2020-02-19 | 테네오바이오, 인코포레이티드 | 항-bcma 중쇄-단독 항체 |
EP3642229A1 (en) | 2017-06-21 | 2020-04-29 | Gilead Sciences, Inc. | Multispecific antibodies that target hiv gp120 and cd3 |
MA49517A (fr) | 2017-06-30 | 2020-05-06 | Xencor Inc | Protéines de fusion fc hétérodimères ciblées contenant il-15/il-15ra et domaines de liaison à l'antigène |
TW201934570A (zh) | 2017-07-06 | 2019-09-01 | 美商雷傑納榮製藥公司 | 供製備糖蛋白之細胞培養方法 |
GB201711068D0 (en) | 2017-07-10 | 2017-08-23 | Crescendo Biologics Ltd | Therapeutic molecules binding PSMA |
TWI799432B (zh) * | 2017-07-27 | 2023-04-21 | 美商再生元醫藥公司 | 抗ctla-4抗體及其用途 |
EP3658125A4 (en) * | 2017-07-28 | 2021-04-28 | National University of Singapore | BIOMOLECULAR COMPOSITES INCLUDING MODIFIED CELL PHANTOMS |
CN111356477A (zh) * | 2017-08-01 | 2020-06-30 | Ab工作室有限公司 | 双特异性抗体及其用途 |
US10981992B2 (en) | 2017-11-08 | 2021-04-20 | Xencor, Inc. | Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors |
JP2021502100A (ja) | 2017-11-08 | 2021-01-28 | ゼンコア インコーポレイテッド | 新規抗pd−1配列を用いた二重特異性および単一特異性抗体 |
JP2021506291A (ja) | 2017-12-19 | 2021-02-22 | ゼンコア インコーポレイテッド | 改変されたil−2 fc融合タンパク質 |
MX2020006639A (es) | 2017-12-22 | 2020-09-14 | Regeneron Pharma | Sistema y metodo para caracterizar las impurezas de un producto farmaceutico. |
US11873336B2 (en) | 2017-12-22 | 2024-01-16 | Teneobio, Inc. | Heavy chain antibodies binding to CD22 |
EP3746471A1 (en) | 2018-01-31 | 2020-12-09 | Regeneron Pharmaceuticals, Inc. | System and method for characterizing size and charge variant drug product impurities |
TW202311746A (zh) | 2018-02-02 | 2023-03-16 | 美商再生元醫藥公司 | 用於表徵蛋白質二聚合之系統及方法 |
JP7475275B2 (ja) | 2018-02-08 | 2024-04-26 | ジェネンテック, インコーポレイテッド | 二重特異性抗原結合分子及びその使用方法 |
GB201802573D0 (en) | 2018-02-16 | 2018-04-04 | Crescendo Biologics Ltd | Therapeutic molecules that bind to LAG3 |
MX2020008988A (es) | 2018-02-28 | 2020-09-28 | Regeneron Pharma | Sistemas y metodos para la identificacion de contaminantes virales. |
PL3765525T3 (pl) * | 2018-03-13 | 2023-12-27 | Zymeworks Bc Inc. | Koniugaty biparatopowe przeciwciało anty-her2 – lek i sposoby stosowania |
EP4317959A3 (en) | 2018-03-19 | 2024-03-27 | Regeneron Pharmaceuticals, Inc. | Microchip capillary electrophoresis assays and reagents |
CN112469477A (zh) | 2018-04-04 | 2021-03-09 | Xencor股份有限公司 | 与成纤维细胞活化蛋白结合的异源二聚体抗体 |
CN112437777A (zh) | 2018-04-18 | 2021-03-02 | Xencor股份有限公司 | 包含IL-15/IL-15RA Fc融合蛋白和TIM-3抗原结合结构域的靶向TIM-3的异源二聚体融合蛋白 |
EP3781599A1 (en) | 2018-04-18 | 2021-02-24 | Xencor, Inc. | Pd-1 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and pd-1 antigen binding domains and uses thereof |
TW202016125A (zh) | 2018-05-10 | 2020-05-01 | 美商再生元醫藥公司 | 用於定量及調節蛋白質黏度之系統與方法 |
EP3569617A1 (en) * | 2018-05-18 | 2019-11-20 | Trion Research GmbH | Pharmaceutical preparation for use in treating epstein- barr virus positive patients with reactivation phenomenon- associated diseases |
CN110540593B (zh) * | 2018-05-29 | 2022-05-17 | 上海药明生物技术有限公司 | 新型的抗cd3/抗cd20双特异性抗体 |
TW202005985A (zh) | 2018-06-21 | 2020-02-01 | 美商再生元醫藥公司 | 用雙特異性抗CD3xMUC16抗體及抗PD-1抗體治療癌症的方法 |
MX2021002279A (es) | 2018-08-27 | 2021-05-27 | Regeneron Pharma | Uso de espectroscopia raman en la purificacion corriente abajo. |
CN112601963A (zh) | 2018-08-30 | 2021-04-02 | 瑞泽恩制药公司 | 用于表征蛋白质复合物的方法 |
JP2021535142A (ja) | 2018-08-31 | 2021-12-16 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | Cd3/c20二重特異性抗体のサイトカイン放出症候群を軽減する投与戦略 |
US11358999B2 (en) | 2018-10-03 | 2022-06-14 | Xencor, Inc. | IL-12 heterodimeric Fc-fusion proteins |
CN109836502B (zh) * | 2018-11-12 | 2021-09-07 | 浙江大学 | 一种双特异性抗体及其应用 |
MX2021008589A (es) | 2019-01-16 | 2021-08-11 | Regeneron Pharma | Metodos para identificar tioles libres en proteinas. |
WO2020159918A2 (en) * | 2019-01-28 | 2020-08-06 | Ab Therapeutics, Inc. | Bispecific antibodies and uses thereof |
CN115093481A (zh) * | 2019-01-28 | 2022-09-23 | 正大天晴药业集团股份有限公司 | 新型双特异性cd3/cd20多肽复合物 |
KR20210120031A (ko) * | 2019-01-28 | 2021-10-06 | 우시 바이올로직스 아일랜드 리미티드 | 신규한 이중특이적 cd3/cd20 폴리펩티드 복합체 |
US20220153819A1 (en) | 2019-02-12 | 2022-05-19 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for using bispecific antibodies to bind complement and a target antigen |
CA3132185A1 (en) | 2019-03-01 | 2020-09-10 | Xencor, Inc. | Heterodimeric antibodies that bind enpp3 and cd3 |
CN113785203A (zh) | 2019-05-13 | 2021-12-10 | 里珍纳龙药品有限公司 | 改进的竞争性配体结合测定 |
AR119746A1 (es) | 2019-06-14 | 2022-01-05 | Teneobio Inc | Anticuerpos multiespecíficos de cadena pesada que se unen a cd22 y cd3 |
JP6881658B2 (ja) | 2019-07-05 | 2021-06-02 | 小野薬品工業株式会社 | Pd−1/cd3二重特異性タンパク質による血液がん治療 |
MX2022003438A (es) | 2019-09-24 | 2022-04-19 | Regeneron Pharma | Sistemas y metodos para uso y regeneracion de cromatografia. |
BR112022009974A2 (pt) | 2019-11-25 | 2022-08-16 | Regeneron Pharma | Métodos de produção de um polímero ou micropartículas revestidas com polímero, para produzir microesferas poliméricas ou revestidas com polímero e para produzir micropartículas, composição de liberação sustentada, micropartículas, e, composição farmacêutica |
CA3163950A1 (en) | 2019-12-13 | 2021-06-17 | Genentech, Inc. | Anti-ly6g6d antibodies and methods of use |
US11835527B2 (en) | 2020-01-21 | 2023-12-05 | Regeneron Pharmaceuticals, Inc. | Deglycosylation methods for electrophoresis of glycosylated proteins |
CN115894703A (zh) | 2020-04-29 | 2023-04-04 | 特尼奥生物股份有限公司 | 具有经修饰重链恒定区的多特异性重链抗体 |
IL297783A (en) | 2020-05-01 | 2022-12-01 | Regeneron Pharma | Testing for neutralizing antibodies to therapeutic proteins |
US11919956B2 (en) | 2020-05-14 | 2024-03-05 | Xencor, Inc. | Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3 |
US20230279138A1 (en) | 2020-07-27 | 2023-09-07 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Novel bispecific anti-cd3/cd20 polypeptide complex formulation |
KR102607909B1 (ko) | 2020-08-19 | 2023-12-01 | 젠코어 인코포레이티드 | 항-cd28 조성물 |
IL300828A (en) | 2020-08-31 | 2023-04-01 | Regeneron Pharma | Asparagine feeding strategies to improve cell culture performance and reduce asparagine sequence variants |
EP4210747A1 (en) | 2020-09-10 | 2023-07-19 | Genmab A/S | Bispecific antibody against cd3 and cd20 in combination therapy for treating diffuse large b-cell lymphoma |
JP2023541858A (ja) | 2020-09-10 | 2023-10-04 | ジェンマブ エー/エス | 慢性リンパ球性白血病を治療するためのcd3及びcd20に対する二重特異性抗体 |
WO2022053656A1 (en) | 2020-09-10 | 2022-03-17 | Genmab A/S | Bispecific antibody against cd3 and cd20 in combination therapy for treating follicular lymphoma |
WO2022053657A1 (en) | 2020-09-10 | 2022-03-17 | Genmab A/S | Bispecific antibody against cd3 and cd20 in combination therapy for treating diffuse large b-cell lymphoma |
JP2023542289A (ja) | 2020-09-10 | 2023-10-06 | ジェンマブ エー/エス | 濾胞性リンパ腫を治療するための併用療法におけるcd3及びcd20に対する二重特異性抗体 |
EP4222171A1 (en) | 2020-10-02 | 2023-08-09 | Regeneron Pharmaceuticals, Inc. | Combination of antibodies for treating cancer with reduced cytokine release syndrome |
EP4251128A1 (en) | 2020-11-25 | 2023-10-04 | Regeneron Pharmaceuticals, Inc. | Sustained release formulations using non-aqueous membrane emulsification |
US20220257707A1 (en) | 2020-12-17 | 2022-08-18 | Regeneron Pharmaceuticals, Inc. | Fabrication of protein-encapsulating microgels |
CN116761880A (zh) | 2021-01-20 | 2023-09-15 | 瑞泽恩制药公司 | 改进细胞培养物中的蛋白质滴度的方法 |
KR20230157315A (ko) | 2021-01-28 | 2023-11-16 | 리제너론 파마슈티칼스 인코포레이티드 | 사이토카인 방출 증후군을 치료하기 위한 조성물 및 방법 |
EP4302098A1 (en) | 2021-03-03 | 2024-01-10 | Regeneron Pharmaceuticals, Inc. | Systems and methods for quantifying and modifying protein viscosity |
CA3212665A1 (en) | 2021-03-09 | 2022-09-15 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and cldn6 |
KR20230154311A (ko) | 2021-03-10 | 2023-11-07 | 젠코어 인코포레이티드 | Cd3 및 gpc3에 결합하는 이종이량체 항체 |
KR20230156921A (ko) | 2021-03-12 | 2023-11-15 | 젠맵 에이/에스 | 비-활성화 항체 변이체 |
CA3211302A1 (en) | 2021-03-26 | 2022-09-29 | Ross Kenyon | Methods and systems for developing mixing protocols |
TW202314240A (zh) | 2021-06-01 | 2023-04-01 | 美商再生元醫藥公司 | 微晶片毛細管電泳分析及試劑 |
EP4355785A1 (en) * | 2021-06-17 | 2024-04-24 | Amberstone Biosciences, Inc. | Anti-cd3 constructs and uses thereof |
TW202326138A (zh) | 2021-09-08 | 2023-07-01 | 美商再生元醫藥公司 | 用於定量抗體及其他含Fc蛋白之高通量及基於質譜之方法 |
WO2023044139A1 (en) | 2021-09-20 | 2023-03-23 | Regeneron Pharmaceuticals, Inc. | Methods of controlling antibody heterogeneity |
US20230116199A1 (en) | 2021-10-07 | 2023-04-13 | Regeneron Pharmaceuticals, Inc. | Systems and methods of ph modeling and control |
CA3230985A1 (en) | 2021-10-07 | 2023-04-13 | Ross BROWNE | Ph meter calibration and correction |
US20230129265A1 (en) | 2021-10-26 | 2023-04-27 | Regeneron Pharmaceuticals, Inc. | Systems and methods for generating laboratory water and distributing laboratory water at different temperatures |
WO2023097030A1 (en) | 2021-11-24 | 2023-06-01 | Regeneron Pharmaceuticals, Inc. | Methods for treating cancer with bispecific anti-cd3 x muc16 antibodies and anti-ctla-4 antibodies |
WO2023133280A1 (en) | 2022-01-07 | 2023-07-13 | Regeneron Pharmaceuticals, Inc. | Methods of treating recurrent ovarian cancer with bispecific anti-muc16 x anti-cd3 antibodies alone or in combination with anti-pd-1 antibodies |
WO2023177772A1 (en) | 2022-03-17 | 2023-09-21 | Regeneron Pharmaceuticals, Inc. | Methods of treating recurrent epithelioid sarcoma with bispecific anti-muc16 x anti-cd3 antibodies alone or in combination with anti-pd-1 antibodies |
US20230296559A1 (en) | 2022-03-18 | 2023-09-21 | Regeneron Pharmaceuticals, Inc. | Methods and systems for analyzing polypeptide variants |
WO2023201226A1 (en) | 2022-04-11 | 2023-10-19 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for universal tumor cell killing |
TW202406571A (zh) | 2022-04-13 | 2024-02-16 | 美商建南德克公司 | 莫蘇妥珠單抗之醫藥組成物及其使用方法 |
WO2023214960A1 (en) | 2022-05-02 | 2023-11-09 | Regeneron Pharmaceuticals, Inc. | Biochemical assays for therapeutic proteins |
WO2023218046A1 (en) | 2022-05-12 | 2023-11-16 | Genmab A/S | Binding agents capable of binding to cd27 in combination therapy |
WO2023224912A1 (en) | 2022-05-16 | 2023-11-23 | Regeneron Pharmaceuticals, Inc. | Methods of treating metastatic castration-resistant prostate cancer with bispecific anti-psma x anti-cd3 antibodies alone or in combination with anti-pd-1 antibodies |
WO2023225098A1 (en) | 2022-05-18 | 2023-11-23 | Regeneron Pharmaceuticals, Inc. | Multispecific antigen binding molecules that bind cd38 and 4-1bb, and uses thereof |
WO2024030453A1 (en) | 2022-08-02 | 2024-02-08 | Regeneron Pharmaceuticals, Inc. | Methods of treating metastatic castration-resistant prostate cancer with bispecific anti-psma x anti-cd28 antibodies in combination with anti-pd-1 antibodies |
WO2024040206A2 (en) * | 2022-08-19 | 2024-02-22 | Eli Lilly And Company | Pd-1 agonist antibodies and methods of treating autoimmune diseases with a pd-1 agonist antibody |
Family Cites Families (136)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4361549A (en) | 1979-04-26 | 1982-11-30 | Ortho Pharmaceutical Corporation | Complement-fixing monoclonal antibody to human T cells, and methods of preparing same |
FR2593830B1 (fr) | 1986-02-06 | 1988-04-08 | Snecma | Superalliage a matrice a base de nickel notamment elabore en metallurgie des poudres et disque de turbomachine constitue en cet alliage |
US6893625B1 (en) | 1986-10-27 | 2005-05-17 | Royalty Pharma Finance Trust | Chimeric antibody with specificity to human B cell surface antigen |
IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
WO1988007089A1 (en) | 1987-03-18 | 1988-09-22 | Medical Research Council | Altered antibodies |
JP3095168B2 (ja) | 1988-02-05 | 2000-10-03 | エル. モリソン,シェリー | ドメイン‐変性不変部を有する抗体 |
JP4124480B2 (ja) | 1991-06-14 | 2008-07-23 | ジェネンテック・インコーポレーテッド | 免疫グロブリン変異体 |
MX9204374A (es) | 1991-07-25 | 1993-03-01 | Idec Pharma Corp | Anticuerpo recombinante y metodo para su produccion. |
EP0752248B1 (en) | 1992-11-13 | 2000-09-27 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
US5736137A (en) | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
US6180377B1 (en) | 1993-06-16 | 2001-01-30 | Celltech Therapeutics Limited | Humanized antibodies |
US6750334B1 (en) | 1996-02-02 | 2004-06-15 | Repligen Corporation | CTLA4-immunoglobulin fusion proteins having modified effector functions and uses therefor |
EP0826696B1 (de) | 1996-09-03 | 2002-05-29 | GSF-Forschungszentrum für Umwelt und Gesundheit GmbH | Verwendung bi-und trispezifischer Antikörper zur Induktion einer Tumorimmunität |
BR9908226A (pt) | 1998-02-25 | 2000-10-24 | Lexigen Pharm Corp | Melhoramento da meia vida de circulação de proteìnas de fusão com base em anticorpo |
US6528624B1 (en) | 1998-04-02 | 2003-03-04 | Genentech, Inc. | Polypeptide variants |
JP4169478B2 (ja) | 1998-04-21 | 2008-10-22 | マイクロメット アーゲー | Cd19×cd3特異的ポリペプチドおよびその使用 |
GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
MY136203A (en) | 1998-08-11 | 2008-08-29 | Idec Pharma Corp | Combination therapies for b-cell lymphomas comprising administration of anti-cd20 antibody |
US6224866B1 (en) | 1998-10-07 | 2001-05-01 | Biocrystal Ltd. | Immunotherapy of B cell involvement in progression of solid, nonlymphoid tumors |
ES2694002T3 (es) | 1999-01-15 | 2018-12-17 | Genentech, Inc. | Polipéptido que comprende una región Fc de IgG1 humana variante |
US7183387B1 (en) | 1999-01-15 | 2007-02-27 | Genentech, Inc. | Polypeptide variants with altered effector function |
PT1914244E (pt) | 1999-04-09 | 2013-07-26 | Kyowa Hakko Kirin Co Ltd | Processo para regular a actividade de moléculas funcionais sob o ponto de vista imunológico |
PL200134B1 (pl) | 1999-05-07 | 2008-12-31 | Genentech Inc | Zastosowanie przeciwciała anty-CD20 |
US7087411B2 (en) | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
ITMI991299A1 (it) | 1999-06-11 | 2000-12-11 | Consiglio Nazionale Ricerche | Uso di anticorpi contro antigeni di superficie per il trattamento della malattia trapianto contro ospite |
US7396917B2 (en) | 2000-12-05 | 2008-07-08 | Alexion Pharmaceuticals, Inc. | Rationally designed antibodies |
CA2437958C (en) | 2001-03-09 | 2018-10-30 | University Of Chicago | Polymeric immunoglobulin fusion proteins that target low-affinity fc.gamma.receptors |
EP1487487A2 (en) | 2001-09-28 | 2004-12-22 | Elusys Therapeutics, Inc. | Methods and compositions for prevention, diagnosis, and treatment of cancer using bispecific molecules |
US20040093621A1 (en) | 2001-12-25 | 2004-05-13 | Kyowa Hakko Kogyo Co., Ltd | Antibody composition which specifically binds to CD20 |
WO2003068821A2 (en) | 2002-02-14 | 2003-08-21 | Immunomedics, Inc. | Anti-cd20 antibodies and fusion proteins thereof and methods of use |
US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
US8673589B2 (en) | 2002-05-29 | 2014-03-18 | Regeneron Pharmaceuticals, Inc. | Inducible eukaryotic expression system |
EP1400534B1 (en) | 2002-09-10 | 2015-10-28 | Affimed GmbH | Human CD3-specific antibody with immunosuppressive properties |
US7820166B2 (en) | 2002-10-11 | 2010-10-26 | Micromet Ag | Potent T cell modulating molecules |
EP2330130B1 (en) | 2002-10-17 | 2014-08-27 | Genmab A/S | Human monoclonal antibodies against CD20 |
US7608260B2 (en) | 2003-01-06 | 2009-10-27 | Medimmune, Llc | Stabilized immunoglobulins |
US7960512B2 (en) | 2003-01-09 | 2011-06-14 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
JP2006524039A (ja) | 2003-01-09 | 2006-10-26 | マクロジェニクス,インコーポレーテッド | 変異型Fc領域を含む抗体の同定および作製ならびにその利用法 |
US8084582B2 (en) | 2003-03-03 | 2011-12-27 | Xencor, Inc. | Optimized anti-CD20 monoclonal antibodies having Fc variants |
KR101412271B1 (ko) | 2003-05-09 | 2014-06-25 | 듀크 유니버시티 | Cd20-특이적 항체 및 이를 이용한 방법 |
AR044388A1 (es) | 2003-05-20 | 2005-09-07 | Applied Molecular Evolution | Moleculas de union a cd20 |
JP2007501021A (ja) | 2003-05-30 | 2007-01-25 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | 遺伝子操作された定常領域を含む、抗体および融合タンパク質 |
JP5010281B2 (ja) | 2003-05-31 | 2012-08-29 | マイクロメット アクツィエン ゲゼルシャフト | Epcamに対する二重特異性抗体を含む薬学的組成物 |
DE602004025101D1 (de) | 2003-05-31 | 2010-03-04 | Micromet Ag | Humane anti-humane cd3-bindungsmoleküle |
EP1641827A2 (en) | 2003-06-27 | 2006-04-05 | Biogen Idec MA Inc. | Use of hydrophobic-interaction-chromatography or hinge-region modifications for the production of homogeneous antibody-solutions |
WO2005023302A2 (en) | 2003-08-29 | 2005-03-17 | Genentech, Inc. | Anti-cd20 therapy of ocular disorders |
US8399618B2 (en) | 2004-10-21 | 2013-03-19 | Xencor, Inc. | Immunoglobulin insertions, deletions, and substitutions |
DK1673398T3 (da) | 2003-10-16 | 2011-04-18 | Micromet Ag | Multispecifikke, deimmuniserede CD3-bindere |
BRPI0417108A (pt) | 2003-12-19 | 2007-02-06 | Genentech Inc | métodos de tratamento de rejeições de transplantes em pacientes |
EP1737890A2 (en) | 2004-03-24 | 2007-01-03 | Xencor, Inc. | Immunoglobulin variants outside the fc region |
CA2885854C (en) | 2004-04-13 | 2017-02-21 | F. Hoffmann-La Roche Ag | Anti-p-selectin antibodies |
WO2005103081A2 (en) | 2004-04-20 | 2005-11-03 | Genmab A/S | Human monoclonal antibodies against cd20 |
WO2005117972A2 (en) | 2004-05-05 | 2005-12-15 | Genentech, Inc. | Preventing autoimmune disease by using an anti-cd20 antibody |
BRPI0511782B8 (pt) | 2004-06-03 | 2021-05-25 | Novimmune Sa | anticorpos anti-cd3, uso e método de produção dos mesmos, composição farmacêutica, molécula de ácido nucleico isolada e vetor |
CA2568336A1 (en) | 2004-06-04 | 2005-12-22 | Genentech, Inc. | Method for treating lupus |
US20060110387A1 (en) | 2004-10-05 | 2006-05-25 | Genentech, Inc. | Method for treating vasculitis |
US20120189643A1 (en) | 2004-11-30 | 2012-07-26 | Carton Jill M | Toll Like Receptor 3 Antagonists, Methods and Uses |
AR051836A1 (es) | 2004-11-30 | 2007-02-14 | Centocor Inc | Antagonistas de receptor 3 simil toll metodos y usos |
WO2006074399A2 (en) | 2005-01-05 | 2006-07-13 | Biogen Idec Ma Inc. | Multispecific binding molecules comprising connecting peptides |
US7700099B2 (en) | 2005-02-14 | 2010-04-20 | Merck & Co., Inc. | Non-immunostimulatory antibody and compositions containing the same |
TW200714289A (en) | 2005-02-28 | 2007-04-16 | Genentech Inc | Treatment of bone disorders |
AR053579A1 (es) | 2005-04-15 | 2007-05-09 | Genentech Inc | Tratamiento de la enfermedad inflamatoria intestinal (eii) |
MX2007012989A (es) | 2005-04-22 | 2008-01-11 | Genentech Inc | Metodo para tratar la demencia o la enfermedad de alheimer. |
EP1891113A2 (en) | 2005-06-02 | 2008-02-27 | AstraZeneca AB | Antibodies directed to cd20 and uses thereof |
AU2006283532B2 (en) | 2005-08-19 | 2012-04-26 | Abbvie Inc. | Dual variable domain immunoglobin and uses thereof |
EP2500353A3 (en) | 2005-08-19 | 2012-10-10 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
CA2625440C (en) | 2005-10-11 | 2023-06-13 | Micromet Ag | Compositions comprising cross-species-specific antibodies and uses thereof |
EP1943332A4 (en) | 2005-10-14 | 2011-04-13 | Medimmune Inc | CELLULAR DISPLAY OF ANTIBODY LIBRARIES |
WO2007084321A2 (en) | 2006-01-12 | 2007-07-26 | Alexion Pharmaceuticals, Inc. | Antibodies to ox-2/cd200 and uses thereof |
EP1820513A1 (en) | 2006-02-15 | 2007-08-22 | Trion Pharma Gmbh | Destruction of tumor cells expressing low to medium levels of tumor associated target antigens by trifunctional bispecific antibodies |
DK2359834T5 (en) | 2006-03-15 | 2017-02-06 | Alexion Pharma Inc | Treatment of paroxysmal nocturnal hemoglobinuria patients with a complement inhibitor |
KR20090013763A (ko) | 2006-03-23 | 2009-02-05 | 기린 파마 가부시끼가이샤 | 인간 트롬보포이에틴 수용체에 대한 아고니스트 항체 |
RS52643B (en) | 2006-06-02 | 2013-06-28 | Regeneron Pharmaceuticals Inc. | HIGH AFINITY ANTIBODIES TO THE HUMAN IL-6 RECEPTOR |
RU2448979C2 (ru) | 2006-12-14 | 2012-04-27 | Ридженерон Фармасьютикалз, Инк. | Антитела человека к дельта-подобному лиганду-4 человека |
WO2008119353A1 (en) | 2007-03-29 | 2008-10-09 | Genmab A/S | Bispecific antibodies and methods for production thereof |
JP2010524851A (ja) | 2007-04-03 | 2010-07-22 | マイクロメット アーゲー | 種間特異的結合ドメイン |
CA2682626A1 (en) | 2007-04-03 | 2008-10-09 | Micromet Ag | Cross-species-specific bispecific binders |
NZ581395A (en) | 2007-05-14 | 2012-08-31 | Biogen Idec Inc | Single-chain fc (scfc) regions, binding polypeptides comprising same, and methods related thereto |
WO2008147143A2 (en) | 2007-05-30 | 2008-12-04 | Postech Academy-Industry Foundation | Immunoglobulin fusion proteins |
JP6071165B2 (ja) | 2007-05-31 | 2017-02-01 | ゲンマブ エー/エス | 安定なIgG4抗体 |
AU2008255387B2 (en) | 2007-05-31 | 2014-06-26 | Genmab A/S | Recombinant non glycosylated monovalent half-antibodies obtained by molecular engineering |
WO2009006520A1 (en) | 2007-07-03 | 2009-01-08 | Medimmune, Llc | Hinge domain engineering |
DK2178916T3 (en) | 2007-07-31 | 2015-01-12 | Regeneron Pharma | Human antibodies to human cd20 and method thereof for use |
PT2187964E (pt) | 2007-08-10 | 2015-01-14 | Regeneron Pharma | Anticorpos humanos de elevada afinidade para o factor de crescimento neural humano |
WO2009030368A1 (en) | 2007-09-05 | 2009-03-12 | F. Hoffmann-La Roche Ag | Combination therapy with type i and type ii anti-cd20 antibodies |
CN101939425B (zh) | 2007-09-26 | 2014-05-14 | 中外制药株式会社 | 抗il-6受体抗体 |
SG10201605394SA (en) | 2007-09-26 | 2016-08-30 | Chugai Pharmaceutical Co Ltd | Modified Antibody Constant Region |
US8268972B2 (en) | 2008-02-20 | 2012-09-18 | G2 Inflammation Pty Ltd | Humanized anti-C5aR antibodies |
WO2009106096A1 (en) | 2008-02-27 | 2009-09-03 | Fresenius Biotech Gmbh | Treatment of resistant tumors with trifunctional antibodies |
WO2010054212A1 (en) | 2008-11-06 | 2010-05-14 | Alexion Pharmaceuticals, Inc. | Engineered antibodies with reduced immunogenicity and methods of making |
NO2918604T3 (el) | 2008-11-07 | 2018-05-19 | ||
AR074438A1 (es) | 2008-12-02 | 2011-01-19 | Pf Medicament | Proceso para la modulacion de la actividad antagonista de un anticuerpo monoclonal |
AU2009324092A1 (en) | 2008-12-03 | 2011-06-23 | Genmab A/S | Antibody variants having modifications in the constant region |
US20120100140A1 (en) | 2009-01-23 | 2012-04-26 | Biogen Idec Ma Inc. | Stabilized fc polypeptides with reduced effector function and methods of use |
US9228017B2 (en) | 2009-03-19 | 2016-01-05 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
JP5787446B2 (ja) | 2009-03-19 | 2015-09-30 | 中外製薬株式会社 | 抗体定常領域改変体 |
PL2975051T3 (pl) * | 2009-06-26 | 2021-09-20 | Regeneron Pharmaceuticals, Inc. | Wyizolowane z łatwością dwuswoiste przeciwciała o formacie natywnej immunoglobuliny |
JO3182B1 (ar) | 2009-07-29 | 2018-03-08 | Regeneron Pharma | مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2 |
EP2481752B1 (en) | 2009-09-24 | 2016-11-09 | Chugai Seiyaku Kabushiki Kaisha | Modified antibody constant regions |
PT2506871T (pt) | 2009-11-30 | 2016-11-07 | Janssen Biotech Inc | Mutantes de fc de anticorpos com funções efetoras inutilizadas |
US20130129723A1 (en) | 2009-12-29 | 2013-05-23 | Emergent Product Development Seattle, Llc | Heterodimer Binding Proteins and Uses Thereof |
SI2519543T1 (sl) | 2009-12-29 | 2016-08-31 | Emergent Product Development Seattle, Llc | Beljakovine, ki se vežejo s heterodimeri in njihova uporaba |
TR201906650T4 (tr) | 2010-02-08 | 2019-05-21 | Regeneron Pharma | Ortak hafif zincirli fare. |
JP5889181B2 (ja) | 2010-03-04 | 2016-03-22 | 中外製薬株式会社 | 抗体定常領域改変体 |
MX341925B (es) | 2010-03-29 | 2016-09-07 | Zymeworks Inc | Anticuerpos con funcion efectora suprimida o mejorada. |
JP2013531476A (ja) | 2010-04-30 | 2013-08-08 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | ヒトにおける免疫原性が低下した抗体 |
GB201014033D0 (en) | 2010-08-20 | 2010-10-06 | Ucb Pharma Sa | Biological products |
PL2616489T3 (pl) | 2010-09-16 | 2017-07-31 | Baliopharm Ag | Przeciwciało anty-huTNFR1 |
BR112013013311A2 (pt) * | 2010-11-30 | 2017-09-19 | Chugai Pharmaceutical Co Ltd | agente terapêutico de indução de citotoxicidade |
MX347077B (es) | 2010-12-23 | 2017-04-10 | Janssen Biotech Inc | Mutantes fc de anticuerpos resistentes a proteasas activas. |
PT2673373T (pt) | 2011-02-08 | 2018-12-05 | Medimmune Llc | Anticorpos que ligam especificamente a toxina alfa de staphylococcus aureus e métodos de utilização |
EP3590965A1 (en) | 2011-03-29 | 2020-01-08 | Roche Glycart AG | Antibody fc variants |
US9738707B2 (en) | 2011-07-15 | 2017-08-22 | Biogen Ma Inc. | Heterodimeric Fc regions, binding molecules comprising same, and methods relating thereto |
RU2605390C2 (ru) | 2011-08-23 | 2016-12-20 | Рош Гликарт Аг | Биспецифические антитела, специфичные к антигенам, активирующим т-клетки, и опухолевому антигену, и способы их применения |
EP2807194A4 (en) | 2012-01-27 | 2015-12-02 | Gliknik Inc | FUSION PROTEINS WITH IGG2 HINGEOMS |
JO3820B1 (ar) | 2012-05-03 | 2021-01-31 | Regeneron Pharma | أجسام مضادة بشرية لـ fel d1وطرق لاستخدامها |
RU2014153674A (ru) | 2012-06-05 | 2016-07-27 | Регенерон Фармасьютикалз, Инк. | Способ получения полностью человеческих биспецифических антител с применением общей легкой цепи |
US20140154253A1 (en) * | 2012-07-13 | 2014-06-05 | Zymeworks Inc. | Bispecific Asymmetric Heterodimers Comprising Anti-CD3 Constructs |
WO2014022540A1 (en) * | 2012-08-02 | 2014-02-06 | Regeneron Pharmaceuticals, Inc. | Multivalent antigen-binding proteins |
JOP20200236A1 (ar) | 2012-09-21 | 2017-06-16 | Regeneron Pharma | الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها |
NZ630563A (en) | 2012-09-27 | 2017-04-28 | Merus Nv | Bispecific igg antibodies as t cell engagers |
US9714291B2 (en) | 2012-10-05 | 2017-07-25 | Kyowa Hakko Kirin Co., Ltd | Heterodimer protein composition |
KR20150064068A (ko) | 2012-10-08 | 2015-06-10 | 로슈 글리카트 아게 | 2개의 Fab 단편을 포함하는 FC-부재 항체 및 이용 방법 |
TWI635098B (zh) * | 2013-02-01 | 2018-09-11 | 再生元醫藥公司 | 含嵌合恆定區之抗體 |
KR20230073341A (ko) * | 2013-07-05 | 2023-05-25 | 젠맵 에이/에스 | 인간화 또는 키메라 cd3 항체 |
BR112016000666A2 (pt) * | 2013-07-12 | 2017-10-03 | Zymeworks Inc | Constructos de ligação de antígeno cd3 e cd19 biespecíficos |
PL3192812T3 (pl) * | 2013-12-17 | 2020-10-19 | Genentech, Inc. | Przeciwciała anty-CD3 i sposoby ich zastosowania |
CA2925677A1 (en) | 2013-12-20 | 2015-06-25 | F. Hoffmann-La Roche Ag | Bispecific her2 antibodies and methods of use |
TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對pd-1的人類抗體 |
TWI754319B (zh) | 2014-03-19 | 2022-02-01 | 美商再生元醫藥公司 | 用於腫瘤治療之方法及抗體組成物 |
EP3699198A1 (en) | 2014-11-17 | 2020-08-26 | Regeneron Pharmaceuticals, Inc. | Methods for tumor treatment using cd3xcd20 bispecific antibody |
JP6773679B2 (ja) | 2015-03-30 | 2020-10-21 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | Fcガンマ受容体に対する結合が低下した重鎖定常領域 |
GB201506407D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
MD3353212T2 (ro) | 2015-09-23 | 2022-03-31 | Regeneron Pharma | Anticorpi bispecifici anti-CD3 optimizați și utilizările acestora |
BR112018012929A2 (pt) | 2015-12-22 | 2018-12-11 | Regeneron Pharma | anticorpos anti-cd20/anti-cd3 biespecíficos para tratar leucemia linfoblástica aguda |
JP2020503260A (ja) | 2016-11-15 | 2020-01-30 | ジェネンテック, インコーポレイテッド | 抗cd20/抗cd3二重特異性抗体による処置のための投与 |
-
2015
- 2015-03-17 TW TW109123150A patent/TWI754319B/zh active
- 2015-03-17 TW TW104108403A patent/TWI701042B/zh active
- 2015-03-18 LT LTEP19188693.6T patent/LT3594238T/lt unknown
- 2015-03-18 RS RS20210618A patent/RS61856B1/sr unknown
- 2015-03-18 ES ES19188693T patent/ES2868330T3/es active Active
- 2015-03-18 ES ES15714116T patent/ES2752156T3/es active Active
- 2015-03-18 EP EP19188693.6A patent/EP3594238B1/en active Active
- 2015-03-18 MX MX2016012094A patent/MX2016012094A/es active IP Right Grant
- 2015-03-18 CN CN202110412625.9A patent/CN113045669A/zh active Pending
- 2015-03-18 US US14/661,334 patent/US10550193B2/en active Active
- 2015-03-18 AU AU2015231295A patent/AU2015231295C1/en active Active
- 2015-03-18 PT PT191886936T patent/PT3594238T/pt unknown
- 2015-03-18 WO PCT/US2015/021322 patent/WO2015143079A1/en active Application Filing
- 2015-03-18 EP EP15714116.9A patent/EP3119808B1/en active Active
- 2015-03-18 RS RS20191516A patent/RS59642B1/sr unknown
- 2015-03-18 SI SI201531600T patent/SI3594238T1/sl unknown
- 2015-03-18 MA MA055629A patent/MA55629A/fr unknown
- 2015-03-18 CN CN201580025902.3A patent/CN106459214B/zh active Active
- 2015-03-18 JP JP2016557946A patent/JP6559697B2/ja active Active
- 2015-03-18 SI SI201530916T patent/SI3119808T1/sl unknown
- 2015-03-18 HU HUE19188693A patent/HUE054397T2/hu unknown
- 2015-03-18 EP EP21151864.2A patent/EP3848395A1/en active Pending
- 2015-03-18 CA CA2943084A patent/CA2943084C/en active Active
- 2015-03-18 LT LTEP15714116.9T patent/LT3119808T/lt unknown
- 2015-03-18 EA EA201691858A patent/EA035164B1/ru unknown
- 2015-03-18 HU HUE15714116A patent/HUE046505T2/hu unknown
- 2015-03-18 PL PL19188693T patent/PL3594238T3/pl unknown
- 2015-03-18 DK DK19188693.6T patent/DK3594238T3/da active
- 2015-03-18 PT PT157141169T patent/PT3119808T/pt unknown
- 2015-03-18 KR KR1020167029122A patent/KR102435081B1/ko active IP Right Grant
- 2015-03-18 ME MEP-2019-303A patent/ME03544B/me unknown
- 2015-03-18 PL PL15714116T patent/PL3119808T3/pl unknown
- 2015-03-18 DK DK15714116T patent/DK3119808T3/da active
-
2016
- 2016-09-15 MX MX2020004410A patent/MX2020004410A/es unknown
- 2016-09-15 IL IL247845A patent/IL247845B/en active IP Right Grant
- 2016-09-23 ZA ZA2016/06597A patent/ZA201606597B/en unknown
-
2019
- 2019-07-16 JP JP2019130949A patent/JP6831426B2/ja active Active
- 2019-11-21 CY CY20191101220T patent/CY1122315T1/el unknown
- 2019-12-02 HR HRP20192170TT patent/HRP20192170T1/hr unknown
- 2019-12-17 US US16/716,980 patent/US11434300B2/en active Active
-
2020
- 2020-02-10 IL IL272572A patent/IL272572B/en active IP Right Grant
-
2021
- 2021-05-06 CY CY20211100383T patent/CY1124090T1/el unknown
-
2022
- 2022-07-27 US US17/875,295 patent/US20230220101A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1124090T1 (el) | Συνθεσεις αντισωματων για τη θεραπεια ογκων | |
CY1124771T1 (el) | Αντισωματα εναντι-σορτιλiνης και μεθοδοι χρησης αυτων | |
CY1124723T1 (el) | Μορια προσδεσης pd-1 και μεθοδοι χρησης αυτων | |
CY1124944T1 (el) | Βελτιστοποιημενα αμφιειδικα αντισωματα αντι-cd3 και χρησεις αυτων | |
CY1124747T1 (el) | Ανθρωπινα αντισωματα σε pd-1 | |
CY1123534T1 (el) | Αντισωματα που περιλαμβανουν τροποποιημενες βαριες σταθερες περιοχες | |
CY1121796T1 (el) | Συνθεσεις μονοσθενεις για δεσμευση cd28 και μεθοδοι χρησης | |
CY1124787T1 (el) | Αντισωματα anti-gitr και μεθοδοι χρησης αυτων | |
JOP20200237A1 (ar) | الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها | |
CL2018003583A1 (es) | Anticuerpos anti-pd-l1 y usos de los mismos. | |
AR106570A1 (es) | Anticuerpos anti-psma, moléculas de unión al antígeno biespecíficas que se unen a psma y cd3, y usos de estos | |
PE20190737A1 (es) | Anticuerpos anti-cd27 | |
EA201690447A1 (ru) | БИСПЕЦИФИЧЕСКИЕ МОНОВАЛЕНТНЫЕ ДИАТЕЛА, КОТОРЫЕ СПОСОБНЫ СВЯЗЫВАТЬСЯ С gpA33 И CD3, И ИХ ПРИМЕНЕНИЯ | |
EA201790060A1 (ru) | Биспецифические cd33- и cd3-связывающие белки | |
EA201491686A1 (ru) | Мультиспецифические антигенсвязывающие молекулы и их применения | |
CY1123275T1 (el) | Μορια συνδεσης ειδικα για il-21 και χρησεις αυτων | |
CY1120326T1 (el) | Αντισωματα αντι-ρ-σελεκτινης και μεθοδοι για τη χρηση και την ταυτοποιηση τους | |
MX2021003756A (es) | Composiciones farmaceuticas que comprenden anticuerpos anti cumulo de diferenciacion 37 (cd37) biespecificos. | |
EA202090303A2 (ru) | Композиции антител для лечения опухолей | |
AR099798A1 (es) | Métodos y composiciones de anticuerpos para el tratamiento de tumores | |
MX2021015882A (es) | Fragmentos de unión a antígeno egfr y composiciones que los comprenden. | |
EA202092279A1 (ru) | Антитела к mica и/или micb и их применение | |
EA201892748A1 (ru) | Антитела к pd-l1 и варианты их применения | |
EA202090579A1 (ru) | Pd-1-связывающие молекулы и способы их применения | |
AR101565A1 (es) | Anticuerpos anti tigit |