MX2021002279A - Uso de espectroscopia raman en la purificacion corriente abajo. - Google Patents

Uso de espectroscopia raman en la purificacion corriente abajo.

Info

Publication number
MX2021002279A
MX2021002279A MX2021002279A MX2021002279A MX2021002279A MX 2021002279 A MX2021002279 A MX 2021002279A MX 2021002279 A MX2021002279 A MX 2021002279A MX 2021002279 A MX2021002279 A MX 2021002279A MX 2021002279 A MX2021002279 A MX 2021002279A
Authority
MX
Mexico
Prior art keywords
protein purification
raman spectroscopy
situ
intermediates
characterize
Prior art date
Application number
MX2021002279A
Other languages
English (en)
Inventor
Andrew Tustian
Christina Passno
Christopher Cowan
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2021002279A publication Critical patent/MX2021002279A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/145—Extraction; Separation; Purification by extraction or solubilisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4044—Concentrating samples by chemical techniques; Digestion; Chemical decomposition
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
    • G01N2001/4088—Concentrating samples by other techniques involving separation of suspended solids filtration

Abstract

Se proveen métodos y sistemas de espectroscopía Raman in situ para la caracterización o la cuantificación de un producto intermedio de purificación de proteínas y/o la fracción concentrada final durante la producción o preparación. En una modalidad, se usa espectroscopía Raman in situ para caracterizar o cuantificar los atributos críticos de calidad de intermedios de purificación de proteínas durante el procesamiento corriente abajo (es decir, después de la obtención del producto intermedio de purificación de proteínas). Por ejemplo, los métodos y sistemas de espectroscopía Raman in situ descritos se pueden usar para caracterizar y cuantificar intermedios de purificación de proteínas a medida que se purifican los productos intermedios de purificación de proteínas, se condensan o se formulan de otra forma en el producto farmacéutico final que se comercializará o se administrará.
MX2021002279A 2018-08-27 2019-08-26 Uso de espectroscopia raman en la purificacion corriente abajo. MX2021002279A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862723188P 2018-08-27 2018-08-27
PCT/US2019/048100 WO2020046793A1 (en) 2018-08-27 2019-08-26 Use of raman spectroscopy in downstream purification

Publications (1)

Publication Number Publication Date
MX2021002279A true MX2021002279A (es) 2021-05-27

Family

ID=68063018

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021002279A MX2021002279A (es) 2018-08-27 2019-08-26 Uso de espectroscopia raman en la purificacion corriente abajo.

Country Status (13)

Country Link
US (2) US11358984B2 (es)
EP (1) EP3774841A1 (es)
JP (1) JP2021535739A (es)
KR (1) KR20210052389A (es)
CN (1) CN112218877A (es)
AU (1) AU2019329686A1 (es)
BR (1) BR112020024296A2 (es)
CA (1) CA3100035A1 (es)
EA (1) EA202092684A1 (es)
IL (1) IL280880A (es)
MX (1) MX2021002279A (es)
SG (1) SG11202011970TA (es)
WO (1) WO2020046793A1 (es)

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