AR051836A1 - Antagonistas de receptor 3 simil toll metodos y usos - Google Patents

Antagonistas de receptor 3 simil toll metodos y usos

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Publication number
AR051836A1
AR051836A1 ARP050104988A ARP050104988A AR051836A1 AR 051836 A1 AR051836 A1 AR 051836A1 AR P050104988 A ARP050104988 A AR P050104988A AR P050104988 A ARP050104988 A AR P050104988A AR 051836 A1 AR051836 A1 AR 051836A1
Authority
AR
Argentina
Prior art keywords
tlr3
toll
antagonists
nros
seq
Prior art date
Application number
ARP050104988A
Other languages
English (en)
Original Assignee
Centocor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centocor Inc filed Critical Centocor Inc
Publication of AR051836A1 publication Critical patent/AR051836A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/567—Framework region [FR]
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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Abstract

Se describen antagonistas de receptor 3 símil Toll (TLR3), polinucleotidos que codifican antagonistas de TLR3 o sus fragmentos, y métodos para su preparacion y uso. Reivindicacion 1: Un antagonista de receptor 3 símil Toll (TLR3) que inhibe la produccion celular de una citoquina seleccionada del grupo que consiste en IL-6, IL-8 y MIP1-alfa. Reivindicacion 2: Un anticuerpo aislado que reacciona con TLR3 que tiene capacidad de union con el antígeno de un anticuerpo monoclonal que comprende las secuencias de aminoácidos de las regiones determinantes de complementariedad (CDR) de cadenas pesadas como se muestra en SEQ ID Nros: 9, 11 y 13 y las secuencias de aminoácidos de los CDR de cadenas livianas como se muestra en SEQ ID Nros: 19, 21 y 23. Reivindicacion 29: Una composicion farmacéutica que comprende el anticuerpo aislado de acuerdo con la reivindicacion 2 y un portador farmacéuticamente aceptable. Reivindicacion 39: Una línea celular de hibridoma que produce el anticuerpo de acuerdo con la reivindicacion 2.
ARP050104988A 2004-11-30 2005-11-29 Antagonistas de receptor 3 simil toll metodos y usos AR051836A1 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US63181504P 2004-11-30 2004-11-30
US63639904P 2004-12-15 2004-12-15
US64187705P 2005-01-06 2005-01-06
US71319505P 2005-08-31 2005-08-31
US72761005P 2005-10-18 2005-10-18

Publications (1)

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AR051836A1 true AR051836A1 (es) 2007-02-14

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ARP050104988A AR051836A1 (es) 2004-11-30 2005-11-29 Antagonistas de receptor 3 simil toll metodos y usos

Country Status (16)

Country Link
US (1) US8153583B2 (es)
EP (2) EP1824514B1 (es)
JP (2) JP5039560B2 (es)
KR (1) KR101317264B1 (es)
AR (1) AR051836A1 (es)
AU (1) AU2005311894A1 (es)
BR (1) BRPI0518664A2 (es)
CA (1) CA2589636C (es)
EA (1) EA200701192A1 (es)
HK (2) HK1111360A1 (es)
IL (1) IL183541A (es)
MX (1) MX2007006442A (es)
NO (1) NO20073293L (es)
NZ (1) NZ555475A (es)
TW (1) TWI487535B (es)
WO (1) WO2006060513A2 (es)

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EP1945820B1 (en) * 2005-10-27 2013-08-28 Janssen Biotech, Inc. Toll like receptor 3 modulators, methods and uses
US8066981B2 (en) * 2006-11-14 2011-11-29 The Texas A & M University System Compositions and methods related to toll-like receptor-3
JP2010527633A (ja) * 2007-05-25 2010-08-19 セントコア・オーソ・バイオテツク・インコーポレーテツド Ｔｏｌｌ様受容体３モジュレーター及びその使用
US8470979B2 (en) 2007-12-07 2013-06-25 Zymogenetics, Inc. Humanized antibody molecules specific for IL-31
US7982007B2 (en) * 2007-12-26 2011-07-19 Centocor, Inc. Cynomolgus toll-like receptor 3
CA2726512A1 (en) * 2008-06-09 2009-12-17 Novartis Ag Antibodies against neisserial factor h binding protein
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