CN1468209A - 0-乙酰水杨酸与碱性氨基酸的稳定盐 - Google Patents
0-乙酰水杨酸与碱性氨基酸的稳定盐 Download PDFInfo
- Publication number
- CN1468209A CN1468209A CNA018158811A CN01815881A CN1468209A CN 1468209 A CN1468209 A CN 1468209A CN A018158811 A CNA018158811 A CN A018158811A CN 01815881 A CN01815881 A CN 01815881A CN 1468209 A CN1468209 A CN 1468209A
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- composition
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- temperature
- acetylsalicylic acid
- glycine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
Description
Claims (21)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10034802A DE10034802A1 (de) | 2000-07-18 | 2000-07-18 | Stabile Salze von O-Acetylsalicylsäure mit basischen Aminosäuren |
DE10034802.5 | 2000-07-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1468209A true CN1468209A (zh) | 2004-01-14 |
CN1205176C CN1205176C (zh) | 2005-06-08 |
Family
ID=7649258
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB018158811A Expired - Fee Related CN1205176C (zh) | 2000-07-18 | 2001-07-05 | O-乙酰水杨酸与碱性氨基酸的稳定盐 |
Country Status (34)
Country | Link |
---|---|
US (2) | US6773724B2 (zh) |
EP (1) | EP1365737B1 (zh) |
JP (2) | JP2004507463A (zh) |
KR (1) | KR100773658B1 (zh) |
CN (1) | CN1205176C (zh) |
AR (1) | AR030305A1 (zh) |
AT (1) | ATE293589T1 (zh) |
AU (2) | AU7847101A (zh) |
BR (1) | BR0112538A (zh) |
CA (1) | CA2416288C (zh) |
CR (1) | CR6888A (zh) |
CZ (1) | CZ300337B6 (zh) |
DE (2) | DE10034802A1 (zh) |
DK (1) | DK1365737T3 (zh) |
EC (1) | ECSP034437A (zh) |
ES (1) | ES2241849T3 (zh) |
GT (1) | GT200100134A (zh) |
HK (1) | HK1061811A1 (zh) |
HR (1) | HRP20030108B1 (zh) |
HU (1) | HUP0302053A3 (zh) |
IL (2) | IL153873A0 (zh) |
MX (1) | MXPA03000510A (zh) |
MY (1) | MY134521A (zh) |
NO (1) | NO20030222D0 (zh) |
PE (1) | PE20020267A1 (zh) |
PL (1) | PL204593B1 (zh) |
PT (1) | PT1365737E (zh) |
RS (1) | RS50329B (zh) |
SK (1) | SK286162B6 (zh) |
SV (1) | SV2002000557A (zh) |
TW (1) | TWI299729B (zh) |
UY (1) | UY26841A1 (zh) |
WO (1) | WO2002005782A2 (zh) |
ZA (1) | ZA200300469B (zh) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101248036A (zh) * | 2005-06-02 | 2008-08-20 | 拜耳医药保健股份公司 | 邻乙酰基水杨酸与碱性氨基酸的盐和甘氨酸的稳定的活性物质络合物 |
CN101633624A (zh) * | 2009-08-04 | 2010-01-27 | 蚌埠丰原医药科技发展有限公司 | 改进的赖氨匹林的制备方法 |
CN101314029B (zh) * | 2008-06-18 | 2010-12-08 | 四川省农业科学院实验场 | 乙酰水杨酸肽及其制备方法 |
CN102503845A (zh) * | 2011-09-28 | 2012-06-20 | 广州普星药业有限公司 | 一种dl-赖氨酸阿司匹林盐的制备方法及其应用 |
CN110114333A (zh) * | 2016-12-23 | 2019-08-09 | 文塔里昂有限责任公司 | 赖氨酸乙酰水杨酸盐·甘氨酸颗粒的改进合成 |
CN113105326A (zh) * | 2021-03-24 | 2021-07-13 | 海南卓华制药有限公司 | 赖氨匹林的制备方法及应用 |
CN114478287A (zh) * | 2021-12-31 | 2022-05-13 | 蚌埠丰原医药科技发展有限公司 | 一种赖氨匹林晶型及制备方法和应用 |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6346510B1 (en) | 1995-10-23 | 2002-02-12 | The Children's Medical Center Corporation | Therapeutic antiangiogenic endostatin compositions |
DE10202019A1 (de) * | 2002-01-18 | 2003-07-24 | Bayer Ag | Stabile Salze von o-Acetylsalicylsäure mit basischen Aminosäuren II |
US8142810B2 (en) | 2002-05-30 | 2012-03-27 | The Procter & Gamble Company | Dietary method for modulating glucose metabolism and associated conditions and increasing longevity |
ATE442352T1 (de) * | 2003-05-16 | 2009-09-15 | Cephalon France | Verfahren zur herstellung von modafinil |
US20060063930A1 (en) * | 2004-08-20 | 2006-03-23 | Agoston Gregory E | Compositions and methods comprising proteinase activated receptor antagonists |
US20060166901A1 (en) * | 2005-01-03 | 2006-07-27 | Yu Ruey J | Compositions comprising O-acetylsalicyl derivatives of aminocarbohydrates and amino acids |
DE102005049293A1 (de) * | 2005-10-15 | 2007-04-26 | Bayer Healthcare Ag | Kombinationspräparate von Salzen oder o-Acetylsalicylsäure |
WO2008007171A1 (en) | 2006-07-09 | 2008-01-17 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of aspirin |
US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
KR101853971B1 (ko) | 2007-06-04 | 2018-05-02 | 테크필즈 인크 | 매우 높은 피부 및 막 침투율을 가지는 비스테로이드성 소염제(nsaia) 약물전구체 및 이들의 새로운 의약적 용도 |
DE102008004386A1 (de) | 2008-01-14 | 2009-07-23 | Activaero Gmbh | Verwendung eines Acetylsalicylsäuresalzes zur Behandlung viraler Infektionen |
US20100120727A1 (en) * | 2008-11-12 | 2010-05-13 | Kyphia Pharmaceuticals, Inc. | Eflornithine Prodrugs, Conjugates and Salts, and Methods of Use Thereof |
BRPI0922263B1 (pt) | 2008-12-04 | 2021-08-31 | Chongxi Yu | Composição de alta penetração de um fármaco principal, e seus usos |
EP2445861B1 (en) * | 2009-06-25 | 2014-03-26 | Tetra, Sia | Novel acetylsalicylic acid salts |
FR2965261B1 (fr) | 2009-09-30 | 2012-10-26 | Holis Technologies | Procede de preparation d'un sel d'acide o-acetylsalicylique d'un acide amine basique et composition obtenue par ce procede |
FR2950625B1 (fr) * | 2009-09-30 | 2016-12-02 | Holis Tech | Procede de preparation d'un sel d'acide o-acetylsalicylique d'un acide amine basique et composition obtenue |
FR2973370B1 (fr) * | 2011-03-29 | 2013-05-03 | Holis Technologies | Procede a faible cout pour la preparation d'un acide o-acetylsalicyclique et d'un acide amine basique |
IN2014KN02583A (zh) | 2012-01-18 | 2015-05-08 | Techfields Pharma Co Ltd | |
CN102976962B (zh) * | 2012-11-20 | 2015-02-04 | 南京工业大学 | L-鸟氨酸阿司匹林复盐及其制备方法和应用 |
FR3021654B1 (fr) | 2014-05-28 | 2016-06-24 | Unither Pharmaceuticals | Procede de preparation d'un sel d'acide acetylsalicylique et d'un acide amine basique |
US11096949B2 (en) | 2017-05-30 | 2021-08-24 | Rhoshan Pharmaceuticals, Inc. | In-vial deposition of a stable, sterile and crystalline O-acetyl salicylic acid |
KR20200035047A (ko) * | 2017-08-03 | 2020-04-01 | 산텐 세이야꾸 가부시키가이샤 | 클로르헥시딘을 함유하는 의약 조성물 |
AU2023205426A1 (en) | 2022-01-05 | 2024-06-13 | Aspiair Gmbh | Improved synthesis of lysine acetylsalicylate · glycine particles |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2115060A1 (en) * | 1970-11-26 | 1972-07-07 | Metabio | Freeze-dried acetylsalicylates of lysine and arginine - easily prepd derivs of aspirin |
ES388158A1 (es) * | 1971-02-11 | 1974-03-16 | Liade Sa Lab | Procedimiento de obtencion de sales solubles del acido ace-til salicilico. |
JPS4856815A (zh) * | 1971-11-13 | 1973-08-09 | ||
JPS55127345A (en) * | 1979-03-23 | 1980-10-02 | Kyowa Hakko Kogyo Co Ltd | Preparation of acetylsalicylic acid salt |
JPS5610110A (en) * | 1979-07-06 | 1981-02-02 | Green Cross Corp:The | Acetyl salicylate salt preparation for injection |
JPS56113741A (en) * | 1980-02-13 | 1981-09-07 | Mitsui Toatsu Chem Inc | Preparation of crystal of acetylsalicylic acid salt |
JPS5721345A (en) * | 1980-07-15 | 1982-02-04 | Mitsui Toatsu Chem Inc | Purification of acetylsalicylate salt |
CS247688B1 (cs) * | 1984-12-22 | 1987-01-15 | Evzen Kasafirek | Způsob výroby soli lysinu s kyselinou acetylsalicylovou |
JPS632929A (ja) * | 1986-06-20 | 1988-01-07 | Kao Corp | アセチルサリチル酸製剤 |
EP0499142A3 (en) * | 1991-02-09 | 1993-05-05 | Hoechst Aktiengesellschaft | Potentiation of the antireactive-antiasthmatic effect of inhaled loop diuretics by inhaled non steroidal anti-flammatory drugs |
DE4332093C2 (de) * | 1993-09-22 | 1995-07-13 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit dem Wirkstoff Acetylsalicylsäure und Verfahren zu seiner Herstellung |
-
2000
- 2000-07-18 DE DE10034802A patent/DE10034802A1/de not_active Withdrawn
-
2001
- 2001-07-05 IL IL15387301A patent/IL153873A0/xx unknown
- 2001-07-05 ES ES01956511T patent/ES2241849T3/es not_active Expired - Lifetime
- 2001-07-05 BR BR0112538-9A patent/BR0112538A/pt not_active IP Right Cessation
- 2001-07-05 AU AU7847101A patent/AU7847101A/xx active Pending
- 2001-07-05 AT AT01956511T patent/ATE293589T1/de not_active IP Right Cessation
- 2001-07-05 JP JP2002511715A patent/JP2004507463A/ja active Pending
- 2001-07-05 DK DK01956511T patent/DK1365737T3/da active
- 2001-07-05 DE DE50105985T patent/DE50105985D1/de not_active Expired - Lifetime
- 2001-07-05 CA CA002416288A patent/CA2416288C/en not_active Expired - Fee Related
- 2001-07-05 MX MXPA03000510A patent/MXPA03000510A/es active IP Right Grant
- 2001-07-05 PL PL365648A patent/PL204593B1/pl not_active IP Right Cessation
- 2001-07-05 SK SK67-2003A patent/SK286162B6/sk not_active IP Right Cessation
- 2001-07-05 WO PCT/EP2001/007669 patent/WO2002005782A2/de active IP Right Grant
- 2001-07-05 KR KR1020037000713A patent/KR100773658B1/ko not_active IP Right Cessation
- 2001-07-05 EP EP01956511A patent/EP1365737B1/de not_active Expired - Lifetime
- 2001-07-05 CN CNB018158811A patent/CN1205176C/zh not_active Expired - Fee Related
- 2001-07-05 CZ CZ20030164A patent/CZ300337B6/cs not_active IP Right Cessation
- 2001-07-05 PT PT01956511T patent/PT1365737E/pt unknown
- 2001-07-05 AU AU2001278471A patent/AU2001278471B2/en not_active Ceased
- 2001-07-05 HU HU0302053A patent/HUP0302053A3/hu unknown
- 2001-07-05 RS YUP-20/03A patent/RS50329B/sr unknown
- 2001-07-11 GT GT200100134A patent/GT200100134A/es unknown
- 2001-07-16 TW TW090117276A patent/TWI299729B/zh active
- 2001-07-16 MY MYPI20013365A patent/MY134521A/en unknown
- 2001-07-16 UY UY26841A patent/UY26841A1/es not_active Application Discontinuation
- 2001-07-16 US US09/906,497 patent/US6773724B2/en not_active Expired - Lifetime
- 2001-07-16 AR ARP010103378A patent/AR030305A1/es unknown
- 2001-07-17 PE PE2001000717A patent/PE20020267A1/es not_active Application Discontinuation
- 2001-07-17 SV SV2001000557A patent/SV2002000557A/es unknown
-
2003
- 2003-01-09 IL IL153873A patent/IL153873A/en not_active IP Right Cessation
- 2003-01-16 NO NO20030222A patent/NO20030222D0/no not_active Application Discontinuation
- 2003-01-17 CR CR6888A patent/CR6888A/es unknown
- 2003-01-17 ZA ZA200300469A patent/ZA200300469B/en unknown
- 2003-01-17 EC EC2003004437A patent/ECSP034437A/es unknown
- 2003-02-17 HR HR20030108A patent/HRP20030108B1/xx not_active IP Right Cessation
-
2004
- 2004-07-07 HK HK04104934A patent/HK1061811A1/xx not_active IP Right Cessation
- 2004-08-09 US US10/915,652 patent/US7449198B2/en not_active Expired - Fee Related
-
2012
- 2012-03-28 JP JP2012072662A patent/JP2012131824A/ja active Pending
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101248036A (zh) * | 2005-06-02 | 2008-08-20 | 拜耳医药保健股份公司 | 邻乙酰基水杨酸与碱性氨基酸的盐和甘氨酸的稳定的活性物质络合物 |
CN101248036B (zh) * | 2005-06-02 | 2016-03-16 | 拜耳知识产权有限责任公司 | 邻乙酰基水杨酸与碱性氨基酸的盐和甘氨酸的稳定的活性物质络合物 |
CN101314029B (zh) * | 2008-06-18 | 2010-12-08 | 四川省农业科学院实验场 | 乙酰水杨酸肽及其制备方法 |
CN101633624A (zh) * | 2009-08-04 | 2010-01-27 | 蚌埠丰原医药科技发展有限公司 | 改进的赖氨匹林的制备方法 |
CN101633624B (zh) * | 2009-08-04 | 2013-05-01 | 蚌埠丰原医药科技发展有限公司 | 改进的赖氨匹林的制备方法 |
CN102503845A (zh) * | 2011-09-28 | 2012-06-20 | 广州普星药业有限公司 | 一种dl-赖氨酸阿司匹林盐的制备方法及其应用 |
CN110114333A (zh) * | 2016-12-23 | 2019-08-09 | 文塔里昂有限责任公司 | 赖氨酸乙酰水杨酸盐·甘氨酸颗粒的改进合成 |
CN110114333B (zh) * | 2016-12-23 | 2022-12-02 | 阿斯皮亚尔股份有限公司 | 赖氨酸乙酰水杨酸盐·甘氨酸颗粒的改进合成 |
CN113105326A (zh) * | 2021-03-24 | 2021-07-13 | 海南卓华制药有限公司 | 赖氨匹林的制备方法及应用 |
CN114478287A (zh) * | 2021-12-31 | 2022-05-13 | 蚌埠丰原医药科技发展有限公司 | 一种赖氨匹林晶型及制备方法和应用 |
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