CN104994879A - 治疗癌症和预防药物抗性的方法 - Google Patents

治疗癌症和预防药物抗性的方法 Download PDF

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Publication number
CN104994879A
CN104994879A CN201480007964.7A CN201480007964A CN104994879A CN 104994879 A CN104994879 A CN 104994879A CN 201480007964 A CN201480007964 A CN 201480007964A CN 104994879 A CN104994879 A CN 104994879A
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China
Prior art keywords
inhibitor
aldh
antibody
cancer
therapeutic agent
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CN201480007964.7A
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English (en)
Chinese (zh)
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D·拉哈
J·赛特尔曼
T·R·威尔逊
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of CN104994879A publication Critical patent/CN104994879A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
CN201480007964.7A 2013-02-22 2014-02-21 治疗癌症和预防药物抗性的方法 Pending CN104994879A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361768253P 2013-02-22 2013-02-22
US61/768,253 2013-02-22
US201361834317P 2013-06-12 2013-06-12
US61/834,317 2013-06-12
PCT/EP2014/053377 WO2014128235A1 (en) 2013-02-22 2014-02-21 Methods of treating cancer and preventing drug resistance

Publications (1)

Publication Number Publication Date
CN104994879A true CN104994879A (zh) 2015-10-21

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Family Applications (1)

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CN201480007964.7A Pending CN104994879A (zh) 2013-02-22 2014-02-21 治疗癌症和预防药物抗性的方法

Country Status (9)

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EP (1) EP2958592A1 (ja)
JP (1) JP2016509045A (ja)
KR (1) KR20150118159A (ja)
CN (1) CN104994879A (ja)
BR (1) BR112015018418A2 (ja)
CA (1) CA2900097A1 (ja)
HK (1) HK1211235A1 (ja)
MX (1) MX2015010791A (ja)
WO (1) WO2014128235A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109069632A (zh) * 2016-04-15 2018-12-21 伊莱利利公司 用于治疗结直肠癌的雷莫芦单抗和merestinib的组合
CN114010624A (zh) * 2021-12-13 2022-02-08 上海纳米技术及应用国家工程研究中心有限公司 双硫仑在增敏甲氨蝶呤对治疗肝癌药物中的应用
CN115429780A (zh) * 2021-06-01 2022-12-06 中国人民解放军军事科学院军事医学研究院 双硫仑防护电离辐射所致胃肠组织损伤的用途

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KR20150038068A (ko) 2012-08-17 2015-04-08 에프. 호프만-라 로슈 아게 코비메티닙 및 베무라피닙을 투여함을 포함하는 흑색종의 조합 치료법
WO2015059677A1 (en) * 2013-10-26 2015-04-30 Glaxosmithkline Intellectual Property (No.2) Limited Methods of treating cancer
WO2015095842A2 (en) * 2013-12-20 2015-06-25 Biomed Valley Discoveries, Inc. Methods and compositions for treating non-erk mapk pathway inhibitor-resistant cancers
WO2016168150A2 (en) * 2015-04-13 2016-10-20 The Board Of Regents Of The University Of Texas System Treatment for cancer metastasis
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MX2019008458A (es) 2017-01-17 2019-12-02 Heparegenix Gmbh Inhibidores de proteina cinasa para promover la regeneracion hepatica o reducir o prevenir la muerte de hepatocitos.
WO2019098288A1 (ja) * 2017-11-15 2019-05-23 学校法人 慶應義塾 抗腫瘍剤及び配合剤
KR20190056758A (ko) 2017-11-17 2019-05-27 주식회사 지뉴브 종양줄기세포 특성의 암을 치료하기 위한 항암 병용 요법
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KR20210049403A (ko) * 2019-10-25 2021-05-06 연세대학교 산학협력단 암의 예방 또는 치료용 조성물

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CA2900097A1 (en) 2014-08-28
EP2958592A1 (en) 2015-12-30
BR112015018418A2 (pt) 2017-07-18
KR20150118159A (ko) 2015-10-21

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