CN102920719A - Compound veterinary medicine preparation for treating avian enteritis type colibacillosis - Google Patents
Compound veterinary medicine preparation for treating avian enteritis type colibacillosis Download PDFInfo
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- CN102920719A CN102920719A CN2012104675825A CN201210467582A CN102920719A CN 102920719 A CN102920719 A CN 102920719A CN 2012104675825 A CN2012104675825 A CN 2012104675825A CN 201210467582 A CN201210467582 A CN 201210467582A CN 102920719 A CN102920719 A CN 102920719A
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Abstract
The invention belongs to a compound veterinary medicine preparation for treating avian enteritis type colibacillosis in veterinary medicine. The preparation consists of three main medicinal components and an adjuvant; three main medicinal components include 3.25%W/W of neomycin sulfate, 0.81%W/W of lactic acid TMP (Trimethoprim) and 10%W/W of glutamine; and the adjuvant includes 85.94%W/W of glucose. The veterinary medicine preparation is utilized to treat the avian enteritis type colibacillosis. A processing technology of the composition is as follows: respectively grinding, screening and accurately weighing the components according to the necessary ratio, mixing for 25 min, and performing semi-finished product quality control, split charging, packaging and finished product quality control to obtain the composition. An application method is as follows: drinking the water in 1% level of the composition, and a course of treatment lasts for 4 days. The compound veterinary medicine preparation provided by the invention is remarkable in efficacy of avian enteritis type colibacillosis, low in drug resistance, safe and low toxicity, thereby having good popularization and application value.
Description
Technical field
The present invention relates to a kind of compound recipe veterinary drug preparation and preparation technology who treats fowl enteritis type colibacillosis.
Background technology
The enteritis type colibacillosis is one of the most common in the poultry cultivation, that harm is the most serious disease.In veterinary clinic, birds infects the enteritis type escherichia coli after being ill, often shows as diarrhoea, and appetite descends, and feather is slightly random, the feedstuff dyspepsia, and poor growth, mortality increases gradually, and fertility performance reduces, and poultry farming is caused more serious economic loss.And infect this after being ill, and can cause the poultry resistance to reduce, be easy to secondary coccidiosis, clostridial disease etc., aggravate disease, therapeutic effect is undesirable, and mortality rate raises, and sometimes up to more than 50%, economic loss is more serious.
Control enteritis type colibacillosis infects, and method commonly used is to use the high-efficiency low-toxicity antimicrobial drug.Polygynax has that cost is lower, antibacterial action is strong, the residual advantage such as low of medicine, thereby is widely used in the treatment of enteritis type colibacillosis.But because of its a large amount of uses, produced certain drug resistance, curative effect is existing at present descends.
Adopt lactic acid TMP and polygynax compatibility can play the effects such as Synergistic, reduction drug resistance, minimizing drug dose, reduction side effect, add in addition intestinal mucosa renovation agent glutamine, can obviously improve the intestinal mucosa cellular metabolism, promote the reparation of intestinal mucosa, strengthen mucosal immunity power and the resistance of poultry, the prevention secondary infection.This makes up not only treating both the principal and secondary aspects of a disease, strengthens therapeutic effect, the prevention secondary infection, and also safe and effective, be difficult for producing drug resistance.For the consideration of these aspects, carried out the development of this compound medicine just.
Summary of the invention
Main purpose of the present invention is for compound recipe veterinary drug preparation and the preparation technology of a kind of sensitivity, the treatment enteritis type colibacillosis that efficient, drug resistance is low, easy to use are provided.
For achieving the above object, the present invention has adopted following embodiment through Multitest:
A kind of compound recipe veterinary drug preparation of preventing and treating fowl enteritis type colibacillosis.Consisting of of said preparation: polygynax 2.75-3.5%, lactic acid TMP 0.69-0.88%, glutamine 10%, other are glucose.
The invention has the beneficial effects as follows:
The present invention is comprised of antibacterials polygynax, Trimethoprim lactic acid TMP, intestinal mucosa renovation agent glutamine and adjuvant glucose.Through a large amount of tests, said preparation has good therapeutic effect to fowl enteritis type colibacillosis, and can prevent secondary infection, be difficult for producing drug resistance, thereby can also reduce side effects of pharmaceutical drugs and drug residue by reducing drug dose, safe and effective, a kind of compound recipe veterinary drug preparation of control fowl enteritis type colibacillosis of efficient, stable, low toxicity is provided for aquaculture.
The specific embodiment
In conjunction with a preferred embodiment, the specific embodiment of the present invention is described in detail, and do not limit the scope of the invention to specific details.
Embodiment 1
| ? | 100g |
| Polygynax | 2.75g(in effective content) |
| Lactic acid TMP | 0.69g(in effective content) |
| Glutamine | 10g(is in effective content) |
| Glucose | Add to 100g |
Preparation method and step: each composition is pulverized respectively, sieved, in the accurate weighing of required ratio, mix 25min, semi-finished product quality inspection, packing, packing, finished product quality inspection and get final product.
In use, this preparation 100g is watered 100L is used for the treatment of clinical fowl enteritis type colibacillosis, being used in conjunction 4 is a course for the treatment of, and withdrawal time is 5.
The effective percentage of said preparation treatment fowl enteritis type colibacillosis is 62%, and cure rate is 50%, compares with 2.75% polygynax soluble powder, and effective percentage and cure rate exceed respectively 18%, 16%, and curative effect is undesirable.
Embodiment 2
| ? | 100g |
| Polygynax | 3g(is in effective content) |
| Lactic acid TMP | 0.75g(in effective content) |
| Glutamine | 10g(is in effective content) |
| Glucose | Add to 100g |
Preparation method and step: each composition is pulverized respectively, sieved, in the accurate weighing of required ratio, mix 25min, semi-finished product quality inspection, packing, packing, finished product quality inspection and get final product.
In use, this preparation 100g is watered 100L is used for the treatment of clinical fowl enteritis type colibacillosis, being used in conjunction 4 is a course for the treatment of, and withdrawal time is 5.
The effective percentage of said preparation treatment fowl enteritis type colibacillosis is 82%, and cure rate is 71%, compares with 3% polygynax soluble powder, and effective percentage and cure rate exceed respectively 18%, 19%, and curative effect is medium.
Embodiment 3
| ? | 100g |
| Polygynax | 3.25g(in effective content) |
| Lactic acid TMP | 0.81g(in effective content) |
| Glutamine | 10g(is in effective content) |
| Glucose | Add to 100g |
Preparation method and step: each composition is pulverized respectively, sieved, in the accurate weighing of required ratio, mix 25min, semi-finished product quality inspection, packing, packing, finished product quality inspection and get final product.
In use, this preparation 100g is watered 100L is used for the treatment of clinical fowl enteritis type colibacillosis, being used in conjunction 4 is a course for the treatment of, and withdrawal time is 5.
The effective percentage of said preparation treatment fowl enteritis type colibacillosis is 93%, and cure rate is 82%, compares with 3.25% polygynax soluble powder, and effective percentage and cure rate exceed respectively 22%, 20%, and curative effect is ideal.
Embodiment 4
| ? | 100g |
| Polygynax | 3.5g(in effective content) |
| Lactic acid TMP | 0.88g(in effective content) |
| Glutamine | 10g(is in effective content) |
| Glucose | Add to 100g |
Preparation method and step: each composition is pulverized respectively, sieved, in the accurate weighing of required ratio, mix 25min, semi-finished product quality inspection, packing, packing, finished product quality inspection and get final product.
In use, this preparation 100g is watered 100L is used for the treatment of clinical fowl enteritis type colibacillosis, being used in conjunction 4 is a course for the treatment of, and withdrawal time is 5.
The effective percentage of said preparation treatment fowl enteritis type colibacillosis is 94%, cure rate is 82%, compare with 3.5% polygynax soluble powder, effective percentage and cure rate exceed respectively 21%, 22%, curative effect is ideal, but very approaching with embodiment three combination curative effects, but the cost increase, not as embodiment three combination ideals.
Polygynax 3.25%W/W, lactic acid TMP0.81%W/W, glutamine 10%W/W, glucose 85.94% are adopted in this combination, have efficient, safe, stable characteristics, are a kind of very good anti-fowl enteritis type colibacillosis compound preparations.
Above-described embodiment; comprise drug regimen, preparation technology and clinical verification; invention has been described; these descriptions are illustrative but not determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (2)
1. compound recipe veterinary drug preparation for the treatment of fowl enteritis type colibacillosis, consisting of of said preparation: polygynax, lactic acid TMP, three kinds of main pharmaceutical compositions of glutamine, wherein polygynax 3.25%W/W, lactic acid TMP 0.81%W/W, glutamine 10%W/W, described adjuvant is glucose, and the adjuvant ratio is 85.94%W/W.
2. the preparation method of described treatment fowl enteritis type colibacillosis compound recipe veterinary drug preparation according to claim 1, it is characterized in that carrying out according to the following steps: polygynax, lactic acid TMP, glutamine and adjuvant are pulverized respectively, sieved, in the accurate weighing of required ratio, mix 25min, make it mix homogeneously, packing and get final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012104675825A CN102920719A (en) | 2012-11-19 | 2012-11-19 | Compound veterinary medicine preparation for treating avian enteritis type colibacillosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012104675825A CN102920719A (en) | 2012-11-19 | 2012-11-19 | Compound veterinary medicine preparation for treating avian enteritis type colibacillosis |
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| CN102920719A true CN102920719A (en) | 2013-02-13 |
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| CN2012104675825A Pending CN102920719A (en) | 2012-11-19 | 2012-11-19 | Compound veterinary medicine preparation for treating avian enteritis type colibacillosis |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973542A (en) * | 2012-12-04 | 2013-03-20 | 中山大学 | Micromolecular substance for improving sensitivity of bacteria to antibiotics |
| CN103690940A (en) * | 2013-12-26 | 2014-04-02 | 南阳新先锋制药有限公司 | Compound dimetridazole premix for preventing and treating poultry enterovirus syndrome |
| CN103705528A (en) * | 2013-12-26 | 2014-04-09 | 南阳新先锋制药有限公司 | Compound colinflosaxin soluble powder for preventing and treating poultry colibacillosis |
| US9962351B2 (en) | 2012-12-04 | 2018-05-08 | Sun Yat-Sen University | Small molecule substance for improving sensitivity of bacteria to antibiotics |
-
2012
- 2012-11-19 CN CN2012104675825A patent/CN102920719A/en active Pending
Non-Patent Citations (3)
| Title |
|---|
| 侯晋兰 等: "抗菌药联合应用可提高畜禽疾病治疗效果", 《山西农业》 * |
| 无: "谷氨酰胺添加物可提高断奶仔猪对大肠杆菌的屏障作用", 《今日养猪业》 * |
| 陈玉楼: "硫酸新霉素治疗鸡大肠杆菌病的疗效观察", 《山东家禽》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973542A (en) * | 2012-12-04 | 2013-03-20 | 中山大学 | Micromolecular substance for improving sensitivity of bacteria to antibiotics |
| CN102973542B (en) * | 2012-12-04 | 2015-04-01 | 中山大学 | Micromolecular substance for improving sensitivity of bacteria to antibiotics |
| US9962351B2 (en) | 2012-12-04 | 2018-05-08 | Sun Yat-Sen University | Small molecule substance for improving sensitivity of bacteria to antibiotics |
| CN103690940A (en) * | 2013-12-26 | 2014-04-02 | 南阳新先锋制药有限公司 | Compound dimetridazole premix for preventing and treating poultry enterovirus syndrome |
| CN103705528A (en) * | 2013-12-26 | 2014-04-09 | 南阳新先锋制药有限公司 | Compound colinflosaxin soluble powder for preventing and treating poultry colibacillosis |
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Application publication date: 20130213 |