CN104288465B - Prevent the combination of enteric plant essential oil and its preparation process of grice diarrhoea - Google Patents
Prevent the combination of enteric plant essential oil and its preparation process of grice diarrhoea Download PDFInfo
- Publication number
- CN104288465B CN104288465B CN201410575910.2A CN201410575910A CN104288465B CN 104288465 B CN104288465 B CN 104288465B CN 201410575910 A CN201410575910 A CN 201410575910A CN 104288465 B CN104288465 B CN 104288465B
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- Prior art keywords
- essential oil
- grice diarrhoea
- combination
- enteric
- prevent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
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- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
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- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of " the enteric plant essential oil combination of prevention grice diarrhoea and its preparation processes ", are mainly used for preventing grice diarrhoea, are particularly suitable for substitute antibiotics to prevent the diarrhea of weaning period piglet.The pharmaceutical composition of the present invention is mainly made of carvacrol, thymol and galic essential oil, after macroporous resin adsorption, enteric coating is used in combination, so that drug reduces volatilizing loss in storage and transportational process, and avoid influence to piglet palatability and feed intake, drug ingedient reaches small intestine and directly plays a role, and curative effect is more preferably.This product can be used to prevent the diarrhea of piglet with substitute antibiotics, there is important social effect and significant economic value.
Description
Technical field
The present invention " the enteric plant essential oil combination of prevention grice diarrhoea and its preparation process " belongs to feed additive field,
It is mainly used for preventing grice diarrhoea, is particularly suitable for substitute antibiotics to prevent the diarrhea of weaning period piglet.
Background technology
Grice diarrhoea, especially weaning period grice diarrhoea are the key common technology problems that pig-breeding industry is faced.
Piglet due to early weaning, in addition its developing immune system is unsound, digestive system development is unsound, weaning stress,
Factors stress be waited by changing feed generation, it is easy to lead to diarrhea, malnutrition, to influence the growth performance of piglet.Statistics
Data show that grice diarrhoea accounts for the 40% of the piglet death rate.Therefore, grice diarrhoea is controlled, is to ensure that the pass of pig farm culture efficiency
Key.Common practice is that the zinc oxide of the antibiotic and high dose of high dose is added in feed at present.Wherein, colistin with
Limitation of the dosage of kitasamycin considerably beyond feed medicated premix as defined in the Ministry of Agriculture.This is primarily due to abuse for a long time
Antibiotic produces drug-fast bacteria.Antibiotic dosage is low at all without effect.Abuse of antibiotics, to depending on for existence for the mankind
Environment does great damage, and the residue of veterinary drug in food affects the food security of people.Therefore, anti-with the products substitution of safety
Raw usually prevention of diarrhea in piglets, at the focus of outer knowledgeable people in the industry.Product " the enteric of prevention grice diarrhoea of the present invention
Plants essential oil combines and its preparation process ", it is exactly for substitute antibiotics, to prevent the diarrhea of piglet.
Invention content
Product " the enteric plant essential oil combination of prevention grice diarrhoea and its preparation process " of the present invention, mainly by by Sheep's-parsley
Phenol, thymol and galic essential oil are composed.Wherein, the formula rate of carvacrol, thymol and galic essential oil is 1 ~ 3 part
Carvacrol, 1 ~ 3 part of thymol, 1 ~ 3 part of galic essential oil are composed.In the preparation, first carvacrol is mixed with galic essential oil
Uniformly, then by thymol with 5% ~ 10% Tween-80 ground and mixed it is uniform, finally the two is uniformly mixed, is configured to essential oil
Mixed liquor.The macroreticular resin of 1 ~ 3 times of amount of above-mentioned blend of essential oils weight is taken, and it is uniformly mixed with above-mentioned blend of essential oils,
Macroreticular resin is allowed to adsorb blend of essential oils completely.The macroreticular resin that this has been adsorbed to blend of essential oils, with ebullated bed coating method,
Wrap up one layer of enteric coating, wherein coatings dry weight is the 3% ~ 10% of essential oil macroreticular resin weight, dry, packaging.
Carvacrol（Carvacrol, Carvacrol）, there is colourless to the faint yellow stiff oil of special odor
Shape liquid.Has the function of anti-oxidant, sterilization.
Thymol（Thymol, 5- methyl -2- isopropyl-phenols）, there is the flaky crystal of special aroma.With disinfection, sterilization
Effect.
Galic essential oil is multicomponent mixture, by allicin（C6H10OS2）, Allicin（C6H10O2S）And a variety of alkene
Propyl and methyl composition sulfide compound composition, have remove free radical, it is antibacterial, sterilize, effect of killing the virus.
After three's compatibility, has the function of good killing intestinal pathogenic micro.After essential oil is adsorbed with macroreticular resin,
The essential oil of liquid is converted into solid, increases the stability of product, also allows for being mixed with feed.
Since above-mentioned three kinds of ingredients all have volatility, in the decline for storing with causing content in transportational process, thus
Influence the performance of curative effect.In addition, the smell of three kinds of ingredients also influences whether the palatability of feed and the feed intake of piglet, and it is right
The oral mucosa of piglet has certain stimulation.Therefore, with the method for enteric coating, it is isolated with air, is made
It is not dissolved in mouth, and only in intestine of young pigs, just dissolving discharges, and gives full play to curative effect.
Specific implementation mode
Facility example 1
1 part of carvacrol is taken to be uniformly mixed with 1 part of galic essential oil.1 part of thymol separately is taken, and takes the tween-of its weight 3%
80, it grinds, is uniformly mixed altogether.Two kinds of mixtures are merged, are uniformly mixed.The macroreticular resin for taking 1 times of amount of blend of essential oils weight, fills
Divide mixing.The macroreticular resin for having adsorbed essential oil is set in ebullated bed, air blast makes into fluidisation shape, sprays into acrylic resin enteric coating
Material, it is the 3% of the macroreticular resin weight for having adsorbed essential oil to make its dry weight.Dry, packaging is to get to finished product.
Facility example 2
2 parts of carvacrols are taken to be uniformly mixed with 1 part of galic essential oil.1 part of thymol separately is taken, and takes the tween-of its weight 5%
80, it grinds, is uniformly mixed altogether.Two kinds of mixtures are merged, are uniformly mixed.The macroreticular resin for taking 2 times of amounts of blend of essential oils weight, fills
Divide mixing.The macroreticular resin for having adsorbed essential oil is set in ebullated bed, air blast makes into fluidisation shape, sprays into acrylic resin enteric coating
Material, it is the 5% of the macroreticular resin weight for having adsorbed essential oil to make its dry weight.Dry, packaging is to get to finished product.
Facility example 3
1 part of carvacrol is taken to be uniformly mixed with 2 parts of galic essential oils.1 part of thymol separately is taken, and takes the tween-of its weight 8%
80, it grinds, is uniformly mixed altogether.Two kinds of mixtures are merged, are uniformly mixed.The macroreticular resin for taking 3 times of amounts of blend of essential oils weight, fills
Divide mixing.The macroreticular resin for having adsorbed essential oil is set in ebullated bed, air blast makes into fluidisation shape, sprays into acrylic resin enteric coating
Material, it is the 6% of the macroreticular resin weight for having adsorbed essential oil to make its dry weight.Dry, packaging is to get to finished product.
Claims (1)
1. preventing the preparation method of the enteric plant essential oil combination of grice diarrhoea, it is characterised in that：The enteric plant essential oil group
Conjunction is composed of 1 part of carvacrol, 1 part of thymol and 1 part of galic essential oil；
First carvacrol is uniformly mixed with galic essential oil, then by thymol with 5% ~ 10% Tween-80 ground and mixed it is uniform, most
The two is uniformly mixed afterwards, is configured to essential oil mixed liquor；
The macroreticular resin of 1 ~ 3 times of amount of the essential oil mixed liquor weight is taken, and it is uniformly mixed with above-mentioned essential oil mixed liquor, is allowed big
Hole resin adsorbs essential oil mixed liquor completely；
The macroreticular resin for having adsorbed essential oil mixed liquor is wrapped up into one layer of enteric coating with ebullated bed coating method, wherein packet
Clothing layer dry weight is the 3% ~ 10% of the macroreticular resin weight for having adsorbed essential oil, dry, packaging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410575910.2A CN104288465B (en) | 2014-10-25 | 2014-10-25 | Prevent the combination of enteric plant essential oil and its preparation process of grice diarrhoea |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410575910.2A CN104288465B (en) | 2014-10-25 | 2014-10-25 | Prevent the combination of enteric plant essential oil and its preparation process of grice diarrhoea |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104288465A CN104288465A (en) | 2015-01-21 |
| CN104288465B true CN104288465B (en) | 2018-08-10 |
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| CN201410575910.2A Expired - Fee Related CN104288465B (en) | 2014-10-25 | 2014-10-25 | Prevent the combination of enteric plant essential oil and its preparation process of grice diarrhoea |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104800525A (en) * | 2015-05-20 | 2015-07-29 | 庞兴伟 | Medicine for preventing and treating pig diarrhoea |
| CN105076717B (en) * | 2015-07-14 | 2019-09-24 | 上海美农生物科技股份有限公司 | For improving breeding performonce fo animals and guaranteeing the feed addictive prescription and processing method of alimentary canal health |
| CN107125440A (en) * | 2016-02-29 | 2017-09-05 | 湖南晶天科技实业有限公司 | A kind of feed addictive enteric coating tannic acid and preparation method thereof and a kind of feed |
| CN107410729A (en) * | 2017-05-18 | 2017-12-01 | 钱信美 | A kind of pig feed additive |
| CN109549001A (en) * | 2018-12-26 | 2019-04-02 | 无锡正大生物股份有限公司 | A kind of suckling piglet nanometer coating plants essential oil and preparation method thereof |
| CN109645241A (en) * | 2019-02-26 | 2019-04-19 | 武汉华扬动物药业有限责任公司 | A kind of plants essential oil feed addictive and its preparation method and application |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101664113A (en) * | 2009-09-08 | 2010-03-10 | 北京资源亚太动物药品有限公司 | Enteric microcapsule of garlic essential oil and production method thereof |
| CN102038842A (en) * | 2010-12-01 | 2011-05-04 | 北京资源亚太动物药品有限公司 | Medicament for improving production performance of pigs and preparation method thereof |
-
2014
- 2014-10-25 CN CN201410575910.2A patent/CN104288465B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101664113A (en) * | 2009-09-08 | 2010-03-10 | 北京资源亚太动物药品有限公司 | Enteric microcapsule of garlic essential oil and production method thereof |
| CN102038842A (en) * | 2010-12-01 | 2011-05-04 | 北京资源亚太动物药品有限公司 | Medicament for improving production performance of pigs and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 大蒜素对断奶仔猪生长性能和腹泻率的影响;刘超良等;《养殖与饲料》;20090401(第4期);第50-51页 * |
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| CN104288465A (en) | 2015-01-21 |
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Granted publication date: 20180810 Termination date: 20191025 |