CN104523822B - A kind of pharmaceutical composition and preparation method thereof preventing and treating animal diarrhea disease - Google Patents
A kind of pharmaceutical composition and preparation method thereof preventing and treating animal diarrhea disease Download PDFInfo
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- CN104523822B CN104523822B CN201410817273.5A CN201410817273A CN104523822B CN 104523822 B CN104523822 B CN 104523822B CN 201410817273 A CN201410817273 A CN 201410817273A CN 104523822 B CN104523822 B CN 104523822B
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Abstract
The present invention provides a kind of pharmaceutical compositions and preparation method thereof for preventing and treating animal diarrhea disease, described pharmaceutical composition is made of scutelloside zinc, origanum oil and allicin, 2.5-30 parts of scutelloside zinc, 2.5-30 parts of origanum oil, 5-30 parts of allicin, are mixed by each component based on its parts by weight；Described pharmaceutical composition has good preventive and therapeutic effect to animal diarrhea disease, and has food calling and improve microbial population of animal intestinal tract effect, can effectively improve animal immunizing power, promote the rehabilitation of disease, long-term to add, and can promote growth of animal.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition and preparation method thereof, especially a kind of medicine for preventing and treating animal diarrhea disease
Compositions and preparation method thereof.
Background technique
In recent years, cultivation animal husbandry in China's had obtained powerful quick development, along with this development, corresponding animal disease
Disease is more and more, wherein by the animal diarrhea disease of the initiations such as bacterium, virus, helminth almost with each of growth of animal
Stage.Diarrhea is usually associated with the syntexis and the disorder of intestinal flora of animal.Up to the present development of the antibiotic in animal husbandry
In played significant role, the drug usage amount of the treatment animal diarrhea such as fluoroquinolones, aminoglycoside, tetracycline significantly increases
Add.But antibiotic not can solve the problem of microbial population of animal intestinal tract disorder, can accelerate the death of profitable strain in enteron aisle instead,
And the residual medicine being concerned, drug resistance, problem of environmental pollution can be caused.Therefore no drug residue, the enzyme of environmental protection, Chinese herbal and crude drugs preparations, micro- life
State preparation etc. is more and more developed and is used.
Application No. is 200810055634.1 applications for a patent for invention to disclose a kind of anti-bacteria agent for feeding, by origanum oil 2-10
Part and allicin 2-10 parts of composition, but in practical applications, discovery antibacterial effect in terms for the treatment of animal diarrhea disease is not good enough.
Summary of the invention
Technical problem to be solved by the present invention lies in provide a kind of pharmaceutical composition for preventing and treating animal diarrhea disease.
Another technical problem to be solved by this invention is to provide the pharmaceutical composition of above-mentioned prevention and treatment animal diarrhea disease
The preparation method of object.
In order to solve the above technical problems, the technical scheme is that
A kind of pharmaceutical composition preventing and treating animal diarrhea disease, is made of scutelloside zinc, origanum oil and allicin, by it
2.5-30 parts of parts by weight meter scutelloside zinc, 2.5-30 parts of origanum oil, 5-30 parts of allicin.
Preferably, the pharmaceutical composition of above-mentioned prevention and treatment animal diarrhea disease, based on its parts by weight 5 parts of scutelloside zinc,
10 parts of origanum oil, 20 parts of allicin.
Preferably, the pharmaceutical composition of above-mentioned prevention and treatment animal diarrhea disease, can by add different auxiliary material and
Conventional formulation preparation method is prepared into any pharmaceutical preparation, for drinking water, spice, injection or spraying uses.
Preferably, the pharmaceutical composition of above-mentioned prevention and treatment animal diarrhea disease, the preparation include tablet, capsule,
Granula, dry suspensoid agent, pulvis, emulsion, suspension, solution, injection or spray.
Preferably, the pharmaceutical composition of above-mentioned prevention and treatment animal diarrhea disease, the preparation are that pulvis makes for spice
With；Preparation is emulsion for drinking water, being sprayed, injecting use；Preparation is solution for drinking water, being sprayed, injecting use.
Preferably, the pharmaceutical composition of above-mentioned prevention and treatment animal diarrhea disease, the auxiliary material group when preparation is pulvis
At be one of potato starch, calcium carbonate, beta-cyclodextrin, converted starch, corn flour, talcum powder, rapeseed oil or soya-bean oil or
It is several, further preferably potato starch.
Preferably, the pharmaceutical composition of above-mentioned prevention and treatment animal diarrhea disease, the auxiliary material composition when preparation is emulsion
Be: emulsifier 0.5-20%, assistant for emulsifying agent 0.5-10%, preservative 0.01-1%, antioxidant 0.005-01%, surplus are pure
Change water；The emulsifier is in Tween-20, Tween-60, Tween-80, soybean lecithin, lecithin or glyceryl monostearate
One or more of mixtures, further preferably Tween-80；The assistant for emulsifying agent be n-butanol, ethylene glycol, ethyl alcohol, propylene glycol,
One or more of glycerol or polyglycerol ester, further preferably propylene glycol；The oil is mutually soybean oil, castor oil, peanut
One or more of oil or tea oil, further preferably peanut oil；The preservative is ethylparaben, phenol, benzoic acid
Or one or more of sorbic acid, further preferably ethylparaben, the antioxidant are butylated hydroxy anisole, two
One or more of mixtures, further preferably VE in butylated hydroxytoluene, citric acid monoglyceride, thioglycerol or VE.
Preferably, the pharmaceutical composition of above-mentioned prevention and treatment animal diarrhea disease, the auxiliary material group when preparation is solution
Cheng Shi: dimethyl sulfoxide 5-30%, dehydrated alcohol 5-60%, propylene glycol 5-50%, polyethylene glycol-400 5-30%, pH adjusting
Appropriate agent, surplus are water for injection, and pH range is in 4-8；The pH adjusting agent is lactic acid, citric acid, sodium hydroxide or ethyl alcohol
One or both of amine.
Preferably, the pharmaceutical composition of above-mentioned prevention and treatment animal diarrhea disease, can be used as feed addictive and directly adds
It is used into feed, premix, concentrate feed or mixed feed can also be made.
The preparation method of the pharmaceutical composition of above-mentioned prevention and treatment animal diarrhea disease, specific preparation process is as follows:
(1) scutelloside zinc, origanum oil and allicin are weighed by prescription amount, and crosses 60-200 mesh respectively；
(2) scutelloside zinc, origanum oil and allicin are uniformly mixed to obtain the final product.
The beneficial effects of the present invention are:
The pharmaceutical composition of above-mentioned prevention and treatment animal diarrhea disease is compounded using scutelloside zinc with origanum oil and allicin,
It significantly improves origanum oil and control efficiency for animal diarrhea disease is applied in combination in allicin, the composition is to animal abdomen
Rushing down property disease has good preventive and therapeutic effect, and has food calling and improve microbial population of animal intestinal tract effect, can effectively improve animal immune
Power promotes the rehabilitation of disease, long-term to add, and can promote growth of animal, and safe and pollution-free, noresidue, have no drug resistance generation, main
It is used for the prevention and treatment of animal diarrhea disease, and improves animal immunizing power, improves animal appetite, maintenance gastrointestinal bacterial flora is flat
Weighing apparatus promotes growth of animal；Preparation method is simple, is suitble to the needs of scale industrial production.
Specific embodiment
Technical solution of the present invention is further described combined with specific embodiments below.
Embodiment 1
A kind of pharmaceutical composition preventing and treating animal diarrhea disease, is made of scutelloside zinc, origanum oil and allicin, by it
5 parts of parts by weight meter scutelloside zinc, 10 parts of origanum oil, 20 parts of allicin.
The preparation method of the pharmaceutical composition of above-mentioned prevention and treatment animal diarrhea disease, specific preparation process is as follows:
(1) scutelloside zinc, origanum oil and allicin are weighed by prescription amount, and sieved with 100 mesh sieve respectively；
(2) scutelloside zinc, origanum oil and allicin are uniformly mixed to obtain the final product.
Embodiment 2
A kind of pharmaceutical composition preventing and treating animal diarrhea disease, is formed sediment by scutelloside zinc, origanum oil, allicin and potato
Powder composition, 5 parts of scutelloside zinc, 10 parts of origanum oil, 30 parts of allicin, 55 parts of potato starch based on its parts by weight.
The preparation method of the pharmaceutical composition of above-mentioned prevention and treatment animal diarrhea disease, specific preparation process is as follows:
(1) scutelloside zinc, origanum oil, allicin and potato starch are weighed by prescription amount, and crosses 60 meshes respectively；
(2) scutelloside zinc, origanum oil, allicin and potato starch are uniformly mixed up to pulvis.
Embodiment 3
A kind of pharmaceutical composition preventing and treating animal diarrhea disease, is mainly made of scutelloside zinc, origanum oil and allicin,
10 parts of scutelloside zinc, 20 parts of origanum oil, 30 parts of allicin based on its parts by weight.
The preparation method of the pharmaceutical composition of above-mentioned prevention and treatment animal diarrhea disease, specific preparation process is as follows:
(1) it takes scutelloside zinc, origanum oil and allicin as bulk pharmaceutical chemicals, and crosses 200 meshes respectively；
(2) scutelloside zinc 10%, origanum oil 20%, allicin 30%, Tween-80 3%, third are weighed by weight percentage
Glycol 0.5%, peanut oil 15%, ethylparaben 0.5%, VE 0.01%, remaining is water for injection, by weighed bulk pharmaceutical chemicals
Be added in high pressure dispersing emulsification machine and be uniformly mixed with auxiliary material and water for injection, stir evenly 10min, pour out, encapsulating, sterilizing, emulsion.
Embodiment 4
A kind of pharmaceutical composition preventing and treating animal diarrhea disease, is mainly made of scutelloside zinc, origanum oil and allicin,
30 parts of scutelloside zinc, 2.5 parts of origanum oil, 5 parts of allicin based on its parts by weight.
The preparation method of the pharmaceutical composition of above-mentioned prevention and treatment animal diarrhea disease, specific preparation process is as follows:
(1) it takes scutelloside zinc, origanum oil and allicin as bulk pharmaceutical chemicals, and crosses 120 meshes respectively；
(2) weigh by weight percentage scutelloside zinc 30%, origanum oil 2.5%, allicin 5%, dimethyl sulfoxide 20%,
Dehydrated alcohol 20%, propylene glycol 20%, remaining be water for injection, first will scutelloside zinc be added dimethyl sulfoxide in dissolution completely,
Then propylene glycol, dehydrated alcohol, origanum oil, allicin is successively added, completely, surplus water for injection, pH adjusting agent is added in dissolution
Adjust pH to 6, filtering, encapsulating, sterilizing, solution.
Embodiment 5
A kind of pharmaceutical composition preventing and treating animal diarrhea disease, is made of scutelloside zinc, origanum oil and allicin, by it
10 parts of parts by weight meter scutelloside zinc, 15 parts of origanum oil, 20 parts of allicin.
The preparation method of the pharmaceutical composition of above-mentioned prevention and treatment animal diarrhea disease, specific preparation process is as follows:
(1) scutelloside zinc, origanum oil and allicin are weighed by prescription amount, and crosses 60 meshes respectively；
(2) scutelloside zinc, origanum oil and allicin are uniformly mixed to obtain the final product.
Embodiment 6
Emulsion, solution prepared by above-described embodiment 3, embodiment 4 are filled into sprayer, spray, can spray
Mist uses, and is promptly prevented and treated.
The recipe principle of pharmaceutical composition of the present invention is as follows:
The green natural drug as generally recognized as safe such as origanum oil, allicin, it is wide in fields such as food, medicine, feeds
General use.Wherein origanum oil is called stop dysentery grass, is the volatile essential oils extracted from plant wild marjoram, has stronger stimulation
Property smell.Origanum oil is a kind of broad spectrum antimicrobial agent, to G+Bacterium and G-Bacterium all has height antibacterial activity, to gut bacteria disease
Sick such as diarrhea, feed just have special efficacy, also have certain anti parasitic effect, " origanum oil is to Intestine of Broiler microbial flora
Influence " article shows that origanum oil can improve Intestine of Broiler microbial bacteria group structure, promotes Bifidobacterium and Bacillus acidi lactici quantity
Increase and inhibits Escherichia coli quantity.
Allicin is present in the bulb of liliaceous plant garlic, is converted under that action of alliinase by existing garlic aminoacid
It generates, allicin is to G+Bacterium and G-The bacterium such as bacterium have apparent inhibition killing effect, also have certain anti parasitic effect, special
Garlic smell, can be enhanced the palatability of feed, increase gastric secretion and gastrointestinal peristalsis, stimulate appetite and promotes the work digested
With.Allicin is clinically taken orally to be mainly used for treating animal enteritis, diarrhea, loss of appetite etc..
Origanum oil and allicin are the drugs that common compatibility is used to prevent and treat animal diarrhea disease in the market, and the two is right
Animal diarrhea has very strong preventive and therapeutic effect, and the addition of scutelloside zinc is mutually improved three's compatibility, to by bacterium, virus, answer
The animal diarrhea disease prevention and cure significant effect of the initiations such as sharp, coccidia, and animal immunizing power is quickly improved, increase feed intake
Amount, promotes the recovery of disease, long-term to add, and can effectively facilitate growth of animal.
Test example
Influence of the pharmaceutical composition of prevention and treatment animal diarrhea disease of the present invention to piglet growth performance and diarrhea
1) test period and place
Test carries out on certain pig farm of Tianjin, which the case where part grice diarrhoea occurs.Test schedules to last totally 30 days.
2) experimental animal
Choose (28 ± 2) age in days weight is close, the doubtful length with piglet epidemic diarrhea it is white × great Bai two-way cross breaks
Milk piglet 120, male and female is fifty-fifty, is randomly divided into 5 groups, and every group 24, each 2 repetitions, each repetition 12.
3) experimental design and drug
Test group 1: scutelloside zinc group is mixed by scutelloside zinc+potato starch, by challenging (Tianjin) animal pharmaceutical estate
Co., Ltd provides；Every 100 kg of water adds this product 50g, freely drinks, and is used in conjunction 30 days；
Test group 2: origanum oil group, origanum oil are purchased from Sichuan Chinese medicine material pharmaceutical factory, prescription: origanum oil 30%+ potato
Starch polishing, conventional method are uniformly mixed and are prepared；Every 100 kg diet adds this product 100g, freely feeding, is used in conjunction 30 days；
Test group 3: allicin group, allicin are purchased from Sichuan Chinese medicine material pharmaceutical factory, prescription: allicin 30%+ potato
Starch polishing, conventional method are uniformly mixed and are prepared；Every 100 kg diet adds this product 100g, freely feeding, is used in conjunction 30 days；
Test group 4: origanum oil and allicin mixture group, origanum oil and allicin are purchased from Sichuan Chinese medicine material medicine
Factory, the two are pressed: origanum oil 10%+ allicin 20%+ potato starch polishing, and conventional method is uniformly mixed and is prepared；Every 100
Kg diet adds this product 100g, freely feeding, is used in conjunction 30 days；
Test group 5: pharmaceutical composition group is prepared as described in embodiment 1；Every 100 kg diet adds this product 100g, from
By feeding, it is used in conjunction 30 days；
Test group 6: scutelloside zinc+olaquindox group, olaquindox are purchased from Shandong fine chemistry industry company, prescription: scutelloside zinc
5%+ olaquindox 10%+ potato starch polishing, conventional be uniformly mixed are prepared；Every 100 kg diet adds this product 100g, from
By feeding, it is used in conjunction 30 days.(note: olaquindox is the veterinary drug clinically commonly feeding for preventing and treating animal diarrhea, promoting growth of animal
Feed additives, but because its medicine is residual, disable the piglet in poultry, being only allowed within 35kg).
Test group 7: blank group is not dealt with, normal to feed.
4) feeding management and disease prevention and cure
It weighs on an empty stomach respectively at formal test the 1st day, the 31st day early morning, records the weight of every group of test piglet, while every
It records every group of grice diarrhoea situation.It during test, allows piglet to be freely eaten daily, records the feed intake of each group；For test
Period, every group of incidence was recorded, and did necessary timely processing.
5) Testing index calculates
Daily gain=(testing last weight-test starting weight)/test number of days
Feed-weight ratio=total feed consumption amount/total augment weight
Average daily gain=total the feed intake of every column pig/(every column pig's head number × test number of days)
Diarrhea cure rate (%)=total diarrhea cures head number/test pig's head number × 100%
Non- cure rate (%)=total dead head number/test pig's head number × 100%, note: non-cure rate refers to that there is also diarrheal diseases
Shape or the case proportion of death.
6) it statisticallys analyze
After test data is handled with Excel software, using SPSS11.5 statistical software carry out " One-Way ANOVA:
Options " analysis, then laterally carries out Duncan method Multiple range test.Test result is indicated with " average ".
7) result and analysis, test result are shown in Table 1.
Table 1
Note: colleague data shoulder mark difference lowercase person indicates significant difference (P ﹤ 0.05), and identical person indicates that difference is not shown
It writes.
Table 1 shows that after test 30 days by a definite date, the daily gain of test group 1,2,3,4,5,6, feed-weight ratio are significantly better than examination
Group 7 is tested, illustrates that six groups of drugs add certain growth promoting function；The wherein daily gain highest of test group 5, and it is significantly higher than examination
Group 1,2,3 is tested, illustrates that test group 5 (pharmaceutical composition i.e. of the present invention) has significant growth promoting function and excellent to animal
In single component group；The feed-weight ratio of test group 1,2,3,4,5,6 is substantially less than test group 7, and wherein 5 feed-weight ratio of test group is most
It is low but not significant with test group 4,6 differences, illustrate that test group 5 (pharmaceutical composition i.e. of the present invention) can remarkably promote feeding
Expect conversion ratio；The diarrhea cure rate of test group 1,2,3,4,5,6 is all remarkably higher than test group 7, and wherein the diarrhea of test group 5 is cured
Rate is 100%, but not significant with the difference of test group 6, illustrates test group 5 (pharmaceutical composition i.e. of the present invention) to diarrhea
Control efficiency is significant.
To sum up, it improving daily gain, reduction feed-weight ratio, curing on diarrhea rate, (the medicine group i.e. of the present invention of test group 5
Close object) it is significantly higher than test group 1 (scutelloside zinc group), test group 2 (origanum oil and allicin mixture group), 3 (garlic of test group
Plain group), test group 4 (origanum oil and allicin mixture group), it is same with having for test group 6 (scutelloside zinc+antibiotic group)
Effect illustrates the advantages of present invention incorporates scutelloside zinc and origanum oils, allicin, and three's compatibility cures diarrhea significant effect,
It can significantly promote the rehabilitation of disease and the growth of animal, and compare test group 6, the present invention has the advantages such as green, no drug residue,
The requirement for meeting sustainable development is the following veterinary drug development direction.
It is above-mentioned that a kind of pharmaceutical composition and preparation method thereof for preventing and treating animal diarrhea disease is carried out referring to embodiment
Detailed description, be illustrative without being restrictive, can enumerate several embodiments according to limited range, thus
The change and modification under present general inventive concept are not departed from, should be belonged within protection scope of the present invention.
Claims (3)
1. a kind of pharmaceutical composition for preventing and treating diarrhea of pigs disease, it is characterised in that: by scutelloside zinc, origanum oil and allicin group
At 2.5-30 parts of scutelloside zinc, 2.5-30 parts of origanum oil, 5-30 parts of allicin based on its parts by weight.
2. the pharmaceutical composition of prevention and treatment diarrhea of pigs disease according to claim 1, it is characterised in that: press its parts by weight
Count 5 parts of scutelloside zinc, 10 parts of origanum oil, 20 parts of allicin.
3. the preparation method of the pharmaceutical composition of prevention and treatment diarrhea of pigs disease described in claim 1, it is characterised in that: specific system
It is standby that steps are as follows:
(1) scutelloside zinc, origanum oil and allicin are weighed by prescription amount, and crosses 60-200 mesh respectively；
(2) scutelloside zinc, origanum oil and allicin are uniformly mixed to obtain the final product.
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105878369A (en) * | 2016-06-22 | 2016-08-24 | 江苏省农业科学院 | Chinese herbal compound for preventing and treating porcine epidemic diarrhea virus |
| CN106667915B (en) * | 2016-10-24 | 2019-09-13 | 武汉轻工大学 | It is a kind of for treating the scutelloside aluminium dry suspensoid agent of grice diarrhoea |
| CN108185148A (en) * | 2018-03-23 | 2018-06-22 | 四川省畜牧科学研究院 | A kind of easy processing compound premix for improving wean rabbit diarrhea |
| CN110665002B (en) * | 2019-10-29 | 2023-01-24 | 信阳市动物疫病预防控制中心 | Antibody preparation for preventing and treating bovine viral diarrhea and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101473897A (en) * | 2008-01-04 | 2009-07-08 | 北京因科瑞斯医药科技有限公司 | Natural anti-bacteria agent for feeding and preparation method thereof |
| CN103655593A (en) * | 2013-12-12 | 2014-03-26 | 挑战（天津）动物药业有限公司 | Composite medicine preparation for prevention and treatment of bacterium and virus polyinfection diseases of livestock as well as preparation method and application thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101473897A (en) * | 2008-01-04 | 2009-07-08 | 北京因科瑞斯医药科技有限公司 | Natural anti-bacteria agent for feeding and preparation method thereof |
| CN103655593A (en) * | 2013-12-12 | 2014-03-26 | 挑战（天津）动物药业有限公司 | Composite medicine preparation for prevention and treatment of bacterium and virus polyinfection diseases of livestock as well as preparation method and application thereof |
Non-Patent Citations (1)
| Title |
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| 黄芩解毒散对仔猪细菌性腹泻的治疗试验;沈国权，等。;《广东畜牧兽医科技》;20130818;第38卷(第4期);第39-41页。 |
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