CN103432162A - Composition for treating poultry intestinal bacteria and anaerobic bacteria mixing infection and preparation method thereof - Google Patents
Composition for treating poultry intestinal bacteria and anaerobic bacteria mixing infection and preparation method thereof Download PDFInfo
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- CN103432162A CN103432162A CN201310390905XA CN201310390905A CN103432162A CN 103432162 A CN103432162 A CN 103432162A CN 201310390905X A CN201310390905X A CN 201310390905XA CN 201310390905 A CN201310390905 A CN 201310390905A CN 103432162 A CN103432162 A CN 103432162A
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Abstract
The invention discloses a composition for treating poultry intestinal bacteria and anaerobic bacteria mixing infection and a preparation method thereof, and aims to provide the composition for treating poultry intestinal bacteria and anaerobic bacteria mixing infection and the preparation method thereof. The composition can effectively treat mixed infection and reduce poultry reaction and is quick in effect and remarkable in effect. The composition is prepared from the following raw materials in percentage by weight: 5-15% of neomycin sulfate, 10-30% of dimetridazole, 5% of sodium chloride, 5% of potassium chloride and the balance of glucosum anhydricum. The composition disclosed by the invention adopts neomycin sulfate and dimetridazole as antibiotic components to remedy the deficiency of the antibiotic ranges of neomycin sulfate and dimetridazole and avoid therapeutic error. Combination of sodium chloride and potassium chloride has supplementing effect to electrolyte loss of diseased poultry caused by a great quantity of defecation and water drainage. The medicines are combined in use, so that the composition has the remarkable treatment effect on intestinal bacteria and anaerobic bacteria mixing infection.
Description
Technical field
The present invention relates to field of veterinary, relate to specifically a kind of composition and method of making the same that is used for the treatment of fowl intestinal bacteria and anaerobe mixed infection.
Background technology
Fowl digestive tract antibacterial and anaerobe mixed infection are the normal diseases occurred of fowl, sick fowl shows as the diarrhoea dysentery, it is just principal character that poultry is drawn feedstuff, mainly by escherichia coli, the gram negative bacterias such as Salmonella and anaerobe mixed infection cause, sick fowl undergrowth, morbidity rapidly, show as diarrhoea, dysentery, serious dyspepsia, half digestion or indigested feedstuff of feces band volume, sick fowl dehydration is serious, inflammatory reaction is serious, and may cause the too much phenomenon of electrolyte loss, malnutrition, weak phenomenon appears very soon, cause mortality rate high.
At present, because this disease causes for MOI, its pathogen is resident bacterium in body, under the stress conditions such as weather or replacing feedstuff, fall ill comparatively general, single drug, as dimetridazole, polygynax etc., often makes therapeutic effect not good because its medicine is single now, to the raiser, brings very large loss.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, and a kind of compositions that can treat fowl intestinal bacteria and anaerobe mixed infection is provided.
It is simple that another object of the present invention is to provide a kind of technique, the preparation method of the compositions that is used for the treatment of fowl intestinal bacteria and anaerobe mixed infection easily realized.
The present invention is achieved through the following technical solutions:
A kind of compositions for fowl treatment intestinal bacteria and anaerobe mixed infection, is characterized in that, following raw material, consists of by mass percentage: polygynax 5～15%, and dimetridazole 10～30%, sodium chloride 5%, potassium chloride 5%, surplus is anhydrous glucose.
The better composition of above-mentioned composition is by weight percentage: polygynax 8～12%, and dimetridazole 15～25%, sodium chloride 5%, potassium chloride 5%, surplus is anhydrous glucose.
The best of above-mentioned composition forms: following raw material, consist of by weight percentage: polygynax 10%, dimetridazole 20%, sodium chloride 5%, potassium chloride 5%, anhydrous glucose 60%.
The preparation method of the above-mentioned compositions for fowl treatment intestinal bacteria and anaerobe mixed infection, is characterized in that, comprises the steps:
Polygynax, dimetridazole, sodium chloride, potassium chloride were pulverized to No. 5 sieves and obtained the compositions of the present invention for fowl treatment intestinal bacteria and anaerobe mixed infection afterwards with after anhydrous glucose fully mixes, wherein the mass percent of compositions is polygynax 5～15%, dimetridazole 10～30%, sodium chloride 5%, potassium chloride 5%, surplus is anhydrous glucose.
The better composition of above-mentioned composition is by weight percentage: polygynax 8～12%, and dimetridazole 15～25%, sodium chloride 5%, potassium chloride 5%, surplus is anhydrous glucose.
The best of above-mentioned composition forms: polygynax 10%, dimetridazole 20%, sodium chloride 5%, potassium chloride 5%, anhydrous glucose 60%.
The present invention has following technique effect:
Compositions of the present invention is compound preparation, adopts polygynax can pass through intestinal, the antibacterial that causes infection in intestinal is had to obvious killing action as escherichia coli, Salmonella etc., but anaerobe is had to drug resistance, poor effect; Dimetridazole is remarkable to the anaerobe effect, but not obvious to antibacterial antibacterial effects such as escherichia coli, Salmonellas; Dimetridazole and polygynax share, make up deficiency each other, meet the treatment condition of fowl intestinal bacteria and anaerobic infection, sodium chloride and potassium chloride are electrolytical combination, a large amount of losses to sick fowl because of a large amount of defecations and moisture, and the electrolyte loss caused has supplementary function, all medicines share, and have the effect that intestinal bacteria and anaerobe mixed infection are had treating both the principal and secondary aspects of a disease, improve therapeutic effect.
The preparation method of composition technique of fowl treatment intestinal bacteria of the present invention and anaerobe mixed infection is simple, easily realizes.
The specific embodiment
Below take and produce the 100kg compositions and the present invention is described in further detail as example.Should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not intended to limit the present invention.
Embodiment 1
By polygynax, it is rear standby that dimetridazole, sodium chloride, potassium chloride were pulverized No. 5 sieves; Accurately take polygynax 15kg, dimetridazole 10kg, sodium chloride 5kg, potassium chloride 5kg, premix 20 minutes, mixture obtains the compositions of the present invention for fowl treatment intestinal bacteria and anaerobe mixed infection again with after anhydrous glucose 65kg fully mixes.
Embodiment 2
By polygynax, it is rear standby that dimetridazole, sodium chloride, potassium chloride were pulverized No. 5 sieves; Accurately take polygynax 5kg, dimetridazole 30kg, sodium chloride 5kg, potassium chloride 5kg, premix 20 minutes, mixture obtains the compositions of the present invention for fowl treatment intestinal bacteria and anaerobe mixed infection again with after anhydrous glucose 55kg fully mixes.
Embodiment 3
By polygynax, it is rear standby that dimetridazole, sodium chloride, potassium chloride were pulverized No. 5 sieves; Accurately take polygynax 12kg, dimetridazole 15kg, sodium chloride 5kg, potassium chloride 5kg, premix 20 minutes, mixture obtains the compositions of the present invention for fowl treatment intestinal bacteria and anaerobe mixed infection again with after anhydrous glucose 63kg fully mixes.
Embodiment 4
By polygynax, it is rear standby that dimetridazole, sodium chloride, potassium chloride were pulverized No. 5 sieves; Accurately take polygynax 8kg, dimetridazole 25kg, sodium chloride 5kg, potassium chloride 5kg, premix 20 minutes, mixture obtains the compositions of the present invention for fowl treatment intestinal bacteria and anaerobe mixed infection again with after anhydrous glucose 57kg fully mixes.
Embodiment 5
By polygynax, it is rear standby that dimetridazole, sodium chloride, potassium chloride were pulverized No. 5 sieves; Accurately take polygynax 11kg, dimetridazole 18kg, sodium chloride 5kg, potassium chloride 5kg, premix 20 minutes, mixture obtains the compositions of the present invention for fowl treatment intestinal bacteria and anaerobe mixed infection again with after anhydrous glucose 61kg fully mixes.
Embodiment 6
By polygynax, it is rear standby that dimetridazole, sodium chloride, potassium chloride were pulverized No. 5 sieves; Accurately take polygynax 10kg, dimetridazole 20kg, sodium chloride 5kg, potassium chloride 5kg, premix 20 minutes, mixture obtains the compositions of the present invention for fowl treatment intestinal bacteria and anaerobe mixed infection again with after anhydrous glucose 60kg fully mixes.
Clinical trial:
Compositions of the present invention both can be for the chicken class, also can be for duck, goose etc.Below take chicken as laboratory animal, the effect of the compositions for fowl treatment intestinal bacteria and anaerobe mixed infection of the present invention is tested.
1. laboratory animal:
Choose at random 1000 of ill one-tenth chickens, body weight is about the 1kg left and right.
2. Experimental agents
The compositions our unit development of the embodiment of the present invention 6 preparations;
10% polygynax powder and 90% anhydrous glucose are mixed with our unit's laboratory preparation;
20% dimetridazole powder and 80% anhydrous glucose are mixed with our unit's laboratory preparation.
3. experimental technique:
Suffer from chicken by 1000 and be divided at random four groups by body weight, 250 every group.
The A group, for the blank group, does not give Drug therapy.
The B group is treated with the anhydrous grape sugar mixture of 10% polygynax powder and 90%, usage: for oral administration, every chicken 0.2g, 1 time on the 1st, be used in conjunction 5 days.
The C group is treated with the anhydrous grape sugar mixture of 20% dimetridazole powder and 80%, usage: for oral administration, every chicken 0.2g, 1 time on the 1st, be used in conjunction 5 days.
The D group is treated by the compositions of the embodiment of the present invention 6 preparations, usage: for oral administration, every chicken 0.2g, 1 time on the 1st, be used in conjunction 5 days.
After treatment starts, every day entry suffers from chicken health situation of change and dead animal distributes, and treat after 7 days and add up therapeutic effect, wherein:
Invalid: as after referring to 7 days, to suffer from the chicken symptom without obvious change, still keep the front symptom for the treatment of.
Effectively: after referring to 7 days, suffer from the chicken symptom and change, symptom is better than the effect before treatment.
Cure: after referring to 7 days, transference cure, suffer from chicken and get well.Its numeral is included in significant digits.
Symptom is arranged: after referring to 7 days, suffer from chicken and still have certain symptom, before its Symptoms is better than treatment or without change, suffers from chicken and do not cure during end.Its numeral has been included in the numeral of invalid number of elements and effective number of elements.
The relative weight gain rate: refer to use after medicine the rate of body weight gain with respect to matched group.
Result of the test is as shown in the table.
4. conclusion:
The result of the test statistical analysis, the embodiment of the present invention 6 is for combination treatment group, 10% polygynax treated powder group and the 20% dimetridazole powder group of fowl treatment intestinal bacteria and anaerobe mixed infection and matched group difference extremely remarkable (P<0.01).Curative effect of the present invention is better than existing two kinds of medicines.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (6)
1. the compositions for the treatment of fowl intestinal bacteria and anaerobe mixed infection, is characterized in that, following raw material, consists of by weight percentage: polygynax 5～15%, and dimetridazole 10～30%, sodium chloride 5%, potassium chloride 5%, surplus is anhydrous glucose.
2. the compositions for the treatment of according to claim 1 fowl intestinal bacteria and anaerobe mixed infection, it is characterized in that consisting of of each compositions in weight percentage: polygynax 8～12%, dimetridazole 15～25%, sodium chloride 5%, potassium chloride 5%, surplus is anhydrous glucose.
3. the compositions for the treatment of fowl intestinal bacteria according to claim 1 and anaerobe mixed infection, is characterized in that consisting of of each compositions in weight percentage: polygynax 10%, dimetridazole 20%, sodium chloride 5%, potassium chloride 5%, anhydrous glucose 60%.
4. treat as claimed in claim 1 the preparation method of the compositions of fowl intestinal bacteria and anaerobe mixed infection, it is characterized in that, comprise the steps: polygynax, dimetridazole, sodium chloride, potassium chloride, pulverized after No. 5 sieves and obtained the compositions that the present invention is used for the treatment of fowl intestinal bacteria and anaerobe mixed infection after anhydrous glucose fully mixes, wherein the mass percent of compositions is polygynax 5～15%, dimetridazole 10～30%, sodium chloride 5%, potassium chloride 5%, surplus is anhydrous glucose.
5. the preparation method of the compositions for the treatment of according to claim 4 fowl intestinal bacteria and anaerobe mixed infection, it is characterized in that consisting of of each compositions in weight percentage: polygynax 8～12%, dimetridazole 15～25%, sodium chloride 5%, potassium chloride 5%, surplus is anhydrous glucose.
6. the preparation method of the compositions for the treatment of according to claim 4 fowl intestinal bacteria and anaerobe mixed infection, it is characterized in that consisting of of each compositions in weight percentage: polygynax 10%, dimetridazole 20%, sodium chloride 5%, potassium chloride 5%, anhydrous glucose 60%.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103690940A (en) * | 2013-12-26 | 2014-04-02 | 南阳新先锋制药有限公司 | Compound dimetridazole premix for preventing and treating poultry enterovirus syndrome |
| CN106074514A (en) * | 2016-08-31 | 2016-11-09 | 上海邦森生物科技有限公司 | A kind of water solublity dimetridazole pre-mixing agent and preparation method thereof |
| CN110772526A (en) * | 2019-10-12 | 2020-02-11 | 佛山市正典生物技术有限公司 | Neomycin sulfate solution and preparation method thereof |
| CN114652716A (en) * | 2022-03-31 | 2022-06-24 | 中国农业科学院兰州畜牧与兽药研究所 | Application of dimetridazole in preparation of anti-beta-lactam drug-resistant escherichia coli drugs |
-
2013
- 2013-08-30 CN CN201310390905XA patent/CN103432162A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103690940A (en) * | 2013-12-26 | 2014-04-02 | 南阳新先锋制药有限公司 | Compound dimetridazole premix for preventing and treating poultry enterovirus syndrome |
| CN106074514A (en) * | 2016-08-31 | 2016-11-09 | 上海邦森生物科技有限公司 | A kind of water solublity dimetridazole pre-mixing agent and preparation method thereof |
| CN110772526A (en) * | 2019-10-12 | 2020-02-11 | 佛山市正典生物技术有限公司 | Neomycin sulfate solution and preparation method thereof |
| CN114652716A (en) * | 2022-03-31 | 2022-06-24 | 中国农业科学院兰州畜牧与兽药研究所 | Application of dimetridazole in preparation of anti-beta-lactam drug-resistant escherichia coli drugs |
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