CN102772703A - Drug for treating porcine reproductive and respiratory syndrome - Google Patents
Drug for treating porcine reproductive and respiratory syndrome Download PDFInfo
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- CN102772703A CN102772703A CN2012102731727A CN201210273172A CN102772703A CN 102772703 A CN102772703 A CN 102772703A CN 2012102731727 A CN2012102731727 A CN 2012102731727A CN 201210273172 A CN201210273172 A CN 201210273172A CN 102772703 A CN102772703 A CN 102772703A
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Abstract
The invention relates to a drug for treating a porcine reproductive and respiratory syndrome. The drug is prepared by Chinese medicinal herbs of pilose asiabell roots, bighead atractylodes rhizome, Indian buead, liquorice roots, radix astragali preparata, rhizome of common yam, Chinese angelica, dried tangerine peel and germinated barley, and the Chinese medicinal herbs are subjected to crushing, screening and mixing to obtain powders according to a conventional method. The drug for treating the porcine reproductive and respiratory syndrome has the advantages of being rapid in effects, good in curative effects and free from obvious side effects.
Description
Technical field
The invention belongs to a kind of technical field of pharmaceuticals, being specifically related to a kind of is the medicine of the treatment pig blue-ear disease processed of raw material with the Chinese herbal medicine.
Background technology
Up to now, reproductive and respiratory syndrome (is claimed Porcine reproductive and respiratory syndrome again, PRRS) is remained one of maximum eqpidemic disease of current pig industry harm.The harm of reproductive and respiratory syndrome not only shows damage that disease itself causes pig and the economic loss that causes; But also because reproductive and respiratory syndrome virus (is claimed porcine reproductive and respiratory syndrome virus again; PRRSV) be the main key cause of disease of pig, be prone to take place serious secondary or mixed infection behind the infection reproductive and respiratory syndrome virus.
Reproductive and respiratory syndrome is a kind of height contagious disease, is endemicity.PRRSV infected pigs, the pig of various kinds, all ages and classes and purposes all can infect, but with in-pig and 1 monthly age with the susceptible of interior piglet.Ill pig be the important source of infection of primary disease with malicious pig.Main route of transmission is that contact infection, air borne and seminal fluid are propagated, and also can pass through the Placenta Hominis vertical transmission.But number of ways such as susceptible pig per os, nasal cavity, muscle, abdominal cavity, vein and intrauterine inoculation and infective virus, 2～14 weeks all can be given other susceptible pigs with virus disseminating through contact behind the pig infective virus.From nasal cavity, feces and the urine of sick pig, all can detect virus.The susceptible pig with directly contact with malicious pig or have means of transport, the apparatus of PRRSV to contact all and can be infected with pollution.Flowing of infected pigs also is the important circulation way of primary disease.
Present reproductive and respiratory syndrome cardinal symptom: in-pig miscarriage and produce stillborn fetus, mummy tire, weak son, the sow postponement of oestrusing again, piglet respiratory symptom, multiple organ dysfunction syndrome and high mortality etc.Should disease still be a kind of immunosuppressive disease simultaneously; Cause the phenomenon of immuning failure that generation is often arranged; Cause easier secondary of infected pigs and concurrent various virus, antibacterial, parasitic disease; Often cause multiple disease such as swine fever, circovurus type 2 disease, colibacillosis to mix or secondary infection, cause the large quantities of death of live pig, pig industry is caused the remarkable economical loss.Therefore, how to remove immunosuppressant, effectively anti-system PRRS is the key issue that current pig industry needs to be resolved hurrily always.
The reproductive and respiratory syndrome clinical symptoms
Brood sow: 1. inappetence appears repeatedly, hyperpyrexia (40～41 ℃), drowsiness, spirit is depressed, breathes and quickens, ventral breathing, mortality rate 3%～5%.2. minority sow (about 5%) ear, nipple, pudendum, abdominal part, afterbody and lower limb cyanosis are the most common with have sharp ears.3. miscarry late trimester of pregnancy, premature labor, stillborn fetus, weak son or mummy tire.
Piglet and growing and fattening pigs: 1. be more common in 50 kilograms with interior piglet and growing and fattening pigs, with the susceptible of the piglet in 1 monthly age, symptom is obvious, mortality rate high (can reach 80～100%), after the piglet birth of premature labor soon or dead in several days.Dyspnea (ventral breathing) appears in 2. most of newborn piglets, muscular tremor, and back acroparalysis, drowsiness, spirit is depressed, and the sick pig of minority is the early infection piglet especially.Ear, body latter end are blue, and anti-to cross piglet growth slow, are prone to other sick or subinfections again of secondary.
Big porker or breeding boar grow up: sickness rate is lower, is generally 2～10%, have 100%, performance heating, cough, asthma, rapid breathing, minority ear, back or body surface are blue.
In clinical treatment, because reproductive and respiratory syndrome belongs to immunosuppressive disease, in case the ill Western medicine of pig is invalid basically, it is more to add secondary infection clinically again, has more increased the treatment difficulty to pig blue-ear disease, presses conventional therapy clinically and is difficult to.Carry out the treatment of viral disease and use Chinese herbal medicine, in China long history is arranged, so far, it still has important practical significance to the control of viral disease.In recent years, the broad research to Chinese herbal medicine shows that it not only has effect disease-resistant, enhancing immunity, can also improve efficiency of feed utilization and conversion ratio, generation growth promotion effect.
Pathological change mainly is that lung and pleura stick together, lung swelling, and lung has dispersivity hemorrhage, is interstitial pneumonia, and the lung atrophy that has is carnification property, seriously loses gas exchange capacity; Cystose mucus or faint yellow purulence mucus that volume is arranged in trachea, the bronchus.The remarkable swelling of inguinal lymph nodes, tangent plane is moistening turns up, and congested, hemorrhage serious, mesenteric lymph node, the obvious swelling of hilar lymph node are khaki or kermesinus.
The Chinese herbal medicine toxic and side effects is little, can not produce drug resistance, the resistance against diseases that stress to regulate allomeric function during application, improves body self, and prolonged application is safe and reliable.
Summary of the invention
The purpose of this invention is to provide a kind of instant effect, good effect, and the medicine of the treatment pig blue-ear disease of non-evident effect.
The medicine of pig blue-ear disease of the present invention; Be that Chinese herbal medicine by following parts by weight is that raw material is processed: Radix Codonopsis 25 ~ 30g, the Rhizoma Atractylodis Macrocephalae 25 ~ 35g, Poria 25 ~ 35g, Radix Glycyrrhizae 20 ~ 30g, Radix Astragali Preparata 30 ~ 40g, Rhizoma Dioscoreae 20 ~ 30g, Radix Angelicae Sinensis 30 ~ 40g, Pericarpium Citri Reticulatae 30 ~ 40g, Fructus Hordei Germinatus 30 ~ 40g.
Can said medicine be processed pill on the pharmaceutics, oral liquid, powder etc., consider that clinical practice is easy to use, be reluctant to search for food after the animal morbidity, practical situation such as product stability, preferred dosage form is a powder.
The method for preparing of drug powder of the present invention is following:
Take by weighing the above-mentioned raw materials medicine according to weight portion, according to conventional method, through pulverizes, sieve, mixed must powder.
From the traditional Chinese veterinary medicine angle analysis, reproductive and respiratory syndrome belongs to Epidemic Febrile Disease, and its morbidity at the pig body changes available three warmers (part of the body cavity above the diaphragm housing the heart and lungs, middle Jiao, the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels), defensive-qi-nutrient-blood comes determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs." exogenous pathogen mutual aid " is predisposing factors, and virus was taken advantage of a weak point when just the five internal organs said of the traditional Chinese medical science were in " void ", caused pathogen being excessive but vital QI weak, disease-resistant unable; This disease is multiple summer, how because of the damp and hot fire-transformation of diseases caused by exogenous pathogenic factor, causes inhibited pulmonary QI, abnormal ascending-descending of QI, imbalance of YIN and YANG.The present invention can YIN and YANG balance regulating, treating both the principal and secondary aspects of a disease, make body constitutionally, think and act in one and the same way in the immunity, equilibrium between yin and yang, thereby the ideal that reaches " ill fewly send out, morbidity die less " is cultured state.
In the prescription of the present invention: the Radix Astragali is the key medicine of invigorating the spleen and replenishing QI, the spleen invigorating lung benefiting, and Radix Angelicae Sinensis sweet in the mouth and weighing, so specially can enrich blood, its gas is light and hot; So again can promoting the circulation of blood, invigorating middle warmer has, in the row benefit is arranged, and is the key medicine in the blood, both can enrich blood; Again can promoting the circulation of blood, can QI invigorating, again can circulation of qi promoting, Pericarpium Citri Reticulatae, Fructus Hordei Germinatus are the key medicine of spleen benefiting and stimulating the appetite simultaneously; Having is good for the stomach increases the effect of food, and all medicines share and gather qi and blood tonifying altogether, and being good for the stomach increases food, improves the effect of autoimmunity.
The present invention treats the medicine of pig blue-ear disease, disease such as spiritual depressed, inappetence that is applicable to that pig blue-ear disease causes, and large-scale application proves, instant effect, good effect.Medicine of the present invention belongs to pure Chinese medicinal preparation, compares no drug residue with Western medicine, has no side effect.
The clinical treatment test report
To 100 occur that spirit is depressed, inappetence, the appearance of the ears back side, edge and tail skin have the pig of clinical symptoms such as dark livid purple mottle point to carry out therapeutic test with medicine of the present invention, matched group is the amoxicillin soluble powder of certain company's production.
Ill chicken is from Fuyang City suburb, Anhui Province and small towns, totally 100 big yorkers.Clinical symptoms shows as slight parainfluenza symptom, depressed, the inappetence of spirit, dyspnea, and the appearance of the ears back side, edge and tail skin have dark livid purple mottle point; Stick together through visible lung of pathological anatomy and pleura, lung swelling, lung has dispersivity hemorrhage; Be interstitial pneumonia; The lung atrophy that has is carnification property, finally is diagnosed as pig blue-ear disease.In 100 sick pigs, with reproductive and respiratory syndrome growing and fattening pigs each half with medicine of the present invention and control drug treatment.Medicine of the present invention is got Radix Codonopsis 30g, Rhizoma Atractylodis Macrocephalae 25g, Poria 28g, Radix Glycyrrhizae 25g, Radix Astragali Preparata 35g, Radix Angelicae Sinensis 35g, Rhizoma Dioscoreae 28g, Pericarpium Citri Reticulatae 35g, Fructus Hordei Germinatus 30g.Through pulverizing, sieving, mix, be prepared into powder, powder of the present invention is pressed the dosage of 50g/ growing and fattening pigs, the amoxicillin soluble powder agent reconstitutes with boiled water with the dosage of 50g/ growing and fattening pigs respectively, waits temperature and irritates clothes.Effective percentage=healing number+significant figure/treatment sum.Result of the test see table 1,
The therapeutic outcome of table 1. medicine of the present invention and control drug
Result of the test shows that medicine of the present invention is 88.0% to the pig blue-ear disease cure rate, and effective percentage is 96.0%; And the cure rate of contrast is 64.0%; Effective percentage is 84.0%, and through statistical analysis, the cure rate of medicine of the present invention and effective percentage comparison all are utmost point significant difference (P ﹤ 0.01) according to medicine.Explain that medicine of the present invention from clinical efficacy, obviously is better than control drug to the pig blue-ear disease therapeutic effect, and have that curative effect is fast, the characteristics of good effect (cure rate is 88.0%, and effective percentage is 96.0%).
The specific embodiment
Embodiment 1
Take by weighing according to weight:
Radix Codonopsis 25g, Rhizoma Atractylodis Macrocephalae 25g, Poria 25g, Radix Glycyrrhizae 20g, Radix Astragali Preparata 30g, Rhizoma Dioscoreae 20g, Radix Angelicae Sinensis 30g, Pericarpium Citri Reticulatae 30g, Fructus Hordei Germinatus 30g.
According to conventional method, pulverize, sieve, mixed powder.
Embodiment 2
Radix Codonopsis 30g, Rhizoma Atractylodis Macrocephalae 35g, Poria 35, Radix Glycyrrhizae 30g, Radix Astragali Preparata 40g, Rhizoma Dioscoreae 30g, Radix Angelicae Sinensis 40g, Pericarpium Citri Reticulatae 40g, Fructus Hordei Germinatus 40g.
According to conventional method, pulverize, sieve, mixed powder.
Embodiment 3
Radix Codonopsis 27, the Rhizoma Atractylodis Macrocephalae 30, Poria 30, Radix Glycyrrhizae 25, Radix Astragali Preparata 35, Rhizoma Dioscoreae 25, Radix Angelicae Sinensis 35, Pericarpium Citri Reticulatae 35, Fructus Hordei Germinatus 35.
According to conventional method, pulverize, sieve, mixed powder.
Claims (1)
1. a treatment pig blue-ear disease medicine is pulverized, is sieved, is mixed and made into powder through conventional method, and it is characterized in that: the raw material by following parts by weight is processed:
Radix Codonopsis 25 ~ 30, the Rhizoma Atractylodis Macrocephalae 25 ~ 35, Poria 25 ~ 35, Radix Glycyrrhizae 20 ~ 30, Radix Astragali Preparata 30 ~ 40, Rhizoma Dioscoreae 20 ~ 30, Radix Angelicae Sinensis 30 ~ 40, Pericarpium Citri Reticulatae 30 ~ 40, Fructus Hordei Germinatus 30 ~ 40.
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| CN2012102731727A CN102772703A (en) | 2012-08-02 | 2012-08-02 | Drug for treating porcine reproductive and respiratory syndrome |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104800300A (en) * | 2015-05-14 | 2015-07-29 | 四川铁骑力士实业有限公司 | Traditional Chinese medicine composition for preventing porcine reproductive and respiratory syndrome and preparation method thereof |
| CN104922258A (en) * | 2015-06-01 | 2015-09-23 | 新疆农业大学 | Strangles powder and application thereof to preparation of drugs for preventing and treating strangles and abscess |
| CN106889341A (en) * | 2017-03-10 | 2017-06-27 | 天津市畜牧兽医研究所 | A kind of feed addictive for improving pigling immunity and preparation method and application |
| CN108815343A (en) * | 2018-09-10 | 2018-11-16 | 黑龙江省庆隆农业高科技综合推广有限公司 | A kind of Chinese medicine composition, feed and its application promoting live pig toxin expelling |
| CN109745477A (en) * | 2019-03-23 | 2019-05-14 | 郑州赛科药业科技有限公司 | A kind of Chinese medicine composition and preparation method thereof for preventing and treating porcine reproductive and respiratory syndrome |
| CN110051770A (en) * | 2019-05-28 | 2019-07-26 | 皖西学院 | Compound Chinese herb Immune-enhancing effect preparation and preparation method thereof for treating weak piglet |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102688417A (en) * | 2012-06-19 | 2012-09-26 | 山西双鹰动物药业有限公司 | Chinese medicinal composition for treating porcine reproductive and respiratory syndrome |
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2012
- 2012-08-02 CN CN2012102731727A patent/CN102772703A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102688417A (en) * | 2012-06-19 | 2012-09-26 | 山西双鹰动物药业有限公司 | Chinese medicinal composition for treating porcine reproductive and respiratory syndrome |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104800300A (en) * | 2015-05-14 | 2015-07-29 | 四川铁骑力士实业有限公司 | Traditional Chinese medicine composition for preventing porcine reproductive and respiratory syndrome and preparation method thereof |
| CN104800300B (en) * | 2015-05-14 | 2017-09-19 | 四川铁骑力士实业有限公司 | It is a kind of to prevent Chinese medicine composition of pig blue-ear disease and preparation method thereof |
| CN104922258A (en) * | 2015-06-01 | 2015-09-23 | 新疆农业大学 | Strangles powder and application thereof to preparation of drugs for preventing and treating strangles and abscess |
| CN104922258B (en) * | 2015-06-01 | 2018-04-20 | 新疆农业大学 | A kind of strangles powder and the application in prevention strangles and abscess medicine is prepared |
| CN106889341A (en) * | 2017-03-10 | 2017-06-27 | 天津市畜牧兽医研究所 | A kind of feed addictive for improving pigling immunity and preparation method and application |
| CN108815343A (en) * | 2018-09-10 | 2018-11-16 | 黑龙江省庆隆农业高科技综合推广有限公司 | A kind of Chinese medicine composition, feed and its application promoting live pig toxin expelling |
| CN108815343B (en) * | 2018-09-10 | 2021-03-16 | 黑龙江省庆隆农业高科技综合推广有限公司 | Traditional Chinese medicine composition for promoting live pig detoxification, feed and application thereof |
| CN109745477A (en) * | 2019-03-23 | 2019-05-14 | 郑州赛科药业科技有限公司 | A kind of Chinese medicine composition and preparation method thereof for preventing and treating porcine reproductive and respiratory syndrome |
| CN110051770A (en) * | 2019-05-28 | 2019-07-26 | 皖西学院 | Compound Chinese herb Immune-enhancing effect preparation and preparation method thereof for treating weak piglet |
| CN110051770B (en) * | 2019-05-28 | 2021-09-10 | 皖西学院 | Compound Chinese herbal medicine immunopotentiator for treating weak piglets and preparation method thereof |
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Application publication date: 20121114 |