CN104800300A - Traditional Chinese medicine composition for preventing porcine reproductive and respiratory syndrome and preparation method thereof - Google Patents
Traditional Chinese medicine composition for preventing porcine reproductive and respiratory syndrome and preparation method thereof Download PDFInfo
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- CN104800300A CN104800300A CN201510244449.7A CN201510244449A CN104800300A CN 104800300 A CN104800300 A CN 104800300A CN 201510244449 A CN201510244449 A CN 201510244449A CN 104800300 A CN104800300 A CN 104800300A
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Abstract
The invention discloses a traditional Chinese medicine composition for preventing porcine reproductive and respiratory syndrome. The traditional Chinese medicine composition is characterized by comprising the following raw materials in parts by weight: 10 to 35 parts of largehead atractylodes rhizome, 20 to 65 parts of giant knot weed, 10 to 35 parts of cyrtomium rhizome, 25 to 75 parts of honeysuckle stem and 5 to 25 parts of licorice root. The invention also discloses an effective ingredient extracting method and a preparation method of the traditional Chinese medicine composition for preventing the porcine reproductive and respiratory syndrome. The raditional Chinese medicine composition has the advantages that the effects of clearing heat and detoxifying, and resisting bacteria and diminishing inflammation are realized, the pig disease-resistant capability is improved, the immunity is enhanced, and the effect of traditional Chinese medicine composition for preventing the porcine reproductive and respiratory syndrome is good.
Description
Technical field
The invention belongs to veterinary medicament technical field, particularly a kind of Chinese medicine composition preventing pig blue-ear disease and preparation method thereof.
Background technology
Reproductive and respiratory syndrome has another name called Porcine reproductive and respiratory syndrome (Porcine reproductive and respiratory syndrome, PRRS) this disease in 1987 at U.S.'s Late Cambrian, China was in this disease of Late Cambrian in 1996, this disease is popular in worldwide at present, causes great economic loss to pig industry.The economic loss that the harm of reproductive and respiratory syndrome not only shows the damage that disease itself causes pig and causes, after most importantly infecting reproductive and respiratory syndrome, causes immunosuppressant to host immune system, other antibacterial of easy secondary or viral infection and disease symptoms is increased the weight of.
At present, to the treatment also not effective especially way of reproductive and respiratory syndrome, mostly adopt: antipyretic-antalgic agent, as dipyrone, An Jibilin, injection of Radix Bupleuri etc.; Antibiotics or sulfa drugs control antibacterial secondary infection, as penicillin, streptomycin, head born of the same parents thiophene furan, tetracycline, sulfadiazine, trimethoprim sulfanilamide 6 Sulfamonomethoxine injection etc.; Antiviral agents is as virus record, Folium Isatidis, Radix Isatidis, the injection such as to relieve internal heat greatly.The weak point that said medicine treatment pig blue-ear disease exists is that cost is higher, and therapeutic effect is undesirable.
Summary of the invention
In view of above-mentioned weak point, the present invention is by a large amount of research and practices, there is provided a kind of and there is compound traditional Chinese medicine composite of prevention pig blue-ear disease and its preparation method and application, the granule of said composition can directly add in feedstuff as feed additive, also directly livestock and fowl drinking water can be mixed in, make it in convenient and simple route of administration and while not affecting drug effect, also can improve its bioavailability.
In order to achieve the above object, present invention employs following technical scheme:
Prevent a Chinese medicine composition for pig blue-ear disease, the crude drug of described Chinese medicine composition comprises the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygoni Cuspidati, Rhizoma Osmundae, Caulis Lonicerae and Radix Glycyrrhizae, and the ratio of weight and number of each crude drug is Rhizoma Atractylodis Macrocephalae 10-35 part, Rhizoma Polygoni Cuspidati 20-65 part, Rhizoma Osmundae 10-35 part, Caulis Lonicerae 25-75 part, Radix Glycyrrhizae 5-25 part.
As preferably, the ratio of weight and number of each crude drug is Rhizoma Atractylodis Macrocephalae 10-15 part, Rhizoma Polygoni Cuspidati 20-30 part, Rhizoma Osmundae 10-15 part, Caulis Lonicerae 25-35 part, Radix Glycyrrhizae 5-10 part.
As preferably, the ratio of weight and number of each crude drug is Rhizoma Atractylodis Macrocephalae 25-35 part, Rhizoma Polygoni Cuspidati 50-65 part, Rhizoma Osmundae 25-35 part, Caulis Lonicerae 65-75 part, Radix Glycyrrhizae 15-25 part.
As preferably, the ratio of weight and number of each crude drug is the Rhizoma Atractylodis Macrocephalae 20 parts, Rhizoma Polygoni Cuspidati 40 parts, Rhizoma Osmundae 20 parts, Caulis Lonicerae 50 parts, 10 parts, Radix Glycyrrhizae.
As preferably, the described Rhizoma Atractylodis Macrocephalae and Rhizoma Polygoni Cuspidati and Rhizoma Osmundae and Caulis Lonicerae and Radix Glycyrrhizae mass ratio are in the composition 2:4:2:5:1.
A kind of Chinese medicine preparation preventing the Chinese medicine composition of pig blue-ear disease, also comprise adjuvant and binding agent, described adjuvant is soluble starch, alpha-lactose, dextrin, is the mixture of 3:1:1 according to mass ratio, and binding agent is the sodium carboxymethyl cellulose solution of mass percent concentration 0.3%.
A kind of extraction process of effective component preventing the Chinese medicine composition of pig blue-ear disease, the herbal mixture of the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygoni Cuspidati, Rhizoma Osmundae, Caulis Lonicerae, Radix Glycyrrhizae composition is ground into after powder with the 50-75%V/V ethanol of 6-10 times amount volume mass ratio, reflux, extract, 1-3 time, each 0.5-1.5h, merge extractive liquid, then concentrating under reduced pressure, obtains the effective extract of herbal mixture.
Prevent a preparation method for the Chinese medicine preparation of the Chinese medicine composition of pig blue-ear disease, it is characterized in that, comprise the following steps:
A. herbal mixture effective extract under agitation dropwise adds in adjuvant according to the ratio of 1:5 (medicine liquid volume mL/ adjuvant quality g), then adds binding agent and makes soft material;
B. the soft material made is crossed a steel sieve series and become wet granular, be placed in 55 DEG C of electric heating constant-temperature blowing drying boxes dry;
C. in dry granule, add magnesium oxide, after mixing, cross a sieve;
D. the granule by a sieve is put into No. five sieves, collect the granule on No. five sieves, obtain a kind of Chinese medicine granules preventing pig blue-ear disease.
Through the Chinese native medicine compound prescription pellet agent that the present invention obtains, uniform particles, color and luster is consistent, without phenomenons such as the moisture absorption, caking, deliquescence, meets Chinese veterinary pharmacopoeia requirement, quality controllable.
The present invention shows through pharmacodynamic study, and the prevention for pig blue-ear disease has good effect.
In prescription of the present invention, each component pharmacological effect is:
1. Rhizoma Atractylodis Macrocephalae effect: Rhizoma Atractylodis Macrocephalae bitter in the mouth; Sweet; Warm in nature.There is invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.
2. Rhizoma Polygoni Cuspidati effect: the micro-hardship of Rhizoma Polygoni Cuspidati, is slightly cold.Root stock hyoscine, invigorate blood circulation, dissipating blood stasis, stimulate the menstrual flow, the effect such as antitussive.
3. Rhizoma Osmundae effect: Rhizoma Osmundae is Lu Sheng Herba pteridii latiusculi, and root stock is uprightly sturdy, leafage is raw, keratin, odd number winglike compound leaf, pinnule is sickle shaped lanceolar, there is serration at edge, and petiole is elongated close by brown fine, soft fur, and Rhizoma Osmundae has the effect such as antiviral, antibacterial therapy biliary ascariasis.
4. Caulis Lonicerae effect: Caulis Lonicerae has heat-clearing and toxic substances removing, the curative effect of dispelling wind dredging collateral.Can be used for epidemic febrile disease heating, sore and toxic, toxic-heat and blood stasis, beriberoid pyretic arthralgia.
5. Radix Glycyrrhizae effect: Radix Glycyrrhizae feeble QI, taste is sweet and special.Function cures mainly heat-clearing and toxic substances removing, expelling phlegm for arresting cough, gastral cavity abdomen etc.Root and Rootstock hyoscine.
Prescription foundation of the present invention: this prescription is with strengthening vital QI to eliminate pathogenic factors, and strengthen pig premunition, diseases prevention ability, raising immunity is principle.In side, Caulis Lonicerae, Radix Glycyrrhizae, Rhizoma Osmundae are heat-clearing and toxic substances removing principal agent, and Rhizoma Polygoni Cuspidati, the Rhizoma Atractylodis Macrocephalae are antiviral, antibacterial accessory drugs.In side all medicine phases and, common anti-inflammation, can improve immunity of organisms and resistance against diseases.When the described Rhizoma Atractylodis Macrocephalae and Rhizoma Polygoni Cuspidati and Rhizoma Osmundae and Caulis Lonicerae and Radix Glycyrrhizae mass ratio are in the composition 2:4:2:5:1, best results.
The Chinese medicine granules made according to this programme has heat-clearing and toxic substances removing, antimicrobial and anti-inflammation efficacy, can strengthen pig resistance against diseases, improves immunity, as the Chinese medicine preparation of prevention reproductive and respiratory syndrome, has good effect.
Detailed description of the invention
Following non-limiting examples is for illustration of the present invention.
Embodiment 1:
The herbal mixture of Rhizoma Atractylodis Macrocephalae 20g, Rhizoma Polygoni Cuspidati 40g, Rhizoma Osmundae 20g, Caulis Lonicerae 50g, Radix Glycyrrhizae 10g composition is ground into after powder with 60% ethanol of 10 times amount volume mass ratios, reflux, extract, 3 times, each 0.5h, merge extractive liquid, then every milliliter of effective extract containing 2g crude drug is evaporated to, then under agitation dropwise adding mass ratio is that (medicine liquid volume is in mL: adjuvant quality is in adjuvant g), and wherein adjuvant is soluble starch: alpha-lactose: the mass ratio of dextrin is 3:1:1 homogeneous mixture for 1:5; Then add 3-5 and drip mass percent concentration 0.3% sodium carboxymethyl cellulose solution and mix homogeneously, make good soft material; The soft material made is put into No. one, rustless steel sieve to sieve, allow soft material granulating make wet granular by a sieve aperture; Obtained wet granular is paved and puts into porcelain dish, and in 55 DEG C of electric heating constant-temperature blowing drying boxes dry 15min, make dry granule; In dry granule, adding 1.5g magnesium oxide powder, (magnesium oxide powder plays lubrication, can regulate voluntarily), put into a sieve after mixing to sieve, granule by a sieve is continued to put into No. five sieve, collect the granule on No. five sieves, obtain a kind of Chinese medicine granules preventing pig blue-ear disease.
Embodiment 2:
The herbal mixture of Rhizoma Atractylodis Macrocephalae 10g, Rhizoma Polygoni Cuspidati 20g, Rhizoma Osmundae 10g, Caulis Lonicerae 25g, Radix Glycyrrhizae 5g composition is ground into after powder with 50% ethanol of 6 times amount volume mass ratios, reflux, extract, 1 time, each 1.5h, merge extractive liquid, then every milliliter of effective extract containing 2g crude drug is evaporated to, then under agitation dropwise adding mass ratio is that (medicine liquid volume is in mL: adjuvant quality is in adjuvant g), and wherein adjuvant is soluble starch: alpha-lactose: the mass ratio of dextrin is 3:1:1 homogeneous mixture for 1:5; Then add 3-5 and drip mass percent concentration 0.3% sodium carboxymethyl cellulose solution and mix homogeneously, make good soft material; The soft material made is put into No. one, rustless steel sieve to sieve, allow soft material granulating make wet granular by a sieve aperture; Obtained wet granular is paved and puts into porcelain dish, and in 55 DEG C of electric heating constant-temperature blowing drying boxes dry 15min, make dry granule; In dry granule, adding 1.5g magnesium oxide powder, (magnesium oxide powder plays lubrication, can regulate voluntarily), put into a sieve after mixing to sieve, granule by a sieve is continued to put into No. five sieve, collect the granule on No. five sieves, obtain a kind of Chinese medicine granules preventing pig blue-ear disease.
Embodiment 3:
The herbal mixture of Rhizoma Atractylodis Macrocephalae 25g, Rhizoma Polygoni Cuspidati 50g, Rhizoma Osmundae 25g, Caulis Lonicerae 62.5g, Radix Glycyrrhizae 12.5g composition is ground into after powder with 75% ethanol of 8 times amount volume mass ratios, reflux, extract, 2 times, each 1h, merge extractive liquid, then every milliliter of effective extract containing 2g crude drug is evaporated to, then under agitation dropwise adding mass ratio is that (medicine liquid volume is in mL: adjuvant quality is in adjuvant g), and wherein adjuvant is soluble starch: alpha-lactose: the mass ratio of dextrin is 3:1:1 homogeneous mixture for 1:5; Then add 3-5 and drip mass percent concentration 0.3% sodium carboxymethyl cellulose solution and mix homogeneously, make good soft material; The soft material made is put into No. one, rustless steel sieve to sieve, allow soft material granulating make wet granular by a sieve aperture; Obtained wet granular is paved and puts into porcelain dish, and in 55 DEG C of electric heating constant-temperature blowing drying boxes dry 15min, make dry granule; In dry granule, adding 1.5g magnesium oxide powder, (magnesium oxide powder plays lubrication, can regulate voluntarily), put into a sieve after mixing to sieve, granule by a sieve is continued to put into No. five sieve, collect the granule on No. five sieves, obtain a kind of Chinese medicine granules preventing pig blue-ear disease.The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., all should be included within protection scope of the present invention.
Compliance test result:
Using embodiment of the present invention 1-3 as the experiment of preventive effects of functional living being feed additive to pig blue-ear disease, 100 negative ablactational baby pig of 30 age in days reproductive and respiratory syndrome are divided into 5 groups at random, are denoted as I, II, III, IV, V group.I group is low dose group (0.5%, (Chinese medicine granules quality/feeding quality %)); II group is middle dosage group (1%); III group is high dose group (2%); IV group is tilmicosin matched group; V group is blank group (not dosing group), often organizes 20, and carries out the spice health care of continuous 15 days, within 40 days, adds up the average weight gain of each group afterwards, extremely washes in a pan quantity, reproductive and respiratory syndrome antigen PCR verification and measurement ratio.Result is as follows:
The above results shows that herbal mixture granule of the present invention has good preventive effect for pig blue-ear disease, its effect is suitable with tilmicosin, but its drug resistance without chemical antimicrobial drug and the drawback of drug residue are that current promotion uses the good potential drug of green non-poisonous Chinese medicine compound prevention pig blue-ear disease to select.
Claims (8)
1. one kind is prevented the Chinese medicine composition of pig blue-ear disease, it is characterized in that, the crude drug of described Chinese medicine composition comprises the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygoni Cuspidati, Rhizoma Osmundae, Caulis Lonicerae and Radix Glycyrrhizae, the ratio of weight and number of each crude drug is Rhizoma Atractylodis Macrocephalae 10-35 part, Rhizoma Polygoni Cuspidati 20-65 part, Rhizoma Osmundae 10-35 part, Caulis Lonicerae 25-75 part, Radix Glycyrrhizae 5-25 part.
2. a kind of Chinese medicine composition preventing pig blue-ear disease as claimed in claim 1, is characterized in that, the ratio of weight and number of each crude drug is Rhizoma Atractylodis Macrocephalae 10-15 part, Rhizoma Polygoni Cuspidati 20-30 part, Rhizoma Osmundae 10-15 part, Caulis Lonicerae 25-35 part, Radix Glycyrrhizae 5-10 part.
3. a kind of Chinese medicine composition preventing pig blue-ear disease as claimed in claim 1, is characterized in that, the ratio of weight and number of each crude drug is Rhizoma Atractylodis Macrocephalae 25-35 part, Rhizoma Polygoni Cuspidati 50-65 part, Rhizoma Osmundae 25-35 part, Caulis Lonicerae 65-75 part, Radix Glycyrrhizae 15-25 part.
4. a kind of Chinese medicine composition preventing pig blue-ear disease as claimed in claim 1, is characterized in that, the ratio of weight and number of each crude drug is the Rhizoma Atractylodis Macrocephalae 20 parts, Rhizoma Polygoni Cuspidati 40 parts, Rhizoma Osmundae 20 parts, Caulis Lonicerae 50 parts, 10 parts, Radix Glycyrrhizae.
5. a kind of Chinese medicine composition preventing pig blue-ear disease as claimed in claim 1, is characterized in that, the described Rhizoma Atractylodis Macrocephalae and Rhizoma Polygoni Cuspidati and Rhizoma Osmundae and Caulis Lonicerae and Radix Glycyrrhizae mass ratio are in the composition 2:4:2:5:1.
6. one kind comprises the Chinese medicine preparation of Chinese medicine composition described in any one of claim 1-5, it is characterized in that, also comprise adjuvant and binding agent, described adjuvant is soluble starch, alpha-lactose, dextrin, be the mixture of 3:1:1 according to mass ratio, binding agent is the sodium carboxymethyl cellulose solution of mass percent concentration 0.3%.
7. the extraction process of effective component of the Chinese medicine composition as described in any one of claim 1-5, it is characterized in that, the herbal mixture of the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygoni Cuspidati, Rhizoma Osmundae, Caulis Lonicerae, Radix Glycyrrhizae composition is ground into after powder with the 50-75%V/V ethanol of 6-10 times amount volume mass ratio, reflux, extract, 1-3 time, each 0.5-1.5h, merge extractive liquid, then concentrating under reduced pressure, obtain the effective extract of herbal mixture.
8. the preparation method of Chinese medicine preparation as claimed in claim 6, is characterized in that, comprise the following steps:
A. herbal mixture effective extract under agitation dropwise adds in adjuvant according to the ratio of 1:5 (medicine liquid volume mL/ adjuvant quality g), then adds binding agent and makes soft material;
B. the soft material made is crossed a steel sieve series and become wet granular, be placed in 55 DEG C of electric heating constant-temperature blowing drying boxes dry;
C. in dry granule, add magnesium oxide, after mixing, cross a sieve;
D. the granule by a sieve is put into No. five sieves, collect the granule on No. five sieves, obtain a kind of Chinese medicine granules preventing pig blue-ear disease.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105053741A (en) * | 2015-09-23 | 2015-11-18 | 青岛华仁技术孵化器有限公司 | Feed capable of preventing and treating porcine reproductive and respiratory syndrome |
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| CN102772703A (en) * | 2012-08-02 | 2012-11-14 | 山西双鹰动物药业有限公司 | Drug for treating porcine reproductive and respiratory syndrome |
| CN104069478A (en) * | 2014-07-26 | 2014-10-01 | 施瑞客（天津）生物技术有限公司 | Traditional Chinese medicine composition for preventing and treating porcine reproductive and respiratory syndrome and preparation method thereof |
| CN104258047A (en) * | 2014-10-11 | 2015-01-07 | 青岛华仁技术孵化器有限公司 | Traditional Chinese medicine composition for preventing and treating porcine reproductive and respiratory syndrome |
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- 2015-05-14 CN CN201510244449.7A patent/CN104800300B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102078419A (en) * | 2010-12-24 | 2011-06-01 | 任先武 | Medicament for preventing and treating porcine reproductive and respiratory syndrome (PRRS) and preparation method thereof |
| CN102688305A (en) * | 2012-06-11 | 2012-09-26 | 殷中琼 | Chinese medicine preparation for controlling livestock escherichia coli diseases as well as preparation method and application thereof |
| CN102772703A (en) * | 2012-08-02 | 2012-11-14 | 山西双鹰动物药业有限公司 | Drug for treating porcine reproductive and respiratory syndrome |
| CN104069478A (en) * | 2014-07-26 | 2014-10-01 | 施瑞客（天津）生物技术有限公司 | Traditional Chinese medicine composition for preventing and treating porcine reproductive and respiratory syndrome and preparation method thereof |
| CN104258047A (en) * | 2014-10-11 | 2015-01-07 | 青岛华仁技术孵化器有限公司 | Traditional Chinese medicine composition for preventing and treating porcine reproductive and respiratory syndrome |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105053741A (en) * | 2015-09-23 | 2015-11-18 | 青岛华仁技术孵化器有限公司 | Feed capable of preventing and treating porcine reproductive and respiratory syndrome |
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Address after: 621100 Luxi Industrial Development concentration area, Santai County, Mianyang City, Sichuan Province Patentee after: Tieqi Lishi Food Co.,Ltd. Address before: 621100 Luxi Industrial Development concentration area, Santai County, Mianyang City, Sichuan Province Patentee before: Sichuan tieqilishi Food Co.,Ltd. |