CN103041124A - Medicament for treating avian infectious bronchitis and preparation method thereof - Google Patents
Medicament for treating avian infectious bronchitis and preparation method thereof Download PDFInfo
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- CN103041124A CN103041124A CN 201110307906 CN201110307906A CN103041124A CN 103041124 A CN103041124 A CN 103041124A CN 201110307906 CN201110307906 CN 201110307906 CN 201110307906 A CN201110307906 A CN 201110307906A CN 103041124 A CN103041124 A CN 103041124A
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Abstract
The invention discloses a medicament for treating avian infectious bronchitis, and the pharmaceutical composition is prepared by isatis roots, radices sileris, belamcanda sinensis, platycodon grandiflorum, mix-fried almond, Sichuan fritillaria cirrhosa, rhizoma atractylodis and licorice; the pharmaceutical composition of the invention has the efficacy of clearing heat and removing toxin, relieving cough and calming panting, relieving exterior syndrome and relieving sore throat, and has good therapeutic effect on avian infectious bronchitis.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of infectious bronchitis of fowl and preparation method thereof, belong to the technical field of veterinary drug.
Background technology
Infectious bronchitis of fowl (IB) is a kind of common multiple acute height contagious disease that the avian infectious bronchitis virus (IBV) by coronaviridae cause, shows as the Various Diseases types such as breathing pattern, kidney type, visible peristalsis visible intestinal peristalsis, Glandular Stomach Type.After the children chicken infects death occurs, weightening finish and the price of deed reduce, the minimizing of laying eggs after laying hen infects, and Egg―qualites descends.Primary disease also usually infects with bacteria mixed infection and secondary antibacterial, thereby it is dead to increase the chicken group.The IBV that has reported both at home and abroad has serotype more than 26 kinds, and numerous because of serotype and new modification, the difficulty of its diagnosis and control is very large, has many technical barriers to need to be resolved hurrily at aspects such as specific aim vaccine and integrated control techniques.According to " world poultry " data in 1999, the most serious with respiratory system disease in the global fowl diseases, wherein IB is the principal disease of the most of area harm in world poultry husbandry.Since 1988, IB is in succession popular at China's most areas, and the sickness rate in epidemic-stricken area can reach 100%, and mortality rate can reach 10%～30%.Only domestic every year, the sick economic loss that causes reached more than 1,000,000,000 yuan thus to the part of feeding chicken in largely scale field statistics in 1996.Under the large-scale breeding condition, the IB infection rate is higher, and sick type is more complicated, and difficulty of prevention and cure is larger, endangers more violent.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of medicine for the treatment of infectious bronchitis of fowl and preparation method thereof; Medicine of the present invention has heat-clearing and toxic substances removing, relieving cough and asthma, and the effect of the sore-throat relieving that induces sweat has good therapeutical effect for infectious bronchitis of fowl.
For solving above technical problem, the present invention by the following technical solutions:
A kind of medicine for the treatment of infectious bronchitis of fowl, calculate according to composition by weight, it is by Radix Isatidis 15-25 part, Radix Saposhnikoviae 10-20 part, Rhizoma Belamcandae 10-20 part, Radix Platycodonis 5-10 part, processs Semen Armeniacae Amarum 10-20 part, Bulbus Fritillariae Cirrhosae 4-8 part, Rhizoma Atractylodis 5-15 part, Radix Glycyrrhizae 10-25 part and be prepared from.
Particularly, the medicine of described treatment infectious bronchitis of fowl calculates according to composition by weight, and it is by 20 parts of Radix Isatidis, 15 parts of Radix Saposhnikoviaes, 15 parts of Rhizoma Belamcandae, 8 parts of Radix Platycodoniss, processs 20 parts in 15 parts in Semen Armeniacae Amarum, 6 parts of Bulbus Fritillariae Cirrhosaes, 10 parts of Rhizoma Atractylodis, Radix Glycyrrhizae and be prepared from.
The preparation method of the medicine of described treatment infectious bronchitis of fowl is: proportionally take by weighing Radix Isatidis, Radix Saposhnikoviae, Rhizoma Belamcandae, Radix Platycodonis, process Semen Armeniacae Amarum, Bulbus Fritillariae Cirrhosae, Rhizoma Atractylodis and Radix Glycyrrhizae, be ground into respectively fine powder, behind the mixing and get final product.
Particularly, the preparation method of the medicine of described treatment infectious bronchitis of fowl is: proportionally take by weighing Radix Isatidis, Radix Saposhnikoviae, Rhizoma Belamcandae, Radix Platycodonis, process Semen Armeniacae Amarum, Bulbus Fritillariae Cirrhosae, Rhizoma Atractylodis and Radix Glycyrrhizae, water decocts 2-3 time, the decocting that each adding 8-12 doubly measures boiled 0.5-3 hour, filtered merging filtrate, concentrated, drying is ground into fine powder, and get final product.
Infectious bronchitis of chicken is the infectious disease that is caused by virus, there is no at present the chemicals of satisfactory effect.In the pharmaceutical composition of the present invention, Radix Isatidis has anti-bacteria and anti-virus, improves the merit of immunologic function, heat-clearing and toxic substances removing removing heat from blood.Radix Saposhnikoviae has expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic and antipruritic effect, is used for the treatment of cold, fever with chills, headache, general pain etc.Rhizoma Belamcandae has heat-clearing and toxic substances removing, throat, the effect of expectorant saliva.Radix Platycodonis has the effect of regulating the flow of vital energy, invigorate blood circulation, helping digestion and calming the nerves.Semen Armeniacae Amarum has expelling phlegm for arresting cough, relievings asthma, the effect of intestine moistening, lower air to open numbness.Bulbus Fritillariae Cirrhosae has clearing heat and moistening lung, the effect of preventing phlegm from forming and stopping coughing.Rhizoma Atractylodis are controlled wet the Sheng and are stranded spleen, the asthenia drowsiness, and gastral cavity painful abdominal mass abdominal distention, inappetence, vomiting is had loose bowels, dysentery, malaria, phlegm retention, edema, seasonal epidemic pathogens flu, anemofrigid-damp arthralgia, flaccidity of the lower limbs and nyctalopia etc.Radix Glycyrrhizae property is flat, sweet in the mouth; Has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the effect of coordinating the actions of various ingredients in a prescription; Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus etc. can also cushion toxicity, strong.
In the side, Radix Saposhnikoviae, Rhizoma Belamcandae, Radix Isatidis heat-clearing and toxic substances removing are with throat; Radix Platycodonis, Semen Armeniacae Amarum, the cough-relieving of Bulbus Fritillariae Cirrhosae lung qi dispersing; The Rhizoma Atractylodis the spleen strengthening and damp drying is to eliminate the phlegm; The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.Above medicament composing prescription is played heat-clearing and toxic substances removing altogether, relieving cough and asthma, the effect of the sore-throat relieving that induces sweat.We all have significant curative effect to infectious bronchitis, infectious laryngotracheitis and mycoplasma etc.
The applicant has carried out pharmacodynamics and anxious poison experiment to medicine of the present invention, and experimental result is as follows:
Experimental example 1: medicine of the present invention is to the clinical observation research of infectious bronchitis
Choose 900 of respiratory infectious bronchitis natural occurrence laying hen groups, be divided into of the present invention group (0.2g/ days/kilogram), medicine matched group (moroxydine 0.05g/ days/kilogram) and blank group.Each group medicine is evenly sneaked in the corresponding feed, tested 7 days.The result: of the present invention group of mortality rate is 0.66%, moroxydine group mortality rate is 4%, blank group mortality rate is 11.6%; Of the present invention group of laying rate improves 4.56% to the medicine matched group, improves 10.5% than blank group.
Choose 900 of the renal type infectious bronchitis natural occurrence laying hen groups of 27 ages in days, be divided at random three groups, 300 every group, of the present invention group (0.2g/ days/kilogram), medicine matched group (NaHCO
30.05g/ my god/kilogram) and the blank group.Treatment is 7 days continuously.The result: of the present invention group of mortality rate is 4%, and medicine matched group mortality rate is 5%, and blank group mortality rate is 22.67%.The matched group experimental chicken after medication the 3rd day of feces normal gradually, but still comparatively thin; After medication front 2 days of medicine group experimental chicken of the present invention, white urate increases in the test chicken feces, and the 3rd day feces after treatment is shaped fully, and feed intake recovers fast than other two groups.
Experimental example 2: anxious malicious experimental result
The acute toxicity testing result of study shows that medicine of the present invention is to the oral LD of mice
50Be 7214mg/kg, LD
5095% the credible 5914-9276mg/kg that is limited to, according to toxicology poisonous substance grade scale, be low toxicity.This shows that safety of medicine scope of the present invention is large, toxicity is low.
The specific embodiment
Embodiment 1:
Prescription: Radix Isatidis 20g, Radix Saposhnikoviae 15g, Rhizoma Belamcandae 15g, Radix Platycodonis 8g, process Semen Armeniacae Amarum 15g, Bulbus Fritillariae Cirrhosae 6g, Rhizoma Atractylodis 10g, Radix Glycyrrhizae 20g.
Preparation technology: proportionally take by weighing Radix Isatidis, Radix Saposhnikoviae, Rhizoma Belamcandae, Radix Platycodonis, process Semen Armeniacae Amarum, Bulbus Fritillariae Cirrhosae, Rhizoma Atractylodis and Radix Glycyrrhizae, water decocts 3 times, add for the first time 12 times of water gagings and decocted 3 hours, add 10 times of water gagings for the second time and decocted 2 hours, add for the third time 8 times of water gagings and decocted 0.5 hour, filter, merging filtrate, concentrated, drying, be ground into fine powder, and get final product.
Usage and dosage: in feedstuff, add every chicken 0.1g every day; The serious symptom person, water-soluble drink-service.
Embodiment 2
Prescription: Radix Isatidis 25g, Radix Saposhnikoviae 20g, Rhizoma Belamcandae 20g, Radix Platycodonis 10g, process Semen Armeniacae Amarum 20g, Bulbus Fritillariae Cirrhosae 8g, Rhizoma Atractylodis 15g, Radix Glycyrrhizae 25g.
Preparation technology: proportionally take by weighing Radix Isatidis, Radix Saposhnikoviae, Rhizoma Belamcandae, Radix Platycodonis, process Semen Armeniacae Amarum, Bulbus Fritillariae Cirrhosae, Rhizoma Atractylodis and Radix Glycyrrhizae, be ground into respectively fine powder, behind the mixing and get final product.
Usage and dosage: in feedstuff, add every chicken 0.2g every day; The serious symptom person, water-soluble drink-service.
Embodiment 3
Prescription: Radix Isatidis 15g, Radix Saposhnikoviae 10g, Rhizoma Belamcandae 10g, Radix Platycodonis 5g, process Semen Armeniacae Amarum 10g, Bulbus Fritillariae Cirrhosae 4g, Rhizoma Atractylodis 5g, Radix Glycyrrhizae 10g.
Preparation technology: proportionally take by weighing Radix Isatidis, Radix Saposhnikoviae, Rhizoma Belamcandae, Radix Platycodonis, process Semen Armeniacae Amarum, Bulbus Fritillariae Cirrhosae, Rhizoma Atractylodis and Radix Glycyrrhizae, water decocts 2 times, adding for the first time 12 times of water gagings decocted 2 hours, add for the second time 10 times of water gagings and decocted 2 hours, filter merging filtrate, concentrated, drying is ground into fine powder, and get final product.
Usage and dosage: in feedstuff, add every chicken 0.1g every day; The serious symptom person, water-soluble drink-service.
Embodiment 4
Prescription: Radix Isatidis 15g, Radix Saposhnikoviae 20g, Rhizoma Belamcandae 10g, Radix Platycodonis 5g, process Semen Armeniacae Amarum 20g, Bulbus Fritillariae Cirrhosae 4g, Rhizoma Atractylodis 5g, Radix Glycyrrhizae 25g.
Preparation technology: proportionally take by weighing Radix Isatidis, Radix Saposhnikoviae, Rhizoma Belamcandae, Radix Platycodonis, process Semen Armeniacae Amarum, Bulbus Fritillariae Cirrhosae, Rhizoma Atractylodis and Radix Glycyrrhizae, water decocts 2 times, adding for the first time 10 times of water gagings decocted 2 hours, add for the second time 8 times of water gagings and decocted 1 hour, filter merging filtrate, concentrated, drying is ground into fine powder, and get final product.
Usage and dosage: in feedstuff, add every chicken 0.1g every day; The serious symptom person, water-soluble drink-service.
Embodiment 5
Prescription: Radix Isatidis 25g, Radix Saposhnikoviae 10g, Rhizoma Belamcandae 20g, Radix Platycodonis 10g, process Semen Armeniacae Amarum 10g, Bulbus Fritillariae Cirrhosae 8g, Rhizoma Atractylodis 15g, Radix Glycyrrhizae 10g.
Preparation technology: proportionally take by weighing Radix Isatidis, Radix Saposhnikoviae, Rhizoma Belamcandae, Radix Platycodonis, process Semen Armeniacae Amarum, Bulbus Fritillariae Cirrhosae, Rhizoma Atractylodis and Radix Glycyrrhizae, be ground into respectively fine powder, behind the mixing and get final product.
Usage and dosage: in feedstuff, add every chicken 0.2g every day; The serious symptom person, water-soluble drink-service.
Claims (4)
1. medicine for the treatment of infectious bronchitis of fowl, it is characterized in that: calculate according to composition by weight, it is by Radix Isatidis 15-25 part, Radix Saposhnikoviae 10-20 part, Rhizoma Belamcandae 10-20 part, Radix Platycodonis 5-10 part, processs Semen Armeniacae Amarum 10-20 part, Bulbus Fritillariae Cirrhosae 4-8 part, Rhizoma Atractylodis 5-15 part, Radix Glycyrrhizae 10-25 part and be prepared from.
2. treat as claimed in claim 1 the medicine of infectious bronchitis of fowl, it is characterized in that: calculate according to composition by weight, it is by 20 parts of Radix Isatidis, 15 parts of Radix Saposhnikoviaes, 15 parts of Rhizoma Belamcandae, 8 parts of Radix Platycodoniss, processs 20 parts in 15 parts in Semen Armeniacae Amarum, 6 parts of Bulbus Fritillariae Cirrhosaes, 10 parts of Rhizoma Atractylodis, Radix Glycyrrhizae and be prepared from.
3. treat as claimed in claim 1 or 2 the preparation method of the medicine of infectious bronchitis of fowl, it is characterized in that: proportionally take by weighing Radix Isatidis, Radix Saposhnikoviae, Rhizoma Belamcandae, Radix Platycodonis, process Semen Armeniacae Amarum, Bulbus Fritillariae Cirrhosae, Rhizoma Atractylodis and Radix Glycyrrhizae, be ground into respectively fine powder, behind the mixing and get final product.
4. treat as claimed in claim 1 or 2 the preparation method of the medicine of infectious bronchitis of fowl, it is characterized in that: proportionally take by weighing Radix Isatidis, Radix Saposhnikoviae, Rhizoma Belamcandae, Radix Platycodonis, process Semen Armeniacae Amarum, Bulbus Fritillariae Cirrhosae, Rhizoma Atractylodis and Radix Glycyrrhizae, water decocts 2-3 time, the decocting that each adding 8-12 doubly measures boiled 0.5-3 hour, filtered merging filtrate, concentrated, drying is ground into fine powder, and get final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110307906 CN103041124A (en) | 2011-10-12 | 2011-10-12 | Medicament for treating avian infectious bronchitis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110307906 CN103041124A (en) | 2011-10-12 | 2011-10-12 | Medicament for treating avian infectious bronchitis and preparation method thereof |
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| CN103041124A true CN103041124A (en) | 2013-04-17 |
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| CN 201110307906 Pending CN103041124A (en) | 2011-10-12 | 2011-10-12 | Medicament for treating avian infectious bronchitis and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105435201A (en) * | 2016-01-06 | 2016-03-30 | 崔仲恩 | Compound medicine for preventing and treating respiratory infectious diseases of Putian black ducks and preparation method thereof |
| CN107669826A (en) * | 2017-10-24 | 2018-02-09 | 丹东瑞丰动物药业有限责任公司 | One kind treats more pathogen respiratory syndrome herbal medicines of chicken and preparation method thereof |
-
2011
- 2011-10-12 CN CN 201110307906 patent/CN103041124A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105435201A (en) * | 2016-01-06 | 2016-03-30 | 崔仲恩 | Compound medicine for preventing and treating respiratory infectious diseases of Putian black ducks and preparation method thereof |
| CN107669826A (en) * | 2017-10-24 | 2018-02-09 | 丹东瑞丰动物药业有限责任公司 | One kind treats more pathogen respiratory syndrome herbal medicines of chicken and preparation method thereof |
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Application publication date: 20130417 |