CN103006892A - Medicine composition for preventing and treating porcine viral diseases, and premix and batch with composition - Google Patents
Medicine composition for preventing and treating porcine viral diseases, and premix and batch with composition Download PDFInfo
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Abstract
The invention relates to a medicine composition for preventing and treating porcine viral diseases, and a premix and a batch with the composition, which belong to the field of veterinary drugs and premixes. The medicine composition provided by the invention comprises the following components in parts by weight: 40-95 parts of Chinese herbal medicine ingredients and 5-50 parts of timicosin. The Chinese herbal medicine ingredients are prepared from rhubarb, radix scutellariae, rhizome of Chinese goldthread, liquorice, puffball, mint, radix scrophulariae, burdock, rhizoma cimicifugae, bupleurum falcatum, radix peucedani, bitter orange, platycodon grandiflorum, dried tangerine or orange peel, forsythia, herba schizonepetae, radix sileris, radix isatidis, indigo naturalis, notopterygium root, radix angelicae pubescentis, tuckahoe, rhizome of chuanxiong, and talcum. The medicine composition provided by the invention is suitable for preventing and treating the porcine viral diseases and has the characteristics of exact curative effect, high safety, stable preparation, controllable quality, simple preparation technology, applicability to industrial production and the like. The medicine composition provided by invention can be added to feed for preparing growth-promoting pig feed such as the premix and the batch.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, premix material and batch for the control porcine viral diseases, belong to veterinary drug and premix material field.
Background technology
Follow the fast development of pig industry, swine diseases is day by day complicated, and chronic illness does not eliminate, and new constantly sick, atypical disease increases, the mixed infection aggravation, and swine diseases more and more restricts the development of pig industry.Only find the root of swine diseases challenge, just can find effective solution, walk out current quagmire.
The main cause that causes present swine diseases complexity is that viral disease is not controlled well.In the prevention and control porcine viral diseases, the most generally use and effective method is immunity.Although vaccine plays an important role preventing and treating infectious disease.But, because immunosuppressive disease is prevalent in each large pig farm, cause humoral immunization and cellular immune function to suffer grievous injury, cause usually and can't play a role at the vaccine of eliminating epidemic disease performance pivotal role, cause the inside and outside virus of cell and the cell of viral infection not to be eliminated, cause pig to be with for a long time poison; In addition, the RNA chain of a lot of RNA viruses vaccines can enter cell, with recombinate with the RNA chain of malicious zooblast infield poison, perhaps the RNA chain between the different wild poison is recombinated, thereby produce the stronger variant of virulence, cause existing vaccine more invalid, the clinical symptoms of disease is changed, performance atypia symptom and mixed infection.So cause swine diseases to be continuous and unbroken, more anti-more, the vicious circle controlling more dead and more dead, exempt from more random and more random appears, and therefore, vaccine can not solve all problems in the swine diseases, sometimes loses more than gain on the contrary.Because the forbidding of antiviral chemical medicine, infection chemical medicine for animals mainly refers to antibacterials, and antibacterials are invalid to virosis.Chinese medicine has been proved to be has widely biological activity, antiviral, antibiotic, improve immunity etc., but no matter in the body or the resisting pathogenic microbes of external Chinese medicine active or than chemical medicine be a little less than.This shows that single a kind of method can't effectively be controlled day by day complicated swine diseases, only has Chinese medicine and chemical medicine are united use, mutually learn from other's strong points to offset one's weaknesses that collaborative playing a role could be controlled the day by day serious virosis in pig farm.
Unite in the process of use at Chinese medicine and western medicine, because not science, improper, the improper use of compatibility of prescription not only do not reach expected effect, can cause more serious infringement to pig on the contrary.Therefore need to hold reasonable formula and principle of medication, just can obtain the effect of getting twice the result with half the effort.
Summary of the invention
The present invention adopts combining method of chinese-western medicine control porcine viral diseases.Traditional Chinese Medicine Anti is viral, antibiotic, antiinflammatory, antipyretic-antalgic, adjusting immunity, and Herba Schizonepetae and Radix Saposhnikoviae are dispersed flesh table wind and cold in the side, and Rhizoma Et Radix Notopterygii and Radix Angelicae Pubescentis are dispelled whole body rheumatism, and Radix Scutellariae and Rhizoma Coptidis let out clearly part of the body cavity above the diaphragm housing the heart and lungs pyretic toxicity, and six medicines share eliminating evil to induce sweat, and are monarch drug; The wind pain relieving of faling apart of Fructus Arctii, Fructus Forsythiae, Herba Menthae and Rhizoma Cimicifugae dispelling wind expelling pathogenic factors from the exterior, Rhizoma Chuanxiong, Radix Bupleuri help Herba Schizonepetae, Radix Saposhnikoviae to evacuate pathogenic factor in the exterior, and Poria eliminating dampness by diuresis spleen invigorating is ministerial drug to help healthy energy altogether; Lasiosphaera Seu Calvatia, Radix Isatidis and Indigo Naturalis removing toxic substances and promoting subsidence of swelling, pharynx-clearing throat-benefiting, the Radix Scrophulariae nourishing YIN to lower pathogenic fire, Pericarpium Citri Reticulatae, the Fructus Aurantii relieving stuffiness of the chest by dispersing aggregation of pathogens of regulating the flow of vital energy, Radix Peucedani and the cough-relieving of Radix Platycodonis lung qi dispersing, priming are up, and Talcum and Radix Et Rhizoma Rhei heat conduction are descending, are adjuvant drug; The Radix Glycyrrhizae QI invigorating and in, coordinating the actions of various ingredients in a prescription, for making medicine.All medicines share, heat-clearing and toxic substances removing, the loose effect that swells, dries and induce sweat of dispelling wind.Western medicine is antibiotic, plays a role fast, and skeptophylaxis is regulated, antiviral, prevents secondary infection, reduces dead.Pharmaceutical composition reasonable recipe of the present invention, take animal as whole, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, treating both the principal and secondary aspects of a disease, thus reach the purpose of effectively controlling fast porcine viral diseases.
The object of the present invention is to provide a kind of efficient, safe, quick-acting pharmaceutical composition that is used for the control porcine viral diseases, thereby address the above problem, and overcome the deficiency of existing means of prevention.
Another object of the present invention provides this preparation method and application thereof of being used for the pharmaceutical composition of control porcine viral diseases.
The present invention also provides premix material, batch or the particulate material that comprises this pharmaceutical composition.
The objective of the invention is to be achieved through the following technical solutions:
The invention provides a kind of pharmaceutical composition for the control porcine viral diseases, comprise the following weight parts component: Chinese medicine ingredients 40-95 part, tilmicosin 5-50 part; Described Chinese medicine ingredients is made by the component of following weight parts: Radix Et Rhizoma Rhei 5-50 part, Radix Scutellariae 5-50 part, Rhizoma Coptidis 5-50 part, Radix Glycyrrhizae 3-30 part, Lasiosphaera Seu Calvatia 3-30 part, Herba Menthae 5-50 part, Radix Scrophulariae 5-50 part, Fructus Arctii 5-60 part, Rhizoma Cimicifugae 5-50 part, Radix Bupleuri 5-50 part, Radix Peucedani 5-50 part, Fructus Aurantii 5-50 part, Radix Platycodonis 3-50 part, Pericarpium Citri Reticulatae 5-50 part, Fructus Forsythiae 5-50 part, Herba Schizonepetae 5-50 part, Radix Saposhnikoviae 5-50 part, Radix Isatidis 5-60 part, Indigo Naturalis 5-50 part, Rhizoma Et Radix Notopterygii 5-50 part, Radix Angelicae Pubescentis 5-50 part, Poria 5-60 part, Rhizoma Chuanxiong 5-50 part, Talcum 30-100 part.
In a preferred embodiment, the pharmaceutical composition of control porcine viral diseases of the present invention comprises the following weight parts component: Chinese medicine ingredients 60-90 part, tilmicosin 10-40 part; Described Chinese medicine ingredients is made by the component of following weight parts: Radix Et Rhizoma Rhei 10-40 part, Radix Scutellariae 10-40 part, Rhizoma Coptidis 10-40 part, Radix Glycyrrhizae 10-25 part, Lasiosphaera Seu Calvatia 10-25 part, Herba Menthae 10-40 part, Radix Scrophulariae 10-40 part, Fructus Arctii 20-60 part, Rhizoma Cimicifugae 10-40 part, Radix Bupleuri 10-40 part, Radix Peucedani 10-40 part, Fructus Aurantii 15-45 part, Radix Platycodonis 10-40 part, Pericarpium Citri Reticulatae 10-40 part, Fructus Forsythiae 10-40 part, Herba Schizonepetae 10-40 part, Radix Saposhnikoviae 15-40 part, Radix Isatidis 15-45 part, Indigo Naturalis 10-40 part, Rhizoma Et Radix Notopterygii 10-40 part, Radix Angelicae Pubescentis 10-40 part, Poria 25-55 part, Rhizoma Chuanxiong 10-40 part, Talcum 50-90 part.
In a further preferred embodiment, the pharmaceutical composition of control porcine viral diseases of the present invention comprises the parts by weight of component of following weight parts: Chinese medicine ingredients 75-85 part, tilmicosin 15-25 part; Described Chinese medicine ingredients is made by following component: Radix Et Rhizoma Rhei 25-35 part, Radix Scutellariae 20-30 part, Rhizoma Coptidis 15-25 part, Radix Glycyrrhizae 10-20 part, Lasiosphaera Seu Calvatia 15-25 part, Herba Menthae 20-30 part, Radix Scrophulariae 20-30 part, Fructus Arctii 30-50 part, Rhizoma Cimicifugae 20-30 part, Radix Bupleuri 20-30 part, Radix Peucedani 20-30 part, Fructus Aurantii 25-35 part, Radix Platycodonis 20-30 part, Pericarpium Citri Reticulatae 15-25 part, Fructus Forsythiae 25-35 part, Herba Schizonepetae 20-30 part, Radix Saposhnikoviae 25-35 part, Radix Isatidis 25-35 part, Indigo Naturalis 20-30 part, Rhizoma Et Radix Notopterygii 20-30 part, Radix Angelicae Pubescentis 20-30 part, Poria 40-50 part, Rhizoma Chuanxiong 20-30 part, Talcum 70-90 part.
In preferred embodiment further, the pharmaceutical composition of control porcine viral diseases of the present invention comprises the following weight parts component: 80 parts of Chinese medicine ingredients, 20 parts of tilmicosins; Described Chinese medicine ingredients is made by the component of following weight parts: 30 parts of Radix Et Rhizoma Rhei, 25 parts of Radix Scutellariaes, 20 parts of Rhizoma Coptidis, 15 parts in Radix Glycyrrhizae, 20 parts of Lasiosphaera Seu Calvatia, 25 parts of Herba Menthaes, 25 parts of Radix Scrophulariaes, 40 parts of Fructus Arctiis, 25 parts of Rhizoma Cimicifugaes, 25 parts of Radix Bupleuri, 25 parts of Radix Peucedanis, 30 parts of Fructus Aurantiis, 25 parts of Radix Platycodoniss, 20 parts of Pericarpium Citri Reticulataes, 30 parts of Fructus Forsythiaes, 25 parts of Herba Schizonepetae, 30 parts of Radix Saposhnikoviaes, 30 parts of Radix Isatidis, 25 parts of Indigo Naturaliss, 25 parts of Rhizoma Et Radix Notopterygiis, 25 parts of Radix Angelicae Pubescentiss, 45 parts in Poria, 25 parts of Rhizoma Chuanxiongs, 80 parts in Talcum.
The present invention also provides the preparation method of this pharmaceutical composition, and it comprises the steps:
(1) takes by weighing respectively by weight ratio the Chinese medicine ingredients of respectively distinguishing the flavor of, Radix Et Rhizoma Rhei, Radix Scutellariae, Rhizoma Coptidis, Radix Glycyrrhizae, Lasiosphaera Seu Calvatia, Herba Menthae, Radix Scrophulariae, Fructus Arctii, Rhizoma Cimicifugae, Radix Bupleuri, Radix Peucedani, Fructus Aurantii, Radix Platycodonis, Pericarpium Citri Reticulatae, Fructus Forsythiae, Herba Schizonepetae, Radix Saposhnikoviae, Radix Isatidis, Indigo Naturalis, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Poria, Rhizoma Chuanxiong and Talcum is dry, be ground into fine powder, namely get Chinese medicine ingredients;
(2) by weight taking by weighing respectively Chinese medicine ingredients and tilmicosin again, with the two mix homogeneously, and get final product.
Pharmaceutical composition of the present invention can be used for preparing the medicine of preventing and treating porcine viral diseases.
Drug component in the pharmaceutical composition of the present invention and consumption thereof get by repeatedly practising in a large number.Pharmaceutical composition of the present invention can be used for preventing and treating porcine viral diseases.
Pharmaceutical composition of the present invention also can add in the feedstuff, for the preparation of the somatotrophic feedstuff of pig, as: premix material provided by the invention also can be used for preparing the feedstuffs such as batch, particulate material.
Advantage and beneficial effect for control porcine viral diseases pharmaceutical composition of the present invention is:
(1) the present invention is the Chinese medicine and western medicine compound preparation, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, treating both the principal and secondary aspects of a disease;
(2) pharmaceutical composition reasonable recipe of the present invention, science;
(3) pharmaceutical composition good effect of the present invention, instant effect, easy to use, safe;
(4) drug combination preparation of the present invention is stable, preparation technology is simple, with low cost, and constant product quality, controlled has the stronger market competitiveness.
The specific embodiment
Following examples are used for explanation the present invention, but are not used for limiting the scope of the invention.
Embodiment 1
(1) takes by weighing the Chinese crude drug that contains following weight: 5 parts of Radix Et Rhizoma Rhei, 5 parts of Radix Scutellariaes, 5 parts of Rhizoma Coptidis, 3 parts in Radix Glycyrrhizae, 3 parts of Lasiosphaera Seu Calvatia, 5 parts of Herba Menthaes, 5 parts of Radix Scrophulariaes, 5 parts of Fructus Arctiis, 5 parts of Rhizoma Cimicifugaes, 5 parts of Radix Bupleuri, 5 parts of Radix Peucedanis, 5 parts of Fructus Aurantiis, 3 parts of Radix Platycodoniss, 5 parts of Pericarpium Citri Reticulataes, 5 parts of Fructus Forsythiaes, 5 parts of Herba Schizonepetae, 5 parts of Radix Saposhnikoviaes, 5 parts of Radix Isatidis, 5 parts of Indigo Naturaliss, 5 parts of Rhizoma Et Radix Notopterygiis, 5 parts of Radix Angelicae Pubescentiss, 5 parts in Poria, 5 parts of Rhizoma Chuanxiongs, 30 parts in Talcum, Chinese crude drug is dry, be ground into fine powder, for subsequent use as Chinese medicine ingredients.
(2) take by weighing respectively again the following weight composition: 40 parts of Chinese medicine ingredients, 5 parts of tilmicosins, mix homogeneously, and get final product.
Embodiment 2
(1) takes by weighing the Chinese crude drug that contains following weight: 50 parts of Radix Et Rhizoma Rhei, 50 parts of Radix Scutellariaes, 50 parts of Rhizoma Coptidis, 30 parts in Radix Glycyrrhizae, 30 parts of Lasiosphaera Seu Calvatia, 50 parts of Herba Menthaes, 50 parts of Radix Scrophulariaes, 60 parts of Fructus Arctiis, 50 parts of Rhizoma Cimicifugaes, 50 parts of Radix Bupleuri, 50 parts of Radix Peucedanis, 50 parts of Fructus Aurantiis, 50 parts of Radix Platycodoniss, 50 parts of Pericarpium Citri Reticulataes, 50 parts of Fructus Forsythiaes, 50 parts of Herba Schizonepetae, 50 parts of Radix Saposhnikoviaes, 60 parts of Radix Isatidis, 50 parts of Indigo Naturaliss, 50 parts of Rhizoma Et Radix Notopterygiis, 50 parts of Radix Angelicae Pubescentiss, 60 parts in Poria, 50 parts of Rhizoma Chuanxiongs, 100 parts in Talcum, Chinese crude drug is dry, be ground into fine powder, for subsequent use as Chinese medicine ingredients.
(2) take by weighing respectively again the following weight composition: 95 parts of Chinese medicine ingredients, 50 parts of tilmicosins, mix homogeneously, and get final product.
Embodiment 3
(1) takes by weighing the Chinese crude drug that contains following weight: 10 parts of Radix Et Rhizoma Rhei, 10 parts of Radix Scutellariaes, 10 parts of Rhizoma Coptidis, 10 parts in Radix Glycyrrhizae, 10 parts of Lasiosphaera Seu Calvatia, 10 parts of Herba Menthaes, 10 parts of Radix Scrophulariaes, 20 parts of Fructus Arctiis, 10 parts of Rhizoma Cimicifugaes, 10 parts of Radix Bupleuri, 10 parts of Radix Peucedanis, 15 parts of Fructus Aurantiis, 10 parts of Radix Platycodoniss, 10 parts of Pericarpium Citri Reticulataes, 10 parts of Fructus Forsythiaes, 10 parts of Herba Schizonepetae, 15 parts of Radix Saposhnikoviaes, 15 parts of Radix Isatidis, 10 parts of Indigo Naturaliss, 10 parts of Rhizoma Et Radix Notopterygiis, 10 parts of Radix Angelicae Pubescentiss, 25 parts in Poria, 10 parts of Rhizoma Chuanxiongs, 50 parts in Talcum, Chinese crude drug is dry, be ground into fine powder, for subsequent use as Chinese medicine ingredients.
(2) take by weighing respectively again the following weight composition: 60 parts of Chinese medicine ingredients, 10 parts of tilmicosins, mix homogeneously, and get final product.
Embodiment 4
(1) takes by weighing the Chinese crude drug that contains following weight: 40 parts of Radix Et Rhizoma Rhei, 40 parts of Radix Scutellariaes, 40 parts of Rhizoma Coptidis, 25 parts in Radix Glycyrrhizae, 25 parts of Lasiosphaera Seu Calvatia, 40 parts of Herba Menthaes, 40 parts of Radix Scrophulariaes, 60 parts of Fructus Arctiis, 40 parts of Rhizoma Cimicifugaes, 40 parts of Radix Bupleuri, 40 parts of Radix Peucedanis, 45 parts of Fructus Aurantiis, 40 parts of Radix Platycodoniss, 40 parts of Pericarpium Citri Reticulataes, 40 parts of Fructus Forsythiaes, 40 parts of Herba Schizonepetae, 40 parts of Radix Saposhnikoviaes, 45 parts of Radix Isatidis, 40 parts of Indigo Naturaliss, 40 parts of Rhizoma Et Radix Notopterygiis, 40 parts of Radix Angelicae Pubescentiss, 55 parts in Poria, 40 parts of Rhizoma Chuanxiongs, 90 parts in Talcum, Chinese crude drug is dry, be ground into fine powder, for subsequent use as Chinese medicine ingredients.
(2) take by weighing respectively again the following weight composition: 90 parts of Chinese medicine ingredients, 40 parts of tilmicosins, mix homogeneously, and get final product.
Embodiment 5
(1) takes by weighing the Chinese crude drug that contains following weight: 25 parts of Radix Et Rhizoma Rhei, 20 parts of Radix Scutellariaes, 15 parts of Rhizoma Coptidis, 10 parts in Radix Glycyrrhizae, 15 parts of Lasiosphaera Seu Calvatia, 20 parts of Herba Menthaes, 20 parts of Radix Scrophulariaes, 30 parts of Fructus Arctiis, 20 parts of Rhizoma Cimicifugaes, 20 parts of Radix Bupleuri, 20 parts of Radix Peucedanis, 25 parts of Fructus Aurantiis, 20 parts of Radix Platycodoniss, 15 parts of Pericarpium Citri Reticulataes, 25 parts of Fructus Forsythiaes, 20 parts of Herba Schizonepetae, 25 parts of Radix Saposhnikoviaes, 25 parts of Radix Isatidis, 20 parts of Indigo Naturaliss, 20 parts of Rhizoma Et Radix Notopterygiis, 20 parts of Radix Angelicae Pubescentiss, 40 parts in Poria, 20 parts of Rhizoma Chuanxiongs, 70 parts in Talcum, Chinese crude drug is dry, be ground into fine powder, for subsequent use as Chinese medicine ingredients.
(2) take by weighing respectively again the following weight composition: 75 parts of Chinese medicine ingredients, 15 parts of tilmicosins, mix homogeneously, and get final product.
Embodiment 6
(1) takes by weighing the Chinese crude drug that contains following weight: 35 parts of Radix Et Rhizoma Rhei, 30 parts of Radix Scutellariaes, 25 parts of Rhizoma Coptidis, 20 parts in Radix Glycyrrhizae, 25 parts of Lasiosphaera Seu Calvatia, 30 parts of Herba Menthaes, 30 parts of Radix Scrophulariaes, 50 parts of Fructus Arctiis, 30 parts of Rhizoma Cimicifugaes, 30 parts of Radix Bupleuri, 30 parts of Radix Peucedanis, 35 parts of Fructus Aurantiis, 30 parts of Radix Platycodoniss, 25 parts of Pericarpium Citri Reticulataes, 35 parts of Fructus Forsythiaes, 30 parts of Herba Schizonepetae, 35 parts of Radix Saposhnikoviaes, 35 parts of Radix Isatidis, 30 parts of Indigo Naturaliss, 30 parts of Rhizoma Et Radix Notopterygiis, 30 parts of Radix Angelicae Pubescentiss, 50 parts in Poria, 30 parts of Rhizoma Chuanxiongs, 90 parts in Talcum, Chinese crude drug is dry, be ground into fine powder, for subsequent use as Chinese medicine ingredients.
(2) take by weighing respectively again the following weight composition: 85 parts of Chinese medicine ingredients, 25 parts of tilmicosins, mix homogeneously, and get final product.
Embodiment 7
(1) takes by weighing the Chinese crude drug that contains following weight: 30 parts of Radix Et Rhizoma Rhei, 25 parts of Radix Scutellariaes, 20 parts of Rhizoma Coptidis, 15 parts in Radix Glycyrrhizae, 20 parts of Lasiosphaera Seu Calvatia, 25 parts of Herba Menthaes, 25 parts of Radix Scrophulariaes, 40 parts of Fructus Arctiis, 25 parts of Rhizoma Cimicifugaes, 25 parts of Radix Bupleuri, 25 parts of Radix Peucedanis, 30 parts of Fructus Aurantiis, 25 parts of Radix Platycodoniss, 20 parts of Pericarpium Citri Reticulataes, 30 parts of Fructus Forsythiaes, 25 parts of Herba Schizonepetae, 30 parts of Radix Saposhnikoviaes, 30 parts of Radix Isatidis, 25 parts of Indigo Naturaliss, 25 parts of Rhizoma Et Radix Notopterygiis, 25 parts of Radix Angelicae Pubescentiss, 45 parts in Poria, 25 parts of Rhizoma Chuanxiongs, 80 parts in Talcum, Chinese crude drug is dry, be ground into fine powder, for subsequent use as Chinese medicine ingredients.
(2) take by weighing respectively again the following weight composition: 80 parts of Chinese medicine ingredients, 20 parts of tilmicosins, mix homogeneously, and get final product.
For showing pharmaceutical composition of the present invention control porcine viral diseases effect, the applicant has further carried out the clinical observation on the therapeutic effect test to this pharmaceutical composition, below further sets forth the beneficial effect of medicine of the present invention by test example.
The observation of 1 pair of pig hyperpyrexia syndrome therapeutic effect of test example
The pig farm growing and fattening pigs of Ji'an, Jiangxi Province and sow sudden onset, body temperature 40.5-42.5 ℃, feed intake descends, and severe patient appetite is absolutely useless, dyspnea, asthma is rapid, serious appearance ventral breathing; Behind the ear in one's ear under edge cyanosis, the abdomen and the health many places skin such as extremity tip the aubergine speckle is arranged; Happiness is lain prostrate, and is disorderly thick by hair, and miscarriage appears in sow, produces the symptoms such as stillborn fetus, weak son and mummy.Cut open the visible inguinal lymph nodes of inspection and hilar lymph node enlargement, lung swelling, hardening, the obvious broadening of interstitial lung, pulmonary presents mottling to the brown pathological changes, liver, spleen swelling, matter are crisp, kidney, bladder, larynx, sulcus coronarius fat and intracardiac adventitia etc. have the petechia, and there is fibrinous oozing out in thoracic cavity and abdominal cavity.Comprehensive diagnos is pig hyperpyrexia syndrome.
400 sows and 3600 growing and fattening pigs to morbidity are treated, the sow of morbidity is divided into 4 groups, sow I group, sow II group, sow III group and sow IV group, every group of 100 sows give respectively embodiment 1, embodiment 3, embodiment 5 and embodiment 7 pharmaceutical compositions; The growing and fattening pigs of morbidity are divided into 4 groups, growing and fattening pigs I group, growing and fattening pigs II group, growing and fattening pigs III group and growing and fattening pigs IV group, every group of 900 growing and fattening pigs give respectively embodiment 1, embodiment 3, embodiment 5 and embodiment 7 pharmaceutical compositions; Adopt the drinking-water medication to give pharmaceutical composition, get 20 kilograms of 80 ℃ of hot water and add pharmaceutical composition 200 grams, soak three times, each 30 minutes, merge three times medicinal liquid, thin up to 100 kilogram, medicinal liquid is drunk for pig, and the medicinal residues spice is fed, and treats continuously 7 days, and observed result, result of the test sees Table 1.
Table 1 pig hyperpyrexia syndrome therapeutic test result
| Group | Cure rate | Effective percentage | Group | Cure rate | Effective percentage |
| Sow I group | 80.4% | 88.1% | Growing and fattening pigs I group | 81.8% | 86.1% |
| Sow II group | 84.6% | 90% | Growing and fattening pigs II group | 86.5% | 90% |
| Sow III group | 86% | 92% | Growing and fattening pigs III group | 88.6% | 90% |
| Sow IV group | 90.3% | 96.6% | Growing and fattening pigs IV group | 92.3% | 98.2% |
Result of the test shows that embodiment 1, embodiment 3, embodiment 5 and embodiment 7 pharmaceutical compositions all have good therapeutic effect to pig hyperpyrexia syndrome, and that wherein effect is best is embodiment 7, secondly is embodiment 5 and embodiment 3, is embodiment 1 at last.
The observation of 2 pairs of swine flue therapeutic effect of test example
It is depressed that spirit appears in pig farm, Shangyu, Zhejiang Province, growing and fattening pigs, loss of appetite or do not eat, and body temperature rises to 40-41.5 ℃, rapid breathing, ventral breathing, paroxysmal cough.Flow out mucus from eye and nose, nasal discharge is with blood sometimes.Cut open inspection visible larynx, trachea and bronchus and be full of and contain alveolate mucus, mucous hyperemia, swelling, interstitial lung broadening, lymphadenectasis, hyperemia, splenomegaly, splanchnocoel, pericardial cavity are accumulated the liquid of cellulose-containing mass.Mortality rate is not high, is swine flue through comprehensive diagnos.
The growing and fattening pigs of morbidity are divided into 4 groups, are respectively A group, B group, C group and D group, every group of 260 growing and fattening pigs give respectively embodiment 2, embodiment 4, embodiment 6 and embodiment 7 pharmaceutical compositions; Adopt the drinking-water medication to give pharmaceutical composition, get 20 kilograms of 80 ℃ of hot water and add pharmaceutical composition 200 grams, soak three times, each 30 minutes, merge three times medicinal liquid, thin up to 100 kilogram, medicinal liquid is drunk for pig, and the medicinal residues spice is fed, and treats continuously 7 days, and observed result, result of the test sees Table 2.
Table 2 swine flue therapeutic test result
Result of the test shows that embodiment 2, embodiment 4, embodiment 6 and embodiment 7 pharmaceutical compositions all have good therapeutic effect to swine flue, and that wherein effect is best is embodiment 7, secondly is embodiment 6 and embodiment 4, is embodiment 2 at last.
The observation of multisystemic exhaustion syndrome therapeutic effect behind 3 pairs of weaned piglets of test example
The In Longyan, Fujian pig farm, lassitude appears in ablactational baby pig, the loss of appetite phenomenon, growth retardation, become thin cough, heating, dyspnea, the inguinal lymph nodes enlargement, multisystemic exhaustion syndrome after comprehensive diagnos is the weaned piglet that causes of pig porcine circovirusⅡ infection.
The pig that will fall ill is divided into 4 groups at random, every group of 160 pigs.The 1st group gives embodiment 1 pharmaceutical composition and treats, the 2nd group gives not the pure Chinese medicine composition of the embodiment 1 of buccal medicine tilmicosin and treats, the 3rd group gives 20% tilmicosin solution and treats, and the 4th group is the blank group, does not give any Drug therapy.The 1st group and the 2nd group adopt the drinking-water medication to give pharmaceutical composition, get 20 kilograms of 80 ℃ of hot water and add pharmaceutical composition 200 grams, soaks three times, and each 30 minutes, merge three times medicinal liquid, thin up to 100 kilogram, medicinal liquid supplies pig to drink, and the medicinal residues spice is fed; The 3rd group is dissolved in the 100ml20% tilmicosin solution in 100 kg of water, drinks for pig, all treated continuously 7 days, and observed result, result of the test sees Table 3.
Multisystemic exhaustion syndrome therapeutic test result behind table 3 weaned piglet
Result of the test shows that the embodiment of the invention 1 pharmaceutical composition obviously is better than pure Chinese medicinal preparation or alone chemical medicine tilmicosin aspect the multisystemic exhaustion syndrome behind the treatment weaned piglet, have synergistic function.
The observation of 4 pairs of pig porcine circovirusⅡ infection preventive effects of test example
Selection has the pig farm of circovirus type II infection morbidity history to carry out the prophylactic tria observation.Once there was circovirus type II infection morbidity history on pig farm, Baoding, Hebei province, so select this pig farm to carry out effect assessment.
1500 ablactational baby pig in this pig farm are divided into 5 groups at random, are respectively the 1st group, the 2nd group, the 3rd group, the 4th group and the 5th group, every group of 300 piglets.The 1st group to the 4th group is the medicine group, the 1st group according to 1 kilogram of the per kilogram feedstuff interpolation embodiment of the invention 2 pharmaceutical composition, the 2nd group according to 1 kilogram of the per kilogram feedstuff interpolation embodiment of the invention 3 pharmaceutical composition, the 3rd group according to 1 kilogram of the per kilogram feedstuff interpolation embodiment of the invention 5 pharmaceutical composition, the 4th group according to 1 kilogram of the per kilogram feedstuff interpolation embodiment of the invention 7 pharmaceutical composition, continuous use 10 days.The 5th group is the blank group, does not give any medicine.Administration was observed 30 days after finishing, and result of the test sees Table 4.
Table 4 Porcine Circovirus infection mitigation result of the test
| Group | Number of animals (head) | Morbidity number of animals (head) | Sickness rate |
| The 1st group | 300 | 8 | 2.7% |
| The 2nd group | 300 | 5 | 1.7% |
| The 3rd group | 300 | 6 | 2% |
| The 4th group | 300 | 0 | 0 |
| The 5th group | 300 | 106 | 35.3% |
Result of the test shows, what prevention pig porcine circovirusⅡ infection effect was best is embodiment 7 pharmaceutical compositions, and sickness rate is 0, and effective percentage can reach 100%, next is embodiment 3, embodiment 5, embodiment 2 pharmaceutical compositions, all compares significant difference with the blank group.
The observation of 5 pairs of swine flue preventive effects of test example
Select pig farm, Huairou, Beijing to carry out the swine flue prophylactic tria, 1500 of growing and fattening pigs are divided into 3 groups at random, 500 every group.The 1st group, add 1 kilogram of the embodiment of the invention 4 pharmaceutical composition according to the per kilogram feedstuff, feed, be used in conjunction 10 days; The 2nd group, add 1 kilogram of the embodiment of the invention 7 pharmaceutical composition according to the per kilogram feedstuff, feed, be used in conjunction 10 days; The 3rd group, do not add any medicine in the feedstuff.Administration was observed 30 days after finishing.Result of the test sees Table 5.
Table 5 swine flue prophylactic tria result
| Group | Number of animals (head) | Morbidity number of animals (head) | Sickness rate |
| The 1st group | 500 | 8 | 1.6% |
| The 2nd group | 500 | 0 | 0 |
| The 3rd group | 500 | 211 | 42.2% |
Result of the test shows that the invention process 4 and embodiment 7 pharmaceutical compositions can reach respectively 98.4 and 100% for swine flue prevention effective percentage, all effectively generations of preventing swine influenza, but take embodiment 7 pharmaceutical compositions as best; And all compare significant difference with the blank group.
The observation of 6 pairs of pig hyperpyrexia syndrome preventive effects of test example
Select pig farm, Shunyi, Beijing to carry out the pig hyperpyrexia syndrome prophylactic tria, 1950 of growing and fattening pigs are divided into 3 groups at random, 650 every group.The 1st group, add 1 kilogram of the embodiment of the invention 6 pharmaceutical composition according to the per kilogram feedstuff, feed, be used in conjunction 10 days; The 2nd group, add 1 kilogram of the embodiment of the invention 7 pharmaceutical composition according to the per kilogram feedstuff, feed, be used in conjunction 10 days; The 3rd group, do not add any medicine in the feedstuff.Administration was observed 30 days after finishing.Result of the test sees Table 6.
Table 6 pig hyperpyrexia syndrome prophylactic tria result
Result of the test shows that the invention process 6 and embodiment 7 pharmaceutical compositions can reach respectively 96.8 and 100% for pig hyperpyrexia syndrome prevention effective percentage, the effectively generation of preventing swine influenza, but take embodiment 7 pharmaceutical compositions as best; And all compare significant difference with the blank group.
The effect observation that 7 pairs of pig farms of test example swine diseases purifies
Choose 3 each large-scale pig farm such as A pig farm, Beijing, B pig farm, Hebei, C pig farm, Tianjin and carry out the swine diseases cleaning test.A pig farm, Beijing, 2200 of livestock on hand sows, the sow abortion ratio is high, stillborn fetus, mummy incidence rate height, a little less than the piglet, diarrhoea, cough sickness rate height, piglet survival ratio is low; B pig farm, Hebei, 1600 of livestock on hand sows, sow triad incidence rate is high, and piglet diarrhea disease and respiratory tract disease are serious, and piglet survival ratio is low, and growing-finishing pigs speed is slow, and feedstuff-meat ratio is high; C pig farm, Tianjin, 3000 of livestock on hand sows were once broken out high fever syndrome, still happen occasionally thereafter, and the growing and fattening pigs respiratory tract disease were serious the impact growth.
Embodiment 7 pharmaceutical compositions are used on A pig farm, Beijing, B pig farm, Hebei, C pig farm, Tianjin, and concrete therapeutic regimen is as follows: feedstuff per ton adds 1 kilogram of embodiment 7 pharmaceutical composition, is used in conjunction 7 days every month, and full group feeding is fed, and uses continuously 6 months.Monitor after 6 months, the swine fever virus detection on three pig farms is negative, the influenza virus detection is negative, reproductive and respiratory syndrome virus detects feminine gender, porcine circovirus detects feminine gender, Pseudorabies virus detects negative; The sow generation abortion ratio on A pig farm, Beijing is 0, and stillborn fetus, mummy incidence rate are 0, and piglet diarrhea, cough sickness rate are 0.Piglet survival ratio is 99.6%; The sow triad incidence rate on B pig farm, Hebei is 0, and piglet diarrhea disease and respiratory tract disease sickness rate are 0, and piglet survival ratio reaches 99.2%, and growing and fattening pigs were delivered for sale in advance in 15 days; C pig farm, Tianjin hyperpyrexia disease incidence rate is 0, and growing and fattening pigs respiratory tract disease incidence rate is 0.Result of the test shows that embodiment 7 pharmaceutical compositions can effectively purify the pig farm disease, improves the pig farm culture benefit.
The above only is preferred implementation of the present invention; should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the technology of the present invention principle; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (7)
1. a pharmaceutical composition that is used for the control porcine viral diseases is characterized in that, comprises the following weight parts component: Chinese medicine ingredients 40-95 part, tilmicosin 5-50 part; Described Chinese medicine ingredients is made by the component of following weight parts: Radix Et Rhizoma Rhei 5-50 part, Radix Scutellariae 5-50 part, Rhizoma Coptidis 5-50 part, Radix Glycyrrhizae 3-30 part, Lasiosphaera Seu Calvatia 3-30 part, Herba Menthae 5-50 part, Radix Scrophulariae 5-50 part, Fructus Arctii 5-60 part, Rhizoma Cimicifugae 5-50 part, Radix Bupleuri 5-50 part, Radix Peucedani 5-50 part, Fructus Aurantii 5-50 part, Radix Platycodonis 3-50 part, Pericarpium Citri Reticulatae 5-50 part, Fructus Forsythiae 5-50 part, Herba Schizonepetae 5-50 part, Radix Saposhnikoviae 5-50 part, Radix Isatidis 5-60 part, Indigo Naturalis 5-50 part, Rhizoma Et Radix Notopterygii 5-50 part, Radix Angelicae Pubescentis 5-50 part, Poria 5-60 part, Rhizoma Chuanxiong 5-50 part, Talcum 30-100 part.
2. pharmaceutical composition according to claim 1 is characterized in that, comprises the following weight parts component: Chinese medicine ingredients 60-90 part, tilmicosin 10-40 part; Described Chinese medicine ingredients is made by the component of following weight parts: Radix Et Rhizoma Rhei 10-40 part, Radix Scutellariae 10-40 part, Rhizoma Coptidis 10-40 part, Radix Glycyrrhizae 10-25 part, Lasiosphaera Seu Calvatia 10-25 part, Herba Menthae 10-40 part, Radix Scrophulariae 10-40 part, Fructus Arctii 20-60 part, Rhizoma Cimicifugae 10-40 part, Radix Bupleuri 10-40 part, Radix Peucedani 10-40 part, Fructus Aurantii 15-45 part, Radix Platycodonis 10-40 part, Pericarpium Citri Reticulatae 10-40 part, Fructus Forsythiae 10-40 part, Herba Schizonepetae 10-40 part, Radix Saposhnikoviae 15-40 part, Radix Isatidis 15-45 part, Indigo Naturalis 10-40 part, Rhizoma Et Radix Notopterygii 10-40 part, Radix Angelicae Pubescentis 10-40 part, Poria 25-55 part, Rhizoma Chuanxiong 10-40 part, Talcum 50-90 part.
3. pharmaceutical composition according to claim 2 is characterized in that, comprises the following weight parts component: Chinese medicine ingredients 75-85 part, tilmicosin 15-25 part; Described Chinese medicine ingredients is made by following ingredients weight parts: Radix Et Rhizoma Rhei 25-35 part, Radix Scutellariae 20-30 part, Rhizoma Coptidis 15-25 part, Radix Glycyrrhizae 10-20 part, Lasiosphaera Seu Calvatia 15-25 part, Herba Menthae 20-30 part, Radix Scrophulariae 20-30 part, Fructus Arctii 30-50 part, Rhizoma Cimicifugae 20-30 part, Radix Bupleuri 20-30 part, Radix Peucedani 20-30 part, Fructus Aurantii 25-35 part, Radix Platycodonis 20-30 part, Pericarpium Citri Reticulatae 15-25 part, Fructus Forsythiae 25-35 part, Herba Schizonepetae 20-30 part, Radix Saposhnikoviae 25-35 part, Radix Isatidis 25-35 part, Indigo Naturalis 20-30 part, Rhizoma Et Radix Notopterygii 20-30 part, Radix Angelicae Pubescentis 20-30 part, Poria 40-50 part, Rhizoma Chuanxiong 20-30 part, Talcum 70-90 part.
4. pharmaceutical composition according to claim 3 is characterized in that, comprises the following weight parts component: 80 parts of Chinese medicine ingredients, 20 parts of tilmicosins; Described Chinese medicine ingredients is made by the component of following weight parts: 30 parts of Radix Et Rhizoma Rhei, 25 parts of Radix Scutellariaes, 20 parts of Rhizoma Coptidis, 15 parts in Radix Glycyrrhizae, 20 parts of Lasiosphaera Seu Calvatia, 25 parts of Herba Menthaes, 25 parts of Radix Scrophulariaes, 40 parts of Fructus Arctiis, 25 parts of Rhizoma Cimicifugaes, 25 parts of Radix Bupleuri, 25 parts of Radix Peucedanis, 30 parts of Fructus Aurantiis, 25 parts of Radix Platycodoniss, 20 parts of Pericarpium Citri Reticulataes, 30 parts of Fructus Forsythiaes, 25 parts of Herba Schizonepetae, 30 parts of Radix Saposhnikoviaes, 30 parts of Radix Isatidis, 25 parts of Indigo Naturaliss, 25 parts of Rhizoma Et Radix Notopterygiis, 25 parts of Radix Angelicae Pubescentiss, 45 parts in Poria, 25 parts of Rhizoma Chuanxiongs, 80 parts in Talcum.
5. the preparation method of each described pharmaceutical composition of claim 1-4 comprises the steps:
(1) takes by weighing respectively by weight ratio the Chinese medicine ingredients of respectively distinguishing the flavor of, Radix Et Rhizoma Rhei, Radix Scutellariae, Rhizoma Coptidis, Radix Glycyrrhizae, Lasiosphaera Seu Calvatia, Herba Menthae, Radix Scrophulariae, Fructus Arctii, Rhizoma Cimicifugae, Radix Bupleuri, Radix Peucedani, Fructus Aurantii, Radix Platycodonis, Pericarpium Citri Reticulatae, Fructus Forsythiae, Herba Schizonepetae, Radix Saposhnikoviae, Radix Isatidis, Indigo Naturalis, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Poria, Rhizoma Chuanxiong and Talcum is dry, be ground into fine powder, namely get Chinese medicine ingredients;
(2) by weight taking by weighing respectively Chinese medicine ingredients and tilmicosin again, with the two mix homogeneously, and get final product.
6. the application of each described pharmaceutical composition of claim 1-4 aspect preparation control porcine viral diseases medicine.
7. a premix material that comprises each described pharmaceutical composition of claim 1-4, batch or particulate material.
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| CN104474083A (en) * | 2014-11-29 | 2015-04-01 | 惠州市易丰农牧有限公司 | Traditional Chinese medicine compound preparation for treating porcine reproductive and respiratory syndrome |
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| CN106692396A (en) * | 2016-12-11 | 2017-05-24 | 衡阳县轩健农牧发展有限公司 | Medicine for preventing and treating swine influenza and preparation method thereof |
| CN107028001A (en) * | 2017-05-18 | 2017-08-11 | 佛山市高明区生产力促进中心 | It is a kind of to be used to strengthen the Chinese medicine fodder of live pig mouthfeel |
| CN109364042A (en) * | 2018-11-26 | 2019-02-22 | 河北地邦动物保健科技有限公司 | A kind of Chinese medicine targeting Tilmicosin pellet and preparation method thereof |
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| CN111905016A (en) * | 2020-09-16 | 2020-11-10 | 北京农学院 | Traditional Chinese medicine prescription for treating porcine reproductive and respiratory syndrome and preparation method thereof |
| CN112843011A (en) * | 2021-02-04 | 2021-05-28 | 广州市和生堂动物药业有限公司 | Tilmicosin premix and preparation method thereof |
| CN112843011B (en) * | 2021-02-04 | 2021-10-15 | 广州市和生堂动物药业有限公司 | Tilmicosin premix and preparation method thereof |
| CN113813393A (en) * | 2021-09-28 | 2021-12-21 | 四川省畜牧科学研究院 | Flavoring controlled release preparation and preparation method and application thereof |
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