CN110051770A - Compound Chinese herb Immune-enhancing effect preparation and preparation method thereof for treating weak piglet - Google Patents
Compound Chinese herb Immune-enhancing effect preparation and preparation method thereof for treating weak piglet Download PDFInfo
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- CN110051770A CN110051770A CN201910449133.XA CN201910449133A CN110051770A CN 110051770 A CN110051770 A CN 110051770A CN 201910449133 A CN201910449133 A CN 201910449133A CN 110051770 A CN110051770 A CN 110051770A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 34
- 150000001875 compounds Chemical class 0.000 title claims abstract description 21
- 230000000694 effects Effects 0.000 title claims abstract description 20
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 claims abstract description 17
- 241000756943 Codonopsis Species 0.000 claims abstract description 10
- 235000002722 Dioscorea batatas Nutrition 0.000 claims abstract description 10
- 235000006536 Dioscorea esculenta Nutrition 0.000 claims abstract description 10
- 240000001811 Dioscorea oppositifolia Species 0.000 claims abstract description 10
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 claims abstract description 10
- 239000009636 Huang Qi Substances 0.000 claims abstract description 10
- 244000197580 Poria cocos Species 0.000 claims abstract description 10
- 235000008599 Poria cocos Nutrition 0.000 claims abstract description 10
- 240000001341 Reynoutria japonica Species 0.000 claims abstract description 10
- 235000018167 Reynoutria japonica Nutrition 0.000 claims abstract description 10
- 238000000034 method Methods 0.000 claims abstract description 5
- 239000003814 drug Substances 0.000 claims description 21
- 239000000843 powder Substances 0.000 claims description 20
- 241000245665 Taraxacum Species 0.000 claims description 16
- 238000009835 boiling Methods 0.000 claims description 11
- 238000002156 mixing Methods 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 239000000706 filtrate Substances 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 3
- 238000010298 pulverizing process Methods 0.000 claims description 3
- 238000010079 rubber tapping Methods 0.000 claims description 3
- 241001180876 Saposhnikovia Species 0.000 claims 1
- 239000011812 mixed powder Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 210000004185 liver Anatomy 0.000 abstract description 5
- 239000000126 substance Substances 0.000 abstract description 5
- 235000021050 feed intake Nutrition 0.000 abstract description 4
- 230000036039 immunity Effects 0.000 abstract description 4
- 210000003734 kidney Anatomy 0.000 abstract description 4
- 241001465754 Metazoa Species 0.000 abstract description 2
- 231100000252 nontoxic Toxicity 0.000 abstract description 2
- 230000003000 nontoxic effect Effects 0.000 abstract description 2
- 230000008569 process Effects 0.000 abstract description 2
- 240000001949 Taraxacum officinale Species 0.000 abstract 1
- 206010008631 Cholera Diseases 0.000 description 6
- 230000003907 kidney function Effects 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 230000003908 liver function Effects 0.000 description 4
- 230000036528 appetite Effects 0.000 description 3
- 235000019789 appetite Nutrition 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 241000345998 Calamus manan Species 0.000 description 2
- 238000008157 ELISA kit Methods 0.000 description 2
- 241000287828 Gallus gallus Species 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000003651 drinking water Substances 0.000 description 2
- 235000020188 drinking water Nutrition 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 235000012950 rattan cane Nutrition 0.000 description 2
- 241000282887 Suidae Species 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000004731 jugular vein Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 230000000405 serological effect Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
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Abstract
The invention discloses a kind of for treating the compound Chinese herb Immune-enhancing effect preparation of weak piglet, according to parts by weight includes: 10-50 parts of Radix Codonopsis, 5-15 parts of rhizoma atractylodis macrocephalae, 10-50 parts of Chinese yam rhizome, 1-15 parts of radix paeoniae rubra, 10-50 parts of fructus persicae immaturus, 10-50 parts of radix ephedrae, 10-30 parts of Poria cocos, 10-30 parts of rhizoma alismatis, it is Radix Astragali 10-30 parts raw, 10-20 parts of Rhizoma Chuanxiong, 10-30 parts of the fleece-flower root, 10-40 parts of Caulis Spatholobi, it is 10-40 parts of dandelion, 1-15 parts windproof；Chinese herbal formula of the invention, which has, obviously restores weak piglet constitution, increases feed intake, and kidney is protected in liver protection, improve the effect of immunity etc., said preparation can substitute part chemicals, achieve the purpose that the weak piglet for the treatment of, simple process, it is low for equipment requirements, easily implement, it is convenient that obtained Chinese herbal formula is fed, nontoxic, harmless, noresidue, safety is good, is able to satisfy demand of the people to publicly harmless animal product.
Description
Technical field
The present invention relates to a kind of compound Chinese herb Immune-enhancing effect preparations and preparation method thereof for treating weak piglet, belong to
In technical field of traditional Chinese medicines.
Background technique
Pigling immunity is poor, it is weak be a kind of typical case under intensive pig production working condition feature, due to weak piglet
Appetite is low, and Liver and kidney function is poor, leads to piglet slow growth, and raising survival rate is low.Current most of pig farms use chemicals
It is treated, although chemicals can improve the constitution of piglet, will also result in medicament residue simultaneously.For this purpose, we mention
A kind of compound Chinese herb Immune-enhancing effect preparation and preparation method thereof for treating weak piglet out.
Summary of the invention
The main purpose of the present invention is to provide a kind of for treating the compound Chinese herb Immune-enhancing effect preparation of weak piglet
And preparation method thereof, having and obviously restore weak piglet constitution, increases feed intake, kidney is protected in liver protection, the effect of immunity etc. is improved,
Part chemicals can be substituted, achievees the purpose that the weak piglet for the treatment of, can effectively solve the problems in background technique.
To achieve the above object, the technical scheme adopted by the invention is as follows:
It is a kind of for treating the compound Chinese herb Immune-enhancing effect preparation of weak piglet, according to parts by weight include: Radix Codonopsis 10-
50 parts, 5-15 parts of rhizoma atractylodis macrocephalae, 10-50 parts of Chinese yam rhizome, 1-15 parts of radix paeoniae rubra, 10-50 parts of fructus persicae immaturus, 10-50 parts of radix ephedrae, Poria cocos
It is 10-30 parts, 10-30 parts of rhizoma alismatis, Radix Astragali 10-30 parts raw, 10-20 parts of Rhizoma Chuanxiong, 10-30 parts of the fleece-flower root, 10-40 parts of Caulis Spatholobi, Pu
It is public English 10-40 parts, 1-15 parts windproof.
The present invention also provides a kind of for treating the preparation method of the compound Chinese herb Immune-enhancing effect preparation of weak piglet, wraps
Include following steps:
(1) by Radix Codonopsis, rhizoma atractylodis macrocephalae, Chinese yam rhizome, radix paeoniae rubra, fructus persicae immaturus, Poria cocos, rhizoma alismatis, raw Radix Astragali, Rhizoma Chuanxiong, the fleece-flower root, chicken blood
Rattan, radix saposhnikoviae etc. is mixed according to above-mentioned parts by weight meter to be pulverized, and obtains mixing Chinese herbal ultra-fine powder；
(2) radix ephedrae, dandelion individually pulverize；
(3) after pulverizing, by mixing Chinese herbal ultra-fine powder, radix ephedrae Ultramicro-powder, dandelion Ultramicro-powder respectively in 10 times of water
It is middle to impregnate 1 hour；
(4) radix ephedrae Ultramicro-powder is put into after being boiled in Chinese medicine extracting tank and is kept for slight boiling condition 0.5 hour, Chinese medicine will be mixed
Ultramicro-powder is put into after Chinese medicine extracting tank boils and is kept for slight boiling condition 1.5 hours, and dandelion Ultramicro-powder is put into Chinese medicine extracting tank
Keep slight boiling condition 1 small after boiling；
(5) tapping respectively, filtering, the dregs of a decoction continue to decoct after adding 4 times of water measured again according to above-mentioned steps, so three times, close
And filtrate, and the filtrate mixing that Chinese medicine, radix ephedrae, dandelion will be mixed three times, it is 0.1g/ that 50-60 DEG C, which is concentrated into crude drug concentration,
ML, bottling sterilize to get Chinese herbal compound preparation.
Chinese herbal formula of the invention, which has, obviously restores weak piglet constitution, increases feed intake, and liver protection is protected kidney, mentioned
The effect of high immunity etc., said preparation can substitute part chemicals, achieve the purpose that the weak piglet for the treatment of, simple process,
It is low for equipment requirements, easily to implement, it is convenient that obtained Chinese herbal formula is fed, and nontoxic, harmless, noresidue, safety is good,
It is able to satisfy demand of the people to publicly harmless animal product.
Specific embodiment
To be easy to understand the technical means, the creative features, the aims and the efficiencies achieved by the present invention, below with reference to
Specific embodiment, the present invention is further explained.
It is a kind of for treating the compound Chinese herb Immune-enhancing effect preparation of weak piglet, according to parts by weight include: Radix Codonopsis 10-
50 parts, 5-15 parts of rhizoma atractylodis macrocephalae, 10-50 parts of Chinese yam rhizome, 1-15 parts of radix paeoniae rubra, 10-50 parts of fructus persicae immaturus, 10-50 parts of radix ephedrae, Poria cocos
It is 10-30 parts, 10-30 parts of rhizoma alismatis, Radix Astragali 10-30 parts raw, 10-20 parts of Rhizoma Chuanxiong, 10-30 parts of the fleece-flower root, 10-40 parts of Caulis Spatholobi, Pu
It is public English 10-40 parts, 1-15 parts windproof.
The present invention also provides a kind of for treating the preparation method of the compound Chinese herb Immune-enhancing effect preparation of weak piglet, wraps
Include following steps:
(1) by Radix Codonopsis, rhizoma atractylodis macrocephalae, Chinese yam rhizome, radix paeoniae rubra, fructus persicae immaturus, Poria cocos, rhizoma alismatis, raw Radix Astragali, Rhizoma Chuanxiong, the fleece-flower root, chicken blood
Rattan, radix saposhnikoviae etc. is mixed according to above-mentioned parts by weight meter to be pulverized, and obtains mixing Chinese herbal ultra-fine powder；
(2) radix ephedrae, dandelion individually pulverize；
(3) after pulverizing, by mixing Chinese herbal ultra-fine powder, radix ephedrae Ultramicro-powder, dandelion Ultramicro-powder respectively in 10 times of water
It is middle to impregnate 1 hour；
(4) radix ephedrae Ultramicro-powder is put into after being boiled in Chinese medicine extracting tank and is kept for slight boiling condition 0.5 hour, Chinese medicine will be mixed
Ultramicro-powder is put into after Chinese medicine extracting tank boils and is kept for slight boiling condition 1.5 hours, and dandelion Ultramicro-powder is put into Chinese medicine extracting tank
Keep slight boiling condition 1 small after boiling；
(5) tapping respectively, filtering, the dregs of a decoction continue to decoct after adding 4 times of water measured again according to above-mentioned steps, so three times, close
And filtrate, and the filtrate mixing that Chinese medicine, radix ephedrae, dandelion will be mixed three times, it is 0.1g/ that 50-60 DEG C, which is concentrated into crude drug concentration,
ML, bottling sterilize to get Chinese herbal compound preparation.
Embodiment 1
It is a kind of for treating the compound Chinese herb Immune-enhancing effect preparation of weak pig, in parts by weight, including following components:
30 parts of Radix Codonopsis, 12 parts of rhizoma atractylodis macrocephalae, 30 parts of Chinese yam rhizome, 12 parts of radix paeoniae rubra, 30 parts of fructus persicae immaturus, 30 parts of radix ephedrae, 15 parts of Poria cocos, rhizoma alismatis 15
Part, raw 20 parts of Radix Astragali, 12 parts of Rhizoma Chuanxiong, 15 parts of the fleece-flower root, 30 parts of Caulis Spatholobi, 30 parts of dandelion, 10 parts of radix saposhnikoviae, according to above-mentioned preparation
Method prepares compound preparation.
Embodiment 2
It is a kind of for treating the compound Chinese herb Immune-enhancing effect preparation of weak pig, in parts by weight, including following components:
25 parts of Radix Codonopsis, 15 parts of rhizoma atractylodis macrocephalae, 35 parts of Chinese yam rhizome, 13 parts of radix paeoniae rubra, 37 parts of fructus persicae immaturus, 40 parts of radix ephedrae, 25 parts of Poria cocos, rhizoma alismatis 18
Part, raw 25 parts of Radix Astragali, 20 parts of Rhizoma Chuanxiong, 20 parts of the fleece-flower root, 40 parts of Caulis Spatholobi, 25 parts of dandelion, 5 parts of radix saposhnikoviae, according to above-mentioned preparation
Method prepares compound preparation.
Embodiment 3
It is a kind of for treating the compound Chinese herb Immune-enhancing effect preparation of weak pig, in parts by weight, including following components:
35 parts of Radix Codonopsis, 5 parts of rhizoma atractylodis macrocephalae, 40 parts of Chinese yam rhizome, 15 parts of radix paeoniae rubra, 25 parts of fructus persicae immaturus, 20 parts of radix ephedrae, 30 parts of Poria cocos, rhizoma alismatis 25
Part, raw 30 parts of Radix Astragali, 18 parts of Rhizoma Chuanxiong, 25 parts of the fleece-flower root, 20 parts of Caulis Spatholobi, 20 parts of dandelion, 15 parts of radix saposhnikoviae, according to above-mentioned preparation
Method prepares compound preparation.
Weak pig 200 of 3 monthly ages are selected, 4 groups, respectively example 1 group, 2 groups of embodiment, 3 groups of embodiment are divided into
And control group, every group 50；3 groups of example 1 group, 2 groups of embodiment, embodiment youth's weak pigles, according to every pig 30g crude drug
Chinese herbal formula is added in drinking-water dosage, and drinking water administration, every morning is primary, once a day, continuous 30 days；Control group
Young weak pig is with no treatment；After medication, weighing, every group takes 10 pigs at random, and non-anticoagulant tube acquires jugular vein blood, from
The heart takes serum, detects liver function (AST, ALT) and renal function (CREA, BUN) according to the requirement of full-automatic biochemical kit；It presses
Hog cholera antibody is detected according to the detection method of hog cholera antibody ELISA kit；It is detected according to the detection method of IgG ELISA kit
IgG is horizontal.
Before test, weak piglet shows spiritual depressed, appetite stimulator, crouches low motionless, and right rolling is shaken on a left side of walking about once in a while, raising
Member drives reactionless, and weight is relatively with the serious symptoms such as relatively low of stage piglet, and after test, the spirit of weak piglet is significantly improved, right
Poultry raiser's drives strong reaction, and appetite enhances, and feed intake dramatically increases, and amount of exercise is dramatically increased with times of exercise, thus may be used
See, Chinese herbal formula of the invention has preferable clinical efficacy in terms for the treatment of weak piglet.
Influence (kg) of 1 Chinese herbal formula of table to weak pig weight
Note: the different letters of same column indicate significant difference (P<0.05), and same letter indicates that difference is not significant (P>0.05).
As shown in Table 1, before test, for the weak pig weight of each group than more uniform, difference is not significant (P > 0.05)；After test,
Example 1 group, 2 groups of embodiment, the weight of 3 groups of weak piglets of embodiment are above control group, significant difference (P < 0.05), wherein
Example 1 group, 2 groups of embodiment, 3 groups of embodiment, with 2 groups of example of weight highest, but difference is not significant compared with other 2 groups
(P > 0.05) shows that Chinese herbal formula has the function of increasing weak pig weight.
Influence of 2 Chinese herbal formula of table to weak piglet hog cholera antibody level
Note: the different letters of same column indicate significant difference (P<0.05), and same letter indicates that difference is not significant (P>0.05).
As shown in Table 2, when off-test, example 1 group, 2 groups of embodiment, 3 groups of weak piglets of embodiment hog cholera antibody
Level is higher than control group, significant difference (P < 0.05), wherein example 1 group, 2 groups of embodiment, 3 groups of embodiment, with 2 groups of example
The horizontal highest of hog cholera antibody, but difference is not significant (P > 0.05) compared with other 2 groups, shows that Chinese herbal formula has and increases
Add the effect of hog cholera antibody level.
Influence of 3 Chinese herbal formula of table to piglet Serological IgG level
Note: the different letters of same column indicate significant difference (P<0.05), and same letter indicates that difference is not significant (P>0.05).
As shown in Table 3, when off-test, example 1 group, 2 groups of embodiment, 3 groups of weak piglets of embodiment serum IgG water
It is flat to be higher than control group, significant difference (P < 0.05), wherein example 1 group, 2 groups of embodiment, 3 groups of embodiment, with 3 groups of blood of example
The horizontal highest of clear IgG antibody, but difference is not significant (P > 0.05) compared with other 2 groups, shows that Chinese herbal formula has
Increase the effect of serum IgG antibody levels.
Influence of 4 Chinese herbal formula of table to piglet hepatic and renal function
Note: the different letters of same column indicate significant difference (P<0.05), and same letter indicates that difference is not significant (P>0.05).
As shown in Table 4, when off-test, example 1 group, 2 groups of embodiment, the liver function of 3 groups of weak piglets of embodiment
(AST, ALT) and renal function (CREA, BUN) index are lower than control group, and significant difference (P < 0.05) shows Chinese herbal formula
With weak piglet kidney function indicator is reduced, have the function that kidney is protected in liver protection.
The basic principles, main features and advantages of the present invention have been shown and described above.The technology of the industry
Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and the above embodiments and description only describe this
The principle of invention, without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, these changes
Change and improvement all fall within the protetion scope of the claimed invention.
Claims (2)
1. a kind of for treating the compound Chinese herb Immune-enhancing effect preparation of weak piglet, it is characterised in that: wrap according to parts by weight
It includes: 10-50 parts of Radix Codonopsis, 5-15 parts of rhizoma atractylodis macrocephalae, 10-50 parts of Chinese yam rhizome, 1-15 parts of radix paeoniae rubra, 10-50 parts of fructus persicae immaturus, radix ephedrae 10-
It is 50 parts, 10-30 parts of Poria cocos, 10-30 parts of rhizoma alismatis, Radix Astragali 10-30 parts raw, 10-20 parts of Rhizoma Chuanxiong, 10-30 parts of the fleece-flower root, Caulis Spatholobi
It is 10-40 parts, 10-40 parts of dandelion, 1-15 parts windproof.
2. according to claim 1 a kind of for treating the preparation side of the compound Chinese herb Immune-enhancing effect preparation of weak piglet
Method, which comprises the steps of:
(1) by Radix Codonopsis, rhizoma atractylodis macrocephalae, Chinese yam rhizome, radix paeoniae rubra, fructus persicae immaturus, Poria cocos, rhizoma alismatis, raw Radix Astragali, Rhizoma Chuanxiong, the fleece-flower root, Caulis Spatholobi,
Radix saposhnikoviaes etc. are mixed according to above-mentioned parts by weight meter and are pulverized, and obtain mixing Chinese herbal ultra-fine powder；
(2) radix ephedrae, dandelion individually pulverize；
(3) after pulverizing, mixing Chinese herbal ultra-fine powder, radix ephedrae Ultramicro-powder, dandelion Ultramicro-powder are soaked in 10 times of water respectively
Bubble 1 hour；
(4) radix ephedrae Ultramicro-powder is put into after being boiled in Chinese medicine extracting tank and is kept for slight boiling condition 0.5 hour, Chinese medicine ultra micro will be mixed
Powder is put into after Chinese medicine extracting tank boils and is kept for slight boiling condition 1.5 hours, and dandelion Ultramicro-powder is put into Chinese medicine extracting tank and is boiled
Keep slight boiling condition 1 small afterwards；
(5) tapping respectively, filtering, the dregs of a decoction continue to decoct after adding 4 times of water measured again according to above-mentioned steps, so three times, merge three
Secondary filtrate, and the filtrate mixing that will mix Chinese medicine, radix ephedrae, dandelion, it is 0.1g/mL, dress that 50-60 DEG C, which is concentrated into crude drug concentration,
Bottle sterilizes to get Chinese herbal compound preparation.
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