CH625801A5 - Process for the preparation of pyrimid-4-one and -thione derivatives and their salts with acids - Google Patents

Process for the preparation of pyrimid-4-one and -thione derivatives and their salts with acids Download PDF

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Publication number
CH625801A5
CH625801A5 CH1248276A CH1248276A CH625801A5 CH 625801 A5 CH625801 A5 CH 625801A5 CH 1248276 A CH1248276 A CH 1248276A CH 1248276 A CH1248276 A CH 1248276A CH 625801 A5 CH625801 A5 CH 625801A5
Authority
CH
Switzerland
Prior art keywords
pyrimidone
methyl
group
general formula
imidazolylmethylthio
Prior art date
Application number
CH1248276A
Other languages
German (de)
English (en)
Inventor
Thomas Henry Brown
Graham John Durant
John Colin Emmett
Charon Robin Ganellin
Original Assignee
Smith Kline French Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline French Lab filed Critical Smith Kline French Lab
Publication of CH625801A5 publication Critical patent/CH625801A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CH1248276A 1975-10-02 1976-10-01 Process for the preparation of pyrimid-4-one and -thione derivatives and their salts with acids CH625801A5 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4034175 1975-10-02

Publications (1)

Publication Number Publication Date
CH625801A5 true CH625801A5 (en) 1981-10-15

Family

ID=10414412

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1248276A CH625801A5 (en) 1975-10-02 1976-10-01 Process for the preparation of pyrimid-4-one and -thione derivatives and their salts with acids

Country Status (36)

Country Link
JP (2) JPS5246087A (es)
AR (1) AR221682A1 (es)
AT (1) AT358045B (es)
AU (1) AU504897B2 (es)
BE (1) BE846452A (es)
BG (1) BG25224A3 (es)
CA (1) CA1067076A (es)
CH (1) CH625801A5 (es)
CS (1) CS203003B2 (es)
DD (1) DD126563A5 (es)
DE (1) DE2643670C2 (es)
DK (1) DK442476A (es)
ES (1) ES452060A1 (es)
FI (1) FI61701C (es)
FR (1) FR2326192A1 (es)
GR (1) GR61307B (es)
HU (1) HU175537B (es)
IE (1) IE44845B1 (es)
IL (1) IL50503A (es)
IN (1) IN146736B (es)
IT (2) IT1070839B (es)
LU (1) LU75922A1 (es)
MW (1) MW3476A1 (es)
MX (1) MX4614E (es)
NL (1) NL7609917A (es)
NO (1) NO145792C (es)
NZ (1) NZ181959A (es)
OA (1) OA05445A (es)
PH (1) PH13921A (es)
PL (1) PL105828B1 (es)
PT (1) PT65590B (es)
RO (1) RO73511A (es)
SE (1) SE431872B (es)
YU (1) YU237276A (es)
ZA (1) ZA765498B (es)
ZM (1) ZM12176A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MW5076A1 (en) * 1975-12-29 1978-02-08 Smith Kline French Lab Pharmacologicalle active compounds
NZ186511A (en) 1977-03-19 1980-11-14 Smith Kline French Lab 3-substituted alkylamino-6-substituted alkyl-1,2,4-triazin-5-ones and pharmaceutical compositions 3-substituted thio-1,2,4-triazin-5-ones
US4165378A (en) 1977-04-20 1979-08-21 Ici Americas Inc. Guanidine derivatives of imidazoles and thiazoles
NZ186965A (en) 1977-04-20 1980-02-21 Ici Ltd Guanidino derivatives and pharmaceutical compositions
JPS54104816A (en) * 1978-01-27 1979-08-17 Memorex Corp Magnetic recorder tape reel
IN151188B (es) * 1978-02-13 1983-03-05 Smith Kline French Lab
IL57005A (en) * 1978-04-11 1983-11-30 Smith Kline French Lab Process for the preparation of 2-amino pyrimid-4-one derivatives and novel 2-nitroaminopyrimid-4-ones as intermediates therefor
IL57416A (en) * 1978-05-30 1983-03-31 Smith Kline French Lab Nitro compounds,processes for preparing them and compositions containing them
ZA793443B (en) * 1978-07-26 1980-12-31 Glaxo Group Ltd Heterocyclic derivatives
US4374836A (en) 1978-10-16 1983-02-22 Imperial Chemical Industries Ltd. Antisecretory heterocyclic derivatives, process for their manufacture and pharmaceutical compositions containing them
US4496567A (en) * 1978-11-13 1985-01-29 Smith Kline & French Laboratories Limited Phenyl alkylaminopyrimidones
US4521418A (en) * 1979-02-21 1985-06-04 Smith Kline & French Laboratories Limited Guanidinothiazolyl derivatives
JPS55145683A (en) * 1979-04-26 1980-11-13 Smith Kline French Lab Pyrimidone derivative
CA1155842A (en) * 1980-03-29 1983-10-25 Thomas H. Brown Compounds
ZW21281A1 (en) * 1980-10-01 1981-11-18 Smith Kline French Lab Amine derivatives
IE53068B1 (en) * 1981-06-15 1988-05-25 Merck & Co Inc Diamino isothiazole-1-oxides and -1,1-dioxides as gastic secretion inhibitors
PT75074B (en) * 1981-06-27 1986-02-26 Smith Kline French Lab Process for preparing certain pyrimidone derivatives and compositions containing them
NZ202797A (en) * 1981-12-28 1985-08-30 Lilly Co Eli Pyrimidine derivatives and pharmaceutical compositions
JPS5993074A (ja) * 1982-10-01 1984-05-29 スミス・クライン・アンド・フレンチ・ラボラトリ−ス・リミテツド ピリミドン誘導体
DE8309239U1 (de) * 1983-03-29 1983-09-29 Basf Ag, 6700 Ludwigshafen Bandspule, insbesondere fuer magnetbaender

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1397436A (en) * 1972-09-05 1975-06-11 Smith Kline French Lab Heterocyclic n-cyanoguinidines
GB1419994A (en) * 1973-05-03 1976-01-07 Smith Kline French Lab Heterocyclicalkylaminotheterocyclic compounds methods for their preparation and compositions comprising them

Also Published As

Publication number Publication date
FR2326192B1 (es) 1979-01-12
CS203003B2 (en) 1981-02-27
ZA765498B (en) 1977-08-31
RO73511A (ro) 1981-04-30
BG25224A3 (en) 1978-08-10
IE44845B1 (en) 1982-04-21
FR2326192A1 (fr) 1977-04-29
HU175537B (hu) 1980-08-28
JPS609755B2 (ja) 1985-03-12
PL105828B1 (pl) 1979-11-30
GR61307B (en) 1978-10-19
ES452060A1 (es) 1977-10-01
PT65590A (en) 1976-10-01
AU1829576A (en) 1978-04-06
DE2643670A1 (de) 1977-04-14
IE44845L (en) 1977-04-02
ATA711976A (de) 1980-01-15
LU75922A1 (es) 1977-05-06
CA1067076A (en) 1979-11-27
NO145792C (no) 1982-06-02
YU237276A (en) 1983-01-21
IL50503A0 (en) 1976-11-30
JPS5246087A (en) 1977-04-12
FI61701C (fi) 1982-09-10
DE2643670C2 (de) 1982-07-01
DD126563A5 (es) 1977-07-27
NO763371L (es) 1977-04-05
PH13921A (en) 1980-11-04
MW3476A1 (en) 1977-11-09
BE846452A (fr) 1977-03-22
MX4614E (es) 1982-07-07
AR221682A1 (es) 1981-03-13
SE7610409L (sv) 1977-04-03
JPS5695186A (en) 1981-08-01
JPS5635674B2 (es) 1981-08-19
AT358045B (de) 1980-08-11
NL7609917A (nl) 1977-04-05
ZM12176A1 (en) 1977-07-21
FI762803A (es) 1977-04-03
DK442476A (da) 1977-04-03
IL50503A (en) 1980-12-31
NO145792B (no) 1982-02-22
SE431872B (sv) 1984-03-05
FI61701B (fi) 1982-05-31
AU504897B2 (en) 1979-11-01
PT65590B (en) 1978-03-28
IN146736B (es) 1979-08-25
IT1070839B (it) 1985-04-02
NZ181959A (en) 1978-07-28
IT7830708A0 (it) 1978-12-11
OA05445A (fr) 1981-03-31

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PL Patent ceased