BR112019003504A2 - compostos de amino-pirrolopirimidinona e métodos de uso dos mesmos - Google Patents
compostos de amino-pirrolopirimidinona e métodos de uso dos mesmosInfo
- Publication number
- BR112019003504A2 BR112019003504A2 BR112019003504-4A BR112019003504A BR112019003504A2 BR 112019003504 A2 BR112019003504 A2 BR 112019003504A2 BR 112019003504 A BR112019003504 A BR 112019003504A BR 112019003504 A2 BR112019003504 A2 BR 112019003504A2
- Authority
- BR
- Brazil
- Prior art keywords
- pyrrolopyrimidinone
- amino
- compounds
- methods
- compound
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/02—Halogenated hydrocarbons
- A61K31/025—Halogenated hydrocarbons carbocyclic
- A61K31/03—Halogenated hydrocarbons carbocyclic aromatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
Abstract
o pedido refere-se a um composto de fórmula (i): (i), ou um sal, hidrato, solvato, pró-fármaco, estereoisômero, ou tautômero farmaceuticamente aceitável do mesmo, que modula a atividade de btk, uma composição farmacêutica compreendendo um composto de fórmula (i), e um método de tratar ou prevenir uma doença em que btk desempenha um papel.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662378871P | 2016-08-24 | 2016-08-24 | |
US201662378868P | 2016-08-24 | 2016-08-24 | |
US201662378872P | 2016-08-24 | 2016-08-24 | |
US62/378,871 | 2016-08-24 | ||
US62/378,868 | 2016-08-24 | ||
US62/378,872 | 2016-08-24 | ||
PCT/US2017/048152 WO2018039310A1 (en) | 2016-08-24 | 2017-08-23 | Amino-pyrrolopyrimidinone compounds and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
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BR112019003504A2 true BR112019003504A2 (pt) | 2019-05-21 |
Family
ID=61241149
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112019003504-4A BR112019003504A2 (pt) | 2016-08-24 | 2017-08-23 | compostos de amino-pirrolopirimidinona e métodos de uso dos mesmos |
Country Status (14)
Country | Link |
---|---|
US (2) | US11020398B2 (pt) |
EP (1) | EP3504213A4 (pt) |
JP (1) | JP2019530650A (pt) |
KR (1) | KR20190035925A (pt) |
CN (1) | CN109890821A (pt) |
AU (1) | AU2017315343A1 (pt) |
BR (1) | BR112019003504A2 (pt) |
CA (1) | CA3034010A1 (pt) |
MX (1) | MX2019002212A (pt) |
PH (1) | PH12019500395A1 (pt) |
RU (1) | RU2019108280A (pt) |
SG (1) | SG11201901197PA (pt) |
TW (1) | TW201811795A (pt) |
WO (1) | WO2018039310A1 (pt) |
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RU2019108280A (ru) | 2016-08-24 | 2020-09-25 | Аркьюл, Инк. | Аминопирролопиримидиноновые соединения и способы их применения |
CA3081751A1 (en) | 2017-11-03 | 2019-05-09 | Aclaris Therapeutics, Inc. | Substituted pyrrolopyrimidine jak inhibitors and methods of making and using the same |
CN109956870A (zh) * | 2017-12-14 | 2019-07-02 | 南京卡文迪许生物工程技术有限公司 | 一种罗沙司他的合成方法及其中间体化合物 |
EP3774767A1 (en) * | 2018-04-05 | 2021-02-17 | Beth Israel Deaconess Medical Center, Inc. | Aryl hydrocarbon receptor modulators and uses thereof |
KR102545594B1 (ko) | 2018-07-31 | 2023-06-21 | 록쏘 온콜로지, 인코포레이티드 | (s)-5-아미노-3-(4-((5-플루오로-2-메톡시벤즈아미도)메틸)페닐)-1-(1,1,1-트리플루오로프로판-2-일)-1h-피라졸-4-카르복스아미드의 분무-건조된 분산물 및 제제 |
SG11202100525SA (en) | 2018-08-10 | 2021-02-25 | Aclaris Therapeutics Inc | Pyrrolopyrimidine itk inhibitors |
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KR20220004726A (ko) | 2019-05-02 | 2022-01-11 | 어클라리스 쎄라퓨틱스, 인코포레이티드 | Jak 억제제로서의 치환된 피롤로피리딘 |
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CN111320634A (zh) * | 2020-04-14 | 2020-06-23 | 浙江工业大学 | 一种乙酰氧取代的吡咯并[2,3-d]嘧啶衍生物的制备方法 |
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CN112574200B (zh) * | 2021-02-26 | 2021-06-11 | 安润医药科技(苏州)有限公司 | Btk和/或btk的突变体c481s的小分子抑制剂 |
CN115028633B (zh) * | 2021-03-08 | 2023-12-22 | 药雅科技(上海)有限公司 | 吡咯并嘧啶类化合物的制备及其应用 |
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2017
- 2017-08-23 RU RU2019108280A patent/RU2019108280A/ru not_active Application Discontinuation
- 2017-08-23 CA CA3034010A patent/CA3034010A1/en not_active Abandoned
- 2017-08-23 TW TW106128629A patent/TW201811795A/zh unknown
- 2017-08-23 CN CN201780065582.3A patent/CN109890821A/zh active Pending
- 2017-08-23 MX MX2019002212A patent/MX2019002212A/es unknown
- 2017-08-23 JP JP2019510826A patent/JP2019530650A/ja active Pending
- 2017-08-23 AU AU2017315343A patent/AU2017315343A1/en not_active Abandoned
- 2017-08-23 BR BR112019003504-4A patent/BR112019003504A2/pt not_active Application Discontinuation
- 2017-08-23 US US15/683,913 patent/US11020398B2/en active Active
- 2017-08-23 EP EP17844325.5A patent/EP3504213A4/en active Pending
- 2017-08-23 KR KR1020197008244A patent/KR20190035925A/ko unknown
- 2017-08-23 WO PCT/US2017/048152 patent/WO2018039310A1/en unknown
- 2017-08-23 SG SG11201901197PA patent/SG11201901197PA/en unknown
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2019
- 2019-02-26 PH PH12019500395A patent/PH12019500395A1/en unknown
- 2019-08-05 US US16/532,378 patent/US20190358233A1/en not_active Abandoned
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US20190358233A1 (en) | 2019-11-28 |
JP2019530650A (ja) | 2019-10-24 |
SG11201901197PA (en) | 2019-03-28 |
US20180055846A1 (en) | 2018-03-01 |
KR20190035925A (ko) | 2019-04-03 |
MX2019002212A (es) | 2019-07-08 |
RU2019108280A (ru) | 2020-09-25 |
CN109890821A (zh) | 2019-06-14 |
PH12019500395A1 (en) | 2019-05-20 |
WO2018039310A1 (en) | 2018-03-01 |
CA3034010A1 (en) | 2018-03-01 |
EP3504213A4 (en) | 2020-01-15 |
AU2017315343A1 (en) | 2019-02-28 |
TW201811795A (zh) | 2018-04-01 |
EP3504213A1 (en) | 2019-07-03 |
US11020398B2 (en) | 2021-06-01 |
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