BR112019006712A2 - composto, composição farmacêutica, composição para uso no tratamento de uma doença, elemento implantável, e, dispositivo. - Google Patents

composto, composição farmacêutica, composição para uso no tratamento de uma doença, elemento implantável, e, dispositivo.

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Publication number
BR112019006712A2
BR112019006712A2 BR112019006712A BR112019006712A BR112019006712A2 BR 112019006712 A2 BR112019006712 A2 BR 112019006712A2 BR 112019006712 A BR112019006712 A BR 112019006712A BR 112019006712 A BR112019006712 A BR 112019006712A BR 112019006712 A2 BR112019006712 A2 BR 112019006712A2
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Brazil
Prior art keywords
composition
disease
treating
compound
pharmaceutical composition
Prior art date
Application number
BR112019006712A
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English (en)
Inventor
Oberli Matthias
VEISEH Omid
Kevin Wotton Paul
Heidebrecht Richard
James Miller Robert
Original Assignee
Sigilon Therapeutics Inc
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Application filed by Sigilon Therapeutics Inc filed Critical Sigilon Therapeutics Inc
Publication of BR112019006712A2 publication Critical patent/BR112019006712A2/pt

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    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2465—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on alpha-galactose-glycoside bonds, e.g. alpha-galactosidase (3.2.1.22)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01022—Alpha-galactosidase (3.2.1.22)

Abstract

a presente invenção fornece compostos, por exemplo, compostos de fórmula (i) e sais, solvatos, hidratos, tautômeros, estereoisômeros, derivados isotopicamente identificados e composições farmaceuticamente aceitáveis dos mesmos. são também fornecidos elementos implantáveis (por exemplo, dispositivos e materiais) que compreendem os mesmos, assim como métodos de uso dos mesmos, por exemplo, para tratar ou prevenir uma doença, distúrbio ou afecção.
BR112019006712A 2016-10-03 2017-10-03 composto, composição farmacêutica, composição para uso no tratamento de uma doença, elemento implantável, e, dispositivo. BR112019006712A2 (pt)

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US201662436832P 2016-12-20 2016-12-20
PCT/US2017/055001 WO2018067615A1 (en) 2016-10-03 2017-10-03 Compounds, devices, and uses thereof

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