BR112016028642A2 - composto, composição farmacêutica, método de tratamento de uma doença ou condição, método de inibição da atividade de um polipeptídeo de fosfatidilinositol 3-quinase, método de inibição de reações imunes ou crescimento excessivo ou destrutivo ou de proliferação de células cancerosas, kit, e, uso de um composto, de um sal, de um isômero ou de uma mistura farmaceuticamente aceitável do mesmo. - Google Patents
composto, composição farmacêutica, método de tratamento de uma doença ou condição, método de inibição da atividade de um polipeptídeo de fosfatidilinositol 3-quinase, método de inibição de reações imunes ou crescimento excessivo ou destrutivo ou de proliferação de células cancerosas, kit, e, uso de um composto, de um sal, de um isômero ou de uma mistura farmaceuticamente aceitável do mesmo.Info
- Publication number
- BR112016028642A2 BR112016028642A2 BR112016028642A BR112016028642A BR112016028642A2 BR 112016028642 A2 BR112016028642 A2 BR 112016028642A2 BR 112016028642 A BR112016028642 A BR 112016028642A BR 112016028642 A BR112016028642 A BR 112016028642A BR 112016028642 A2 BR112016028642 A2 BR 112016028642A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- inhibiting
- pharmaceutically acceptable
- phosphatidylinositol
- treating
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462012172P | 2014-06-13 | 2014-06-13 | |
PCT/US2015/035126 WO2015191726A1 (en) | 2014-06-13 | 2015-06-10 | Phosphatidylinositol 3-kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112016028642A2 true BR112016028642A2 (pt) | 2017-08-22 |
Family
ID=53674245
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112016028642A BR112016028642A2 (pt) | 2014-06-13 | 2015-06-10 | composto, composição farmacêutica, método de tratamento de uma doença ou condição, método de inibição da atividade de um polipeptídeo de fosfatidilinositol 3-quinase, método de inibição de reações imunes ou crescimento excessivo ou destrutivo ou de proliferação de células cancerosas, kit, e, uso de um composto, de um sal, de um isômero ou de uma mistura farmaceuticamente aceitável do mesmo. |
Country Status (18)
Country | Link |
---|---|
US (1) | US11021467B2 (pt) |
EP (1) | EP3154960A1 (pt) |
JP (1) | JP6455995B2 (pt) |
KR (1) | KR20170012560A (pt) |
CN (1) | CN106459005A (pt) |
AR (1) | AR100808A1 (pt) |
AU (1) | AU2015274696B2 (pt) |
BR (1) | BR112016028642A2 (pt) |
CA (1) | CA2952012A1 (pt) |
EA (1) | EA201692268A1 (pt) |
HK (1) | HK1231476A1 (pt) |
IL (1) | IL248897A0 (pt) |
MA (1) | MA40059A (pt) |
MX (1) | MX2016016530A (pt) |
NZ (1) | NZ726360A (pt) |
SG (1) | SG11201609877XA (pt) |
TW (1) | TW201625560A (pt) |
WO (1) | WO2015191726A1 (pt) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6667300B2 (en) | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
CN101031569B (zh) | 2004-05-13 | 2011-06-22 | 艾科斯有限公司 | 作为人磷脂酰肌醇3-激酶δ抑制剂的喹唑啉酮 |
CN106660994A (zh) | 2014-06-13 | 2017-05-10 | 吉利德科学公司 | 磷脂酰肌醇3‑激酶抑制剂 |
SG11201610095SA (en) | 2014-06-13 | 2016-12-29 | Gilead Sciences Inc | Phosphatidylinositol 3-kinase inhibitors |
EP3154961B1 (en) | 2014-06-13 | 2019-10-09 | Gilead Sciences, Inc. | Quinazolinone derivatives as phosphatidylinositol 3-kinase inhibitors |
CN106573922A (zh) | 2014-06-13 | 2017-04-19 | 吉利德科学公司 | 磷脂酰肌醇3‑激酶抑制剂 |
EA201692268A1 (ru) | 2014-06-13 | 2017-06-30 | Джилид Сайэнс, Инк. | Ингибиторы фосфатидилинозитол-3-киназы |
US9765060B2 (en) * | 2014-06-24 | 2017-09-19 | Gilead Sciences, Inc. | Phosphatidylinositol 3-kinase inhibitors |
EA201692557A1 (ru) | 2014-07-04 | 2017-05-31 | Люпин Лимитед | Хинолизиноновые производные в качестве ингибиторов pi3k |
HUE056470T2 (hu) | 2014-12-26 | 2022-02-28 | Univ Emory | Vírusellenes N4-Hidroxicitidin származékok |
TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Hdac抑制劑與pd-l1抑制劑之組合治療 |
GB2590198B (en) | 2017-12-07 | 2022-02-23 | Univ Emory | N4-hydroxycytidine derivatives and anti-viral uses related thereto |
AU2019209960B2 (en) | 2018-01-20 | 2023-11-23 | Sunshine Lake Pharma Co., Ltd. | Substituted aminopyrimidine compounds and methods of use |
CN110590681B (zh) * | 2019-09-30 | 2021-06-01 | 中山大学 | 一种新型喹唑啉酮类化合物及其制备方法和应用 |
CN111440173B (zh) * | 2020-03-27 | 2021-05-14 | 山东大学 | 一种pi3k抑制剂的制备方法 |
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-
2015
- 2015-06-10 EA EA201692268A patent/EA201692268A1/ru unknown
- 2015-06-10 BR BR112016028642A patent/BR112016028642A2/pt not_active IP Right Cessation
- 2015-06-10 AU AU2015274696A patent/AU2015274696B2/en not_active Ceased
- 2015-06-10 SG SG11201609877XA patent/SG11201609877XA/en unknown
- 2015-06-10 MA MA040059A patent/MA40059A/fr unknown
- 2015-06-10 US US14/735,244 patent/US11021467B2/en active Active
- 2015-06-10 CN CN201580030997.8A patent/CN106459005A/zh active Pending
- 2015-06-10 MX MX2016016530A patent/MX2016016530A/es unknown
- 2015-06-10 EP EP15739038.6A patent/EP3154960A1/en not_active Ceased
- 2015-06-10 WO PCT/US2015/035126 patent/WO2015191726A1/en active Application Filing
- 2015-06-10 NZ NZ726360A patent/NZ726360A/en not_active IP Right Cessation
- 2015-06-10 CA CA2952012A patent/CA2952012A1/en not_active Abandoned
- 2015-06-10 JP JP2016570309A patent/JP6455995B2/ja not_active Expired - Fee Related
- 2015-06-10 KR KR1020177000749A patent/KR20170012560A/ko not_active Application Discontinuation
- 2015-06-11 TW TW104118964A patent/TW201625560A/zh unknown
- 2015-06-11 AR ARP150101858A patent/AR100808A1/es unknown
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2016
- 2016-11-10 IL IL248897A patent/IL248897A0/en unknown
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Publication number | Publication date |
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CA2952012A1 (en) | 2015-12-17 |
EP3154960A1 (en) | 2017-04-19 |
KR20170012560A (ko) | 2017-02-02 |
TW201625560A (zh) | 2016-07-16 |
MA40059A (fr) | 2015-12-17 |
WO2015191726A1 (en) | 2015-12-17 |
US20150361068A1 (en) | 2015-12-17 |
NZ726360A (en) | 2018-04-27 |
MX2016016530A (es) | 2017-03-27 |
AU2015274696A1 (en) | 2016-12-01 |
IL248897A0 (en) | 2017-01-31 |
EA201692268A1 (ru) | 2017-06-30 |
JP2017517527A (ja) | 2017-06-29 |
JP6455995B2 (ja) | 2019-01-23 |
AR100808A1 (es) | 2016-11-02 |
US11021467B2 (en) | 2021-06-01 |
SG11201609877XA (en) | 2016-12-29 |
CN106459005A (zh) | 2017-02-22 |
AU2015274696B2 (en) | 2018-09-27 |
HK1231476A1 (zh) | 2017-12-22 |
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