BR112014017882A2 - formulações estabilizadas contendo anticorpos anti-ang-2 - Google Patents
formulações estabilizadas contendo anticorpos anti-ang-2Info
- Publication number
- BR112014017882A2 BR112014017882A2 BR112014017882A BR112014017882A BR112014017882A2 BR 112014017882 A2 BR112014017882 A2 BR 112014017882A2 BR 112014017882 A BR112014017882 A BR 112014017882A BR 112014017882 A BR112014017882 A BR 112014017882A BR 112014017882 A2 BR112014017882 A2 BR 112014017882A2
- Authority
- BR
- Brazil
- Prior art keywords
- ang
- antibodies
- antibody
- containing anti
- formulations containing
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/06—Ampoules or carpules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/10—Bag-type containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D85/00—Containers, packaging elements or packages, specially adapted for particular articles or materials
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Abstract
resumo patente de invenção: "formulações estabilizadas contendo anticorpos anti-ang-2". a presente revelação proporciona formulações farmacêuticas que compreendem um anticorpo que se liga especificamente a angiopoietina 2 (ang-2). as formulações podem conter, além de um anticorpo anti-ang-2, pelo menos um aminoácido, pelo menos um açúcar ou pelo menos um surfactante não iônico. as formulações farmacêuticas da presente invenção apresentam um grau substancial de estabilidade do anticorpo após armazenagem por vários meses e após serem submetidas ao estresse térmico e a outros estresses físicos. 21846557v1 1/1 21846557v1
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261589427P | 2012-01-23 | 2012-01-23 | |
PCT/US2013/022473 WO2013112438A1 (en) | 2012-01-23 | 2013-01-22 | Stabilized formulations containing anti-ang2 antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112014017882A2 true BR112014017882A2 (pt) | 2017-06-27 |
Family
ID=47633582
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014017882A BR112014017882A2 (pt) | 2012-01-23 | 2013-01-22 | formulações estabilizadas contendo anticorpos anti-ang-2 |
Country Status (23)
Country | Link |
---|---|
US (1) | US9402898B2 (pt) |
EP (1) | EP2807190B1 (pt) |
JP (1) | JP6113756B2 (pt) |
KR (1) | KR102063028B1 (pt) |
CN (1) | CN104169299B (pt) |
AR (1) | AR089787A1 (pt) |
AU (1) | AU2013212587B2 (pt) |
BR (1) | BR112014017882A2 (pt) |
CA (1) | CA2861062A1 (pt) |
CL (1) | CL2014001930A1 (pt) |
EA (1) | EA033387B1 (pt) |
HK (1) | HK1204631A1 (pt) |
IL (1) | IL233482B (pt) |
JO (1) | JO3533B1 (pt) |
MA (1) | MA35904B1 (pt) |
MX (1) | MX357393B (pt) |
MY (1) | MY164611A (pt) |
NZ (1) | NZ627859A (pt) |
PH (1) | PH12014501628B1 (pt) |
SG (1) | SG11201403792TA (pt) |
TW (1) | TWI615149B (pt) |
UY (1) | UY34587A (pt) |
WO (1) | WO2013112438A1 (pt) |
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JO3417B1 (ar) | 2010-01-08 | 2019-10-20 | Regeneron Pharma | الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r |
NZ609557A (en) | 2010-10-06 | 2014-12-24 | Regeneron Pharma | Stabilized formulations containing anti-interleukin-4 receptor (il-4r) antibodies |
SG11201403792TA (en) | 2012-01-23 | 2014-10-30 | Regeneron Pharma | Stabilized formulations containing anti-ang2 antibodies |
US8613919B1 (en) * | 2012-08-31 | 2013-12-24 | Bayer Healthcare, Llc | High concentration antibody and protein formulations |
-
2013
- 2013-01-22 SG SG11201403792TA patent/SG11201403792TA/en unknown
- 2013-01-22 KR KR1020147023205A patent/KR102063028B1/ko active IP Right Grant
- 2013-01-22 NZ NZ627859A patent/NZ627859A/en not_active IP Right Cessation
- 2013-01-22 MY MYPI2014001985A patent/MY164611A/en unknown
- 2013-01-22 MX MX2014008874A patent/MX357393B/es active IP Right Grant
- 2013-01-22 EA EA201491414A patent/EA033387B1/ru unknown
- 2013-01-22 EP EP13702556.5A patent/EP2807190B1/en active Active
- 2013-01-22 WO PCT/US2013/022473 patent/WO2013112438A1/en active Application Filing
- 2013-01-22 BR BR112014017882A patent/BR112014017882A2/pt not_active Application Discontinuation
- 2013-01-22 US US13/746,669 patent/US9402898B2/en active Active
- 2013-01-22 CN CN201380006367.8A patent/CN104169299B/zh not_active Expired - Fee Related
- 2013-01-22 JP JP2014553508A patent/JP6113756B2/ja not_active Expired - Fee Related
- 2013-01-22 JO JOP/2013/0020A patent/JO3533B1/ar active
- 2013-01-22 AU AU2013212587A patent/AU2013212587B2/en not_active Ceased
- 2013-01-22 CA CA2861062A patent/CA2861062A1/en not_active Abandoned
- 2013-01-23 UY UY0001034587A patent/UY34587A/es not_active Application Discontinuation
- 2013-01-23 TW TW102102503A patent/TWI615149B/zh not_active IP Right Cessation
- 2013-01-23 AR ARP130100204A patent/AR089787A1/es not_active Application Discontinuation
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2014
- 2014-07-02 IL IL233482A patent/IL233482B/en active IP Right Grant
- 2014-07-15 PH PH12014501628A patent/PH12014501628B1/en unknown
- 2014-07-22 CL CL2014001930A patent/CL2014001930A1/es unknown
- 2014-08-07 MA MA37279A patent/MA35904B1/fr unknown
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2015
- 2015-06-01 HK HK15105209.9A patent/HK1204631A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EA033387B1 (ru) | 2019-10-31 |
PH12014501628A1 (en) | 2014-10-13 |
AR089787A1 (es) | 2014-09-17 |
KR102063028B1 (ko) | 2020-01-07 |
NZ627859A (en) | 2015-09-25 |
TWI615149B (zh) | 2018-02-21 |
EP2807190A1 (en) | 2014-12-03 |
US20130186797A1 (en) | 2013-07-25 |
JP2015505539A (ja) | 2015-02-23 |
KR20150000873A (ko) | 2015-01-05 |
MX2014008874A (es) | 2014-09-01 |
US9402898B2 (en) | 2016-08-02 |
IL233482B (en) | 2019-06-30 |
IL233482A0 (en) | 2014-08-31 |
EP2807190B1 (en) | 2018-12-26 |
AU2013212587B2 (en) | 2017-07-20 |
EA201491414A1 (ru) | 2014-12-30 |
CN104169299B (zh) | 2018-06-05 |
JP6113756B2 (ja) | 2017-04-12 |
MY164611A (en) | 2018-01-30 |
WO2013112438A1 (en) | 2013-08-01 |
MX357393B (es) | 2018-07-06 |
CA2861062A1 (en) | 2013-08-01 |
TW201343177A (zh) | 2013-11-01 |
HK1204631A1 (en) | 2015-11-27 |
UY34587A (es) | 2013-07-31 |
PH12014501628B1 (en) | 2014-10-13 |
JO3533B1 (ar) | 2020-07-05 |
CN104169299A (zh) | 2014-11-26 |
SG11201403792TA (en) | 2014-10-30 |
MA35904B1 (fr) | 2014-12-01 |
CL2014001930A1 (es) | 2014-10-03 |
AU2013212587A1 (en) | 2014-08-21 |
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