BR112013025294A2 - moléculas de ligação biespecífica ligando a dll4 e ang2 - Google Patents

moléculas de ligação biespecífica ligando a dll4 e ang2

Info

Publication number
BR112013025294A2
BR112013025294A2 BR112013025294A BR112013025294A BR112013025294A2 BR 112013025294 A2 BR112013025294 A2 BR 112013025294A2 BR 112013025294 A BR112013025294 A BR 112013025294A BR 112013025294 A BR112013025294 A BR 112013025294A BR 112013025294 A2 BR112013025294 A2 BR 112013025294A2
Authority
BR
Brazil
Prior art keywords
ang2
dll4
binding
binding molecules
bispecific
Prior art date
Application number
BR112013025294A
Other languages
English (en)
Inventor
Gschwind Andreas
Depla Erik
Boucneau Joachim
-Ange Buyse Marie
Georg Ott Rene
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44314095&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112013025294(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of BR112013025294A2 publication Critical patent/BR112013025294A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

resumo patente de invenção: "moléculas de ligação biespecífica ligando a dll4 e ang2". a presente invenção refere-se a moléculas de ligação biespecífica ligando tanto a dll4 quanto a ang2, preferencialmente sob a forma de domínios únicos variáveis de imunoglobulina como vhhs e domínios de anticorpos, composições farmacêuticas contendo os mesmos e sua utilização no tratamento de doenças que são associadas com efeitos sobre a angiogênese mediados por dll4 e/ou mediados por ang2. adicionalmente, também são descritos ácidos nucleicos codificando moléculas de ligação biespecífica, células hospedeiras e métodos para preparar os mesmos.
BR112013025294A 2011-04-01 2012-03-30 moléculas de ligação biespecífica ligando a dll4 e ang2 BR112013025294A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11160920 2011-04-01
PCT/EP2012/055897 WO2012131076A1 (en) 2011-04-01 2012-03-30 BISPECIFIC BINDING MOLECULES BINDING TO Dll4 AND Ang2

Publications (1)

Publication Number Publication Date
BR112013025294A2 true BR112013025294A2 (pt) 2017-06-13

Family

ID=44314095

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013025294A BR112013025294A2 (pt) 2011-04-01 2012-03-30 moléculas de ligação biespecífica ligando a dll4 e ang2

Country Status (23)

Country Link
US (1) US20130078247A1 (pt)
EP (1) EP2694545B1 (pt)
JP (1) JP2014511682A (pt)
KR (1) KR20140016345A (pt)
CN (2) CN103596977B (pt)
AP (1) AP2013007086A0 (pt)
AR (1) AR085919A1 (pt)
AU (1) AU2012234218A1 (pt)
BR (1) BR112013025294A2 (pt)
CA (1) CA2827809A1 (pt)
CL (1) CL2013002622A1 (pt)
CO (1) CO6801638A2 (pt)
EA (1) EA201301109A1 (pt)
EC (1) ECSP13012996A (pt)
MA (1) MA35233B1 (pt)
MX (1) MX337115B (pt)
PE (1) PE20141157A1 (pt)
PH (1) PH12013502031A1 (pt)
SG (1) SG193557A1 (pt)
TN (1) TN2013000389A1 (pt)
TW (2) TWI551612B (pt)
UY (1) UY33997A (pt)
WO (1) WO2012131076A1 (pt)

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US9527925B2 (en) 2011-04-01 2016-12-27 Boehringer Ingelheim International Gmbh Bispecific binding molecules binding to VEGF and ANG2
JP5970734B2 (ja) * 2012-03-30 2016-08-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ａｎｇ２結合分子
WO2014049100A1 (en) * 2012-09-28 2014-04-03 Boehringer Ingelheim International Gmbh Pharmaceutical combinations comprising dual angiopoietin-2 / dll4 binders and anti-vegf agents
WO2014049099A1 (en) * 2012-09-28 2014-04-03 Boehringer Ingelheim International Gmbh Pharmaceutical combinations comprising dual angiopoietin-2 / dll4 binders and anti-vegf-r agents
DK3143138T3 (da) 2014-05-13 2022-04-25 Bioatla Inc Betinget aktive biologiske proteiner
CN107540747B (zh) * 2017-08-09 2020-01-24 苏州大学附属儿童医院 抗人dll4单克隆抗体6f12
CN110950967B (zh) * 2019-12-13 2022-05-13 山东民康生物科技有限公司 抗人血清白蛋白纳米抗体与il-2融合蛋白及制备方法
CN116444675B (zh) * 2023-05-11 2023-12-22 亲和(武汉)生命科技有限责任公司 一种Pfu DNA聚合酶纳米抗体及其制备方法和应用

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US6329516B1 (en) 1997-04-28 2001-12-11 Fmc Corporation Lepidopteran GABA-gated chloride channels
JP2003530847A (ja) 2000-04-12 2003-10-21 ヒューマン ゲノム サイエンシズ インコーポレイテッド アルブミン融合タンパク質
CA2433877C (en) 2001-01-17 2014-11-18 Genecraft, Inc. Binding domain-immunoglobulin fusion proteins
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Also Published As

Publication number Publication date
MA35233B1 (fr) 2014-07-03
MX2013011032A (es) 2013-12-06
CO6801638A2 (es) 2013-11-29
TW201302789A (zh) 2013-01-16
WO2012131076A1 (en) 2012-10-04
TW201302797A (zh) 2013-01-16
UY33997A (es) 2012-09-28
TWI535735B (zh) 2016-06-01
PE20141157A1 (es) 2014-09-24
CA2827809A1 (en) 2012-10-04
KR20140016345A (ko) 2014-02-07
CL2013002622A1 (es) 2014-02-14
ECSP13012996A (es) 2013-12-31
TWI551612B (zh) 2016-10-01
CN106046167A (zh) 2016-10-26
JP2014511682A (ja) 2014-05-19
CN103596977A (zh) 2014-02-19
EP2694545B1 (en) 2016-08-24
SG193557A1 (en) 2013-11-29
PH12013502031A1 (en) 2013-12-16
CN103596977B (zh) 2016-07-06
EA201301109A1 (ru) 2014-08-29
NZ614243A (en) 2015-04-24
EP2694545A1 (en) 2014-02-12
US20130078247A1 (en) 2013-03-28
AP2013007086A0 (en) 2013-08-31
AU2012234218A1 (en) 2013-09-05
TN2013000389A1 (en) 2015-01-20
AR085919A1 (es) 2013-11-06
MX337115B (es) 2016-02-12

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]