BR112014028997A2 - formulações estabilizadas contendo anticorpos anti-dll4 - Google Patents

formulações estabilizadas contendo anticorpos anti-dll4

Info

Publication number
BR112014028997A2
BR112014028997A2 BR112014028997A BR112014028997A BR112014028997A2 BR 112014028997 A2 BR112014028997 A2 BR 112014028997A2 BR 112014028997 A BR112014028997 A BR 112014028997A BR 112014028997 A BR112014028997 A BR 112014028997A BR 112014028997 A2 BR112014028997 A2 BR 112014028997A2
Authority
BR
Brazil
Prior art keywords
dll4
containing anti
formulations containing
antibody
dll4 antibodies
Prior art date
Application number
BR112014028997A
Other languages
English (en)
Inventor
Dix Daniel
Walsh Scott
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48670784&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112014028997(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of BR112014028997A2 publication Critical patent/BR112014028997A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

resumo patente de invenção: "formulações estabilizadas contendo anticorpos anti-dll4". a presente invenção provê formulações farmacêuticas compreendendo um anticorpo que se liga especificamente a um ligante 4 semelhante a delta humano (dll4). as formulações podem conter, em adição a anticorpo anti-dll4, um tampão fosfato, um co-solvente orgânico, um dissacarídeo, e um sal. as formulações farmacêuticas da presente invenção exibem um grau substancial de estabilidade de anticorpo após estocagem por vários meses e após serem submetidas a tensão térmica ou outras tensões físicas. 23095915v1 1/1 23095915v1
BR112014028997A 2012-05-31 2013-05-31 formulações estabilizadas contendo anticorpos anti-dll4 BR112014028997A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261653478P 2012-05-31 2012-05-31
PCT/US2013/043516 WO2013181486A1 (en) 2012-05-31 2013-05-31 Stabilized formulations containing anti-dll4 antibodies

Publications (1)

Publication Number Publication Date
BR112014028997A2 true BR112014028997A2 (pt) 2017-07-25

Family

ID=48670784

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014028997A BR112014028997A2 (pt) 2012-05-31 2013-05-31 formulações estabilizadas contendo anticorpos anti-dll4

Country Status (29)

Country Link
US (1) US9675692B2 (pt)
EP (1) EP2854849B1 (pt)
JP (1) JP6144758B2 (pt)
KR (1) KR20150033615A (pt)
CN (1) CN104349791A (pt)
AR (1) AR092325A1 (pt)
AU (1) AU2013267301B2 (pt)
BR (1) BR112014028997A2 (pt)
CA (1) CA2872275C (pt)
CL (1) CL2014003237A1 (pt)
CO (1) CO7151478A2 (pt)
DK (1) DK2854849T3 (pt)
EA (1) EA029779B1 (pt)
ES (1) ES2668900T3 (pt)
HK (1) HK1207305A1 (pt)
IL (1) IL235468A0 (pt)
LT (1) LT2854849T (pt)
MA (1) MA37645B1 (pt)
MX (1) MX357146B (pt)
NO (1) NO2887943T3 (pt)
NZ (1) NZ702288A (pt)
PH (1) PH12014502429A1 (pt)
PL (1) PL2854849T3 (pt)
PT (1) PT2854849T (pt)
SG (1) SG11201407171XA (pt)
SI (1) SI2854849T1 (pt)
TW (1) TWI609696B (pt)
UY (1) UY34842A (pt)
WO (1) WO2013181486A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR201818814T4 (tr) 2009-10-16 2019-01-21 Oncomed Pharm Inc Dll4 antagonist antikorlarının ve anti-hipertansif ajanların terapötik kombinasyonu ve kullanımı.
EP3485903B1 (en) 2011-09-23 2022-11-16 Mereo BioPharma 5, Inc. Vegf/dll4 binding agents and uses thereof
CA2966042A1 (en) 2014-10-31 2016-05-06 Oncomed Pharmaceuticals, Inc. Combination therapy for treatment of disease
US20180200325A1 (en) * 2014-11-18 2018-07-19 Shionogi & Co., Ltd. Stabilized peptide composition
CN109071644B (zh) 2015-09-23 2023-09-19 昂考梅德药品有限公司 治疗癌症的方法和组合物
US20210379186A1 (en) * 2018-04-16 2021-12-09 Merck Patent Gmbh Additives for protein formulations to improve thermal stability
PE20212185A1 (es) 2019-02-18 2021-11-11 Lilly Co Eli Formulacion de anticuerpos terapeuticos
WO2022010988A1 (en) * 2020-07-08 2022-01-13 Regeneron Pharmaceuticals, Inc. Stabilized formulations containing anti-ctla-4 antibodies

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0747045B2 (ja) 1986-10-15 1995-05-24 株式会社大協精工 積層した注射器用滑栓
US5016784A (en) 1990-02-15 1991-05-21 Dexus Research Inc. Applicator for highly reactive materials
AU2309692A (en) 1991-07-03 1993-02-11 Cryolife, Inc. Method for stabilization of biomaterials
JP3100727B2 (ja) 1992-01-23 2000-10-23 株式会社大協精工 変性ポリシロキサン組成物及び該組成物を被覆した衛生ゴム製品
NZ255101A (en) 1992-07-24 1997-08-22 Cell Genesys Inc A yeast artificial chromosome (yac) vector containing an hprt minigene expressible in murine stem cells and genetically modified rodent therefor
JP3172057B2 (ja) 1995-04-05 2001-06-04 株式会社大協精工 ラミネートゴム栓
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
US6685940B2 (en) 1995-07-27 2004-02-03 Genentech, Inc. Protein formulation
EP0852951A1 (de) 1996-11-19 1998-07-15 Roche Diagnostics GmbH Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern
US7312196B2 (en) 1997-01-08 2007-12-25 Amylin Pharmaceuticals, Inc. Formulations for amylin agonist peptides
US6171586B1 (en) 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
ATE230277T1 (de) 1997-06-13 2003-01-15 Genentech Inc Stabilisierte antikörperformulierung
JP3512349B2 (ja) 1999-01-29 2004-03-29 株式会社大協精工 柱状ゴム要素の成形型
US7001892B1 (en) 1999-06-11 2006-02-21 Purdue Research Foundation Pharmaceutical materials and methods for their preparation and use
US6949245B1 (en) 1999-06-25 2005-09-27 Genentech, Inc. Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies
US6629949B1 (en) 2000-05-08 2003-10-07 Sterling Medivations, Inc. Micro infusion drug delivery device
US6659982B2 (en) 2000-05-08 2003-12-09 Sterling Medivations, Inc. Micro infusion drug delivery device
ES2644275T3 (es) 2000-08-11 2017-11-28 Chugai Seiyaku Kabushiki Kaisha Preparaciones estabilizadas que contienen anticuerpos
PT1324776E (pt) 2000-10-12 2009-12-23 Genentech Inc Formulações de proteína concentradas de viscosidade reduzida
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
JP2002209975A (ja) 2001-01-19 2002-07-30 Daikyo Seiko Ltd 医薬バイアル用ラミネートゴム栓
JP4317010B2 (ja) 2001-07-25 2009-08-19 ピーディーエル バイオファーマ，インコーポレイティド ＩｇＧ抗体の安定な凍結乾燥医薬製剤
EP3578168A1 (en) 2002-02-14 2019-12-11 Chugai Seiyaku Kabushiki Kaisha Formulation of antibody-containing solutions comprising a sugar as a stabilizer
US20040191243A1 (en) 2002-12-13 2004-09-30 Bei Chen System and method for stabilizing antibodies with histidine
ZA200507757B (en) 2003-04-04 2007-01-31 Genentech Inc High concentration antibody and protein formulations
WO2005072772A1 (en) 2004-01-30 2005-08-11 Suomen Punainen Risti Veripalvelu Pharmaceutical compositions
JO3000B1 (ar) 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
EP2586459B1 (en) 2005-03-25 2017-05-24 Regeneron Pharmaceuticals, Inc. Vegf antagonist formulations
US20080311078A1 (en) 2005-06-14 2008-12-18 Gokarn Yatin R Self-Buffering Protein Formulations
HUE053612T2 (hu) 2006-06-16 2021-07-28 Regeneron Pharma Intravitreális bevitelre alkalmas VEGF-antagonista készítmények
US20100129354A1 (en) 2006-10-27 2010-05-27 Ablynx N.V. Intranasal delivery of polypeptides and proteins
RU2448979C2 (ru) 2006-12-14 2012-04-27 Ридженерон Фармасьютикалз, Инк. Антитела человека к дельта-подобному лиганду-4 человека
TW201039854A (en) 2009-03-06 2010-11-16 Genentech Inc Antibody formulation
TR201818814T4 (tr) * 2009-10-16 2019-01-21 Oncomed Pharm Inc Dll4 antagonist antikorlarının ve anti-hipertansif ajanların terapötik kombinasyonu ve kullanımı.
CA2781467C (en) 2009-11-20 2015-10-13 Biocon Limited Formulations of antibody
AU2011223919B2 (en) 2010-03-02 2015-03-19 Abbvie Inc. Therapeutic DLL4 binding proteins
SG189220A1 (en) * 2010-10-06 2013-05-31 Regeneron Pharma Stabilized formulations containing anti-interleukin-4 receptor (il-4r) antibodies

Also Published As

Publication number Publication date
CA2872275A1 (en) 2013-12-05
PT2854849T (pt) 2018-05-09
WO2013181486A1 (en) 2013-12-05
EP2854849B1 (en) 2018-02-28
PH12014502429B1 (en) 2015-01-12
JP6144758B2 (ja) 2017-06-07
AR092325A1 (es) 2015-04-15
KR20150033615A (ko) 2015-04-01
CA2872275C (en) 2021-05-18
ES2668900T3 (es) 2018-05-23
PL2854849T3 (pl) 2018-07-31
NO2887943T3 (pt) 2018-05-05
US20130323260A1 (en) 2013-12-05
MA37645B1 (fr) 2018-10-31
MX357146B (es) 2018-06-28
UY34842A (es) 2013-12-31
CN104349791A (zh) 2015-02-11
PH12014502429A1 (en) 2015-01-12
SI2854849T1 (en) 2018-05-31
TWI609696B (zh) 2018-01-01
TW201400130A (zh) 2014-01-01
AU2013267301B2 (en) 2018-02-08
MA37645A3 (fr) 2017-07-31
LT2854849T (lt) 2018-05-10
IL235468A0 (en) 2014-12-31
HK1207305A1 (en) 2016-01-29
AU2013267301A1 (en) 2014-12-18
MX2014014363A (es) 2015-02-05
DK2854849T3 (en) 2018-04-30
US9675692B2 (en) 2017-06-13
EA029779B1 (ru) 2018-05-31
JP2015520173A (ja) 2015-07-16
CO7151478A2 (es) 2014-12-29
NZ702288A (en) 2016-12-23
SG11201407171XA (en) 2014-11-27
EP2854849A1 (en) 2015-04-08
CL2014003237A1 (es) 2015-07-10
MA37645A2 (fr) 2016-08-31
EA201492186A1 (ru) 2015-08-31

Similar Documents

Publication Publication Date Title
BR112014028997A2 (pt) formulações estabilizadas contendo anticorpos anti-dll4
BR112014017882A2 (pt) formulações estabilizadas contendo anticorpos anti-ang-2
AR125268A2 (es) Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos
BR112013002764A2 (pt) formulações esatabilizadas contendo anticorpos anti-ngf.
BR112013008366A2 (pt) formulações estabilizadas contendo anticorpos de receptor de anti-interleucina-4 (il-4r)
BR112014020826A8 (pt) Anticorpo que se liga especificamente a um epítopo, ácido nucleico, vetor ou célula hospedeira, conjugado de fármaco – anticorpo, composição farmacêutica compreendendo o referido anticorpo, uso do mesmo, kit e método de preparação do conjugado
BR112017009398A2 (pt) moléculas de ligação específicas para cd73 e seus usos
BR112012022223A8 (pt) Formulação de proteína concentrada, uso e método de preparação da mesma
BR112015031883A2 (pt) anti-pd-1 anticorpo e o uso dele
BR112016014284A2 (pt) anticorpo caninizado isolado ou um fragmento de ligação de antígeno do mesmo, ácido nucleico isolado, vetor de expressão, célula hospedeira, composição farmacêutica, e, métodos para aumentar a atividade de uma célula imune e para produzir um anticorpo caninizado ou fragmento de ligação de antígeno do mesmo
BR112014028600A8 (pt) Formulações de suspensão compreendendo anticorpo monoclonal de alta concentração, seu método de preparação, seu uso e dispositivo para sua administração subcutânea, e método para produção de um artigo de fabricação
BR112018002196A2 (pt) formulação anti-ifnar1 estável
CL2015001314A1 (es) Anticuerpo de unión a tau; vector; célula hospedadora; hibridoma; péptido que comprende epítope de tau; composición farmacéutica que comprende al anticuerpo o al péptido de tau; dispositivo médico para administrarlos; y uso para tratar, prevenir o diagnosticar enfermedad de alzheimer o tautología relacionada (div. sol. n° 679-14).
BRPI0917470B8 (pt) anticorpo anti-lag-3 ou uma porção de ligação ao antígeno do mesmo, seu método de preparação, seus usos, composição, imunoconjugado, molécula de ácido nucleico isolado, vetor de expressão e método de estímulo de uma resposta de células t antígenoespecífica
BR112015011171A2 (pt) compostos de pirrolopirimidina como inibidores da quinase
UA118441C2 (uk) Антитіло, що розпізнає альфа-синуклеїн
BRPI0610235B8 (pt) anticorpos monoclonais geneticamente modificados e diferentes daqueles encontrados na natureza, ou porção de ligação ao antígeno dos mesmos, usos terapêuticos dos mesmos, composições, imunoconjugado, molécula biespecífica compreendendo os mesmos, molécula de ácido nucléico e vetor de expressão
BR112014021102A2 (pt) Anticorpo, composição farmacêutica, droga de combinação, dna, método de tratamento e uso de anticorpo
BRPI0516299A (pt) formulações farmacêuticas, frascos com uma rolha perfurável por uma seringa, tanques de aço inoxidável, método de tratamento de uma doença ou disfunção, método para redução de deamidação ou agregação de um anticorpo monoclonal, métodos de tratamento de cáncer e método de preparação de uma formulação farmacêutica
BR112017002183A2 (pt) conjugado, composição farmacêutica, e, método para aumentar uma resposta imune em um mamífero
BR112012022258A2 (pt) anticorpos monoclonais otimizados contra inibidor de trajetória de fator de tecido ( tfpi)
BR112015004477A8 (pt) uso de composto na preparação de um sedativo e composição farmacêutica
BR112015022650A2 (pt) inibidores de cinase induzível por sal macrocíclico
BR112013029417A2 (pt) composições de vacina de matriz proteica incluindo policátions
BR112013000779A2 (pt) composições farmacêuticas de combinação, métodos de tratamento de paciente e uso de forma potencializada ativada de anticorpo para receptor at1 de angiotensina ii e forma potencializada ativada de anticorpo para sintase no endotelial

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2517 DE 02-04-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B350 Update of information on the portal [chapter 15.35 patent gazette]