JO3533B1 - تركيبات ثابته تحتوي على مضادات حيوية مقاومة لـ ang2 - Google Patents

تركيبات ثابته تحتوي على مضادات حيوية مقاومة لـ ang2

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Publication number
JO3533B1
JO3533B1 JOP/2013/0020A JOP20130020A JO3533B1 JO 3533 B1 JO3533 B1 JO 3533B1 JO P20130020 A JOP20130020 A JO P20130020A JO 3533 B1 JO3533 B1 JO 3533B1
Authority
JO
Jordan
Prior art keywords
formulations containing
containing anti
antibody
stabilized formulations
ang2 antibodies
Prior art date
Application number
JOP/2013/0020A
Other languages
English (en)
Inventor
B Dix Daniel
M Walsh Scott
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47633582&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JO3533(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Application granted granted Critical
Publication of JO3533B1 publication Critical patent/JO3533B1/ar

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D85/00—Containers, packaging elements or packages, specially adapted for particular articles or materials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Abstract

يتعلق الاختراع الحالي بتوفير صيغ صيدلانية تشتمل على جسم مضاد يرتبط على وجه التحديد بأنجيوبيوتين 2 <span dir="LTR">(Ang-2)</span>. يمكن أن تتضمن الصيغ، بالإضافة إلى الجسم المضاد ل <span dir="LTR">Ang-2</span>. حمض أميني واحد على الأقل، و مادة سكرية واحدة على الأقل، و مادة حافظة واحدة للتوتر السطحي غير أيونية واحدة على الأقل. و تظهر الصيغ الصيدلانية للاختراع الحالي درجة كبيرة من ثبات الجسم المضاد بعد التخزين لعدة أشهر بعد التعرض لإجهاد حراري و إجهادات فيزيائية أخرى.
JOP/2013/0020A 2012-01-23 2013-01-22 تركيبات ثابته تحتوي على مضادات حيوية مقاومة لـ ang2 JO3533B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261589427P 2012-01-23 2012-01-23

Publications (1)

Publication Number Publication Date
JO3533B1 true JO3533B1 (ar) 2020-07-05

Family

ID=47633582

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2013/0020A JO3533B1 (ar) 2012-01-23 2013-01-22 تركيبات ثابته تحتوي على مضادات حيوية مقاومة لـ ang2

Country Status (23)

Country Link
US (1) US9402898B2 (ar)
EP (1) EP2807190B1 (ar)
JP (1) JP6113756B2 (ar)
KR (1) KR102063028B1 (ar)
CN (1) CN104169299B (ar)
AR (1) AR089787A1 (ar)
AU (1) AU2013212587B2 (ar)
BR (1) BR112014017882A2 (ar)
CA (1) CA2861062A1 (ar)
CL (1) CL2014001930A1 (ar)
EA (1) EA033387B1 (ar)
HK (1) HK1204631A1 (ar)
IL (1) IL233482B (ar)
JO (1) JO3533B1 (ar)
MA (1) MA35904B1 (ar)
MX (1) MX357393B (ar)
MY (1) MY164611A (ar)
NZ (1) NZ627859A (ar)
PH (1) PH12014501628B1 (ar)
SG (1) SG11201403792TA (ar)
TW (1) TWI615149B (ar)
UY (1) UY34587A (ar)
WO (1) WO2013112438A1 (ar)

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