US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
US5336603A
(en)
*
|
1987-10-02 |
1994-08-09 |
Genentech, Inc. |
CD4 adheson variants
|
US5750375A
(en)
*
|
1988-01-22 |
1998-05-12 |
Zymogenetics, Inc. |
Methods of producing secreted receptor analogs and biologically active dimerized polypeptide fusions
|
US5567584A
(en)
*
|
1988-01-22 |
1996-10-22 |
Zymogenetics, Inc. |
Methods of using biologically active dimerized polypeptide fusions to detect PDGF
|
US6018026A
(en)
|
1988-01-22 |
2000-01-25 |
Zymogenetics, Inc. |
Biologically active dimerized and multimerized polypeptide fusions
|
US6685941B1
(en)
|
1988-11-23 |
2004-02-03 |
The Regents Of The University Of Michigan |
Methods of treating autoimmune disease via CTLA-4Ig
|
US6406697B1
(en)
|
1989-02-23 |
2002-06-18 |
Genentech, Inc. |
Hybrid immunoglobulins
|
US5225538A
(en)
*
|
1989-02-23 |
1993-07-06 |
Genentech, Inc. |
Lymphocyte homing receptor/immunoglobulin fusion proteins
|
US5242687A
(en)
*
|
1989-03-15 |
1993-09-07 |
Tkb Associates Limited Partnership |
Method of reducing cellular immune response involving T-cells using CD8-bearing antigen presenting cells
|
US7264944B1
(en)
|
1989-04-21 |
2007-09-04 |
Amgen Inc. |
TNF receptors, TNF binding proteins and DNAs coding for them
|
DK0393438T3
(da)
|
1989-04-21 |
2005-05-30 |
Amgen Inc |
TNF-receptor, TNF-bindende proteiner og DNAér, der koder herfor
|
US6143866A
(en)
*
|
1989-07-18 |
2000-11-07 |
Amgen, Inc. |
Tumor necrosis factor (TNF) inhibitor and method for obtaining the same
|
IL95031A
(en)
|
1989-07-18 |
2007-03-08 |
Amgen Inc |
A method of producing a recombinant human necrotic factor absorber
|
US6267964B1
(en)
*
|
1989-08-01 |
2001-07-31 |
Affibody Technology Sweden Ab |
Stabilized protein or peptide conjugates able to bond albumin having extended biological half-lives
|
US6541610B1
(en)
*
|
1989-09-05 |
2003-04-01 |
Immunex Corporation |
Fusion proteins comprising tumor necrosis factor receptor
|
US5395760A
(en)
*
|
1989-09-05 |
1995-03-07 |
Immunex Corporation |
DNA encoding tumor necrosis factor-α and -β receptors
|
US5605690A
(en)
*
|
1989-09-05 |
1997-02-25 |
Immunex Corporation |
Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor
|
US5945397A
(en)
*
|
1989-09-05 |
1999-08-31 |
Immunex Corporation |
Purified p75 (type II) tumor necrosis factor receptor polypeptides
|
NZ235148A
(en)
*
|
1989-09-05 |
1991-12-23 |
Immunex Corp |
Tumour necrosis factor receptor protein and dna sequences
|
EP1132471A3
(de)
|
1989-09-12 |
2001-11-28 |
F. Hoffmann-La Roche Ag |
TNF-bindende Proteine
|
US5216132A
(en)
*
|
1990-01-12 |
1993-06-01 |
Protein Design Labs, Inc. |
Soluble t-cell antigen receptor chimeric antigens
|
US6552170B1
(en)
*
|
1990-04-06 |
2003-04-22 |
Amgen Inc. |
PEGylation reagents and compounds formed therewith
|
GB9022543D0
(en)
*
|
1990-10-17 |
1990-11-28 |
Wellcome Found |
Antibody production
|
DE4037837A1
(de)
*
|
1990-11-28 |
1992-06-04 |
Behringwerke Ag |
Zellfreie rezeptorbindungsteste, ihre herstellung und verwendung
|
DE69233480T2
(de)
|
1991-02-08 |
2006-01-05 |
Progenics Pharmaceuticals, Inc. |
CD4-gamma2- und CD4-IgG2-Chimären
|
US7070991B2
(en)
*
|
1991-02-08 |
2006-07-04 |
Progenics Pharmaceuticals, Inc. |
Cells expressing a CD4-IgG2 chimeric heterotetramer
|
CA2081028C
(en)
*
|
1991-03-12 |
1999-12-14 |
Barbara P. Wallner |
Cd2 binding domain of lymphocyte function associated antigen 3
|
MX9203138A
(es)
*
|
1991-03-12 |
1992-09-01 |
Biogen Inc |
Dominio de enlace cd2-de antigeno 3 (lfa-3) asociado con funcion linfositos.
|
US20030206899A1
(en)
*
|
1991-03-29 |
2003-11-06 |
Genentech, Inc. |
Vascular endothelial cell growth factor antagonists
|
US6582959B2
(en)
*
|
1991-03-29 |
2003-06-24 |
Genentech, Inc. |
Antibodies to vascular endothelial cell growth factor
|
US5318890A
(en)
*
|
1991-05-06 |
1994-06-07 |
The Regents Of The University Of California |
Assays for inhibitors of leukocyte adhesion
|
US6797492B2
(en)
|
1991-05-17 |
2004-09-28 |
Merck & Co., Inc. |
Method for reducing the immunogenicity of antibody variable domains
|
US5844095A
(en)
*
|
1991-06-27 |
1998-12-01 |
Bristol-Myers Squibb Company |
CTLA4 Ig fusion proteins
|
US5851795A
(en)
*
|
1991-06-27 |
1998-12-22 |
Bristol-Myers Squibb Company |
Soluble CTLA4 molecules and uses thereof
|
EP0533006A1
(de)
*
|
1991-09-18 |
1993-03-24 |
F.Hoffmann-La Roche & Co. Aktiengesellschaft |
Chimäre Interleukin 5-Rezeptor/Immunoglobulin-Polypeptide
|
US6764681B2
(en)
*
|
1991-10-07 |
2004-07-20 |
Biogen, Inc. |
Method of prophylaxis or treatment of antigen presenting cell driven skin conditions using inhibitors of the CD2/LFA-3 interaction
|
US5871734A
(en)
*
|
1992-01-13 |
1999-02-16 |
Biogen, Inc. |
Treatment for asthma with VLA-4 blocking agents
|
US6399368B1
(en)
|
1992-01-17 |
2002-06-04 |
Board Of Regents, The University Of Texas System |
Secretion of T cell receptor fragments from recombinant Escherichia coli cells
|
FR2686899B1
(fr)
*
|
1992-01-31 |
1995-09-01 |
Rhone Poulenc Rorer Sa |
Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
|
US5932214A
(en)
*
|
1994-08-11 |
1999-08-03 |
Biogen, Inc. |
Treatment for inflammatory bowel disease with VLA-4 blockers
|
NZ251820A
(en)
*
|
1992-03-30 |
1996-07-26 |
Immunex Corp |
Fusion proteins with tnf-r (tumour necrosis factor-receptor) peptide linked to another tnf-r or an il-1r (interleukin-1-receptor) peptide
|
CA2118508A1
(en)
*
|
1992-04-24 |
1993-11-11 |
Elizabeth S. Ward |
Recombinant production of immunoglobulin-like domains in prokaryotic cells
|
US5540926A
(en)
*
|
1992-09-04 |
1996-07-30 |
Bristol-Myers Squibb Company |
Soluble and its use in B cell stimulation
|
WO1994005314A1
(en)
*
|
1992-09-08 |
1994-03-17 |
Centocor, Inc. |
Peptide inhibitors of leukocyte adhesion
|
EP0620739A4
(en)
*
|
1992-09-15 |
1997-01-15 |
Immunex Corp |
Method of treating tnf-dependent inflammation using tumor necrosis factor antagonists.
|
CA2144081C
(en)
*
|
1992-09-16 |
2004-11-30 |
Filip Roos |
Protection against liver damage by hgf
|
WO1994006469A1
(en)
*
|
1992-09-18 |
1994-03-31 |
La Jolla Institute For Allergy And Immunology |
Hiv fusion polypeptide
|
US6270766B1
(en)
|
1992-10-08 |
2001-08-07 |
The Kennedy Institute Of Rheumatology |
Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease
|
WO1994014836A1
(en)
*
|
1992-12-18 |
1994-07-07 |
Centocor, Inc. |
Peptide inhibitors of selectin binding
|
US5474766A
(en)
*
|
1992-12-18 |
1995-12-12 |
Washington University |
Methods and compositions for inhibition of hepatic clearance of tissue-type plasminogen activator
|
AU694933B2
(en)
*
|
1993-01-25 |
1998-08-06 |
Dana-Farber Cancer Institute, Inc. |
Chimeric L- and P-selectin by exchange of domains - uses thereof
|
US7537932B1
(en)
|
1993-05-19 |
2009-05-26 |
Schering Corporation |
Antibodies that bind purified mammalian FLT3 ligands
|
US5861310A
(en)
*
|
1993-11-03 |
1999-01-19 |
Dana-Farber Cancer Institute |
Tumor cells modified to express B7-2 with increased immunogenicity and uses therefor
|
US20050129670A1
(en)
*
|
1993-07-26 |
2005-06-16 |
Genetics Institute, Llc. |
Tumor cells modified to express B7-2 with increased immunogenicity and uses therefor
|
US6723705B1
(en)
|
1993-08-19 |
2004-04-20 |
Gentics Institute, Inc. |
Tumor cells modified to express B7-2 with increased immunogenicity and uses therefor
|
US6824779B1
(en)
|
1993-07-26 |
2004-11-30 |
Dana-Farber Cancer Institute, Inc. |
Methods for inhibiting the interaction of B7-2 with its natural ligand
|
US6130316A
(en)
*
|
1993-07-26 |
2000-10-10 |
Dana Farber Cancer Institute |
Fusion proteins of novel CTLA4/CD28 ligands and uses therefore
|
US6084067A
(en)
*
|
1993-07-26 |
2000-07-04 |
Dana-Farber Cancer Institute |
CTLA4/CD28 ligands and uses therefor
|
SE9302855D0
(sv)
*
|
1993-09-06 |
1993-09-06 |
Martin Lindberg |
Method and means for producing plasmaproteinase inhibitor binding proteins
|
WO1995014787A1
(en)
*
|
1993-11-22 |
1995-06-01 |
Centocor, Inc. |
Peptide inhibitors of selecting binding
|
WO1995021258A1
(en)
*
|
1994-02-01 |
1995-08-10 |
United States Of America, Represented By The Secretary, Department Of Health And Human Services |
Fusion proteins that include antibody and nonantibody portions
|
US7294331B2
(en)
*
|
1994-03-07 |
2007-11-13 |
Immunex Corporation |
Methods of using flt3-ligand in hematopoietic cell transplantation
|
DK0749323T3
(da)
*
|
1994-03-08 |
2001-02-05 |
Dana Farber Cancer Inst Inc |
Fremgangsmåder til modulering af T-celle-anergi
|
US5877016A
(en)
|
1994-03-18 |
1999-03-02 |
Genentech, Inc. |
Human trk receptors and neurotrophic factor inhibitors
|
IL113484A0
(en)
*
|
1994-04-28 |
1995-07-31 |
Immunex Corp |
Viral proteins pharmaceutical compositions containing them their preparation and use
|
IL113617A
(en)
|
1994-05-06 |
2007-09-20 |
Florence Faure |
Use of LAG-3 antibodies to prepare a therapeutic agent that stimulates the immune system
|
US6350730B1
(en)
|
1994-08-17 |
2002-02-26 |
The Rockefeller University |
OB polypeptides and modified forms as modulators of body weight
|
US6124448A
(en)
*
|
1994-08-17 |
2000-09-26 |
The Rockfeller University |
Nucleic acid primers and probes for the mammalian OB gene
|
US6471956B1
(en)
|
1994-08-17 |
2002-10-29 |
The Rockefeller University |
Ob polypeptides, modified forms and compositions thereto
|
US6001968A
(en)
|
1994-08-17 |
1999-12-14 |
The Rockefeller University |
OB polypeptides, modified forms and compositions
|
US6048837A
(en)
*
|
1994-08-17 |
2000-04-11 |
The Rockefeller University |
OB polypeptides as modulators of body weight
|
US6309853B1
(en)
|
1994-08-17 |
2001-10-30 |
The Rockfeller University |
Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
|
US6429290B1
(en)
|
1994-08-17 |
2002-08-06 |
The Rockefeller University |
OB polypeptides, modified forms and derivatives
|
US5541087A
(en)
*
|
1994-09-14 |
1996-07-30 |
Fuji Immunopharmaceuticals Corporation |
Expression and export technology of proteins as immunofusins
|
US5814464A
(en)
*
|
1994-10-07 |
1998-09-29 |
Regeneron Pharma |
Nucleic acids encoding TIE-2 ligand-2
|
US6410008B1
(en)
*
|
1994-12-12 |
2002-06-25 |
Beth Israel Hospital Association |
Chimeric IL-10 proteins and uses thereof
|
EP0793504B1
(de)
*
|
1994-12-12 |
2005-06-08 |
Beth Israel Deaconess Medical Center, Inc. |
Chimäre zytokine und ihre verwendung
|
US6808709B1
(en)
*
|
1994-12-30 |
2004-10-26 |
The Regents Of The University Of California |
Immunoglobulins containing protection proteins and their use
|
US6485726B1
(en)
*
|
1995-01-17 |
2002-11-26 |
The Brigham And Women's Hospital, Inc. |
Receptor specific transepithelial transport of therapeutics
|
US6086875A
(en)
*
|
1995-01-17 |
2000-07-11 |
The Brigham And Women's Hospital, Inc. |
Receptor specific transepithelial transport of immunogens
|
US6030613A
(en)
*
|
1995-01-17 |
2000-02-29 |
The Brigham And Women's Hospital, Inc. |
Receptor specific transepithelial transport of therapeutics
|
US6066322A
(en)
|
1995-03-03 |
2000-05-23 |
Millennium Pharmaceuticals, Inc. |
Methods for the treatment of immune disorders
|
US6455685B1
(en)
|
1995-03-03 |
2002-09-24 |
Millennium Pharmaceuticals, Inc. |
Compositions and methods for the treatment and diagnosis of immune disorders
|
US20030069196A1
(en)
*
|
1995-03-03 |
2003-04-10 |
Millennium Pharmaceuticals, Inc. |
Compositions and methods for the treatment and diagnosis of immune disorders
|
US6211142B1
(en)
*
|
1995-03-10 |
2001-04-03 |
Genentech, Inc. |
Compositions comprising gas6 polypeptides and articles of manufacture comprising the same
|
US5869286A
(en)
*
|
1995-03-23 |
1999-02-09 |
Immunex Corporation |
Receptor that binds IL-17
|
US6680057B1
(en)
*
|
1995-03-23 |
2004-01-20 |
Immunex Corporation |
Methods of treating autoimmune disease by administering interleukin-17 receptor
|
IL117645A
(en)
*
|
1995-03-30 |
2005-08-31 |
Genentech Inc |
Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration
|
US20060193862A1
(en)
*
|
1995-03-30 |
2006-08-31 |
Genentech, Inc. |
Vascular endothelial cell growth factor antagonists
|
US7175847B1
(en)
*
|
1995-06-07 |
2007-02-13 |
Biogen Idec Inc. |
Treating intestinal inflammation with anti-CD80 antibodies that do not inhibit CD80 binding to CTLA-4
|
US6113898A
(en)
*
|
1995-06-07 |
2000-09-05 |
Idec Pharmaceuticals Corporation |
Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies
|
US7153508B2
(en)
*
|
1995-06-07 |
2006-12-26 |
Biogen Idec Inc. |
Treatment of B cell lymphoma using anti-CD80 antibodies that do not inhibit the binding of CD80 to CTLA-4
|
US20020034517A1
(en)
*
|
1995-10-04 |
2002-03-21 |
Kenneth Brasel |
Dendritic cell stimulatory factor
|
US7150992B1
(en)
|
1995-10-04 |
2006-12-19 |
Innunex Corporation |
Methods of preparing dendritic cells with flt3-ligand and antigen
|
US7361330B2
(en)
*
|
1995-10-04 |
2008-04-22 |
Immunex Corporation |
Methods of using flt3-ligand in the treatment of fibrosarcoma
|
US20030040467A1
(en)
*
|
1998-06-15 |
2003-02-27 |
Mary Ann Pelleymounter |
Ig/ob fusions and uses thereof.
|
US6936439B2
(en)
*
|
1995-11-22 |
2005-08-30 |
Amgen Inc. |
OB fusion protein compositions and methods
|
US20030026779A1
(en)
*
|
1999-10-15 |
2003-02-06 |
Liming Yu |
Treatment of tumors and viral infections with a hybrid conjugate of interferon and an immunoglobulin Fc
|
GB9526733D0
(en)
*
|
1995-12-30 |
1996-02-28 |
Delta Biotechnology Ltd |
Fusion proteins
|
AU721129B2
(en)
|
1996-01-08 |
2000-06-22 |
Genentech Inc. |
WSX receptor and ligands
|
US6750334B1
(en)
*
|
1996-02-02 |
2004-06-15 |
Repligen Corporation |
CTLA4-immunoglobulin fusion proteins having modified effector functions and uses therefor
|
US5917026A
(en)
*
|
1996-02-05 |
1999-06-29 |
Loewenadler; Bjoern |
Fusion proteins of immunopotentiating activity
|
ATE448797T1
(de)
|
1996-02-09 |
2009-12-15 |
Amgen Inc |
Zusammensetzung enthaltend il-1ra als interleukin-1 inhibitor und hyaluronan als polymer mit verzögerter wirkstofffreigabe
|
US6194177B1
(en)
*
|
1996-02-20 |
2001-02-27 |
Applied Research Systems Ars Holding N.V. |
DNA encoding a hybrid heterodimeric protein
|
EP0894141B1
(de)
|
1996-02-20 |
2005-05-18 |
Applied Research Systems ARS Holding N.V. |
Heterodimerebildende hybrid-proteine
|
GB9604518D0
(en)
*
|
1996-03-02 |
1996-05-01 |
Smithkline Beecham Plc |
Novel compounds
|
US6458354B1
(en)
|
1996-03-28 |
2002-10-01 |
The Johns Hopkins University |
Molecular complexes which modify immune responses
|
AU729406B2
(en)
*
|
1996-03-28 |
2001-02-01 |
Johns Hopkins University, The |
Soluble divalent and multivalent heterodimeric analogs of proteins
|
US7026116B1
(en)
|
1996-04-04 |
2006-04-11 |
Bio-Rad Laboratories, Inc. |
Polymorphisms in the region of the human hemochromatosis gene
|
US6140305A
(en)
|
1996-04-04 |
2000-10-31 |
Bio-Rad Laboratories, Inc. |
Hereditary hemochromatosis gene products
|
US7063965B2
(en)
*
|
1996-04-05 |
2006-06-20 |
Regeneron Pharmaceuticals, Inc. |
Nucleic acid encoding TIE-2 ligand
|
US6060054A
(en)
|
1996-04-10 |
2000-05-09 |
National Jewish Medical And Research Center |
Product for T lymphocyte immunosuppression
|
US6117977A
(en)
*
|
1996-04-24 |
2000-09-12 |
Genentech, Inc. |
Type C lectins
|
WO1997041232A1
(en)
*
|
1996-04-26 |
1997-11-06 |
Beth Israel Deaconess Medical Center |
Antagonists of interleukin-15
|
US6451308B1
(en)
*
|
1996-04-26 |
2002-09-17 |
Beth Israel Deaconess Medical Center |
Antagonists of interleukin-15
|
US6306395B1
(en)
|
1996-05-02 |
2001-10-23 |
Mochida Pharmaceutical Co., Ltd. |
Fas antigen derivatives
|
US6100071A
(en)
|
1996-05-07 |
2000-08-08 |
Genentech, Inc. |
Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production
|
US6849399B1
(en)
|
1996-05-23 |
2005-02-01 |
Bio-Rad Laboratories, Inc. |
Methods and compositions for diagnosis and treatment of iron misregulation diseases
|
TW555765B
(en)
*
|
1996-07-09 |
2003-10-01 |
Amgen Inc |
Low molecular weight soluble tumor necrosis factor type-I and type-II proteins
|
BR9710357A
(pt)
|
1996-07-12 |
1999-08-17 |
Genentech Inc |
Adesina heteromultimera quimerica recomvinante isolada sequencia de acido nucleiro isolada acido nucleico isolado vetor celula hospedeira anticorpo metodo para formar um complexo adesina-ligante heteromultimera quimerica metodo para inibir a ativa-ao metodo para ativar um receptor hetermultimerico natural composicao farmaceutica artigo manufaturado e metodo para produzir anticorpo
|
JP4382879B2
(ja)
*
|
1996-07-12 |
2009-12-16 |
ジェネンテック・インコーポレーテッド |
ガンマ―ヘレグリン
|
US5851984A
(en)
*
|
1996-08-16 |
1998-12-22 |
Genentech, Inc. |
Method of enhancing proliferation or differentiation of hematopoietic stem cells using Wnt polypeptides
|
US6159462A
(en)
*
|
1996-08-16 |
2000-12-12 |
Genentech, Inc. |
Uses of Wnt polypeptides
|
PT942740E
(pt)
|
1996-12-06 |
2004-01-30 |
Amgen Inc |
Terapia de combinacao utilizando uma proteina de ligacao de tnf para tratamento de doencas mediadas por tnf
|
EP2002846B1
(de)
|
1996-12-06 |
2017-01-25 |
Amgen Inc. |
Kombinationstherapie mit einem IL-1-Inhibitor zur Behandlung von IL-1-vermittelten Krankheiten
|
WO1998033914A1
(en)
*
|
1997-01-31 |
1998-08-06 |
University Of Rochester |
Chimeric antibody fusion proteins for the recruitment and stimulation of an antitumor immune response
|
US6268411B1
(en)
|
1997-09-11 |
2001-07-31 |
The Johns Hopkins University |
Use of multivalent chimeric peptide-loaded, MHC/ig molecules to detect, activate or suppress antigen-specific T cell-dependent immune responses
|
US20020137890A1
(en)
*
|
1997-03-31 |
2002-09-26 |
Genentech, Inc. |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
|
US7435793B2
(en)
*
|
1998-05-15 |
2008-10-14 |
Genentech, Inc. |
Peptides that induce chondrocyte redifferentiation
|
AU7137398A
(en)
|
1997-04-16 |
1998-11-11 |
Millennium Pharmaceuticals, Inc. |
Crsp protein (cysteine-rich secreted proteins), nucleic acid molecules encoding them and uses therefor
|
US6190909B1
(en)
*
|
1997-04-17 |
2001-02-20 |
Millennium Pharmaceuticals, Inc. |
TH2-specific gene
|
JP2002514079A
(ja)
*
|
1997-05-01 |
2002-05-14 |
アムジエン・インコーポレーテツド |
キメラopgポリペプチド
|
JP4213224B2
(ja)
*
|
1997-05-02 |
2009-01-21 |
ジェネンテック,インコーポレーテッド |
ヘテロマルチマー及び共通成分を有する多重特異性抗体の製造方法
|
US20020062010A1
(en)
*
|
1997-05-02 |
2002-05-23 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
US20030207346A1
(en)
*
|
1997-05-02 |
2003-11-06 |
William R. Arathoon |
Method for making multispecific antibodies having heteromultimeric and common components
|
US7951917B1
(en)
*
|
1997-05-02 |
2011-05-31 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
DE69835519T2
(de)
|
1997-06-13 |
2007-04-05 |
Bio-Rad Laboratories, Inc., Hercules |
Verfahren und zusammensetzungen für die diagnose und die behandlung von krankheiten, die mit eisenüberschuss oder eisenmangel assoziiert sind.
|
US20020198149A1
(en)
*
|
1997-06-16 |
2002-12-26 |
Genentech, Inc. |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
|
US20040191256A1
(en)
*
|
1997-06-24 |
2004-09-30 |
Genentech, Inc. |
Methods and compositions for galactosylated glycoproteins
|
KR100220645B1
(ko)
*
|
1997-07-04 |
1999-09-15 |
구광시 |
벤젠유도체의 제조방법
|
US6165476A
(en)
*
|
1997-07-10 |
2000-12-26 |
Beth Israel Deaconess Medical Center |
Fusion proteins with an immunoglobulin hinge region linker
|
US6187564B1
(en)
|
1997-07-10 |
2001-02-13 |
Beth Israel Deaconess Medical Center |
DNA encoding erythropoietin multimers having modified 5′ and 3′ sequences and its use to prepare EPO therapeutics
|
US6242570B1
(en)
|
1997-07-10 |
2001-06-05 |
Beth Israel Deaconess Medical Center |
Production and use of recombinant protein multimers with increased biological activity
|
US20030170794A1
(en)
*
|
1997-09-18 |
2003-09-11 |
Genentech, Inc. |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
|
US6391311B1
(en)
*
|
1998-03-17 |
2002-05-21 |
Genentech, Inc. |
Polypeptides having homology to vascular endothelial cell growth factor and bone morphogenetic protein 1
|
US6503184B1
(en)
|
1997-10-21 |
2003-01-07 |
Human Genome Sciences, Inc. |
Human tumor necrosis factor receptor-like proteins TR11, TR11SV1 and TR11SV2
|
US6509173B1
(en)
*
|
1997-10-21 |
2003-01-21 |
Human Genome Sciences, Inc. |
Human tumor necrosis factor receptor-like proteins TR11, TR11SV1, and TR11SV2
|
US6689607B2
(en)
|
1997-10-21 |
2004-02-10 |
Human Genome Sciences, Inc. |
Human tumor, necrosis factor receptor-like proteins TR11, TR11SV1 and TR11SV2
|
US20040136986A1
(en)
*
|
1997-10-31 |
2004-07-15 |
Genentech, Inc. |
Methods and compositions comprising glycoprotein glycoforms
|
US6576743B1
(en)
|
1997-11-26 |
2003-06-10 |
Zymogenetics, Inc. |
Mammalian cytokine-like polypeptide-10
|
ES2221717T3
(es)
|
1997-12-08 |
2005-01-01 |
Emd Lexigen Research Center Corp. |
Proteinas de fusion heterodimeras utiles para inmunoterapia dirigida e inmunoestimulacion general.
|
US6207413B1
(en)
*
|
1998-01-22 |
2001-03-27 |
Regeneron Pharmaceuticals, Inc. |
Nucleic acids encoding novel orphan cytokine receptors
|
US20030105294A1
(en)
*
|
1998-02-25 |
2003-06-05 |
Stephen Gillies |
Enhancing the circulating half life of antibody-based fusion proteins
|
US7198789B2
(en)
*
|
1998-03-17 |
2007-04-03 |
Genetics Institute, Llc |
Methods and compositions for modulating interleukin-21 receptor activity
|
US6057128A
(en)
*
|
1998-03-17 |
2000-05-02 |
Genetics Institute, Inc. |
MU-1, member of the cytokine receptor family
|
US7189400B2
(en)
*
|
1998-03-17 |
2007-03-13 |
Genetics Institute, Llc |
Methods of treatment with antagonists of MU-1
|
US7723488B2
(en)
*
|
1998-03-27 |
2010-05-25 |
Genentech, Inc. |
Monoclonal antibodies to secreted and transmembrane polypeptides
|
US7371836B2
(en)
*
|
1998-03-27 |
2008-05-13 |
Genentech, Inc. |
PRO526 nucleic acids
|
RU2229305C2
(ru)
*
|
1998-04-15 |
2004-05-27 |
Лексиген Фармасьютикэлс Корпорейшн |
Усиление иммунных ответов, опосредованных белками, слитыми из антитела и цитокина, посредством совместного введения ингибитора ангиогенеза
|
US20020192751A1
(en)
*
|
1998-05-15 |
2002-12-19 |
Genentech, Inc. |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
|
AU740405B2
(en)
*
|
1998-05-15 |
2001-11-01 |
Genentech Inc. |
IL-17 homologous polypeptides and therapeutic uses thereof
|
EP1086138B1
(de)
|
1998-06-12 |
2009-09-23 |
Genentech, Inc. |
Monoklonale antikörper, kreuz-reaktive antikörper und deren produktionsverfahren
|
US20050181482A1
(en)
*
|
2004-02-12 |
2005-08-18 |
Meade Harry M. |
Method for the production of an erythropoietin analog-human IgG fusion proteins in transgenic mammal milk
|
WO1999066054A2
(en)
*
|
1998-06-15 |
1999-12-23 |
Genzyme Transgenics Corp. |
Erythropoietin analog-human serum albumin fusion protein
|
US7291712B2
(en)
*
|
1998-06-25 |
2007-11-06 |
Genentech, Inc. |
Interleukin-8 homologous polypeptides and therapeutic uses thereof
|
US20070003545A9
(en)
*
|
1999-06-02 |
2007-01-04 |
Eaton Dan L |
Interleukin-8 homologous polypeptides and therapeutic uses thereof
|
US7339033B2
(en)
*
|
1998-06-26 |
2008-03-04 |
Genentech, Inc. |
Pro1481
|
US20020099197A1
(en)
*
|
1998-07-21 |
2002-07-25 |
Rory A.J. Curtis |
Novel potassium channel molecules and uses therefor
|
MXPA01002111A
(es)
*
|
1998-08-31 |
2003-03-27 |
Biogen Inc |
Metodo para modular celulas t efectoras de memoria y composiciones.
|
MXPA01003790A
(es)
*
|
1998-10-16 |
2002-09-18 |
Biogen Inc |
Proteinas de fusion beta - interferon y sus usos.
|
ES2630278T3
(es)
*
|
1998-10-16 |
2017-08-21 |
Biogen Ma Inc. |
Conjugados poliméricos de interferón beta-1a y usos de los mismos
|
US7488590B2
(en)
|
1998-10-23 |
2009-02-10 |
Amgen Inc. |
Modified peptides as therapeutic agents
|
PT2319928E
(pt)
|
1998-10-23 |
2013-06-28 |
Kirin Amgen Inc |
Péptidos diméricos de trombopoietina que simulam a ligação ao receptor mpl e têm actividade trombopoiética
|
US6660843B1
(en)
|
1998-10-23 |
2003-12-09 |
Amgen Inc. |
Modified peptides as therapeutic agents
|
WO2000027885A1
(fr)
*
|
1998-11-05 |
2000-05-18 |
Kyowa Hakko Kogyo Co., Ltd. |
Nouveau popypeptide chimerique
|
US6495128B1
(en)
*
|
1998-11-10 |
2002-12-17 |
Human Genome Sciences, Inc. |
Human chemokine β-7 deletion and substitution proteins
|
US7294482B2
(en)
*
|
1998-11-19 |
2007-11-13 |
Millennium Pharmaceuticals, Inc. |
EGF-like nucleic acids
|
US7235642B1
(en)
*
|
1999-01-12 |
2007-06-26 |
Genentech, Inc. |
Anti-PRO 1313 antibodies
|
US6656728B1
(en)
|
1999-02-08 |
2003-12-02 |
Chiron Corporation |
Fibroblast growth factor receptor-immunoglobulin fusion
|
DE60042735D1
(de)
|
1999-03-19 |
2009-09-24 |
Genentech Inc |
Behandlung von lfa-1 assozieerten krankheiten durch gesteigerte dosen von lfa-1 antagonist
|
US7011833B1
(en)
*
|
1999-05-06 |
2006-03-14 |
Genetics Institute, Inc. |
Enhancing immune responses with B7-1 or B7-2 in the absence of a crosslinking agent
|
US20050079577A1
(en)
*
|
1999-05-14 |
2005-04-14 |
Ashkenazi Avi J. |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
|
MXPA01011845A
(es)
*
|
1999-05-19 |
2002-06-21 |
Lexigen Pharm Corp |
Expresion y exportacion de proteinas de interferon-alfa como proteinas de fusion fc.
|
CA2375700A1
(en)
*
|
1999-06-01 |
2000-12-07 |
Biogen, Inc. |
Polymer conjugates of hedgehog proteins and uses
|
WO2000073498A1
(en)
*
|
1999-06-02 |
2000-12-07 |
Millennium Pharmaceuticals, Inc. |
Compositions and methods for the treatment and diagnosis of immune disorders
|
US6924359B1
(en)
*
|
1999-07-01 |
2005-08-02 |
Yale University |
Neovascular-targeted immunoconjugates
|
WO2001001749A2
(en)
*
|
1999-07-02 |
2001-01-11 |
Genentech, Inc. |
FVIIa ANTAGONISTS
|
DE60028970T2
(de)
|
1999-07-02 |
2007-02-15 |
Genentech Inc., San Francisco |
An her2 bindende peptidverbindungen
|
CA2378796A1
(en)
*
|
1999-07-12 |
2001-01-18 |
Merck Patent Gesellschaft Mit Beschraenkter Haftung |
Seripancrin
|
US7067110B1
(en)
|
1999-07-21 |
2006-06-27 |
Emd Lexigen Research Center Corp. |
Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens
|
SK782002A3
(en)
*
|
1999-07-21 |
2003-08-05 |
Lexigen Pharm Corp |
FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
|
WO2001007084A1
(en)
*
|
1999-07-23 |
2001-02-01 |
Regents Of The University Of California |
Anti-growth factor receptor avidin fusion proteins as universal vectors for drug delivery
|
ATE279437T1
(de)
*
|
1999-08-06 |
2004-10-15 |
Genentech Inc |
Peptidantagonisten des faktors viia
|
HUP0202442A3
(en)
*
|
1999-08-09 |
2005-01-28 |
Lexigen Pharmaceuticals Corp L |
Multiple cytokine-antibody complexes
|
BR0013581A
(pt)
|
1999-08-23 |
2002-07-02 |
Dana Faber Cancer Inst Inc |
Pd-1, um receptor para b7-4, e usos para isto
|
US20030166858A1
(en)
*
|
1999-09-16 |
2003-09-04 |
Samuel Davis |
TIE-2 ligands, methods of making and uses thereof
|
US6323334B1
(en)
|
1999-09-24 |
2001-11-27 |
Millennium Pharmaceuticals, Inc. |
Nucleic acid molecules encoding a 103 gene product and uses therefor
|
EP1230271A1
(de)
*
|
1999-11-05 |
2002-08-14 |
Biogen, Inc. |
Hedgehog fusionsproteine und deren verwendung
|
AU2154401A
(en)
|
1999-11-12 |
2001-05-30 |
Merck Patent Gmbh |
Erythropoietin forms with improved properties
|
US20050202538A1
(en)
*
|
1999-11-12 |
2005-09-15 |
Merck Patent Gmbh |
Fc-erythropoietin fusion protein with improved pharmacokinetics
|
US6610286B2
(en)
|
1999-12-23 |
2003-08-26 |
Zymogenetics, Inc. |
Method for treating inflammation using soluble receptors to interleukin-20
|
US7307153B2
(en)
*
|
1999-12-23 |
2007-12-11 |
Genentech, Inc. |
Antibodies that bind PRO9912
|
US7122632B2
(en)
*
|
1999-12-23 |
2006-10-17 |
Zymogenetics, Inc. |
Soluble Interleukin-20 receptor
|
US7164001B2
(en)
*
|
2000-01-20 |
2007-01-16 |
Genentech, Inc. |
Compositions and methods for the treatment of immune related diseases
|
ES2269366T3
(es)
|
2000-02-11 |
2007-04-01 |
Merck Patent Gmbh |
Mejoramiento de la vida media en circulacion de proteinas de fusion basadas en anticuerpos.
|
EA005583B1
(ru)
*
|
2000-02-21 |
2005-04-28 |
Апплайд Резеч Системз Арс Холдинг Н.В. |
Применение ингибиторов il-18
|
US7541184B2
(en)
*
|
2000-02-24 |
2009-06-02 |
Invitrogen Corporation |
Activation and expansion of cells
|
US7572631B2
(en)
*
|
2000-02-24 |
2009-08-11 |
Invitrogen Corporation |
Activation and expansion of T cells
|
US20060073547A1
(en)
*
|
2000-03-01 |
2006-04-06 |
Genentech, Inc. |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
|
US6984519B2
(en)
|
2000-03-01 |
2006-01-10 |
Genetech, Inc. |
Nucleic acids encoding peptides that induce chondrocyte redifferentiation
|
US20060002943A1
(en)
*
|
2000-03-02 |
2006-01-05 |
Genentech, Inc. |
Compositions and methods for the treatment of tumor of hematopoietic origin
|
US20020064820A1
(en)
*
|
2000-03-13 |
2002-05-30 |
Jean-Michel Dayer |
Apo-A-I regulation of T-cell signaling
|
US7514239B2
(en)
*
|
2000-03-28 |
2009-04-07 |
Amgen Inc. |
Nucleic acid molecules encoding beta-like glycoprotein hormone polypeptides and heterodimers thereof
|
CA2405800A1
(en)
*
|
2000-04-10 |
2001-10-18 |
Merck Patent Gesellschaft Mit Beschraenkter Haftung |
Novel secreted protein
|
US20050100991A1
(en)
*
|
2001-04-12 |
2005-05-12 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
US6946134B1
(en)
|
2000-04-12 |
2005-09-20 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
CA2405563A1
(en)
*
|
2000-04-12 |
2001-10-25 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
MXPA02010507A
(es)
*
|
2000-04-25 |
2003-05-14 |
Idec Pharma Corp |
Administracion intratecal de rituximab para el tratamiento de linfomas del sistema nervioso central.
|
US6756480B2
(en)
|
2000-04-27 |
2004-06-29 |
Amgen Inc. |
Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
|
EP1290027B1
(de)
*
|
2000-04-28 |
2009-09-09 |
Planet Biotechnology, Inc. |
Immunoadhesin zur impfung gegen rhinovirus
|
US20060015969A1
(en)
*
|
2000-04-28 |
2006-01-19 |
Planet Biotechnology, Inc. |
Novel immunoadhesins for treating and prventing toxicity and pathogen-mediated diseases
|
WO2001083525A2
(en)
*
|
2000-05-03 |
2001-11-08 |
Amgen Inc. |
Modified peptides, comprising an fc domain, as therapeutic agents
|
US20020102232A1
(en)
*
|
2000-05-11 |
2002-08-01 |
Chang Tse W. |
Compositions and methods for induction of active autoimmunity
|
CA2408691A1
(en)
|
2000-05-12 |
2001-11-22 |
Beth Israel Deaconess Medical Center, Inc. |
Compositions and methods for achieving immune suppression
|
EP1714661A3
(de)
|
2000-05-19 |
2012-03-14 |
The Center for Blood Research, INC. |
Verfahren zur Diagnose und Behandlung von hämostatischen Störungen durch Modulation der P-Selectin Aktivität
|
US20050048614A1
(en)
*
|
2000-06-13 |
2005-03-03 |
Children's Medical Center Corporation |
Biosynthetic oncolytic molecules and uses therefor
|
US20040034193A1
(en)
*
|
2001-06-13 |
2004-02-19 |
Samy Ashkar |
Biosynthetic oncolytic molecules and uses therefor
|
US20030096339A1
(en)
|
2000-06-26 |
2003-05-22 |
Sprecher Cindy A. |
Cytokine receptor zcytor17
|
PT1325115T
(pt)
*
|
2000-06-26 |
2016-09-28 |
Zymogenetics Inc |
Recetor de citocina zcytor17
|
NZ522844A
(en)
|
2000-06-28 |
2005-02-25 |
Brigham & Womens Hospital |
PD-L2 molecules: novel PD-1 ligands and methods to identify compounds to modulate T cell activation
|
AU7172901A
(en)
*
|
2000-06-29 |
2002-01-14 |
Lexigen Pharm Corp |
Enhancement of antibody-cytokine fusion protein mediated immune responses by combined treatment with immunocytokine uptake enhancing agents
|
US6902734B2
(en)
|
2000-08-07 |
2005-06-07 |
Centocor, Inc. |
Anti-IL-12 antibodies and compositions thereof
|
US7288390B2
(en)
|
2000-08-07 |
2007-10-30 |
Centocor, Inc. |
Anti-dual integrin antibodies, compositions, methods and uses
|
UA81743C2
(uk)
|
2000-08-07 |
2008-02-11 |
Центокор, Инк. |
МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ
|
JP5015404B2
(ja)
*
|
2000-08-08 |
2012-08-29 |
ザイモジェネティクス, インコーポレイテッド |
可溶性zcytor11サイトカイン受容体
|
US20030215916A1
(en)
*
|
2000-08-18 |
2003-11-20 |
Feder John N. |
Novel imidazoline receptor homologs
|
US20020119148A1
(en)
*
|
2000-09-01 |
2002-08-29 |
Gerritsen Mary E. |
ErbB4 antagonists
|
AU2001287000A1
(en)
|
2000-09-01 |
2002-03-13 |
The Center For Blood Research, Inc. |
Modified polypeptides stabilized in a desired conformation and methods for producing same
|
IL154925A0
(en)
*
|
2000-09-14 |
2003-10-31 |
Beth Israel Hospital |
Modulation of il-2 and il-15-mediated t cell responses
|
DE60135158D1
(de)
|
2000-09-26 |
2008-09-11 |
Genentech Inc |
Antagonisten des ige-rezeptors
|
US7241590B2
(en)
*
|
2000-09-29 |
2007-07-10 |
Bristol-Myers Squibb Company |
Identification and cloning of a full-length human Clnk-related gene, MIST (mast cell immunoreceptor signal transducer)
|
US20030211549A1
(en)
*
|
2000-10-06 |
2003-11-13 |
Murphy Andrew J. |
Functional proteins and therapeutic and diagnostic methods for use thereof
|
EP1364019A2
(de)
*
|
2000-11-07 |
2003-11-26 |
Board of Regents, The University of Texas System |
Verfahren und zusammensetzungen bezogen auf muskelnspezifischen sarkomerischen calcineurinbindungsproteine (calsarine)
|
AU1648102A
(en)
*
|
2000-12-04 |
2002-06-18 |
Auckland Uniservices Ltd |
Immunomodulatory constructs and their uses
|
US7396917B2
(en)
*
|
2000-12-05 |
2008-07-08 |
Alexion Pharmaceuticals, Inc. |
Rationally designed antibodies
|
EP1370589B1
(de)
*
|
2000-12-05 |
2006-03-15 |
Alexion Pharmaceuticals, Inc. |
Rationell entworfene antikörper
|
US20040253242A1
(en)
*
|
2000-12-05 |
2004-12-16 |
Bowdish Katherine S. |
Rationally designed antibodies
|
CA2438386A1
(en)
*
|
2001-02-16 |
2002-08-29 |
Bristol-Myers Squibb Company |
Polynucleotides encoding a novel glycine receptor alpha subunit expressed in the gastrointestinal tract, hgra4, and splice variant thereof
|
DK1366067T3
(da)
*
|
2001-03-07 |
2012-10-22 |
Merck Patent Gmbh |
Ekspressionsteknologi for proteiner indeholdende en hybrid isotype-antistof-enhed
|
US8163289B2
(en)
|
2001-03-09 |
2012-04-24 |
Iterative Therapeutics, Inc. |
Methods and compositions involving polymeric immunoglobulin fusion proteins
|
US7511121B2
(en)
|
2001-03-09 |
2009-03-31 |
Arnason Barry G W |
Polymeric immunoglobulin fusion proteins that target low-affinity Fcγreceptors
|
WO2002079415A2
(en)
*
|
2001-03-30 |
2002-10-10 |
Lexigen Pharmaceuticals Corp. |
Reducing the immunogenicity of fusion proteins
|
CA2442066C
(en)
|
2001-04-02 |
2005-11-01 |
Wyeth |
Pd-1, a receptor for b7-4, and uses therefor
|
US20060084794A1
(en)
*
|
2001-04-12 |
2006-04-20 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
US20050244931A1
(en)
*
|
2001-04-12 |
2005-11-03 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
US20050054051A1
(en)
*
|
2001-04-12 |
2005-03-10 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
US7507413B2
(en)
|
2001-04-12 |
2009-03-24 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
ITRE20010042A1
(it)
*
|
2001-04-24 |
2002-10-24 |
Corghi Spa |
Dispositivo sollevatore per macchine smontagomme
|
US20050089932A1
(en)
*
|
2001-04-26 |
2005-04-28 |
Avidia Research Institute |
Novel proteins with targeted binding
|
US7265208B2
(en)
|
2001-05-01 |
2007-09-04 |
The Regents Of The University Of California |
Fusion molecules and treatment of IgE-mediated allergic diseases
|
RU2306320C9
(ru)
*
|
2001-05-03 |
2008-01-27 |
Мерк Патент Гмбх |
Рекомбинантное опухолеспецифичное антитело (варианты) и его применение
|
US20100056762A1
(en)
|
2001-05-11 |
2010-03-04 |
Old Lloyd J |
Specific binding proteins and uses thereof
|
ES2387546T3
(es)
|
2001-05-11 |
2012-09-25 |
Amgen Inc. |
Péptidos y moléculas relacionadas que se unen a TALL-1
|
EP1478748A4
(de)
*
|
2001-06-15 |
2005-09-21 |
Tanox Inc |
Fce-fusionsproteine zur behandlung von allergien und asthma
|
US20060073141A1
(en)
*
|
2001-06-28 |
2006-04-06 |
Domantis Limited |
Compositions and methods for treating inflammatory disorders
|
US7858095B2
(en)
*
|
2001-07-24 |
2010-12-28 |
Astellas Us Llc |
Method for treating or preventing sclerotic disorders using CD-2 binding agents
|
AU2002355955A1
(en)
*
|
2001-08-13 |
2003-03-03 |
University Of Southern California |
Interleukin-2 mutants with reduced toxicity
|
US6900292B2
(en)
*
|
2001-08-17 |
2005-05-31 |
Lee-Hwei K. Sun |
Fc fusion proteins of human erythropoietin with increased biological activities
|
KR101008734B1
(ko)
|
2001-08-29 |
2011-01-14 |
제넨테크, 인크. |
유사분열촉진 활성을 가진 Bv8 핵산 및 폴리펩티드
|
MXPA04001804A
(es)
*
|
2001-08-30 |
2005-03-07 |
Biorexis Pharmaceutical Corp |
Proteinas de fusion de transferrina modificada.
|
US6797493B2
(en)
*
|
2001-10-01 |
2004-09-28 |
Lee-Hwei K. Sun |
Fc fusion proteins of human granulocyte colony-stimulating factor with increased biological activities
|
AU2002332041A1
(en)
*
|
2001-10-05 |
2003-04-22 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
US7205275B2
(en)
*
|
2001-10-11 |
2007-04-17 |
Amgen Inc. |
Methods of treatment using specific binding agents of human angiopoietin-2
|
US7138370B2
(en)
*
|
2001-10-11 |
2006-11-21 |
Amgen Inc. |
Specific binding agents of human angiopoietin-2
|
AU2002337920A1
(en)
*
|
2001-10-19 |
2003-04-28 |
Zymogenetics, Inc. |
Dimerized growth factor and materials and methods for producing it
|
DE60236953D1
(de)
*
|
2001-10-25 |
2010-08-19 |
Us Gov Health & Human Serv |
Effiziente hemmung des eintritts von hiv-1-virus durch ein neues fusionsprotein mit cd4
|
US20070118934A1
(en)
*
|
2001-10-26 |
2007-05-24 |
Planet Biotechnology, Inc. |
Chimeric toxin receptor proteins and chimeric toxin receptor proteins for treatment and prevention of anthrax
|
RU2312677C9
(ru)
*
|
2001-12-04 |
2008-03-27 |
Мерк Патент Гмбх |
Иммуноцитокины с модулированной селективностью
|
US7858297B2
(en)
*
|
2001-12-18 |
2010-12-28 |
Centre National De La Recherche Scientifique Cnrs |
Chemokine-binding protein and methods of use
|
US7572886B2
(en)
*
|
2001-12-18 |
2009-08-11 |
Centre National De La Recherche Scientifique |
Death associated proteins, and THAP1 and PAR4 pathways in apoptosis control
|
ES2500918T3
(es)
|
2001-12-21 |
2014-10-01 |
Human Genome Sciences, Inc. |
Proteínas de fusión de albúmina e interferón beta
|
KR101271635B1
(ko)
*
|
2001-12-21 |
2013-06-12 |
휴먼 게놈 사이언시즈, 인코포레이티드 |
알부민 융합 단백질
|
AU2002364587A1
(en)
*
|
2001-12-21 |
2003-07-30 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
JP2005526151A
(ja)
|
2002-01-18 |
2005-09-02 |
バイオゲン アイデック エムエー インク. |
生物学的に活性な化合物の結合のための部分を有するポリアルキレングリコール
|
WO2003060090A2
(en)
|
2002-01-18 |
2003-07-24 |
Zymogenetics, Inc. |
Novel cytokine zcytor17 ligand
|
US7164002B2
(en)
|
2002-02-06 |
2007-01-16 |
Genentech, Inc. |
FVIIa antagonists
|
US20030211470A1
(en)
*
|
2002-03-15 |
2003-11-13 |
Olson William C. |
CD4-IgG2-based salvage therapy of HIV-1 infection
|
EP1495050A1
(de)
*
|
2002-04-10 |
2005-01-12 |
Applied Research Systems ARS Holding N.V. |
Neue mcp-protein-antagonisten
|
US20040016010A1
(en)
*
|
2002-04-17 |
2004-01-22 |
Marion Kasaian |
IL-21 receptor knockout animal and methods of use thereof
|
CA2499885C
(en)
|
2002-05-29 |
2010-04-20 |
Yamasa Corporation |
Novel polyphosphate:amp phosphotransferase
|
ATE483472T1
(de)
*
|
2002-05-30 |
2010-10-15 |
Macrogenics Inc |
Cd16a bindungsproteine und verwendung zur behandlung von immunkrankheiten
|
NZ519371A
(en)
*
|
2002-06-04 |
2004-11-26 |
Auckland Uniservices Ltd |
Immunomodulatory constructs and their uses
|
US20070071744A1
(en)
*
|
2002-06-07 |
2007-03-29 |
Gotz Munch |
Agents which bind to epitopes of glycoprotein VI
|
US20090130021A1
(en)
*
|
2002-06-07 |
2009-05-21 |
Gotz Munch |
Methods, products and uses involving platelets and/or the vasculature
|
US7531178B2
(en)
*
|
2002-06-07 |
2009-05-12 |
Trigen Gmbh |
Immunoadhesin comprising a glycoprotein VI domain
|
EP1369128A1
(de)
*
|
2002-06-07 |
2003-12-10 |
Procorde GmbH |
Glycoprotein VI Inhibitoren und deren therapeutische Verwendung
|
US8025873B2
(en)
|
2002-06-20 |
2011-09-27 |
Paladin Labs, Inc. |
Chimeric antigens for eliciting an immune response
|
US8029803B2
(en)
|
2002-06-20 |
2011-10-04 |
Paladin Labs, Inc. |
Chimeric antigens for eliciting an immune response
|
US20070104710A1
(en)
*
|
2002-06-28 |
2007-05-10 |
Domants Limited |
Ligand that has binding specificity for IL-4 and/or IL-13
|
PT1517921E
(pt)
*
|
2002-06-28 |
2006-09-29 |
Domantis Ltd |
Ligandos duplamente especificos com semi-vida no soro aumentada
|
CA2490409A1
(en)
|
2002-06-28 |
2004-01-08 |
Centocor, Inc. |
Mammalian ch1 deleted mimetibodies, compositions, methods and uses
|
CN1241946C
(zh)
*
|
2002-07-01 |
2006-02-15 |
美国福源集团 |
对多种细胞具刺激增生作用的人血清白蛋白重组融合蛋白
|
WO2004006951A1
(en)
*
|
2002-07-12 |
2004-01-22 |
The Johns Hopkins University |
Reagents and methods for engaging unique clonotypic lymphocyte receptors
|
CA2491320A1
(en)
|
2002-07-15 |
2004-01-22 |
Wyeth |
Methods and compositions for modulating t helper (th) cell development and function
|
US20040110681A1
(en)
*
|
2002-08-08 |
2004-06-10 |
Xiao-Min Fan |
Method to identify targeting molecules
|
CA2496795C
(en)
|
2002-08-28 |
2014-06-03 |
Paul B. Burton |
Compositions and methods for treating cardiovascular disease
|
DE10251463A1
(de)
*
|
2002-11-05 |
2004-05-19 |
BSH Bosch und Siemens Hausgeräte GmbH |
Elektrisch angetriebene Pumpe
|
US20050054054A1
(en)
*
|
2002-11-12 |
2005-03-10 |
Foss Francine M. |
Interleukin-7 molecules with altered biological properties
|
DK1572748T3
(da)
*
|
2002-12-17 |
2010-08-23 |
Merck Patent Gmbh |
Humaniseret antistof (H14.18) af muse-14.18-antistof der binder til GD2 og dets fusionsprotein med IL-2
|
GB0230203D0
(en)
*
|
2002-12-27 |
2003-02-05 |
Domantis Ltd |
Fc fusion
|
US20110223168A1
(en)
*
|
2002-12-27 |
2011-09-15 |
Greg Winter |
Ligand that has binding specificity for il-4 and/or il-13
|
JP2006523090A
(ja)
*
|
2002-12-27 |
2006-10-12 |
ドマンティス リミテッド |
リガンドに、そしてリガンド受容体に特異的な二重特異性単一ドメイン抗体
|
WO2004062619A2
(en)
*
|
2003-01-13 |
2004-07-29 |
Macrogenics, Inc. |
SOLUBLE FcϜR FUSION PROTEINS AND METHODS OF USE THEREOF
|
EP1594530A4
(de)
|
2003-01-22 |
2006-10-11 |
Human Genome Sciences Inc |
Albuminfusionsproteine
|
JP2007506405A
(ja)
*
|
2003-02-06 |
2007-03-22 |
ノボザイムス アクティーゼルスカブ |
糸状菌におけるヒトh鎖抗体の発現
|
US20050096264A1
(en)
*
|
2003-02-25 |
2005-05-05 |
Macdonald Lynn |
Methods for treating obesity and related conditions with glycoprotein hormone beta family hormones
|
KR101118340B1
(ko)
|
2003-03-12 |
2012-04-12 |
제넨테크, 인크. |
조혈을 촉진하기 위한 bv8 및(또는) eg-vegf의용도
|
US20050142139A1
(en)
*
|
2003-03-21 |
2005-06-30 |
Norbert Schulke |
CD4-IgG2 formulations
|
JP2007525437A
(ja)
*
|
2003-03-24 |
2007-09-06 |
ザイモジェネティクス, インコーポレイテッド |
抗il−20抗体および結合パートナーならびに炎症において用いる方法
|
WO2004085478A2
(en)
|
2003-03-26 |
2004-10-07 |
Apogenix Gmbh |
Improved fc fusion proteins
|
TWI353991B
(en)
|
2003-05-06 |
2011-12-11 |
Syntonix Pharmaceuticals Inc |
Immunoglobulin chimeric monomer-dimer hybrids
|
EP2298347B1
(de)
†
|
2003-05-06 |
2015-09-30 |
Biogen Hemophilia Inc. |
Chimäre Proteine mit Gerinnungsfaktor zur Behandlung von hämostatischen Erkrankungen
|
AU2004238263A1
(en)
*
|
2003-05-06 |
2004-11-25 |
Syntonix Pharmaceuticals, Inc. |
Inhibition of drug binding to serum albumin
|
US7348004B2
(en)
|
2003-05-06 |
2008-03-25 |
Syntonix Pharmaceuticals, Inc. |
Immunoglobulin chimeric monomer-dimer hybrids
|
PL1622939T3
(pl)
*
|
2003-05-13 |
2012-08-31 |
Merck Serono Sa |
Aktywne warianty białka wiążącego IL-18 i ich medyczne zastosowania
|
US8273347B2
(en)
*
|
2003-05-13 |
2012-09-25 |
Depuy Spine, Inc. |
Autologous treatment of degenerated disc with cells
|
US7429378B2
(en)
*
|
2003-05-13 |
2008-09-30 |
Depuy Spine, Inc. |
Transdiscal administration of high affinity anti-MMP inhibitors
|
US20040229878A1
(en)
*
|
2003-05-13 |
2004-11-18 |
Depuy Spine, Inc. |
Transdiscal administration of specific inhibitors of P38 kinase
|
US7344716B2
(en)
*
|
2003-05-13 |
2008-03-18 |
Depuy Spine, Inc. |
Transdiscal administration of specific inhibitors of pro-inflammatory cytokines
|
EP2286804A1
(de)
|
2003-05-13 |
2011-02-23 |
DePuy Spine, Inc. |
Verfahren zur Behandlung von degenerativer Bandscheibenerkrankung
|
US7553827B2
(en)
*
|
2003-08-13 |
2009-06-30 |
Depuy Spine, Inc. |
Transdiscal administration of cycline compounds
|
US7435808B2
(en)
*
|
2003-06-25 |
2008-10-14 |
Bristol-Myers Squibb Company |
Polynucleotides encoding novel adiponectin receptor variant, AdipoR2v2
|
SI1639011T1
(sl)
*
|
2003-06-30 |
2009-04-30 |
Domantis Ltd |
Pegilirana protitelesa z enojno domeno (dAb)
|
US7569215B2
(en)
*
|
2003-07-18 |
2009-08-04 |
Massachusetts Institute Of Technology |
Mutant interleukin-2 (IL-2) polypeptides
|
US8361467B2
(en)
*
|
2003-07-30 |
2013-01-29 |
Depuy Spine, Inc. |
Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints
|
US8007805B2
(en)
*
|
2003-08-08 |
2011-08-30 |
Paladin Labs, Inc. |
Chimeric antigens for breaking host tolerance to foreign antigens
|
US7850970B2
(en)
|
2003-08-26 |
2010-12-14 |
The Regents Of The University Of Colorado |
Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections
|
US20050069521A1
(en)
*
|
2003-08-28 |
2005-03-31 |
Emd Lexigen Research Center Corp. |
Enhancing the circulating half-life of interleukin-2 proteins
|
UA89481C2
(uk)
|
2003-09-30 |
2010-02-10 |
Центокор, Инк. |
Еритропоетинові міметичні шарнірно-серцевинні міметитіла людини, композиції, способи та застосування
|
WO2005035569A2
(en)
*
|
2003-10-10 |
2005-04-21 |
Five Prime Therapeutics, Inc. |
Kiaa0779, splice variants thereof, and methods of their use
|
US20050239700A1
(en)
*
|
2003-10-14 |
2005-10-27 |
Biogen Idec Inc. |
Treatment of cancer using antibodies to LRRC15
|
WO2005042573A1
(en)
*
|
2003-10-24 |
2005-05-12 |
Dana-Farber Cancer Institute, Inc. |
Modulation of the interaction of muc1 with muc1 ligands
|
WO2005047327A2
(en)
|
2003-11-12 |
2005-05-26 |
Biogen Idec Ma Inc. |
NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO
|
US8846874B2
(en)
*
|
2003-11-13 |
2014-09-30 |
Hanmi Science Co., Ltd |
IgG Fc fragment for a drug carrier and method for the preparation thereof
|
US8110665B2
(en)
|
2003-11-13 |
2012-02-07 |
Hanmi Holdings Co., Ltd. |
Pharmaceutical composition comprising an immunoglobulin FC region as a carrier
|
US8895540B2
(en)
*
|
2003-11-26 |
2014-11-25 |
DePuy Synthes Products, LLC |
Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor
|
CN100467488C
(zh)
*
|
2003-12-30 |
2009-03-11 |
默克专利有限公司 |
Il-7融合蛋白
|
KR20060124656A
(ko)
*
|
2003-12-31 |
2006-12-05 |
메르크 파텐트 게엠베하 |
개선된 약물동태를 가지는 Fc-에리스로포이에틴 융합단백질
|
CA2553883C
(en)
|
2004-01-22 |
2013-04-02 |
Merck Patent Gesellschaft Mit Beschraenkter Haftung |
Anti-cancer antibodies with reduced complement fixation
|
MXPA06008918A
(es)
*
|
2004-02-06 |
2007-03-07 |
Astellas Llc |
Metodos de tratamiento de trastornos de la piel.
|
NZ549040A
(en)
|
2004-02-17 |
2009-07-31 |
Schering Corp |
Use for interleukin-33 (IL33) and the IL-33 receptor complex
|
US20100028995A1
(en)
*
|
2004-02-23 |
2010-02-04 |
Anaphore, Inc. |
Tetranectin Trimerizing Polypeptides
|
CA2563379A1
(en)
*
|
2004-03-31 |
2005-10-20 |
Centocor, Inc. |
Human glp-1 mimetibodies, compositions, methods and uses
|
KR20070011558A
(ko)
*
|
2004-05-04 |
2007-01-24 |
제네상스 파머슈티컬스, 아이엔씨. |
일배체형 마커 및 치료에 대한 반응을 측정하기 위해 이를이용하는 방법
|
EP1750747A1
(de)
*
|
2004-05-07 |
2007-02-14 |
Astellas US LLC |
Lösliches lfa-3 polypeptid zur behandlung viraler erkrankungen
|
US20060063208A1
(en)
|
2004-08-02 |
2006-03-23 |
Woolf Clifford J |
DRG11-responsive (DRAGON) gene and uses thereof
|
US7393662B2
(en)
*
|
2004-09-03 |
2008-07-01 |
Centocor, Inc. |
Human EPO mimetic hinge core mimetibodies, compositions, methods and uses
|
PL2229956T3
(pl)
|
2004-09-13 |
2013-09-30 |
Genzyme Corp |
Konstrukty multimeryczne
|
CN101103045B
(zh)
|
2004-09-24 |
2015-11-25 |
安姆根有限公司 |
修饰的Fc分子
|
SI1802334T1
(sl)
|
2004-10-21 |
2012-12-31 |
Genentech, Inc. |
Postopek za zdravljenje intraokularnih neovaskularnih bolezni
|
BRPI0516975A
(pt)
|
2004-10-22 |
2008-09-30 |
Zymogenetics Inc |
anticorpo ou seu fragmento de ligação a antìgeno, composição farmacêutica, imunoconjugado, hibridoma, anticorpo monoclonal, e, uso de um anticorpo ou seu fragmento de ligação a antìgeno
|
US20090311259A1
(en)
*
|
2004-11-17 |
2009-12-17 |
Victoria Smith |
Compositions and Methods for Treatment of Tumor of Hematopoietic Origin
|
JP4937132B2
(ja)
*
|
2004-12-09 |
2012-05-23 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング |
免疫原性の低下したil−7変種
|
CN100515491C
(zh)
*
|
2005-01-04 |
2009-07-22 |
健能隆医药技术(上海)有限公司 |
白介素-22的医药用途
|
SG173313A1
(en)
|
2005-01-05 |
2011-08-29 |
Biogen Idec Inc |
Cripto binding molecules
|
AU2006208241B2
(en)
|
2005-01-25 |
2011-08-04 |
Five Prime Therapeutics, Inc. |
Compositions and methods for treating cardiac conditions
|
US20090155267A1
(en)
*
|
2005-02-09 |
2009-06-18 |
Apollo Life Sciences Limited |
Molecule and chimeric molecules thereof
|
KR100754667B1
(ko)
|
2005-04-08 |
2007-09-03 |
한미약품 주식회사 |
비펩타이드성 중합체로 개질된 면역글로불린 Fc 단편 및이를 포함하는 약제학적 조성물
|
US11254748B2
(en)
|
2005-04-15 |
2022-02-22 |
Macrogenics, Inc. |
Covalent diabodies and uses thereof
|
US9296816B2
(en)
*
|
2005-04-15 |
2016-03-29 |
Macrogenics, Inc. |
Covalent diabodies and uses thereof
|
US9963510B2
(en)
*
|
2005-04-15 |
2018-05-08 |
Macrogenics, Inc. |
Covalent diabodies and uses thereof
|
US9284375B2
(en)
|
2005-04-15 |
2016-03-15 |
Macrogenics, Inc. |
Covalent diabodies and uses thereof
|
PE20061324A1
(es)
|
2005-04-29 |
2007-01-15 |
Centocor Inc |
Anticuerpos anti-il-6, composiciones, metodos y usos
|
BRPI0611069A2
(pt)
|
2005-05-06 |
2010-11-09 |
Zymogenetics Inc |
anticorpo monoclonal, anticorpo humanizado, fragmento de anticorpo, uso de um antagonista, e, hibridoma
|
SG162806A1
(en)
|
2005-06-17 |
2010-07-29 |
Elan Pharma Int Ltd |
Methods of purifying anti a beta antibodies
|
JP2009501006A
(ja)
|
2005-06-30 |
2009-01-15 |
セントカー・インコーポレーテツド |
抗il−23抗体、組成物、方法および用途
|
AU2006269458B2
(en)
|
2005-07-08 |
2012-11-08 |
Biogen Ma Inc. |
Sp35 antibodies and uses thereof
|
US8008453B2
(en)
|
2005-08-12 |
2011-08-30 |
Amgen Inc. |
Modified Fc molecules
|
EP1926747A1
(de)
*
|
2005-08-12 |
2008-06-04 |
Schering Corporation |
Mcp1-fusionen
|
JP2009507003A
(ja)
|
2005-09-01 |
2009-02-19 |
アレス トレーディング ソシエテ アノニム |
視神経炎の治療
|
US20070104689A1
(en)
*
|
2005-09-27 |
2007-05-10 |
Merck Patent Gmbh |
Compositions and methods for treating tumors presenting survivin antigens
|
WO2007041861A1
(en)
*
|
2005-10-13 |
2007-04-19 |
Virexx Medical Corp. |
Chimeric antigen containing hepatitis c virus polypeptide and fc fragment for eliciting an immune response
|
TW200722436A
(en)
*
|
2005-10-21 |
2007-06-16 |
Hoffmann La Roche |
A peptide-immunoglobulin-conjugate
|
WO2007058776A2
(en)
*
|
2005-11-10 |
2007-05-24 |
Receptor Biologix, Inc. |
Hepatocyte growth factor intron fusion proteins
|
BRPI0618705B8
(pt)
|
2005-11-14 |
2021-05-25 |
Labrys Biologics Inc |
anticorpos antagonistas humanizados direcionados contra peptídeo relacionado ao gene da calcitonina, composição farmacêutica e uso dos mesmos
|
US20090155283A1
(en)
*
|
2005-12-01 |
2009-06-18 |
Drew Philip D |
Noncompetitive Domain Antibody Formats That Bind Interleukin 1 Receptor Type 1
|
WO2007064911A1
(en)
*
|
2005-12-02 |
2007-06-07 |
Biogen Idec Inc. |
Anti-mouse cd20 antibodies and uses thereof
|
WO2007078615A2
(en)
*
|
2005-12-15 |
2007-07-12 |
Cavit Sciences, Inc |
Methods and compositions for treatment of cancer
|
AU2006330573A1
(en)
*
|
2005-12-22 |
2007-07-05 |
Dhy & Co., Ltd |
Antibodies against interleukin-22 binding protein and its uses
|
HUE034269T2
(en)
|
2005-12-29 |
2018-02-28 |
Janssen Biotech Inc |
Human anti-IL-23 antibodies, preparations, methods and applications
|
JP2009521912A
(ja)
|
2005-12-30 |
2009-06-11 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング |
低減された免疫原性を有する抗cd19抗体
|
JP5175214B2
(ja)
|
2005-12-30 |
2013-04-03 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング |
改良された安定性を有するインターロイキン−12p40変種
|
EP2594585A1
(de)
|
2006-01-10 |
2013-05-22 |
Zymogenetics, Inc. |
Verfahren zur Behandlung von Schmerzen und Entzündungen im Nervengewebe mithilfe von IL-31-Antagonisten
|
US7625564B2
(en)
|
2006-01-27 |
2009-12-01 |
Novagen Holding Corporation |
Recombinant human EPO-Fc fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo
|
AR059193A1
(es)
|
2006-01-31 |
2008-03-12 |
Bayer Schering Pharma Ag |
Modulacion de la actividad de mdl-1 para el tratamiento de enfermedades inflamatorias
|
GB0604187D0
(en)
*
|
2006-03-02 |
2006-04-12 |
Fusion Antibodies Ltd |
Peptide and uses thereof
|
CA2648053A1
(en)
*
|
2006-03-31 |
2007-10-11 |
Centocor, Inc. |
Binding partners with immunoglobulin domains modified to have extended half-life
|
JP2009537605A
(ja)
|
2006-05-24 |
2009-10-29 |
メルク セローノ ソシエテ アノニム |
多発性硬化症を治療するためのクラドリビン・レジメン
|
KR20090031897A
(ko)
*
|
2006-06-12 |
2009-03-30 |
리셉터 바이오로직스 인크 |
전-세포 표면 수용체-특이적 치료제
|
JP2009544574A
(ja)
*
|
2006-06-22 |
2009-12-17 |
バクシネックス インコーポレーティッド |
癌を処置するための抗c35抗体
|
US20100021379A1
(en)
*
|
2006-06-29 |
2010-01-28 |
The Regents Of The University Of California |
Chemical Antibodies for Immunotherapy and Imaging
|
EP2043603A4
(de)
|
2006-07-11 |
2010-10-27 |
Arubor Corp |
Prävention und therapie von rhinosinusitis mit proinflammatorischen zytokinhemmern
|
US20080014285A1
(en)
*
|
2006-07-13 |
2008-01-17 |
Di Mauro Thomas M |
Method of treating neurodegenerative brain disease with a composite comprising superparamagnetic nanoparticles and a therapeutic compound
|
PL2068889T3
(pl)
|
2006-08-10 |
2020-06-29 |
Roy C. Levitt |
Anakinra do zastosowania do leczenia zespołu zarostowego zapalenia oskrzelików
|
US8629244B2
(en)
|
2006-08-18 |
2014-01-14 |
Ablynx N.V. |
Interleukin-6 receptor binding polypeptides
|
US7833527B2
(en)
*
|
2006-10-02 |
2010-11-16 |
Amgen Inc. |
Methods of treating psoriasis using IL-17 Receptor A antibodies
|
US20120282245A1
(en)
|
2006-10-03 |
2012-11-08 |
Biogen Idec Ma Inc. |
Biomarkers and assays for the treatment of cancer
|
WO2008140477A2
(en)
|
2006-11-02 |
2008-11-20 |
Capon Daniel J |
Hybrid immunoglobulins with moving parts
|
PE20081250A1
(es)
|
2006-11-28 |
2008-10-07 |
Centelion |
FUSIONES Fc CON RECEPTOR PARA FGF SOLUBLE MODIFICADAS, CON ACTIVIDAD BIOLOGICA MEJORADA
|
CN103408661B
(zh)
|
2007-01-05 |
2016-04-06 |
苏黎世大学 |
提供疾患特异性结合分子和靶的方法
|
ES2673153T3
(es)
|
2007-01-09 |
2018-06-20 |
Biogen Ma Inc. |
Anticuerpos Sp35 y usos de los mismos
|
CN101663047B
(zh)
|
2007-02-23 |
2014-07-09 |
纽约哥伦比亚大学理事会 |
通过激活或阻断HLA-E/Qa-1限制性CD8+T细胞调控途径来治疗免疫疾病的方法
|
SG187521A1
(en)
*
|
2007-03-07 |
2013-02-28 |
Glycofi Inc |
Production of glycoproteins with modified fucosylation
|
CA2690825C
(en)
|
2007-05-11 |
2019-02-12 |
Altor Bioscience Corporation |
Fusion molecules and il-15 variants
|
US7906149B2
(en)
*
|
2007-05-25 |
2011-03-15 |
Boval Company, L.P. |
Method for treating allergic dermatitis
|
ES2456963T3
(es)
*
|
2007-06-04 |
2014-04-24 |
Rappaport Family Institute For Research In The Medical Sciences |
Agentes para el tratamiento de enfermedades inflamatorias y métodos para usar los mismos
|
CN101679511A
(zh)
*
|
2007-06-06 |
2010-03-24 |
杜门蒂斯有限公司 |
多肽、抗体可变域和拮抗剂
|
WO2009012600A1
(en)
|
2007-07-26 |
2009-01-29 |
Novagen Holding Corporation |
Fusion proteins
|
GB0717337D0
(en)
*
|
2007-09-06 |
2007-10-17 |
Ucb Pharma Sa |
Method of treatment
|
US20100239578A1
(en)
|
2007-10-11 |
2010-09-23 |
University Health Network |
Modulation of sirp-alpha - cd47 interaction for increasing human hematopoietic stem cell engraftment and compounds therefor
|
MX2010003757A
(es)
*
|
2007-10-16 |
2010-04-27 |
Symphogen As |
Composiciones que comprenden multimeros optimizados de her1 y her3 y sus metodos de uso.
|
PL2612868T3
(pl)
*
|
2007-11-01 |
2018-12-31 |
Astellas Pharma Inc. |
Immunosupresyjne polipeptydy i kwasy nukleinowe
|
US8906356B2
(en)
*
|
2007-11-05 |
2014-12-09 |
Massachusetts Institute Of Technology |
Mutant interleukin-2 (IL-2) polypeptides
|
US20090226441A1
(en)
|
2007-11-09 |
2009-09-10 |
Minhong Yan |
Activin receptor-like kinase-1 compositions and methods of use
|
WO2009067660A2
(en)
|
2007-11-21 |
2009-05-28 |
Oregon Health & Science University |
Anti-factor xi monoclonal antibodies and methods of use thereof
|
US20090312249A1
(en)
*
|
2007-12-06 |
2009-12-17 |
Korea Advanced Institute Of Science And Technology |
TLR4 decoy receptor protein
|
PT2796466T
(pt)
|
2007-12-07 |
2018-02-23 |
Zymogenetics Inc |
Moléculas de anticorpo humanizado específicas para il-31
|
US20090162351A1
(en)
*
|
2007-12-21 |
2009-06-25 |
Depuy Spine, Inc. |
Transdiscal administration of inhibitors of p38 MAP kinase
|
US8986696B2
(en)
*
|
2007-12-21 |
2015-03-24 |
Depuy Mitek, Inc. |
Trans-capsular administration of p38 map kinase inhibitors into orthopedic joints
|
WO2009109911A1
(en)
|
2008-03-04 |
2009-09-11 |
Pfizer Limited |
Methods of treating chronic pain
|
KR101614494B1
(ko)
|
2008-04-02 |
2016-04-22 |
마크로제닉스, 인크. |
Bcr-복합체-특이적 항체 및 그것의 사용 방법
|
PL2274331T3
(pl)
*
|
2008-05-02 |
2014-04-30 |
Novartis Ag |
Ulepszone cząsteczki wiążące oparte na fibronektynie i ich zastosowanie
|
KR101690590B1
(ko)
|
2008-05-06 |
2016-12-28 |
제넨테크, 인크. |
친화력-성숙 CRIg 변이체
|
US20110081347A1
(en)
*
|
2008-06-04 |
2011-04-07 |
Macrogenics, Inc. |
Antibodies with Altered Binding to FcRn and Methods of Using Same
|
JP2011527572A
(ja)
|
2008-07-09 |
2011-11-04 |
バイオジェン・アイデック・エムエイ・インコーポレイテッド |
Lingo抗体または断片を含む組成物
|
CA2731546C
(en)
|
2008-07-23 |
2013-11-19 |
Hanmi Holdings Co., Ltd. |
A polypeptide complex comprising non-peptidyl polymer having three functional ends
|
MX2011006422A
(es)
|
2008-12-19 |
2011-09-15 |
Panima Pharmaceuticals Ag |
Autoanticuerpos humanos anti-alfa-sinucleina.
|
US20100159485A1
(en)
*
|
2008-12-19 |
2010-06-24 |
Centre For Dna Fingerprinting And Diagnostics |
Detection of mycobacterium tuberculosis
|
WO2010078526A1
(en)
|
2008-12-31 |
2010-07-08 |
Biogen Idec Ma Inc. |
Anti-lymphotoxin antibodies
|
CA2756186A1
(en)
|
2009-03-24 |
2010-09-30 |
Teva Biopharmaceuticals Usa, Inc. |
Humanized antibodies against light and uses thereof
|
BRPI1011535A2
(pt)
|
2009-04-01 |
2016-03-29 |
Genentech Inc |
tratamento de distúrbios resistentes à insulina.
|
US10618964B2
(en)
|
2009-04-10 |
2020-04-14 |
Ablynx N.V. |
Nanobody against IL-6R
|
EP2417163B1
(de)
|
2009-04-10 |
2019-02-27 |
Ablynx N.V. |
Verbesserte, gegen il-6r gerichtete aminosauresequenzen und polypeptide, die diese enthalten, zur behandlung von erkrankungen und storungen, die mit il-6r in zusammenhang stehen
|
AU2010239861B2
(en)
|
2009-04-22 |
2013-07-11 |
Alteogen, Inc |
In vivo half life increased fusion protein or peptide maintained by sustained in vivo release, and method for increasing in vivo half-life using same
|
EP2421896A1
(de)
|
2009-04-22 |
2012-02-29 |
Merck Patent GmbH |
Antikörperfusionsproteine mit modifizierten fcrn-bindungsstellen
|
CA2760890C
(en)
|
2009-05-08 |
2019-08-20 |
Vaccinex, Inc. |
Anti-cd100 antibodies and methods for using the same
|
PL2995315T3
(pl)
|
2009-05-15 |
2024-04-22 |
University Health Network |
Kompozycje i sposoby leczenia nowotworów hematologicznych celujące w oddziaływanie sirp alfa-cd47
|
MX2011013457A
(es)
|
2009-06-15 |
2012-05-08 |
Biokine Therapeutics Ltd |
Polipeptidos que enlazan quimioquina novedosos capaces de inhibir el curso de autoinmunidad, inflamacion y cancer.
|
US20110039300A1
(en)
|
2009-08-10 |
2011-02-17 |
Robert Bayer |
Antibodies with enhanced adcc functions
|
US20110053223A1
(en)
|
2009-08-14 |
2011-03-03 |
Robert Bayer |
Cell culture methods to make antibodies with enhanced adcc function
|
IN2012DN02521A
(de)
|
2009-08-28 |
2015-08-28 |
Rinat Neuroscience Corp |
|
RU2583298C2
(ru)
|
2009-10-07 |
2016-05-10 |
Макродженикс, Инк. |
ПОЛИПЕПТИДЫ, СОДЕРЖАЩИЕ Fc-УЧАСТОК, КОТОРЫЕ ДЕМОНСТРИРУЮТ ПОВЫШЕННУЮ ЭФФЕКТОРНУЮ ФУНКЦИЮ БЛАГОДАРЯ ИЗМЕНЕНИЯМ СТЕПЕНИ ФУКОЗИЛИРОВАНИЯ, И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
|
TW201117824A
(en)
|
2009-10-12 |
2011-06-01 |
Amgen Inc |
Use of IL-17 receptor a antigen binding proteins
|
WO2011056497A1
(en)
|
2009-10-26 |
2011-05-12 |
Genentech, Inc. |
Activin receptor type iib compositions and methods of use
|
WO2011056494A1
(en)
|
2009-10-26 |
2011-05-12 |
Genentech, Inc. |
Activin receptor-like kinase-1 antagonist and vegfr3 antagonist combinations
|
WO2011056502A1
(en)
|
2009-10-26 |
2011-05-12 |
Genentech, Inc. |
Bone morphogenetic protein receptor type ii compositions and methods of use
|
US20110165122A1
(en)
*
|
2009-11-10 |
2011-07-07 |
The Regents Of The University Of California |
Method for targeted and sustained antiviral therapy
|
WO2011071957A1
(en)
|
2009-12-07 |
2011-06-16 |
Sea Lane Biotechnologies, Llc |
Conjugates comprising an antibody surrogate scaffold with improved pharmacokinetic properties
|
WO2011079308A2
(en)
|
2009-12-23 |
2011-06-30 |
Emergent Product Development Seattle, Llc |
Compositions comprising tnf-alpha and il-6 antagonists and methods of use thereof
|
US8637637B2
(en)
|
2010-01-12 |
2014-01-28 |
Bill Nai-Chau Sun |
Fc fusion proteins of human growth hormone
|
SI3295957T1
(sl)
|
2010-01-15 |
2020-02-28 |
Kirin-Amgen, Inc. |
Formulacija protitelesa proti IL-17RA in terapevtski režim za zdravljenje luskavice
|
WO2011103164A1
(en)
|
2010-02-18 |
2011-08-25 |
Centocor Ortho Biotech Inc. |
Monkey homolog of human interferon omega
|
US8802091B2
(en)
|
2010-03-04 |
2014-08-12 |
Macrogenics, Inc. |
Antibodies reactive with B7-H3 and uses thereof
|
AU2011223782B2
(en)
|
2010-03-04 |
2014-09-18 |
Macrogenics, Inc. |
Antibodies reactive with B7-H3, immunologically active fragments thereof and uses thereof
|
WO2011109280A1
(en)
|
2010-03-05 |
2011-09-09 |
Lerner Research Institute |
Methods and compositions to treat immune-mediated disorders
|
US10745467B2
(en)
|
2010-03-26 |
2020-08-18 |
The Trustees Of Dartmouth College |
VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders
|
US20150231215A1
(en)
|
2012-06-22 |
2015-08-20 |
Randolph J. Noelle |
VISTA Antagonist and Methods of Use
|
MX342017B
(es)
|
2010-03-26 |
2016-09-09 |
Dartmouth College |
Proteina mediadora de celula t regulatoria vista, agentes de enlace de vista y uso de los mismos.
|
US20110243942A1
(en)
*
|
2010-04-02 |
2011-10-06 |
Athena Discovery, Inc. |
Relaxin-fusion proteins with extended in vivo half-lives
|
JP5908888B2
(ja)
|
2010-04-16 |
2016-04-26 |
ヤンセン バイオテツク,インコーポレーテツド |
改変された植物のシステインプロテアーゼ及びその使用
|
US8524217B2
(en)
|
2010-05-11 |
2013-09-03 |
Merck Sharp & Dohme Corp. |
MCP1-Ig fusion variants
|
WO2011160062A2
(en)
|
2010-06-17 |
2011-12-22 |
The Usa As Represented By The Secretary, National Institutes Of Health |
Compositions and methods for treating inflammatory conditions
|
US9611310B2
(en)
|
2010-07-09 |
2017-04-04 |
Bioverativ Therapeutics Inc. |
Systems for factor VIII processing and methods thereof
|
CA2807127C
(en)
|
2010-08-02 |
2019-02-12 |
Leslie S. Johnson |
Covalent diabodies and uses thereof
|
SI2601214T1
(en)
|
2010-08-06 |
2018-03-30 |
Genzyme Corporation |
VEGF antagonist compositions and their use
|
KR101862236B1
(ko)
|
2010-09-02 |
2018-05-29 |
백시넥스 인코포레이티드 |
항-cxcl13 항체 및 이의 이용 방법
|
US11053299B2
(en)
|
2010-09-21 |
2021-07-06 |
Immunity Bio, Inc. |
Superkine
|
KR20140020228A
(ko)
|
2010-09-21 |
2014-02-18 |
알토 바이오사이언스 코포레이션 |
다량체성 아이엘 15 용해성 융합 분자 및 그의 제조 및 사용 방법
|
EP2621950A4
(de)
|
2010-09-27 |
2015-09-02 |
Janssen Biotech Inc |
Antikörper zur bindung von humanem kollagen ii
|
ES2686550T3
(es)
|
2010-10-11 |
2018-10-18 |
Biogen International Neuroscience Gmbh |
Anticuerpos anti-tau humanos
|
US8883134B2
(en)
*
|
2010-10-20 |
2014-11-11 |
Handok Pharmaceuticals, Inc. |
Human interleukin-1 receptor antagonist—hybrid Fc fusion protein
|
TW201307385A
(zh)
|
2010-10-25 |
2013-02-16 |
Genentech Inc |
胃腸炎症和銀屑病以及哮喘的治療
|
MX343085B
(es)
|
2010-11-08 |
2016-10-24 |
Novartis Ag |
Polipeptidos que se enlazan a cxcr2.
|
WO2012080518A1
(en)
|
2010-12-17 |
2012-06-21 |
Neurimmune Holding Ag |
Human anti-sod1 antibodies
|
BR112013029932A2
(pt)
|
2011-05-20 |
2017-01-31 |
Alderbio Holdings Llc |
composições anti-cgrp e usos das mesmas
|
EP2709662B1
(de)
|
2011-05-20 |
2019-07-31 |
AlderBio Holdings LLC |
Verwendung von anti-cgrp- oder anti-cgrp-r-antikörpern oder antikörperfragmenten zur behandlung oder prävention chronischer und akuter formen von diarrhöe
|
CA2836800A1
(en)
|
2011-05-20 |
2012-11-29 |
Alderbio Holdings Llc |
Use of anti-cgrp antibodies and antibody fragments to prevent or inhibit photophobia or light aversion in subjects in need thereof, especially migraine sufferers
|
UA111612C2
(uk)
|
2011-05-21 |
2016-05-25 |
Макродженікс, Інк. |
Домени, які зв'язуються з деімунізованою сироваткою, і їхнє застосування для збільшення часу напівжиття в сироватці
|
JP6342325B2
(ja)
|
2011-05-25 |
2018-06-13 |
イナート・ファルマ・ソシエテ・アノニムInnate Pharma Pharma S.A. |
炎症性障害の治療のための抗kir抗体
|
PL2723379T3
(pl)
|
2011-06-23 |
2019-05-31 |
Biogen Int Neuroscience Gmbh |
Cząsteczki wiążące przeciwko alfa-synukleinie
|
WO2012178102A2
(en)
|
2011-06-24 |
2012-12-27 |
The Regents Of The Unversity Of Colorado, A Body Corporate |
Compositions, methods and uses for alpha-1 antitrypsin fusion molecules
|
JP2014529293A
(ja)
*
|
2011-07-08 |
2014-11-06 |
バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH |
レラキシンを放出する融合タンパク質およびその使用
|
WO2013012733A1
(en)
|
2011-07-15 |
2013-01-24 |
Biogen Idec Ma Inc. |
Heterodimeric fc regions, binding molecules comprising same, and methods relating thereto
|
US20140234330A1
(en)
|
2011-07-22 |
2014-08-21 |
Amgen Inc. |
Il-17 receptor a is required for il-17c biology
|
US10138302B2
(en)
*
|
2011-09-23 |
2018-11-27 |
Ablynx N.V. |
Methods for treating rheumatoid arthritis by administering interleukin-6 receptor antibodies
|
US11951157B2
(en)
|
2011-10-11 |
2024-04-09 |
Universitat Zurich |
Methods of treating malignant tumour with IL-12 and anti-PD-1 antibody
|
EP2766035B1
(de)
|
2011-10-11 |
2018-03-28 |
Universität Zürich Prorektorat MNW |
Kombinationsmedikament mit il-12 und einem mittel zur blockade von t-zellen-hemmer-molekülen zur tumortherapie
|
BR112014009797A2
(pt)
|
2011-10-24 |
2020-10-27 |
Halozyme, Inc. |
diagnóstico de companhia para terapia de agente anti-hialuronano e métodos de uso do mesmo
|
EP2802653A4
(de)
|
2012-01-10 |
2015-09-02 |
Univ Colorado Regents |
Zusammensetzungen, verfahren und verwendung für alpha-1-antitrypsin-fusionsmoleküle
|
CA2865928C
(en)
|
2012-03-02 |
2021-02-16 |
Vaccinex, Inc. |
Cxcl13 antagonist for the treatment of sjogren's syndrome
|
WO2013172967A1
(en)
|
2012-05-17 |
2013-11-21 |
Extend Biosciences, Inc |
Carriers for improved drug delivery
|
EP2852610B1
(de)
|
2012-05-23 |
2018-07-11 |
Glykos Finland Oy |
Herstellung von fucosylierten glykoproteinen
|
US9890215B2
(en)
|
2012-06-22 |
2018-02-13 |
King's College London |
Vista modulators for diagnosis and treatment of cancer
|
FI3421486T3
(fi)
|
2012-06-22 |
2023-12-15 |
Dartmouth College |
Uusia vista-ig-rakenteita ja vista-ig:n käyttö autoimmuuni-, allergia- ja tulehdushäiriöiden hoitamiseksi
|
CA2878404A1
(en)
|
2012-07-10 |
2014-01-16 |
The Trustees Of The University Of Pennsylvania |
Biomaterials for enhanced implant-host integration
|
EP2879710B1
(de)
|
2012-08-03 |
2019-11-13 |
Dana-Farber Cancer Institute, Inc. |
Medizinische verwendungen von immunzellenaktivierungsmodulierenden substanzen und entsprechende screeningverfahren
|
DK2888283T3
(en)
|
2012-08-24 |
2018-11-19 |
Univ California |
ANTIBODIES AND VACCINES FOR TREATING ROR1 CANCER AND INHIBITIVE METASTASE
|
JP6368308B2
(ja)
|
2012-09-07 |
2018-08-01 |
トラスティーズ・オブ・ダートマス・カレッジ |
癌の診断および治療のためのvista調節剤
|
WO2014062856A1
(en)
|
2012-10-16 |
2014-04-24 |
Halozyme, Inc. |
Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods
|
HUE047221T2
(hu)
|
2012-12-17 |
2020-04-28 |
Trillium Therapeutics Inc |
A CD47+ kóros sejtek kezelése SIRP alfa-FC fúziókkal
|
MY184251A
(en)
|
2012-12-21 |
2021-03-29 |
Biogen Int Neuroscience Gmbh |
Human anti-tau antibodies
|
WO2014102399A1
(en)
|
2012-12-31 |
2014-07-03 |
Neurimmune Holding Ag |
Recombinant human antibodies for therapy and prevention of polyomavirus-related diseases
|
US9487587B2
(en)
|
2013-03-05 |
2016-11-08 |
Macrogenics, Inc. |
Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof
|
BR112015021964A2
(pt)
|
2013-03-08 |
2017-08-29 |
Vaccinex Inc |
Anticorpo isolado ou um fragmento ligante de antígenos do mesmo que se liga especificamente a cxcl13, composição e seus usos
|
US9458246B2
(en)
|
2013-03-13 |
2016-10-04 |
Amgen Inc. |
Proteins specific for BAFF and B7RP1
|
JOP20140087B1
(ar)
|
2013-03-13 |
2021-08-17 |
Amgen Inc |
بروتينات مخصصة ل baff و b7rp1 وإستخداماتها
|
DK2968520T3
(da)
|
2013-03-14 |
2021-08-09 |
Macrogenics Inc |
Bispecifikke molekyler som er immunoreaktive med immuneffektorceller der udtrykker en aktiverende receptor
|
DK2970921T3
(en)
|
2013-03-15 |
2019-01-14 |
Atyr Pharma Inc |
Histidyl-tRNA synthetase-Fc conjugates
|
TWI788044B
(zh)
|
2013-03-15 |
2022-12-21 |
美商百歐維拉提夫治療公司 |
因子ix多肽調配物
|
BR112015023140A8
(pt)
|
2013-03-15 |
2018-01-23 |
Genentech Inc |
proteínas de fusão, método para a fabricação da proteína de fusão, composições, ácido nucleico,vetor, célula hospedeira, métodos de produção de uma proteína de fusão, de tratamento da doença inflamatória intestinal, de inibição da infecção microbiana, de tratamento da lesão renal, para acelerar ou melhorar a cicatrização, para a prevenção ou tratamento de uma condição cardiovascular, para tratamento da síndrome metabólica e para tratamento da endotoxemia.
|
SG10201800800YA
(en)
|
2013-05-06 |
2018-03-28 |
Scholar Rock Inc |
Compositions and methods for growth factor modulation
|
WO2014197369A1
(en)
|
2013-06-06 |
2014-12-11 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for identification, assessment prevention, and treatment of cancer using pd-l1 isoforms
|
AR096891A1
(es)
|
2013-07-12 |
2016-02-03 |
Hanmi Pharm Ind Co Ltd |
Conjugado de monómero polipéptido biológicamente activo y conjugado de fragmento fc de inmunoglobulina, que muestra aclaramiento mediado por receptor reducido, y el método para la preparación del mismo
|
US11384149B2
(en)
|
2013-08-09 |
2022-07-12 |
Macrogenics, Inc. |
Bi-specific monovalent Fc diabodies that are capable of binding CD32B and CD79b and uses thereof
|
UA116479C2
(uk)
|
2013-08-09 |
2018-03-26 |
Макродженікс, Інк. |
БІСПЕЦИФІЧНЕ МОНОВАЛЕНТНЕ Fc-ДІАТІЛО, ЯКЕ ОДНОЧАСНО ЗВ'ЯЗУЄ CD32B I CD79b, ТА ЙОГО ЗАСТОСУВАННЯ
|
EP2839842A1
(de)
|
2013-08-23 |
2015-02-25 |
MacroGenics, Inc. |
Bispezifische monovalente Diabodies mit Fähigkeit zur Bindung von CD123 und CD3 und Verwendungen davon
|
EP2840091A1
(de)
|
2013-08-23 |
2015-02-25 |
MacroGenics, Inc. |
Bispezifische Diabodies, die gpA33 und CD3 binden können und Anwendungen dieser
|
EP3049442A4
(de)
|
2013-09-26 |
2017-06-28 |
Costim Pharmaceuticals Inc. |
Verfahren zur behandlung von blutkrebs
|
EP3077048B1
(de)
|
2013-12-07 |
2019-07-17 |
Case Western Reserve University |
Zusammensetzungen und verfahren zur behandlung von thrombose
|
WO2015095868A1
(en)
|
2013-12-20 |
2015-06-25 |
Wake Forest University Health Sciences |
Methods and compositions for increasing protective antibody levels induced by pneumococcal polysaccharide vaccines
|
DK3712174T3
(da)
|
2013-12-24 |
2022-04-25 |
Janssen Pharmaceutica Nv |
Anti-vista antibodies and fragments
|
US11014987B2
(en)
|
2013-12-24 |
2021-05-25 |
Janssen Pharmaceutics Nv |
Anti-vista antibodies and fragments, uses thereof, and methods of identifying same
|
US10047133B2
(en)
*
|
2014-01-22 |
2018-08-14 |
Antagonis Biotherapeutics Gmbh |
Glycosaminoglycan-antagonising fusion proteins and methods of using same
|
US10556945B2
(en)
|
2014-03-21 |
2020-02-11 |
Teva Pharmaceuticals International Gmbh |
Antagonist antibodies directed against calcitonin gene-related peptide and methods using same
|
KR20200126018A
(ko)
|
2014-03-21 |
2020-11-05 |
테바 파마슈티컬스 인터내셔널 게엠베하 |
칼시토닌 유전자-관련 펩티드에 대한 길항제 항체 및 그의 사용 방법
|
KR102530900B1
(ko)
|
2014-03-31 |
2023-05-12 |
암젠 케이-에이, 인크. |
손발톱 및 두피 건선의 치료 방법
|
EP3154585B1
(de)
|
2014-06-11 |
2022-02-23 |
Kathy A. Green |
Verwendung von vista-agonisten und antagonisten zur unterdrückung oder verbesserung der humoralen immunität
|
EP3673915A1
(de)
|
2014-06-30 |
2020-07-01 |
Altor BioScience Corporation |
Il-15-basierte moleküle und verfahren zur verwendung davon
|
WO2016012468A1
(en)
|
2014-07-21 |
2016-01-28 |
Novartis Ag |
Production of glycoproteins with mammalian-like n-glycans in filamentous fungi
|
WO2016022597A1
(en)
|
2014-08-04 |
2016-02-11 |
Case Western Reserve University |
Targeting peptides and methods of use
|
US9616114B1
(en)
|
2014-09-18 |
2017-04-11 |
David Gordon Bermudes |
Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
|
WO2016054101A1
(en)
|
2014-09-29 |
2016-04-07 |
Duke University |
Bispecific molecules comprising an hiv-1 envelope targeting arm
|
KR20230104759A
(ko)
|
2014-09-30 |
2023-07-10 |
뉴리뮨 홀딩 아게 |
인간-유래의 항-디펩티드 반복체(dpr) 항체
|
CN107074954A
(zh)
|
2014-10-21 |
2017-08-18 |
埃博灵克斯股份有限公司 |
Il‑6r相关疾病的治疗
|
CA2964463C
(en)
|
2014-10-22 |
2024-02-13 |
Extend Biosciences, Inc. |
Therapeutic vitamin d conjugates
|
US9789197B2
(en)
|
2014-10-22 |
2017-10-17 |
Extend Biosciences, Inc. |
RNAi vitamin D conjugates
|
US9616109B2
(en)
|
2014-10-22 |
2017-04-11 |
Extend Biosciences, Inc. |
Insulin vitamin D conjugates
|
MX2017007136A
(es)
|
2014-12-05 |
2017-12-04 |
Immunext Inc |
Identificacion de vsig8 como el receptor vista putativo y su uso para producir moduladores vista/vsig8.
|
US11220545B2
(en)
|
2014-12-08 |
2022-01-11 |
Dana-Farber Cancer Institute, Inc. |
Methods for upregulating immune responses using combinations of anti-RGMb and anti-PD-1 agents
|
JP2018506275A
(ja)
|
2015-01-28 |
2018-03-08 |
ジェネンテック, インコーポレイテッド |
多発性硬化症の遺伝子発現マーカー及び治療
|
US11820807B2
(en)
|
2015-06-12 |
2023-11-21 |
Ubi Pharma Inc |
Immunoglobulin fusion proteins and uses thereof
|
CA2990360C
(en)
|
2015-06-24 |
2024-02-13 |
Janssen Pharmaceutica Nv |
Anti-vista antibodies and fragments
|
MY185014A
(en)
|
2015-08-07 |
2021-04-30 |
Alx Oncology Inc |
Contructs having a sirp-alpha domain or variant thereof
|
CA2997673A1
(en)
|
2015-09-15 |
2017-03-23 |
Board Of Regents, The University Of Texas System |
T-cell receptor (tcr)-binding antibodies and uses thereof
|
US11338065B2
(en)
|
2015-10-08 |
2022-05-24 |
Massachusetts Institute Of Technology |
In situ expansion of engineered devices for regeneration
|
US11207393B2
(en)
|
2015-10-16 |
2021-12-28 |
President And Fellows Of Harvard College |
Regulatory T cell PD-1 modulation for regulating T cell effector immune responses
|
KR20180100135A
(ko)
|
2015-12-17 |
2018-09-07 |
바이오카인 테라퓨틱스 리미티드 |
케모카인 활성, 키나아제 활성 및/또는 암세포 성장 억제용 저분자
|
US10646465B2
(en)
|
2015-12-17 |
2020-05-12 |
Biokine Therapeutics Ltd. |
Small molecules against cancer
|
CA3048613A1
(en)
|
2015-12-31 |
2017-07-06 |
The Regents Of The University Of Colorado, A Body Corporate |
Methods and uses for alpha-1 antitrypsin or recombinant forms thereof, on steroid-refractory graft versus host disease involving gastrointestinal complications
|
CN109069626A
(zh)
|
2016-02-12 |
2018-12-21 |
詹森药业有限公司 |
抗-vista(b7h5)抗体
|
KR102603010B1
(ko)
|
2016-03-10 |
2023-11-16 |
비엘라 바이오, 인크. |
Ilt7 결합 분자 및 이의 사용 방법
|
TWI781098B
(zh)
|
2016-04-15 |
2022-10-21 |
美商宏觀基因股份有限公司 |
新穎的b7-h3-結合分子、其抗體藥物綴合物及其使用方法
|
BR112018071153A2
(pt)
|
2016-04-15 |
2019-04-16 |
Immunext, Inc. |
anticorpos anti-vista humano e uso dos mesmos
|
JP7037506B2
(ja)
|
2016-05-27 |
2022-03-16 |
アルター・バイオサイエンス・コーポレーション |
Cd3結合ドメインを有する多量体il-15系分子の構築及び特性評価
|
JP2018035137A
(ja)
|
2016-07-13 |
2018-03-08 |
マブイミューン ダイアグノスティックス エイジーMabimmune Diagnostics Ag |
新規な抗線維芽細胞活性化タンパク質(fap)結合薬剤およびその使用
|
AU2017331593B2
(en)
|
2016-09-23 |
2022-04-28 |
Teva Pharmaceuticals International Gmbh |
Treating refractory migraine
|
EP3529263A4
(de)
|
2016-10-21 |
2020-07-08 |
Altor BioScience Corporation |
Multimere auf il-15-basierende moleküle
|
US11129906B1
(en)
|
2016-12-07 |
2021-09-28 |
David Gordon Bermudes |
Chimeric protein toxins for expression by therapeutic bacteria
|
US11180535B1
(en)
|
2016-12-07 |
2021-11-23 |
David Gordon Bermudes |
Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
|
CA3052095A1
(en)
|
2017-01-30 |
2018-08-02 |
Janssen Biotech, Inc. |
Anti-tnf antibodies, compositions, and methods for the treatment of active psoriatic arthritis
|
WO2018148224A1
(en)
|
2017-02-07 |
2018-08-16 |
Seattle Children's Hospital (dba Seattle Children's Research Institute) |
Phospholipid ether (ple) car t cell tumor targeting (ctct) agents
|
CA3052578A1
(en)
|
2017-02-07 |
2018-08-16 |
Janssen Biotech, Inc. |
Anti-tnf antibodies, compositions, and methods for the treatment of active ankylosing spondylitis
|
BR112019017743A2
(pt)
|
2017-02-28 |
2020-04-07 |
Sanofi Sa |
rna terapêutico
|
EP3589295A4
(de)
|
2017-02-28 |
2020-11-04 |
Endocyte, Inc. |
Zusammensetzungen und verfahren für car-t-zelltherapie
|
KR20230170821A
(ko)
|
2017-03-06 |
2023-12-19 |
알토 바이오사이언스 코포레이션 |
Il-12 및 il-18로의 il-15-기반 융합
|
US20190048055A1
(en)
|
2017-03-31 |
2019-02-14 |
Altor Bioscience Corporation |
Alt-803 in combination with anti-cd38 antibody for cancer therapies
|
CN110536694A
(zh)
|
2017-04-20 |
2019-12-03 |
Atyr 医药公司 |
用于治疗肺部炎症的组合物和方法
|
MX2019013110A
(es)
|
2017-05-05 |
2019-12-16 |
Vaccinex Inc |
Anticuerpo anti-semaforina 4d humano.
|
CA3074635A1
(en)
|
2017-08-28 |
2019-03-07 |
Altor Bioscience Llc |
Il-15-based fusions to il-7 and il-21
|
JP7417542B2
(ja)
|
2018-01-22 |
2024-01-18 |
シアトル チルドレンズ ホスピタル (ディービーエイ シアトル チルドレンズ リサーチ インスティテュート) |
Car t細胞の使用方法
|
PE20212075A1
(es)
|
2018-01-26 |
2021-10-26 |
Genentech Inc |
PROTEINAS DE FUSION Fc IL-22 Y METODOS DE USO
|
PT3743088T
(pt)
|
2018-01-26 |
2022-12-05 |
Hoffmann La Roche |
Composições il-22 fc e métodos de utilização
|
CN111757751A
(zh)
|
2018-02-21 |
2020-10-09 |
豪夫迈·罗氏有限公司 |
用于使用IL-22 Fc融合蛋白的治疗的剂量方案
|
US11168138B2
(en)
|
2018-03-26 |
2021-11-09 |
Altor Bioscience, Llc |
Anti-PDL1, IL-15 and TGF-beta receptor combination molecules
|
EP3792276A4
(de)
|
2018-04-26 |
2022-02-16 |
Good T Cells, Inc. |
Neuartiges fusionsprotein und pharmazeutische zusammensetzung zur vorbeugung oder behandlung von krebs damit
|
EP3815706A4
(de)
*
|
2018-06-28 |
2022-03-16 |
National University Corporation Okayama University |
Mittel zur verbesserung der phagozytosefähigkeit von neutrophilen
|
CA3107159A1
(en)
|
2018-07-24 |
2020-01-30 |
Good T Cells, Inc. |
Composition for preventing or treating immune-related diseases
|
CN110964116A
(zh)
|
2018-09-26 |
2020-04-07 |
北京辅仁瑞辉生物医药研究院有限公司 |
GLP1-Fc融合蛋白及其缀合物
|
BR112020018192A2
(pt)
|
2019-01-08 |
2021-08-24 |
H. Lundbeck A/S |
Tratamento agudo e tratamento rápido de dor de cabeça com o uso de anticorpos anti-cgrp
|
MA54750A
(fr)
|
2019-01-15 |
2021-11-24 |
Janssen Biotech Inc |
Compositions d'anticorps anti-tnf et procédés pour le traitement de l'arthrite idiopathique juvénile
|
JP2022518250A
(ja)
|
2019-01-23 |
2022-03-14 |
ヤンセン バイオテツク,インコーポレーテツド |
乾癬性関節炎の治療方法で使用するための抗tnf抗体組成物
|
CA3130103A1
(en)
|
2019-02-13 |
2020-08-20 |
The Brigham And Women's Hospital, Inc. |
Anti-peripheral lymph node addressin antibodies and uses thereof
|
EA202192505A1
(ru)
|
2019-03-14 |
2022-03-29 |
Янссен Байотек, Инк. |
Способы получения композиций антитела к фно
|
JP2022525179A
(ja)
|
2019-03-14 |
2022-05-11 |
ヤンセン バイオテツク,インコーポレーテツド |
抗tnf抗体組成物を産生するための産生方法
|
MA55284A
(fr)
|
2019-03-14 |
2022-01-19 |
Janssen Biotech Inc |
Procédés de production de compositions d'anticorps anti-tnf
|
IL288144B2
(en)
|
2019-05-15 |
2024-03-01 |
Alonbio Ltd |
Compounds to treat cancer, to inhibit chemokines and/or to kill cells
|
WO2020234834A1
(en)
|
2019-05-23 |
2020-11-26 |
Janssen Biotech, Inc. |
Method of treating inflammatory bowel disease with a combination therapy of antibodies to il-23 and tnf alpha
|
CA3141130A1
(en)
|
2019-05-31 |
2020-12-03 |
ALX Oncology Inc. |
Methods of treating cancer with sirp alpha fc fusion in combination with an immune checkpoint inhibitor
|
MA56015A
(fr)
|
2019-06-03 |
2022-04-06 |
Janssen Biotech Inc |
Compositions d'anticorps anti-tnf et méthodes pour le traitement de l'arthrite psoriasique
|
MA56026A
(fr)
|
2019-06-03 |
2022-04-06 |
Janssen Biotech Inc |
Anticorps anti-tnf, compositions et méthodes pour le traitement de la spondylarthrite ankylosante active
|
WO2021028752A1
(en)
|
2019-08-15 |
2021-02-18 |
Janssen Biotech, Inc. |
Anti-tfn antibodies for treating type i diabetes
|
EP4114428A1
(de)
|
2020-03-05 |
2023-01-11 |
Diamedica USA Inc. |
Ulinastatinpolypeptide
|
WO2021207662A1
(en)
|
2020-04-10 |
2021-10-14 |
Genentech, Inc. |
Use of il-22fc for the treatment or prevention of pneumonia, acute respiratory distress syndrome, or cytokine release syndrome
|
WO2021230233A1
(ja)
*
|
2020-05-14 |
2021-11-18 |
学校法人日本医科大学 |
感染症の治療又は予防剤
|
WO2022261183A2
(en)
|
2021-06-08 |
2022-12-15 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for treating and/or identifying an agent for treating intestinal cancers
|
WO2023281462A1
(en)
|
2021-07-09 |
2023-01-12 |
Janssen Biotech, Inc. |
Manufacturing methods for producing anti-tnf antibody compositions
|
US20230042465A1
(en)
|
2021-07-09 |
2023-02-09 |
Janssen Biotech, Inc. |
Manufacturing Methods for Producing Anti-TNF Antibody Compositions
|
WO2023097119A2
(en)
|
2021-11-29 |
2023-06-01 |
Dana-Farber Cancer Institute, Inc. |
Methods and compositions to modulate riok2
|
WO2023168426A1
(en)
|
2022-03-03 |
2023-09-07 |
Enosi Therapeutics Corporation |
Compositions and cells containing mixtures of oligo-trap fusion proteins (ofps) and uses thereof
|
WO2023173084A1
(en)
|
2022-03-11 |
2023-09-14 |
University Of Rochester |
Cyclopeptibodies and uses thereof
|
WO2023213779A1
(en)
|
2022-05-02 |
2023-11-09 |
Novo Nordisk A/S |
Novel anti-angptl3 antibodies suitable for high concentration compositions and subcutaneous administration
|