PL2274331T3 - Ulepszone cząsteczki wiążące oparte na fibronektynie i ich zastosowanie - Google Patents
Ulepszone cząsteczki wiążące oparte na fibronektynie i ich zastosowanieInfo
- Publication number
- PL2274331T3 PL2274331T3 PL09738252T PL09738252T PL2274331T3 PL 2274331 T3 PL2274331 T3 PL 2274331T3 PL 09738252 T PL09738252 T PL 09738252T PL 09738252 T PL09738252 T PL 09738252T PL 2274331 T3 PL2274331 T3 PL 2274331T3
- Authority
- PL
- Poland
- Prior art keywords
- binding molecules
- based binding
- improved fibronectin
- fibronectin
- improved
- Prior art date
Links
- 102000016359 Fibronectins Human genes 0.000 title 1
- 108010067306 Fibronectins Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5014208P | 2008-05-02 | 2008-05-02 | |
PCT/EP2009/055365 WO2009133208A1 (en) | 2008-05-02 | 2009-05-04 | Improved fibronectin-based binding molecules and uses thereof |
EP09738252.7A EP2274331B1 (en) | 2008-05-02 | 2009-05-04 | Improved fibronectin-based binding molecules and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
PL2274331T3 true PL2274331T3 (pl) | 2014-04-30 |
Family
ID=41114864
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL09738252T PL2274331T3 (pl) | 2008-05-02 | 2009-05-04 | Ulepszone cząsteczki wiążące oparte na fibronektynie i ich zastosowanie |
PL11191379T PL2439212T3 (pl) | 2008-05-02 | 2009-05-04 | Ulepszone cząsteczki wiążące na bazie fibronektyny oraz ich zastosowanie |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL11191379T PL2439212T3 (pl) | 2008-05-02 | 2009-05-04 | Ulepszone cząsteczki wiążące na bazie fibronektyny oraz ich zastosowanie |
Country Status (14)
Country | Link |
---|---|
US (3) | US9296810B2 (pl) |
EP (4) | EP2383292A1 (pl) |
JP (3) | JP6192891B2 (pl) |
KR (1) | KR20110021832A (pl) |
CN (1) | CN102076713B (pl) |
AU (1) | AU2009242038B2 (pl) |
BR (1) | BRPI0913007A2 (pl) |
CA (1) | CA2723277A1 (pl) |
EA (1) | EA201001734A1 (pl) |
ES (2) | ES2620285T3 (pl) |
MX (1) | MX2010011957A (pl) |
PL (2) | PL2274331T3 (pl) |
PT (2) | PT2439212T (pl) |
WO (1) | WO2009133208A1 (pl) |
Families Citing this family (98)
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BRPI0417302A (pt) | 2003-12-05 | 2007-03-06 | Compound Therapeutics Inc | inibidores de receptores de fator de crescimento endotelial vascular do tipo 2 |
AU2007325838B2 (en) | 2006-11-22 | 2013-09-19 | Bristol-Myers Squibb Company | Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including IGF-IR |
ATE516814T1 (de) * | 2007-02-02 | 2011-08-15 | Bristol Myers Squibb Co | 10fn3 domain zur behandlung von krankheiten begleitet von unerwünschter angiogenese |
EP2215246B1 (en) | 2007-10-31 | 2015-01-07 | MedImmune, LLC | Protein scaffolds |
EP2247615B1 (en) | 2008-02-14 | 2014-07-30 | Bristol-Myers Squibb Company | Targeted therapeutics based on engineered proteins that bind egfr |
AU2009242038B2 (en) * | 2008-05-02 | 2013-05-30 | Novartis Ag | Improved fibronectin-based binding molecules and uses thereof |
JP2011520961A (ja) * | 2008-05-22 | 2011-07-21 | ブリストル−マイヤーズ スクイブ カンパニー | 多価フィブロネクチンをベースとする足場ドメインタンパク質 |
KR101781907B1 (ko) | 2008-10-31 | 2017-09-26 | 얀센 바이오테크 인코포레이티드 | 파이브로넥틴 타입 ⅲ 도메인 기반 스캐폴드 조성물, 방법 및 용도 |
TWI496582B (zh) | 2008-11-24 | 2015-08-21 | 必治妥美雅史谷比公司 | 雙重專一性之egfr/igfir結合分子 |
EP2464663A4 (en) * | 2009-08-13 | 2013-05-29 | Massachusetts Inst Technology | RECOMBINANT PROTEINS COMPRISING MUTANT DOMAINS OF FIBRONECTIN |
US9139825B2 (en) | 2009-10-30 | 2015-09-22 | Novartis Ag | Universal fibronectin type III bottom-side binding domain libraries |
WO2011092233A1 (en) * | 2010-01-29 | 2011-08-04 | Novartis Ag | Yeast mating to produce high-affinity combinations of fibronectin-based binders |
EA201270713A1 (ru) * | 2010-02-18 | 2013-01-30 | Бристол-Майерс Сквибб Компани | Белки на основе фибронектина с каркасными доменами, которые связывают ил-23 |
WO2011130324A1 (en) | 2010-04-13 | 2011-10-20 | Medimmune, Llc | Fibronectin type iii domain-based multimeric scaffolds |
EA036055B1 (ru) | 2010-04-13 | 2020-09-21 | Бристол-Майерс Сквибб Компани | Применение полипептида, связывающего pcsk9, для лечения атеросклероза или гиперхолистеринемии |
PT2571531T (pt) | 2010-04-30 | 2016-08-31 | Janssen Biotech Inc | Composições do domínio da fibronectina estabilizadas, métodos e utilizações |
AU2013202913B2 (en) * | 2010-05-03 | 2016-06-16 | Bristol-Myers Squibb Company | Serum albumin binding molecules |
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CN103403027A (zh) * | 2010-07-30 | 2013-11-20 | 诺华有限公司 | 纤连蛋白摇篮分子和其库 |
KR101830344B1 (ko) * | 2010-10-26 | 2018-02-22 | 한미사이언스 주식회사 | 피브로넥틴 단편 및 면역글로불린 단편의 융합 단백질 및 이의 용도 |
PL2697257T3 (pl) | 2011-04-13 | 2017-04-28 | Bristol-Myers Squibb Company | Białka fuzyjne fc o nowatorskim układzie lub zawierające nowatorskie łączniki |
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PL2439212T3 (pl) | 2017-06-30 |
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CA2723277A1 (en) | 2009-11-05 |
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EP2383292A1 (en) | 2011-11-02 |
MX2010011957A (es) | 2011-03-04 |
JP2011522517A (ja) | 2011-08-04 |
US20160376345A1 (en) | 2016-12-29 |
WO2009133208A1 (en) | 2009-11-05 |
AU2009242038A1 (en) | 2009-11-05 |
PT2274331E (pt) | 2014-02-27 |
ES2620285T3 (es) | 2017-06-28 |
EP2274331B1 (en) | 2013-11-06 |
EP2439212A1 (en) | 2012-04-11 |
EP2439212B1 (en) | 2016-12-21 |
PT2439212T (pt) | 2017-03-29 |
EP2274331A1 (en) | 2011-01-19 |
EA201001734A1 (ru) | 2011-10-31 |
KR20110021832A (ko) | 2011-03-04 |
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