ES2387546T3 - Péptidos y moléculas relacionadas que se unen a TALL-1 - Google Patents
Péptidos y moléculas relacionadas que se unen a TALL-1 Download PDFInfo
- Publication number
- ES2387546T3 ES2387546T3 ES10178373T ES10178373T ES2387546T3 ES 2387546 T3 ES2387546 T3 ES 2387546T3 ES 10178373 T ES10178373 T ES 10178373T ES 10178373 T ES10178373 T ES 10178373T ES 2387546 T3 ES2387546 T3 ES 2387546T3
- Authority
- ES
- Spain
- Prior art keywords
- amino acid
- residue
- independently
- absent
- tall
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000016605 B-Cell Activating Factor Human genes 0.000 title 1
- 108010028006 B-Cell Activating Factor Proteins 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 125000000539 amino acid group Chemical group 0.000 abstract 4
- 230000007935 neutral effect Effects 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 125000001165 hydrophobic group Chemical group 0.000 abstract 1
- 230000005847 immunogenicity Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
Abstract
Una composición objeto del presente que tiene la fórmula (%'_V1_(X2hy multímeros de la misma, donde:V1 es una molécula que evita la degradación y/o aumenta la vida media, reduce la toxicidad, reduce la inmunogenicidad,o aumenta la actividad biológica de una proteína terapéutica;X' y X2 comprenden, cada uno de ellos independientemente, la ¡órmula -(L' )c _P1_(L2)d_ p2 o p2_(L2)d_P' _(L ')c-,donde X'y X2 están unidos a V1 mediante (L 1)c;a,b,c y d son, cada uno de ellos independientemente, O 01, siempre que al menos uno de a o b sea 1;P1 Y P2 comprenden, cada uno de ellos independientemente, la secuencia de aminoácidos recogida en SECo ID. N°: 109(¡1¡2¡3 K¡5 D¡7 Lf9¡' 0Q¡12¡13¡14);f1 es un residuo de aminoácido o está ausente;f2 Y f3 son residuos de aminoácidos;¡ es W, Y, o F;f7 es un residuo de aminoácido;¡1O es K, R, o H;f12 es e, un residuo hidrófobo neutro, o un residuo básico (preferiblemente W, C o R);f13 es C, un residuo hidrófobo neutro o está ausente;f14 es cualquier residuo de aminoácido o está ausente;siempre que solamente uno de f1, f2, o f3, pueda ser C, y solamente uno de f12, f13 Y f14 pueda ser C; yL 1 Y L 2 son, cada uno de ellos independientemente, enlazadores.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29019601P | 2001-05-11 | 2001-05-11 | |
US290196P | 2001-05-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2387546T3 true ES2387546T3 (es) | 2012-09-25 |
Family
ID=23114926
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES07019762.9T Expired - Lifetime ES2527471T3 (es) | 2001-05-11 | 2002-05-13 | Péptidos y moléculas relacionadas que se unen a TALL-1 |
ES10178373T Expired - Lifetime ES2387546T3 (es) | 2001-05-11 | 2002-05-13 | Péptidos y moléculas relacionadas que se unen a TALL-1 |
ES02769739T Expired - Lifetime ES2295404T3 (es) | 2001-05-11 | 2002-05-13 | Peptidos y moleculas relacionadas que se unen a tall-1. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES07019762.9T Expired - Lifetime ES2527471T3 (es) | 2001-05-11 | 2002-05-13 | Péptidos y moléculas relacionadas que se unen a TALL-1 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES02769739T Expired - Lifetime ES2295404T3 (es) | 2001-05-11 | 2002-05-13 | Peptidos y moleculas relacionadas que se unen a tall-1. |
Country Status (30)
Country | Link |
---|---|
US (5) | US7259137B2 (es) |
EP (4) | EP1921088B1 (es) |
JP (1) | JP4516719B2 (es) |
KR (1) | KR100902687B1 (es) |
CN (3) | CN1970077A (es) |
AT (2) | ATE549354T1 (es) |
AU (1) | AU2002342669C1 (es) |
BG (1) | BG66270B1 (es) |
BR (1) | BR0209546A (es) |
CA (1) | CA2446189C (es) |
CY (1) | CY1107131T1 (es) |
CZ (1) | CZ304592B6 (es) |
DE (1) | DE60222882T2 (es) |
DK (1) | DK1385882T3 (es) |
EA (1) | EA010435B1 (es) |
EE (1) | EE05294B1 (es) |
ES (3) | ES2527471T3 (es) |
HK (3) | HK1059269A1 (es) |
HU (1) | HU229910B1 (es) |
IL (2) | IL158719A0 (es) |
MX (1) | MXPA03010210A (es) |
NO (1) | NO331785B1 (es) |
NZ (2) | NZ529267A (es) |
PL (2) | PL393317A1 (es) |
PT (1) | PT1385882E (es) |
RS (1) | RS51708B (es) |
SI (1) | SI1385882T1 (es) |
SK (1) | SK288175B6 (es) |
WO (1) | WO2002092620A2 (es) |
ZA (1) | ZA200308513B (es) |
Families Citing this family (142)
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US6812327B1 (en) * | 1996-10-25 | 2004-11-02 | Human Genome Sciences, Inc. | Neutrokine-alpha polypeptides |
US7879328B2 (en) | 2000-06-16 | 2011-02-01 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to B lymphocyte stimulator |
PT2275449T (pt) * | 2000-06-16 | 2016-12-27 | Human Genome Sciences Inc | Anticorpos que se ligam imunoespecificamente a blys |
WO2002016412A2 (en) | 2000-08-18 | 2002-02-28 | Dyax Corp. | Binding polypeptides for b lymphocyte stimulator protein (blys) |
US20030091565A1 (en) * | 2000-08-18 | 2003-05-15 | Beltzer James P. | Binding polypeptides and methods based thereon |
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