ES2155819T3 - Inmunoglobulinas hibridas. - Google Patents

Inmunoglobulinas hibridas.

Info

Publication number
ES2155819T3
ES2155819T3 ES91901202T ES91901202T ES2155819T3 ES 2155819 T3 ES2155819 T3 ES 2155819T3 ES 91901202 T ES91901202 T ES 91901202T ES 91901202 T ES91901202 T ES 91901202T ES 2155819 T3 ES2155819 T3 ES 2155819T3
Authority
ES
Spain
Prior art keywords
hybrid immunoglobulins
useful
methods
peptides
immunoglobulins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91901202T
Other languages
English (en)
Other versions
ES2155819T5 (es
Inventor
Daniel J Capon
Laurence A Lasky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23749509&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2155819(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ES2155819T3 publication Critical patent/ES2155819T3/es
Publication of ES2155819T5 publication Critical patent/ES2155819T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/04—Fusion polypeptide containing a localisation/targetting motif containing an ER retention signal such as a C-terminal HDEL motif
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/705—Fusion polypeptide containing domain for protein-protein interaction containing a protein-A fusion

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Physics & Mathematics (AREA)
  • Neurology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)

Abstract

Procedimiento de fabricación de un dímero de cadena pesada de inmunoglobulina, en el cual una secuencia aminoacídica de una pareja de unión al ligando que es una cadena única y es un receptor, una proteína transportadora, una hormona, un factor de crecimiento o una enzima y no es un receptor de localización de linfocitos, no es un miembro de la superfamilia de genes de inmunoglobulinas ni una proteína homóloga a éstos, ni tampoco un polipéptido de subunidades múltiples codificadas por genes discretos, se sustituye por las regiones variables de las cadenas pesadas de inmunoglobulina, en donde dichas cadenas pesadas de inmunoglobulina retienen al menos bisagra y los dominios CH2 y CH3 de la región constante de cadena pesada.
ES91901202T 1989-11-22 1990-11-21 Inmunoglobulinas hibridas. Expired - Lifetime ES2155819T5 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US440625 1989-11-22
US07/440,625 US5116964A (en) 1989-02-23 1989-11-22 Hybrid immunoglobulins

Publications (2)

Publication Number Publication Date
ES2155819T3 true ES2155819T3 (es) 2001-06-01
ES2155819T5 ES2155819T5 (es) 2007-09-16

Family

ID=23749509

Family Applications (2)

Application Number Title Priority Date Filing Date
ES99123412T Expired - Lifetime ES2308826T3 (es) 1989-11-22 1990-11-21 Inmunoglobulinas hibridas para su uso en metodos terapeuticos.
ES91901202T Expired - Lifetime ES2155819T5 (es) 1989-11-22 1990-11-21 Inmunoglobulinas hibridas.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES99123412T Expired - Lifetime ES2308826T3 (es) 1989-11-22 1990-11-21 Inmunoglobulinas hibridas para su uso en metodos terapeuticos.

Country Status (13)

Country Link
US (1) US5116964A (es)
EP (3) EP1970386A2 (es)
JP (2) JPH05503009A (es)
AT (2) ATE199261T1 (es)
CA (1) CA2072642C (es)
DE (3) DE122008000063I2 (es)
DK (2) DK0526452T4 (es)
ES (2) ES2308826T3 (es)
GR (1) GR3035856T3 (es)
HK (2) HK1030222A1 (es)
LU (1) LU91498I2 (es)
NL (1) NL300372I1 (es)
WO (1) WO1991008298A2 (es)

Families Citing this family (611)

* Cited by examiner, † Cited by third party
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EP0526452B1 (en) 2001-02-21
WO1991008298A2 (en) 1991-06-13
DE122008000063I1 (de) 2009-02-19
EP1029870A2 (en) 2000-08-23
ATE396735T1 (de) 2008-06-15
DE69033705T3 (de) 2007-07-12
DE69034253D1 (de) 2008-07-10
ES2155819T5 (es) 2007-09-16
HK1013298A1 (en) 1999-08-20
DE69033705T2 (de) 2001-08-02
LU91498I2 (fr) 2009-01-19
JP2002325589A (ja) 2002-11-12
DK1029870T3 (da) 2008-09-29
DK0526452T3 (da) 2001-06-18
ES2308826T3 (es) 2008-12-01
CA2072642C (en) 2002-07-23
EP1029870A3 (en) 2000-12-13
NL300372I1 (nl) 2009-02-02
CA2072642A1 (en) 1991-05-23
DK0526452T4 (da) 2007-05-07
US5116964A (en) 1992-05-26
DE122008000063I2 (de) 2011-06-16
WO1991008298A3 (en) 1991-10-17
EP1970386A2 (en) 2008-09-17
GR3035856T3 (en) 2001-08-31
ATE199261T1 (de) 2001-03-15
EP1029870B1 (en) 2008-05-28
DE69033705D1 (de) 2001-03-29
EP0526452A1 (en) 1993-02-10
EP0526452B2 (en) 2007-01-03
EP1970386A8 (en) 2009-07-08
HK1030222A1 (en) 2001-04-27

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