PE20081250A1 - FUSIONES Fc CON RECEPTOR PARA FGF SOLUBLE MODIFICADAS, CON ACTIVIDAD BIOLOGICA MEJORADA - Google Patents

FUSIONES Fc CON RECEPTOR PARA FGF SOLUBLE MODIFICADAS, CON ACTIVIDAD BIOLOGICA MEJORADA

Info

Publication number
PE20081250A1
PE20081250A1 PE2007001663A PE2007001663A PE20081250A1 PE 20081250 A1 PE20081250 A1 PE 20081250A1 PE 2007001663 A PE2007001663 A PE 2007001663A PE 2007001663 A PE2007001663 A PE 2007001663A PE 20081250 A1 PE20081250 A1 PE 20081250A1
Authority
PE
Peru
Prior art keywords
receiver
fgf
fusions
modified soluble
biological activity
Prior art date
Application number
PE2007001663A
Other languages
English (en)
Inventor
Mark Nesbit
Beatrice Cameron
Sylvie Sordello
Francis Blanche
Marc Trombe
Celine Nicolazi
Original Assignee
Centelion
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39431092&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20081250(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Centelion filed Critical Centelion
Publication of PE20081250A1 publication Critical patent/PE20081250A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"

Abstract

SE REFIERE A UNA PROTEINA DE FUSION Fc CON RECEPTOR PARA EL FACTOR DE CRECIMIENTO FIBROBLASTICO (FGF) SOLUBLE MODIFICADA QUE COMPRENDE UNA FUSION DE A) UN FRAGMENTO O DOMINIO SOLUBLE DEL RECEPTOR PARA FGF QUE TIENE UNA SECUENCIA POLIPEPTIDICA SEQ ID Nº: 4; B) UNA REGION Fc DE UNA INMUNOGLOBULINA QUE TIENE UNA SECUENCIA POLIPEPTIDICA SEQ ID Nº: 6; Y C) UNA SECUENCIA ENLAZADORA DE 3 RESTOS DE AMINOACIDOS TAL COMO SAL (SER-ALA-LEU), DONDE AL MENOS EL 5º SITIO DE N-GLICOSILACION DE LA PORCION DEL RECEPTOR PARA FGF ESTA OCUPADO Y COMO MAXIMO 45% DE LOS N-GLICANOS DEL RECEPTOR NO TIENEN GRUPO SIALILO. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA DE LA PROTEINA DE FUSION QUE ADEMAS PUEDE CONTENER TAXOL O TAXOTERE. DICHAS PROTEINAS DE FUSION TIENEN ACTIVIDAD ANTIANGIOGENICA Y CITOTOXICA SIENDO UTILES EN EL TRATAMIENTO DE CARCINOMA DE MAMA, COLON, DE RINON, LEUCEMIA, MELANOMA
PE2007001663A 2006-11-28 2007-11-27 FUSIONES Fc CON RECEPTOR PARA FGF SOLUBLE MODIFICADAS, CON ACTIVIDAD BIOLOGICA MEJORADA PE20081250A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06291824 2006-11-28
EP07290042 2007-01-11

Publications (1)

Publication Number Publication Date
PE20081250A1 true PE20081250A1 (es) 2008-10-07

Family

ID=39431092

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007001663A PE20081250A1 (es) 2006-11-28 2007-11-27 FUSIONES Fc CON RECEPTOR PARA FGF SOLUBLE MODIFICADAS, CON ACTIVIDAD BIOLOGICA MEJORADA

Country Status (33)

Country Link
US (3) US8119770B2 (es)
EP (1) EP2092069B2 (es)
JP (1) JP2010510801A (es)
KR (1) KR20090102769A (es)
AR (1) AR063975A1 (es)
AT (1) ATE509106T1 (es)
AU (1) AU2007326985C1 (es)
BR (1) BRPI0719290A2 (es)
CA (1) CA2668932A1 (es)
CL (1) CL2007003411A1 (es)
CO (1) CO6190564A2 (es)
CR (1) CR10777A (es)
CY (1) CY1112435T1 (es)
DK (1) DK2092069T3 (es)
EA (1) EA018700B1 (es)
EC (1) ECSP099361A (es)
GT (1) GT200900137A (es)
HR (1) HRP20110503T1 (es)
IL (1) IL198480A0 (es)
MA (1) MA31143B1 (es)
MX (1) MX2009005692A (es)
MY (1) MY145914A (es)
NI (1) NI200900097A (es)
NO (1) NO20092414L (es)
PE (1) PE20081250A1 (es)
PL (1) PL2092069T3 (es)
PT (1) PT2092069E (es)
RS (1) RS51911B (es)
SI (1) SI2092069T1 (es)
SV (1) SV2009003272A (es)
TN (1) TN2009000184A1 (es)
TW (1) TW200839012A (es)
WO (1) WO2008065543A2 (es)

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Also Published As

Publication number Publication date
EA200970515A1 (ru) 2009-12-30
AU2007326985B2 (en) 2013-08-15
MX2009005692A (es) 2009-10-12
BRPI0719290A2 (pt) 2014-02-25
US20100061979A1 (en) 2010-03-11
ATE509106T1 (de) 2011-05-15
TN2009000184A1 (en) 2010-10-18
US20140030265A1 (en) 2014-01-30
CO6190564A2 (es) 2010-08-19
DK2092069T3 (da) 2011-08-29
US20120195851A1 (en) 2012-08-02
SI2092069T1 (sl) 2011-09-30
US8481487B2 (en) 2013-07-09
EP2092069B2 (en) 2013-12-18
PL2092069T3 (pl) 2011-10-31
GT200900137A (es) 2011-09-02
PT2092069E (pt) 2011-07-29
TW200839012A (en) 2008-10-01
SV2009003272A (es) 2010-02-05
US8119770B2 (en) 2012-02-21
WO2008065543A3 (en) 2008-08-14
CL2007003411A1 (es) 2008-07-04
AU2007326985C1 (en) 2014-02-20
HRP20110503T1 (hr) 2011-08-31
EA018700B1 (ru) 2013-10-30
RS51911B (en) 2012-02-29
CA2668932A1 (en) 2008-06-05
ECSP099361A (es) 2009-06-30
MY145914A (en) 2012-05-15
CR10777A (es) 2009-07-23
KR20090102769A (ko) 2009-09-30
NI200900097A (es) 2010-01-26
CY1112435T1 (el) 2015-12-09
EP2092069A2 (en) 2009-08-26
WO2008065543A2 (en) 2008-06-05
MA31143B1 (fr) 2010-02-01
IL198480A0 (en) 2011-08-01
AR063975A1 (es) 2009-03-04
JP2010510801A (ja) 2010-04-08
EP2092069B1 (en) 2011-05-11
AU2007326985A1 (en) 2008-06-05
NO20092414L (no) 2009-08-21

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