ATE551329T1 - Chinazolinonderivate und deren verwendung als cb- agonisten - Google Patents

Chinazolinonderivate und deren verwendung als cb- agonisten

Info

Publication number: ATE551329T1
Authority: AT; Austria
Prior art keywords: agonists; quinazolinone derivatives; quinazolinone; derivatives
Prior art date: 2002-02-06

Application number

AT03737316T

Other languages

English (en)

Inventor

Christopher Brain

Edward Dziadulewicz

Terance Hart

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-02-06

Filing date

2003-02-05

Publication date

2012-04-15

2002-02-06 Priority claimed from GB0202755A external-priority patent/GB0202755D0/en

2002-06-10 Priority claimed from GB0213285A external-priority patent/GB0213285D0/en

2002-09-16 Priority claimed from GB0221460A external-priority patent/GB0221460D0/en

2002-09-16 Priority claimed from GB0221459A external-priority patent/GB0221459D0/en

2003-02-05 Application filed by Novartis Ag filed Critical Novartis Ag

2012-04-15 Application granted granted Critical

2012-04-15 Publication of ATE551329T1 publication Critical patent/ATE551329T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

AT03737316T 2002-02-06 2003-02-05 Chinazolinonderivate und deren verwendung als cb- agonisten ATE551329T1 (de)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
GB0202755A GB0202755D0 (en)	2002-02-06	2002-02-06	Organic compounds
GB0213285A GB0213285D0 (en)	2002-06-10	2002-06-10	Organic compound
GB0221460A GB0221460D0 (en)	2002-09-16	2002-09-16	Organic compound
GB0221459A GB0221459D0 (en)	2002-09-16	2002-09-16	Organic compound
PCT/EP2003/001140 WO2003066603A1 (en)	2002-02-06	2003-02-05	Quinazolinone derivatives and their use as cb agonists

Publications (1)

Publication Number	Publication Date
ATE551329T1 true ATE551329T1 (de)	2012-04-15

Family

ID=27739227

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03737316T ATE551329T1 (de)	2002-02-06	2003-02-05	Chinazolinonderivate und deren verwendung als cb- agonisten

Country Status (22)

Country	Link
US (2)	US20050085493A1 (de)
EP (2)	EP1472234B1 (de)
JP (2)	JP4428479B2 (de)
KR (1)	KR100954626B1 (de)
CN (1)	CN100579968C (de)
AR (1)	AR038483A1 (de)
AT (1)	ATE551329T1 (de)
AU (1)	AU2003210212A1 (de)
BR (1)	BR0307461A (de)
CA (1)	CA2471974C (de)
CO (1)	CO5601021A2 (de)
EC (1)	ECSP045219A (de)
ES (1)	ES2384967T3 (de)
HK (1)	HK1079518A1 (de)
MX (1)	MXPA04007641A (de)
MY (1)	MY143958A (de)
NO (1)	NO328305B1 (de)
NZ (1)	NZ571615A (de)
PE (1)	PE20030867A1 (de)
PL (1)	PL370657A1 (de)
TW (1)	TW200306839A (de)
WO (1)	WO2003066603A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1163237B1 (de)	1999-03-17	2004-05-06	AstraZeneca AB	Amid-derivate
TW200306839A (en)	2002-02-06	2003-12-01	Novartis Ag	Quinazolinone derivatives and their use as CB agonists
GB0324790D0 (en)	2003-10-24	2003-11-26	Astrazeneca Ab	Amide derivatives
ATE452890T1 (de)	2003-11-04	2010-01-15	Merck & Co Inc	Substituierte naphthyridinonderivate
SE0303491D0 (sv) *	2003-12-19	2003-12-19	Astrazeneca Ab	New use VI
CN100506802C (zh) *	2004-06-04	2009-07-01	中国科学院上海药物研究所	一类甲酰肽样受体-1调节剂、其制备方法和用途
GB0413618D0 (en) *	2004-06-17	2004-07-21	Novartis Ag	Organic compounds
EP1904068A1 (de) *	2005-07-11	2008-04-02	N.V. Organon	Synergistische kombination zur behandlung von schmerzen (cannabinoid-rezeptor-agonist und opioid-rezeptor-agonist)
GB0525068D0 (en)	2005-12-08	2006-01-18	Novartis Ag	Organic compounds
US20090209536A1 (en) *	2007-06-17	2009-08-20	Kalypsys, Inc.	Aminoquinazoline cannabinoid receptor modulators for treatment of disease
US8349852B2 (en)	2009-01-13	2013-01-08	Novartis Ag	Quinazolinone derivatives useful as vanilloid antagonists
FR2944013B1 (fr) *	2009-04-07	2011-07-15	Sanofi Aventis	Derives de 1-alkyl-cinnolin-4(1h)-one substitues,leur preparation et leur application en therapeutique.
WO2011092293A2 (en)	2010-02-01	2011-08-04	Novartis Ag	Cyclohexyl amide derivatives as crf receptor antagonists
JP2013518085A (ja)	2010-02-01	2013-05-20	ノバルティスアーゲー	ＣＲＦ−１受容体アンタゴニストとしてのピラゾロ［５，１ｂ］オキサゾール誘導体
JP5748777B2 (ja)	2010-02-02	2015-07-15	ノバルティスアーゲー	Ｃｒｆ受容体アンタゴニストとしてのシクロヘキシルアミド誘導体
US8546416B2 (en)	2011-05-27	2013-10-01	Novartis Ag	3-spirocyclic piperidine derivatives as ghrelin receptor agonists
EA201491990A1 (ru)	2012-05-03	2015-02-27	Новартис Аг	L-малатная соль 2,7-диазаспиро[4.5]дец-7-иловых производных и их кристаллические формы в качестве агонистов грелиновых рецепторов
UY35675A (es)	2013-07-24	2015-02-27	Novartis Ag	Derivados sustituidos de quinazolin-4-ona
CN106146414A (zh) *	2016-07-07	2016-11-23	浙江大学	喹唑啉二酮类衍生物及其制备方法和用途
CN106831502A (zh) *	2017-03-13	2017-06-13	苏州市泽宸贸易有限公司	邻硝基苯磺酰氯、其合成方法及应用
CN109796360B (zh) *	2019-01-30	2022-03-18	上海阿拉丁生化科技股份有限公司	一种3-氨基-2-萘甲酸类化合物的制备工艺

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR6200M (de)	1967-04-18	1968-07-22
DE1803210A1 (de)	1968-10-16	1970-05-14	Troponwerke Dinklage & Co	2-Methyl-3-(3-[4-phenylpiperazinyl-(1)]-2-hydroxypropyl)-chinazolinon-(4) und Verfahren zu seiner Herstellung
JPS5657768A (en) *	1979-10-18	1981-05-20	Masayuki Ishikawa	Novel 4-quinazolone derivative substituted by aromatic residue at 3-position
NZ192392A (en) *	1978-12-19	1983-02-15	M Ishikawa	3-(substituted (phenyl or pyridyl)) -3,4-dihydroquinazolin-4-ones
AU543928B2 (en) *	1981-01-16	1985-05-09	Masayuki Ishikawa	4(311)-quinazolinone derivatives
JPS57118570A (en) *	1981-01-16	1982-07-23	Masayuki Ishikawa	Novel 3-phenyl-4-quinazolone derivative
WO1993023082A1 (en) *	1992-05-13	1993-11-25	Alcon Laboratories, Inc.	Topical ophthalmic compositions comprising a combination of calcium antagonists with known antiglaucoma agents
KR19990082330A (ko)	1996-02-06	1999-11-25	미즈노 마사루	신규 화합물 및 이의 의약 용도
TW200306839A (en)	2002-02-06	2003-12-01	Novartis Ag	Quinazolinone derivatives and their use as CB agonists
SE0303491D0 (sv)	2003-12-19	2003-12-19	Astrazeneca Ab	New use VI
GB0413618D0 (en) *	2004-06-17	2004-07-21	Novartis Ag	Organic compounds

2003
- 2003-01-30 TW TW092102105A patent/TW200306839A/zh unknown
- 2003-02-04 PE PE2003000129A patent/PE20030867A1/es not_active Application Discontinuation
- 2003-02-04 AR ARP030100347A patent/AR038483A1/es unknown
- 2003-02-05 ES ES03737316T patent/ES2384967T3/es not_active Expired - Lifetime
- 2003-02-05 AT AT03737316T patent/ATE551329T1/de active
- 2003-02-05 BR BR0307461-7A patent/BR0307461A/pt active Search and Examination
- 2003-02-05 PL PL03370657A patent/PL370657A1/xx unknown
- 2003-02-05 EP EP03737316A patent/EP1472234B1/de not_active Expired - Lifetime
- 2003-02-05 CA CA2471974A patent/CA2471974C/en not_active Expired - Fee Related
- 2003-02-05 EP EP10175740A patent/EP2319839A1/de not_active Withdrawn
- 2003-02-05 WO PCT/EP2003/001140 patent/WO2003066603A1/en active Application Filing
- 2003-02-05 JP JP2003565977A patent/JP4428479B2/ja not_active Expired - Fee Related
- 2003-02-05 KR KR1020047012147A patent/KR100954626B1/ko not_active IP Right Cessation
- 2003-02-05 CN CN03803448A patent/CN100579968C/zh not_active Expired - Fee Related
- 2003-02-05 US US10/503,779 patent/US20050085493A1/en not_active Abandoned
- 2003-02-05 MY MYPI20030387A patent/MY143958A/en unknown
- 2003-02-05 NZ NZ571615A patent/NZ571615A/en not_active IP Right Cessation
- 2003-02-05 MX MXPA04007641A patent/MXPA04007641A/es unknown
- 2003-02-05 AU AU2003210212A patent/AU2003210212A1/en not_active Abandoned
2004
- 2004-08-04 EC EC2004005219A patent/ECSP045219A/es unknown
- 2004-08-25 CO CO04083224A patent/CO5601021A2/es not_active Application Discontinuation
- 2004-08-27 NO NO20043580A patent/NO328305B1/no not_active IP Right Cessation
2005
- 2005-12-14 HK HK05111474.7A patent/HK1079518A1/xx not_active IP Right Cessation
2007
- 2007-06-26 US US11/823,315 patent/US8552015B2/en not_active Expired - Fee Related
2009
- 2009-01-22 JP JP2009012064A patent/JP2009149658A/ja active Pending

Also Published As

Publication number	Publication date
WO2003066603A1 (en)	2003-08-14
CN1628104A (zh)	2005-06-15
TW200306839A (en)	2003-12-01
US8552015B2 (en)	2013-10-08
PE20030867A1 (es)	2003-12-04
ES2384967T3 (es)	2012-07-16
CO5601021A2 (es)	2006-01-31
NO328305B1 (no)	2010-01-25
EP1472234B1 (de)	2012-03-28
BR0307461A (pt)	2004-11-09
PL370657A1 (en)	2005-05-30
NZ571615A (en)	2010-01-29
ECSP045219A (es)	2004-09-28
CN100579968C (zh)	2010-01-13
NO20043580L (no)	2004-09-21
EP2319839A1 (de)	2011-05-11
KR100954626B1 (ko)	2010-04-27
KR20040083501A (ko)	2004-10-02
JP4428479B2 (ja)	2010-03-10
HK1079518A1 (en)	2006-04-07
JP2009149658A (ja)	2009-07-09
CA2471974A1 (en)	2003-08-14
MY143958A (en)	2011-07-29
CA2471974C (en)	2011-11-22
US20050085493A1 (en)	2005-04-21
US20070265285A1 (en)	2007-11-15
NO20043580D0 (no)	2004-08-27
EP1472234A1 (de)	2004-11-03
AU2003210212A1 (en)	2003-09-02
JP2005522439A (ja)	2005-07-28
AR038483A1 (es)	2005-01-19
MXPA04007641A (es)	2004-11-10

Publication	Publication Date	Title
ATE551329T1 (de)	2012-04-15	Chinazolinonderivate und deren verwendung als cb- agonisten
ATE419849T1 (de)	2009-01-15	Diaminotriazole derivate und deren verwendung als protein kinase inhibitoren
ATE394102T1 (de)	2008-05-15	Substituierte chinazolin-derivate und deren verwendung als aurora-2-kinase inhibitoren
DE602004021037D1 (de)	2009-06-18	Phosphororganische indazolderivate und deren verwendung als proteinkinaseinhibitoren
DE60332023D1 (de)	2010-05-20	Chinolinderivate und deren verwendung als mycobakterielle inhibitoren
DE60321043D1 (de)	2008-06-26	Biphenylderivate und deren verwendung als fungizide
ATE398108T1 (de)	2008-07-15	Chinolinderivate und deren verwendung als 5-ht6 liganden
DE60328087D1 (de)	2009-08-06	Aryl substituierte pyrimidine und deren verwendung
DE60317093D1 (de)	2007-12-06	Chinolin-; isochinolin- und chinazolinoxyalkylamide und ihre verwendung als fungizide
DE602005004144D1 (de)	2008-02-14	Octahydropyrroloä3,4-cüpyrrolderivate und deren verwendung als antivirale mitteln
ATE378338T1 (de)	2007-11-15	Pyrrolopyridinderivate und deren verwendung als crth2-antagonisten
ATE377591T1 (de)	2007-11-15	Pyrimidinderivate und deren verwendung als cb2- modulatoren
DE60314600D1 (de)	2007-08-09	O-cyclopropyl-carboxanilide und ihre verwendung als fungizide
DE60113719D1 (de)	2006-02-09	Chinuclidincarbamat derivate und deren verwendung als m3 antagonisten
DE60208661D1 (de)	2006-04-06	Diaminothiazole und ihre verwendung als cyclinabhängige kinase inhibitoren
ATE418543T1 (de)	2009-01-15	Substituierte 1,4-dipiperidin-4-yl- piperazinderivate und deren verwendung als neurokininantagonisten
DE50311397D1 (de)	2009-05-20	Heterocyclisch substituierte indolinone und deren verwendung als rezeptor-tyrosinkinasen inhibitoren
ATE396185T1 (de)	2008-06-15	Substituierte 4-alkyl- und 4- alkanoylpiperidinderivate und deren verwendung als neurokininantagonisten
DE60321958D1 (de)	2008-08-14	Indazolderivate und ihre verwendung als crf antagonisten
ATE500242T1 (de)	2011-03-15	Substituierte 1-piperidin-4-yl-pyrrolidin-3-yl- piperazinderivate und deren verwendung als neurokinin antagonisten
ATE348805T1 (de)	2007-01-15	2-acyl-indolderivate und deren verwendung als antitumormittel
ATE555097T1 (de)	2012-05-15	4-cycloalkyl-substituierte tetrahydrochinolinderivate und deren verwendung als medikamente
DE50206476D1 (de)	2006-05-24	Cyanoanthranylamid-derivate und deren verwendung als arzneimittel
ATE353083T1 (de)	2007-02-15	Naphthyridin-derivate und ihre verwendung als fungizide
ATE361295T1 (de)	2007-05-15	Substituierte diketopiperazine und deren verwendung als oxytocynantagonisten