ATE234830T1 - 4-alkenyl (und alkinyl)oxoindole als inhibitoren cyclinabhängiger kinasen, insbesondere cdk2 - Google Patents

4-alkenyl (und alkinyl)oxoindole als inhibitoren cyclinabhängiger kinasen, insbesondere cdk2

Info

Publication number
ATE234830T1
ATE234830T1 AT99963422T AT99963422T ATE234830T1 AT E234830 T1 ATE234830 T1 AT E234830T1 AT 99963422 T AT99963422 T AT 99963422T AT 99963422 T AT99963422 T AT 99963422T AT E234830 T1 ATE234830 T1 AT E234830T1
Authority
AT
Austria
Prior art keywords
oxoindoles
alkinyl
cyclin
alkenyl
inhibitors
Prior art date
Application number
AT99963422T
Other languages
English (en)
Inventor
Yi Chen
Wendy Lea Corbett
Apostolos Dermatakis
Jin-Jun Liu
Kin-Chun Luk
Paige E Mahaney
Steven Gregory Mischke
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE234830T1 publication Critical patent/ATE234830T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
AT99963422T 1998-12-17 1999-12-08 4-alkenyl (und alkinyl)oxoindole als inhibitoren cyclinabhängiger kinasen, insbesondere cdk2 ATE234830T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11259198P 1998-12-17 1998-12-17
US14907399P 1999-08-16 1999-08-16
PCT/EP1999/009624 WO2000035908A1 (en) 1998-12-17 1999-12-08 4-alkenyl (and alkynyl) oxindoles as inhibitors of cyclin-dependent kinases, in particular cdk2

Publications (1)

Publication Number Publication Date
ATE234830T1 true ATE234830T1 (de) 2003-04-15

Family

ID=26810131

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99963422T ATE234830T1 (de) 1998-12-17 1999-12-08 4-alkenyl (und alkinyl)oxoindole als inhibitoren cyclinabhängiger kinasen, insbesondere cdk2

Country Status (20)

Country Link
US (3) US6130239A (de)
EP (1) EP1157019B1 (de)
JP (1) JP2002532492A (de)
KR (1) KR100649925B1 (de)
CN (1) CN1138773C (de)
AR (1) AR024847A1 (de)
AT (1) ATE234830T1 (de)
AU (1) AU770375B2 (de)
BR (1) BR9916327A (de)
CA (1) CA2354873A1 (de)
CO (1) CO5261600A1 (de)
DE (1) DE69906152T2 (de)
DK (1) DK1157019T3 (de)
ES (1) ES2192877T3 (de)
PE (1) PE20001537A1 (de)
PT (1) PT1157019E (de)
TR (1) TR200101860T2 (de)
TW (1) TW550262B (de)
UY (1) UY25857A1 (de)
WO (1) WO2000035908A1 (de)

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US6878733B1 (en) 1999-11-24 2005-04-12 Sugen, Inc. Formulations for pharmaceutical agents ionizable as free acids or free bases
ATE514676T1 (de) * 1999-11-24 2011-07-15 Sugen Inc Ionisierbare indolinon derivate und deren verwendung als ptk liganden
MXPA02006263A (es) * 1999-12-22 2004-02-26 Sugen Inc Metodos de modulacion de la funcion de la cinasa de tirosina c-kit de la proteina con compuestos de indolinona.
ME00415B (me) * 2000-02-15 2011-10-10 Pharmacia & Upjohn Co Llc Pirol supstituisani 2-indol protein kinazni inhibitori
EP1272483A2 (de) * 2000-03-24 2003-01-08 Millenium Pharmaceuticals, Inc. Oxindole als faktor xa inhibitoren
TWI270545B (en) 2000-05-24 2007-01-11 Sugen Inc Mannich base prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
AU2001268154A1 (en) 2000-06-02 2001-12-17 Sugen, Inc. Indolinone derivatives as protein kinase/phosphatase inhibitors
WO2002002551A1 (en) * 2000-06-30 2002-01-10 Sugen, Inc. 4-heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors
JP2004518669A (ja) * 2000-12-20 2004-06-24 スージェン・インコーポレーテッド ４−アリール置換インドリノン
US6504034B2 (en) 2001-01-23 2003-01-07 Hoffmann-La Roche Inc. Naphthostyrils
AR042586A1 (es) * 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
FR2822155B1 (fr) 2001-03-13 2003-12-12 Aventis Pharma Sa Composes derives des oxindoles et leur application therapeutique en cancerologie
EA006445B9 (ru) * 2001-08-15 2017-02-28 Фармация Энд Апджон Компани Кристаллы, содержащие соль яблочной кислоты n-[2-(диэтиламино)этил]-5-[(5-фторо-2-оксо-1,2-дигидро-3h-индол-3-илиден)метил]-2,4-диметил-1h-пиррол-3-карбоксамида, способы их получения и их композиции
WO2003031438A1 (en) 2001-10-10 2003-04-17 Sugen, Inc. 3-[4-(substituted heterocyclyl)-pyrrol-2-ylmethylidene]-2-indolinone derivatives as kinase inhibitors
EP1458713B1 (de) * 2001-12-27 2005-08-24 Theravance, Inc. Indolinon-derivative als protein-kinasehemmer
FR2948940B1 (fr) * 2009-08-04 2011-07-22 Servier Lab Nouveaux derives dihydroindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2012178015A2 (en) * 2011-06-24 2012-12-27 Zenobia Therapeutics, Inc. Lrrk2 inhibitors
CN106187904B (zh) * 2015-05-25 2021-07-06 中国医学科学院药物研究所 含丙炔酰胺基的2-苯基咪唑类衍生物及其制法和药物组合物与用途
MX2020002944A (es) 2017-09-14 2020-09-28 Daiichi Sankyo Co Ltd Compuesto que tiene estructura ciclica.
AR124154A1 (es) 2020-11-27 2023-02-22 Rhizen Pharmaceuticals Ag Inhibidores de cdk
WO2022149057A1 (en) 2021-01-05 2022-07-14 Rhizen Pharmaceuticals Ag Cdk inhibitors

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EP1247803A3 (de) * 1996-08-23 2002-10-16 Sugen, Inc. Indolinon-Verbindungen und deren Verwendung als Protein- Kinase-Modulatoren
WO1998024432A2 (en) * 1996-12-05 1998-06-11 Sugen, Inc. Use of indolinone compounds as modulators of protein kinases
JP2002511852A (ja) * 1997-05-07 2002-04-16 スージェン・インコーポレーテッド 蛋白質キナーゼ活性の調節剤としての２−インドリノン誘導体
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EP1066257A2 (de) * 1998-03-26 2001-01-10 Sugen, Inc. Heterozyklische stoffklassen für die modulation der tyrosine protein kinase
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Also Published As

Publication number Publication date
DK1157019T3 (da) 2003-07-14
US6303793B1 (en) 2001-10-16
AU1972700A (en) 2000-07-03
AU770375B2 (en) 2004-02-19
EP1157019B1 (de) 2003-03-19
CN1138773C (zh) 2004-02-18
UY25857A1 (es) 2001-07-31
US6252086B1 (en) 2001-06-26
JP2002532492A (ja) 2002-10-02
PT1157019E (pt) 2003-06-30
TW550262B (en) 2003-09-01
BR9916327A (pt) 2001-09-18
PE20001537A1 (es) 2001-01-09
DE69906152T2 (de) 2004-02-12
US6130239A (en) 2000-10-10
CO5261600A1 (es) 2003-03-31
CN1330647A (zh) 2002-01-09
ES2192877T3 (es) 2003-10-16
KR20010101274A (ko) 2001-11-14
KR100649925B1 (ko) 2007-02-28
WO2000035908A1 (en) 2000-06-22
EP1157019A1 (de) 2001-11-28
TR200101860T2 (tr) 2001-12-21
CA2354873A1 (en) 2000-06-22
DE69906152D1 (de) 2003-04-24
AR024847A1 (es) 2002-10-30

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